Genetic and Neuroimaging Features of Personality Disorders: State of the Art
Personality disorders often act as a common denominator for many psychiatric problems, and studies on personality disorders contribute to the etiopathology, diagnosis, and treatment of many mental disorders. In recent years, increasing evidence from various studies has shown distinctive features of...
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| Published in | Neuroscience bulletin Vol. 32; no. 3; pp. 286 - 306 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Singapore
Springer Singapore
01.06.2016
Springer |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1673-7067 1995-8218 |
| DOI | 10.1007/s12264-016-0027-8 |
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| Abstract | Personality disorders often act as a common denominator for many psychiatric problems, and studies on personality disorders contribute to the etiopathology, diagnosis, and treatment of many mental disorders. In recent years, increasing evidence from various studies has shown distinctive features of personality disorders, and that from genetic and neuroimaging studies has been especially valuable. Genetic studies primarily target the genes encoding neurotransmitters and enzymes in the serotoninergic and dopaminergic systems, and neuroimaging studies mainly focus on the frontal and temporal lobes as well as the limbic-paralimbic system in patients with personality disorders. Although some studies have suffered due to unclear diagnoses of personality disorders and some have included few patients for a given personality disorder, great opportunities remain for investigators to launch new ideas and technologies in the field. |
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| AbstractList | Personality disorders often act as a common denominator for many psychiatric problems, and studies on personality disorders contribute to the etiopathology, diagnosis, and treatment of many mental disorders. In recent years, increasing evidence from various studies has shown distinctive features of personality disorders, and that from genetic and neuroimaging studies has been especially valuable. Genetic studies primarily target the genes encoding neurotransmitters and enzymes in the serotoninergic and dopaminergic systems, and neuroimaging studies mainly focus on the frontal and temporal lobes as well as the limbic-paralimbic system in patients with personality disorders. Although some studies have suffered due to unclear diagnoses of personality disorders and some have included few patients for a given personality disorder, great opportunities remain for investigators to launch new ideas and technologies in the field. |
| Audience | Academic |
| Author | Shen, Chanchan Wang, Wei Ma, Guorong Fan, Hongying |
| Author_xml | – sequence: 1 givenname: Guorong surname: Ma fullname: Ma, Guorong organization: Department of Clinical Psychology and Psychiatry, Zhejiang University School of Medicine, Department of Psychology and Behavioral Sciences, Zhejiang University College of Science – sequence: 2 givenname: Hongying surname: Fan fullname: Fan, Hongying organization: Department of Clinical Psychology and Psychiatry, Zhejiang University School of Medicine – sequence: 3 givenname: Chanchan surname: Shen fullname: Shen, Chanchan organization: Department of Psychology and Behavioral Sciences, Zhejiang University College of Science – sequence: 4 givenname: Wei surname: Wang fullname: Wang, Wei email: wangmufan@msn.com, drwangwei@zju.edu.cn organization: Department of Clinical Psychology and Psychiatry, Zhejiang University School of Medicine, Department of Psychology and Behavioral Sciences, Zhejiang University College of Science |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27037690$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Anatomy Anesthesiology Biomedical and Life Sciences Biomedicine Calcium Channels, L-Type - genetics Care and treatment Catechol O-Methyltransferase - genetics Enzymes Genetic Predisposition to Disease - genetics Genetic research Human Physiology Humans Neuroimaging Neurology Neurophysiology Neurosciences Pain Medicine Personality disorders Personality Disorders - diagnostic imaging Personality Disorders - genetics Polymorphism, Single Nucleotide - genetics Review Serotonin Plasma Membrane Transport Proteins - genetics Temporal Lobe - diagnostic imaging |
| Title | Genetic and Neuroimaging Features of Personality Disorders: State of the Art |
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