Use of kernel-based Bayesian models to predict late osteolysis after hip replacement

• Published in: Journal of the Royal Society interface Vol. 10; no. 88; p. 20130678
• Main Authors: Aram, P., Kadirkamanathan, V., Wilkinson, J. M.
• Format: Journal Article
• Language: English
• Published: England The Royal Society 06.11.2013
• Subjects: Age Factors; Aged; Arthroplasty, Replacement, Hip - adverse effects; Bayes Theorem; Biomaterials; Female; Follow-Up Studies; Humans; Kernel Density Estimation; Male; Middle Aged; Models, Biological; Osteolysis; Osteolysis - epidemiology; Osteolysis - etiology; Prosthesis Failure; Retrospective Studies; Risk Factors; Sex Factors; kernel density estimation; biomaterials; osteolysis; Bayes theorem
• DOI: 10.1098/rsif.2013.0678
• ISSN: 1742-5689; 1742-5662

We studied the relationship between osteolysis and polyethylene wear, age at surgery, body mass index and height in 463 subjects (180 osteolysis and 283 controls) after cemented Charnley total hip arthroplasty (THA), in order to develop a kernel-based Bayesian model to quantitate risk of osteolysis. Such tools may be integrated into decision-making algorithms to help personalize clinical decision-making. A predictive model was constructed, and the estimated posterior probability of the implant failure calculated. Annual wear provided the greatest discriminatory information. Age at surgery provided additional predictive information and was added to the model. Body mass index and height did not contain valuable discriminatory information over the range in which observations were densely sampled. The robustness and misclassification rate of the predictive model was evaluated by a five-times cross-validation method. This yielded a 70% correct predictive classification of subjects into osteolysis versus non-osteolysis groups at a mean of 11 years after THA. Finally, the data were divided into male and female subsets to further explore the relationship between wear rate, age at surgery and incidence of osteolysis. The correct classification rate using age and wear rate in the model was approximately 66% for males and 74% for females.