Serum exosomal hsa-circ-0004771 modulates the resistance of colorectal cancer to 5-fluorouracil via regulating miR-653/ZEB2 signaling pathway

• Published in: Cancer cell international Vol. 23; no. 1; pp. 1 - 16
• Main Authors: Qiao, Xiao-Xue, Shi, Hui-Bo, Xiao, Li
• Format: Journal Article
• Language: English
• Published: London BioMed Central 16.10.2023; BMC
• Subjects: 5-Fluorouracil; Apoptosis; Biomarkers; Breast cancer; Cancer; Cancer therapies; Cell culture; Cell growth; Cell migration; Cell proliferation; Chemoresistance; Chemotherapy; Colorectal cancer; Colorectal carcinoma; Culture media; Drug resistance; Exosomes; Flow cytometry; Hsa-circ-0004771/miR-653/ZEB2 axis; Liver; Medical prognosis; Metastasis; mRNA; Patients; Prognosis; Proteins; Serum exosome; Signal transduction; Tumor suppressor genes; Tumors; Wound healing; United States > US

BackgroundDrug resistance is a major obstacle causing chemotherapy failure, and enabling cancer progression. Exosome excreted by cancer cells is participated in cancer progression and chemoresistance, and can be used as an prognostic biomarker. Previous studies have revealed that serum exosomal hsa-...