Effects of pantoprazole and esomeprazole on platelet inhibition by clopidogrel

• Published in: The American heart journal Vol. 157; no. 1; pp. 148.e1 - 148.e5
• Main Authors: Siller-Matula, Jolanta M., Spiel, Alexander O., Lang, Irene M., Kreiner, Gerhard, Christ, Guenter, Jilma, Bernd
• Format: Journal Article
• Language: English
• Published: United States Mosby, Inc 2009; Elsevier Limited
• Subjects: 2-Pyridinylmethylsulfinylbenzimidazoles - pharmacology; Aged; Blood platelets; Blood Platelets - drug effects; Blood Platelets - physiology; Cardiovascular; Cardiovascular disease; Confidence intervals; Coronary vessels; Demographics; Diabetes; Drug dosages; Drug Interactions; Drug therapy; Enzymes; Esomeprazole; Family medical history; Female; Heart attacks; Humans; Hypertension; Logistics; Male; Middle Aged; Omeprazole - pharmacology; Phosphorylation; Platelet Aggregation Inhibitors - pharmacology; Proton Pump Inhibitors - pharmacology; Ticlopidine - analogs & derivatives; Ticlopidine - pharmacology

Clopidogrel is activated by CYP2C19, which also metabolizes proton pump inhibitors (PPI). As proton pump inhibitors are metabolized to varying degrees by CYP2C19, we hypothesized that the reported negative omeprazole-clopidogrel drug interaction may not be a class effect. Responsiveness to clopidogr...