Kynurenine 3-monooxygenase upregulates pluripotent genes through β-catenin and promotes triple-negative breast cancer progression

• Published in: EBioMedicine Vol. 54; p. 102717
• Main Authors: Huang, Tzu-Ting, Tseng, Ling-Ming, Chen, Ji-Lin, Chu, Pei-Yi, Lee, Chia-Han, Huang, Chun-Teng, Wang, Wan-Lun, Lau, Ka-Yi, Tseng, Mei-Fang, Chang, Yuan-Ya, Chiang, Tzu-Yi, Ueng, Yune-Fang, Lee, Hsin-Chen, Dai, Ming-Shen, Liu, Chun-Yu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2020; Elsevier
• Subjects: Animals; beta Catenin - genetics; beta Catenin - metabolism; Cell Line, Tumor; Cells, Cultured; Female; Gene Expression Regulation, Neoplastic; Hyaluronan Receptors - genetics; Hyaluronan Receptors - metabolism; KMO; Kynurenine 3-Monooxygenase - genetics; Kynurenine 3-Monooxygenase - metabolism; Mammary Neoplasms, Experimental - genetics; Mammary Neoplasms, Experimental - metabolism; Mammary Neoplasms, Experimental - pathology; Mice; Mice, Inbred BALB C; Mice, Nude; Nanog Homeobox Protein - genetics; Nanog Homeobox Protein - metabolism; Research paper; Signal Transduction; Triple negative breast cancer; Triple Negative Breast Neoplasms - genetics; Triple Negative Breast Neoplasms - metabolism; Triple Negative Breast Neoplasms - pathology; Up-Regulation; β-catenin; KMO; β-catenin; Triple negative breast cancer

Triple-negative breast cancer (TNBC) is aggressive and has a poor prognosis. Kynurenine 3-monooxygenase (KMO), a crucial kynurenine metabolic enzyme, is involved in inflammation, immune response and tumorigenesis. We aimed to study the role of KMO in TNBC. KMO alteration and expression data from pub...