Integration of CpG-free DNA induces de novo methylation of CpG islands in pluripotent stem cells - Takahashi, Yuta; Wu, Jun; Suzuki, Keiichiro; Martinez-Redondo, Paloma; Li, Mo; Liao, Hsin-Kai; Wu, Min-Zu; Hernández-Benítez, Reyna; Hishida, Tomoaki; Shokhirev, Maxim Nikolaievich; Esteban, Concepcion Rodriguez; Sancho-Martinez, Ignacio; et al. (Science (American Association for the Advancement of Science), 2017)
Keywords: Aberration; Cancer; CpG Islands; Deoxyribonucleic acid; Differentiation; Disorders; DNA; DNA - metabolism; DNA Methylation; DNA Mismatch Repair - genetics; DNA repair; DNA Repair - genetics; Editing; Epigenesis, Genetic; Gene expression; Gene sequencing; Genomes; Genomic imprinting; Humans; Individualized Instruction; Insertion; Integration; Islands; Mammals; Methylation; Mismatch repair; MLH1 protein; Mutagenesis, Insertional; MutL Protein Homolog 1 - genetics; Neurons - metabolism; Nucleotide sequence; Pluripotency; Pluripotent Stem Cells - metabolism; Proteins; Purines; Pyrimidines; Stem cells; Ubiquitin-Protein Ligases - genetics