Lack of Gut Secretory Immunoglobulin A in Memory B-Cell Dysfunction-Associated Disorders: A Possible Gut-Spleen Axis

• Published in: Frontiers in immunology Vol. 10; p. 2937
• Main Authors: Carsetti, Rita, Di Sabatino, Antonio, Rosado, Maria Manuela, Cascioli, Simona, Piano Mortari, Eva, Milito, Cinzia, Grimsholm, Ola, Aranburu, Alaitz, Giorda, Ezio, Tinozzi, Francesco Paolo, Pulvirenti, Federica, Donato, Giuseppe, Morini, Francesco, Bagolan, Pietro, Corazza, Gino Roberto, Quinti, Isabella
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 08.01.2020
• Subjects: common variable immune deficiency; gut mucosal immunology; Immunology; plasma cell; splenectomy; transmembrane activator and calcium-modulator and cyclophilin ligand interactor; gut mucosal immunology; transmembrane activator and calcium-modulator and cyclophilin ligand interactor; common variable immune deficiency; plasma cell; splenectomy

B-1a B cells and gut secretory IgA (SIgA) are absent in asplenic mice. Human immunoglobulin M (IgM) memory B cells, which are functionally equivalent to mouse B-1a B cells, are reduced after splenectomy. To demonstrate whether IgM memory B cells are necessary for generating IgA-secreting plasma cell...