Molecular Mechanism to Maintain Stem Cell Renewal of ES Cells
Embryonic stem (ES) cells are pluripotent cells directly derived from early stage embryos that retain the ability to differentiate into all cell types. This unique feature is the basis of various applications of ES cell technology such as in vitro models of mammalian development, germline transgenes...
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| Published in | Cell Structure and Function Vol. 26; no. 3; pp. 137 - 148 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Japan
Japan Society for Cell Biology
01.06.2001
Japan Science and Technology Agency |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Embryonic stem (ES) cells are pluripotent cells directly derived from early stage embryos that retain the ability to differentiate into all cell types. This unique feature is the basis of various applications of ES cell technology such as in vitro models of mammalian development, germline transgenesis to make knockout mice, and a generic source for cell therapy in regenerative medicine. To achieve success in these applications, the pluripotency of ES cells has to be kept stable during long-term culture in vitro, leading to the necessity of determining the molecular basis for maintaining ES self-renewal. This paper summarizes the recent progress in this area, focusing mainly on the LIF signaling pathway and the transcription factor Oct-3/4. Although it is still unclear how these components works together, a model is presented here that provides a plan to solve this problem. |
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| AbstractList | Embryonic stem (ES) cells are pluripotent cells directly derived from early stage embryos that retain the ability to differentiate into all cell types. This unique feature is the basis of various applications of ES cell technology such as in vitro models of mammalian development, germline transgenesis to make knockout mice, and a generic source for cell therapy in regenerative medicine. To achieve success in these applications, the pluripotency of ES cells has to be kept stable during long-term culture in vitro, leading to the necessity of determining the molecular basis for maintaining ES self-renewal. This paper summarizes the recent progress in this area, focusing mainly on the LIF signaling pathway and the transcription factor Oct-3/4. Although it is still unclear how these components works together, a model is presented here that provides a plan to solve this problem. |
| Author | Niwa, Hitoshi |
| Author_xml | – sequence: 1 fullname: Niwa, Hitoshi organization: Stem Cell Regulation Research, Area of Molecular Therapeutics, Course of Advanced Medicine, Osaka University Graduate School of Medicine |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/11565806$$D View this record in MEDLINE/PubMed |
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| Snippet | Embryonic stem (ES) cells are pluripotent cells directly derived from early stage embryos that retain the ability to differentiate into all cell types. This... |
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| SubjectTerms | Animals Base Sequence Cattle DNA-Binding Proteins - physiology Embryo, Mammalian - physiology ES cell Evolution, Molecular Gene Expression Regulation, Developmental Growth Inhibitors - physiology Humans Interleukin-6 Leukemia Inhibitory Factor LIF Lymphokines - physiology Mice Models, Biological Molecular Sequence Data Oct-3/4 Octamer Transcription Factor-3 pluripotency Signal Transduction - physiology Stat3 Stem Cells - metabolism Stem Cells - physiology Transcription Factors |
| Title | Molecular Mechanism to Maintain Stem Cell Renewal of ES Cells |
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