Insulin receptor substrate in brain-enriched exosomes in subjects with major depression: on the path of creation of biosignatures of central insulin resistance - Nasca, Carla; Dobbin, Josh; Bigio, Benedetta; Watson, Kathleen; de Angelis, Paolo; Kautz, Marin; Cochran, Ashly; Mathé, Aleksander A.; Kocsis, James H.; Lee, Francis S.; Murrough, James W.; McEwen, Bruce S.; et al. (Molecular psychiatry, 2021)
Keywords: 631/337; 631/378; Behavioral plasticity; Behavioral Sciences; Biological Psychology; Brain; Brain - metabolism; Cell organelles; Complications and side effects; Depression; Depressive Disorder, Major - metabolism; Development and progression; Energy metabolism; Exosomes; Exosomes - metabolism; Female; Health aspects; Hedonic response; Humans; Insulin; Insulin - metabolism; Insulin receptor substrate 1; Insulin Resistance; Major depressive disorder; Male; Medicine; Medicine & Public Health; Mental depression; Metabolism; Molecular modelling; Neuroplasticity; Neurosciences; Pharmacotherapy; Phosphoproteins - metabolism; Phosphorylation; Physiological aspects; Precision medicine; Psychiatry; Receptor, Insulin - metabolism; Sex differences; Synaptic plasticity; United States