Non-invasive quantification of cerebral glucose metabolism using Gjedde-Patlak plot and image-derived input function from the aorta

• Published in: NeuroImage (Orlando, Fla.) Vol. 253; p. 119079
• Main Authors: Henriksen, Alexander Cuculiza, Lonsdale, Markus Nowak, Fuglø, Dan, Kondziella, Daniel, Nersesjan, Vardan, Marner, Lisbeth
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2022; Elsevier Limited; Elsevier
• Subjects: [18F]FDG; Algorithms; Aorta; Aorta - diagnostic imaging; Aorta - metabolism; Blood levels; Brain; Brain - diagnostic imaging; Brain - metabolism; Cannulation; Cerebellum; Cerebral glucose metabolism; CMRglc; Coronary vessels; Cortex (frontal); Fluorodeoxyglucose F18 - metabolism; Glucose; Glucose - metabolism; Hippocampus; Humans; Metabolic rate; Metabolism; PET; Plasma; Positron emission tomography; Positron-Emission Tomography - methods; Radiopharmaceuticals - metabolism; Software; Values; Veins & arteries; United States > US; Chicago Illinois; [18F]FDG; Brain; Positron emission tomography; CMRglc; PET; Cerebral glucose metabolism; [F]FDG

We aimed at evaluating a Gjedde-Patlak plot and non-invasive image-derived input functions (IDIF) from the aorta to quantify cerebral glucose metabolic rate (CMRglc) in comparison to the reference standard based on sampling the arterial input function (AIF). Six healthy subjects received 200 MBq [18...