Scientific validation of the antimicrobial and antiproliferative potential of Berberis aristata DC root bark, its phytoconstituents and their biosafety

• Published in: AMB Express Vol. 9; no. 1; pp. 143 - 16
• Main Authors: Sood, Henna, Kumar, Yashwant, Gupta, Vipan Kumar, Arora, Daljit Singh
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 11.09.2019; Springer Nature B.V; SpringerOpen
• Subjects: Acetic acid; Acute oral toxicity; Antibiotics; Antiinfectives and antibacterials; Antimicrobial; Antimicrobial activity; Antimicrobial agents; Antiproliferatives; Bark; Berberis; Berberis aristata; Biomedical and Life Sciences; Biosafety; Biotechnology; Body weight; Cell lines; Cytotoxicity; Diterpenes; Ethyl acetate; Flavonoids; Life Sciences; Microbial Genetics and Genomics; Microbicides; Microbiology; Minimum inhibitory concentration; Optimization; Organs; Original; Original Article; Phytoconstituents; Post-antibiotic effect; Toxicity; Antimicrobial; Acute oral toxicity; Biosafety; Post-antibiotic effect; Phytoconstituents; Berberis aristata

Berberis aristata is an important part of traditional healing system from more than 2500 years. The aqueous extract of Berberis aristata root bark displayed broad spectrum activity against 13 test pathogens, ranging from 12 to 25 mm. In classical optimization, 15% concentration prepared at 40 °C for...