Single-cell characterization of self-renewing primary trophoblast organoids as modeling of EVT differentiation and interactions with decidual natural killer cells

• Published in: BMC genomics Vol. 24; no. 1; pp. 1 - 18
• Main Authors: Zhuang, Bai-Mei, Cao, Dan-Dan, Li, Tian-Xi, Liu, Xiao-Feng, Lyu, Min-Min, Wang, Si-Dong, Cui, Xin-Yuan, Wang, Li, Chen, Xiao-Lin, Lin, Xiao-Li, Lee, Cheuk-Lun, Chiu, Philip C.N., Yeung, William S.B., Yao, Yuan-Qing
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 18.10.2023; BioMed Central; BMC
• Subjects: Achievement tests; Angiogenesis; Cell differentiation; Cell interactions; Cells; Cytokines; Decidua; DNA binding proteins; Extravillous trophoblast; Fibroblasts; Gene sequencing; Genetic aspects; Genomics; Growth; Health aspects; Immune system; Immunomodulation; Killer cells; Methods; Modelling; Natural killer cells; Network analysis; Organoids; Placentation; Pregnancy; RNA; RNA sequencing; Subpopulations; Trajectory analysis; Transcription factors; Trophoblast; Trophoblast differentiation; Trophoblast organoid; China

Extravillous trophoblast cell (EVT) differentiation and its communication with maternal decidua especially the leading immune cell type natural killer (NK) cell are critical events for placentation. However, appropriate in vitro modelling system and regulatory programs of these two events are still...