Targeted inhibition of tumor-derived exosomes as a novel therapeutic option for cancer

• Published in: Experimental & molecular medicine Vol. 54; no. 9; pp. 1379 - 1389
• Main Authors: Li, Ye, Chen, Zhuo-Kun, Duan, Xu, Zhang, He-Jing, Xiao, Bo-Lin, Wang, Kui-Ming, Chen, Gang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2022; Springer Nature B.V; 생화학분자생물학회
• Subjects: 101/47; 42/89; 631/67/1059/602; 631/67/327; 96/44; Antitumor activity; Antitumor agents; Autocrine signalling; Biomedical and Life Sciences; Biomedicine; Cancer; Cancer therapies; Chemotherapy; Dialysis; Drug resistance; Exosomes; Exosomes - pathology; Humans; Immune clearance; Immune response; Immunosuppressive agents; Immunotherapy; Invasiveness; Medical Biochemistry; Molecular Medicine; Neoplasms - pathology; Paracrine signalling; Patients; Review; Review Article; Stem Cells; Tumor Microenvironment; Tumors; 생화학

Mounting evidence indicates that tumor-derived exosomes (TDEs) play critical roles in tumor development and progression by regulating components in the tumor microenvironment (TME) in an autocrine or paracrine manner. Moreover, due to their delivery of critical molecules that react to chemotherapy a...