Insulin receptor substrate in brain-enriched exosomes in subjects with major depression: on the path of creation of biosignatures of central insulin resistance

• Published in: Molecular psychiatry Vol. 26; no. 9; pp. 5140 - 5149
• Main Authors: Nasca, Carla, Dobbin, Josh, Bigio, Benedetta, Watson, Kathleen, de Angelis, Paolo, Kautz, Marin, Cochran, Ashly, Mathé, Aleksander A., Kocsis, James H., Lee, Francis S., Murrough, James W., McEwen, Bruce S., Rasgon, Natalie
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2021; Nature Publishing Group
• Subjects: 631/337; 631/378; Behavioral plasticity; Behavioral Sciences; Biological Psychology; Brain; Brain - metabolism; Cell organelles; Complications and side effects; Depression; Depressive Disorder, Major - metabolism; Development and progression; Energy metabolism; Exosomes; Exosomes - metabolism; Female; Health aspects; Hedonic response; Humans; Insulin; Insulin - metabolism; Insulin receptor substrate 1; Insulin Resistance; Major depressive disorder; Male; Medicine; Medicine & Public Health; Mental depression; Metabolism; Molecular modelling; Neuroplasticity; Neurosciences; Pharmacotherapy; Phosphoproteins - metabolism; Phosphorylation; Physiological aspects; Precision medicine; Psychiatry; Receptor, Insulin - metabolism; Sex differences; Synaptic plasticity; United States

Insulin signaling is critical for neuroplasticity, cerebral metabolism as well as for systemic energy metabolism. In rodent studies, impaired brain insulin signaling with resultant insulin resistance (IR) modulates synaptic plasticity and the corresponding behavioral functions. Despite discoveries o...