Platelets favor the outgrowth of established metastases

Despite abundant evidence demonstrating that platelets foster metastasis, anti-platelet agents have low therapeutic potential due to the risk of hemorrhages. In addition, whether platelets can regulate metastasis at the late stages of the disease remains unknown. In this study, we subject syngeneic...

Full description

Saved in:
Bibliographic Details
Published inNature communications Vol. 15; no. 1; pp. 3297 - 19
Main Authors Garcia-Leon, Maria J., Liboni, Cristina, Mittelheisser, Vincent, Bochler, Louis, Follain, Gautier, Mouriaux, Clarisse, Busnelli, Ignacio, Larnicol, Annabel, Colin, Florent, Peralta, Marina, Osmani, Naël, Gensbittel, Valentin, Bourdon, Catherine, Samaniego, Rafael, Pichot, Angélique, Paul, Nicodème, Molitor, Anne, Carapito, Raphaël, Jandrot-Perrus, Martine, Lefebvre, Olivier, Mangin, Pierre H., Goetz, Jacky G.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 13.05.2024
Nature Publishing Group
Nature Portfolio
Subjects
13/1
13/51
14
14/19
14/5
45/91
631/67/1059
631/67/322
64/116
64/60
Animal models
Animals
Binding
Blood Platelets - drug effects
Blood Platelets - metabolism
Cell Line, Tumor
Female
Glycoprotein VI
Glycoproteins
Hematology
Hemorrhage
Human health and pathology
Humanities and Social Sciences
Humans
Life Sciences
Metastases
Metastasis
Mice
Mice, Inbred C57BL
multidisciplinary
Neoplasm Metastasis
Pharmacology
Platelet Membrane Glycoproteins - genetics
Platelet Membrane Glycoproteins - metabolism
Platelets
Receptors
Science
Science (multidisciplinary)
Tumor cells
Tumors
Online AccessGet full text

Cover

Abstract Despite abundant evidence demonstrating that platelets foster metastasis, anti-platelet agents have low therapeutic potential due to the risk of hemorrhages. In addition, whether platelets can regulate metastasis at the late stages of the disease remains unknown. In this study, we subject syngeneic models of metastasis to various thrombocytopenic regimes to show that platelets provide a biphasic contribution to metastasis. While potent intravascular binding of platelets to tumor cells efficiently promotes metastasis, platelets further support the outgrowth of established metastases via immune suppression. Genetic depletion and pharmacological targeting of the glycoprotein VI (GPVI) platelet-specific receptor in humanized mouse models efficiently reduce the growth of established metastases, independently of active platelet binding to tumor cells in the bloodstream. Our study demonstrates therapeutic efficacy when targeting animals bearing growing metastases. It further identifies GPVI as a molecular target whose inhibition can impair metastasis without inducing collateral hemostatic perturbations. It is unclear if platelets regulate the growth of established metastases. Using syngeneic mouse models of metastasis, the authors show that platelets support the outgrowth of established metastases via immune suppression, and that targeting the platelet-specific receptor GPVI, efficiently reduces established metastases, providing a promising therapeutic avenue for inhibiting cancer metastasis.
AbstractList Despite abundant evidence demonstrating that platelets foster metastasis, anti-platelet agents have low therapeutic potential due to the risk of hemorrhages. In addition, whether platelets can regulate metastasis at the late stages of the disease remains unknown. In this study, we subject syngeneic models of metastasis to various thrombocytopenic regimes to show that platelets provide a biphasic contribution to metastasis. While potent intravascular binding of platelets to tumor cells efficiently promotes metastasis, platelets further support the outgrowth of established metastases via immune suppression. Genetic depletion and pharmacological targeting of the glycoprotein VI (GPVI) platelet-specific receptor in humanized mouse models efficiently reduce the growth of established metastases, independently of active platelet binding to tumor cells in the bloodstream. Our study demonstrates therapeutic efficacy when targeting animals bearing growing metastases. It further identifies GPVI as a molecular target whose inhibition can impair metastasis without inducing collateral hemostatic perturbations. It is unclear if platelets regulate the growth of established metastases. Using syngeneic mouse models of metastasis, the authors show that platelets support the outgrowth of established metastases via immune suppression, and that targeting the platelet-specific receptor GPVI, efficiently reduces established metastases, providing a promising therapeutic avenue for inhibiting cancer metastasis.
Despite abundant evidence demonstrating that platelets foster metastasis, anti-platelet agents have low therapeutic potential due to the risk of hemorrhages. In addition, whether platelets can regulate metastasis at the late stages of the disease remains unknown. In this study, we subject syngeneic models of metastasis to various thrombocytopenic regimes to show that platelets provide a biphasic contribution to metastasis. While potent intravascular binding of platelets to tumor cells efficiently promotes metastasis, platelets further support the outgrowth of established metastases via immune suppression. Genetic depletion and pharmacological targeting of the glycoprotein VI (GPVI) platelet-specific receptor in humanized mouse models efficiently reduce the growth of established metastases, independently of active platelet binding to tumor cells in the bloodstream. Our study demonstrates therapeutic efficacy when targeting animals bearing growing metastases. It further identifies GPVI as a molecular target whose inhibition can impair metastasis without inducing collateral hemostatic perturbations.
Abstract Despite abundant evidence demonstrating that platelets foster metastasis, anti-platelet agents have low therapeutic potential due to the risk of hemorrhages. In addition, whether platelets can regulate metastasis at the late stages of the disease remains unknown. In this study, we subject syngeneic models of metastasis to various thrombocytopenic regimes to show that platelets provide a biphasic contribution to metastasis. While potent intravascular binding of platelets to tumor cells efficiently promotes metastasis, platelets further support the outgrowth of established metastases via immune suppression. Genetic depletion and pharmacological targeting of the glycoprotein VI (GPVI) platelet-specific receptor in humanized mouse models efficiently reduce the growth of established metastases, independently of active platelet binding to tumor cells in the bloodstream. Our study demonstrates therapeutic efficacy when targeting animals bearing growing metastases. It further identifies GPVI as a molecular target whose inhibition can impair metastasis without inducing collateral hemostatic perturbations.
Despite abundant evidence demonstrating that platelets foster metastasis, anti-platelet agents have low therapeutic potential due to the risk of hemorrhages. In addition, whether platelets can regulate metastasis at the late stages of the disease remains unknown. In this study, we subject syngeneic models of metastasis to various thrombocytopenic regimes to show that platelets provide a biphasic contribution to metastasis. While potent intravascular binding of platelets to tumor cells efficiently promotes metastasis, platelets further support the outgrowth of established metastases via immune suppression. Genetic depletion and pharmacological targeting of the glycoprotein VI (GPVI) platelet-specific receptor in humanized mouse models efficiently reduce the growth of established metastases, independently of active platelet binding to tumor cells in the bloodstream. Our study demonstrates therapeutic efficacy when targeting animals bearing growing metastases. It further identifies GPVI as a molecular target whose inhibition can impair metastasis without inducing collateral hemostatic perturbations.Despite abundant evidence demonstrating that platelets foster metastasis, anti-platelet agents have low therapeutic potential due to the risk of hemorrhages. In addition, whether platelets can regulate metastasis at the late stages of the disease remains unknown. In this study, we subject syngeneic models of metastasis to various thrombocytopenic regimes to show that platelets provide a biphasic contribution to metastasis. While potent intravascular binding of platelets to tumor cells efficiently promotes metastasis, platelets further support the outgrowth of established metastases via immune suppression. Genetic depletion and pharmacological targeting of the glycoprotein VI (GPVI) platelet-specific receptor in humanized mouse models efficiently reduce the growth of established metastases, independently of active platelet binding to tumor cells in the bloodstream. Our study demonstrates therapeutic efficacy when targeting animals bearing growing metastases. It further identifies GPVI as a molecular target whose inhibition can impair metastasis without inducing collateral hemostatic perturbations.
Despite abundant evidence demonstrating that platelets foster metastasis, anti-platelet agents have low therapeutic potential due to the risk of hemorrhages. In addition, whether platelets can regulate metastasis at the late stages of the disease remains unknown. In this study, we subject syngeneic models of metastasis to various thrombocytopenic regimes to show that platelets provide a biphasic contribution to metastasis. While potent intravascular binding of platelets to tumor cells efficiently promotes metastasis, platelets further support the outgrowth of established metastases via immune suppression. Genetic depletion and pharmacological targeting of the glycoprotein VI (GPVI) platelet-specific receptor in humanized mouse models efficiently reduce the growth of established metastases, independently of active platelet binding to tumor cells in the bloodstream. Our study demonstrates therapeutic efficacy when targeting animals bearing growing metastases. It further identifies GPVI as a molecular target whose inhibition can impair metastasis without inducing collateral hemostatic perturbations.It is unclear if platelets regulate the growth of established metastases. Using syngeneic mouse models of metastasis, the authors show that platelets support the outgrowth of established metastases via immune suppression, and that targeting the platelet-specific receptor GPVI, efficiently reduces established metastases, providing a promising therapeutic avenue for inhibiting cancer metastasis.
ArticleNumber 3297
Author Mouriaux, Clarisse
Garcia-Leon, Maria J.
Jandrot-Perrus, Martine
Bourdon, Catherine
Mangin, Pierre H.
Bochler, Louis
Colin, Florent
Paul, Nicodème
Samaniego, Rafael
Carapito, Raphaël
Busnelli, Ignacio
Gensbittel, Valentin
Peralta, Marina
Larnicol, Annabel
Follain, Gautier
Osmani, Naël
Pichot, Angélique
Liboni, Cristina
Goetz, Jacky G.
Lefebvre, Olivier
Molitor, Anne
Mittelheisser, Vincent
Author_xml – sequence: 1
  givenname: Maria J.
  surname: Garcia-Leon
  fullname: Garcia-Leon, Maria J.
  email: mgarcialeon@domaintherapeutics.com
  organization: Tumor Biomechanics, INSERM UMR_S1109, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Equipe Labellisée Ligue Contre le Cancer, Domain therapeutics, Parc d’Innovation − 220 Boulevard Gonthier D’Andernach
– sequence: 2
  givenname: Cristina
  orcidid: 0000-0002-2139-7794
  surname: Liboni
  fullname: Liboni, Cristina
  organization: Tumor Biomechanics, INSERM UMR_S1109, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Equipe Labellisée Ligue Contre le Cancer
– sequence: 3
  givenname: Vincent
  surname: Mittelheisser
  fullname: Mittelheisser, Vincent
  organization: Tumor Biomechanics, INSERM UMR_S1109, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Equipe Labellisée Ligue Contre le Cancer
– sequence: 4
  givenname: Louis
  orcidid: 0009-0003-7050-3287
  surname: Bochler
  fullname: Bochler, Louis
  organization: Tumor Biomechanics, INSERM UMR_S1109, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Equipe Labellisée Ligue Contre le Cancer
– sequence: 5
  givenname: Gautier
  orcidid: 0000-0003-0495-9529
  surname: Follain
  fullname: Follain, Gautier
  organization: Tumor Biomechanics, INSERM UMR_S1109, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Equipe Labellisée Ligue Contre le Cancer, Turku Bioscience Centre, University of Turku and Åbo Akademi University
– sequence: 6
  givenname: Clarisse
  surname: Mouriaux
  fullname: Mouriaux, Clarisse
  organization: UMR_S 1255, INSERM, Etablissement Français du Sang-Alsace, Université de Strasbourg
– sequence: 7
  givenname: Ignacio
  surname: Busnelli
  fullname: Busnelli, Ignacio
  organization: Tumor Biomechanics, INSERM UMR_S1109, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Equipe Labellisée Ligue Contre le Cancer
– sequence: 8
  givenname: Annabel
  surname: Larnicol
  fullname: Larnicol, Annabel
  organization: Tumor Biomechanics, INSERM UMR_S1109, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Equipe Labellisée Ligue Contre le Cancer
– sequence: 9
  givenname: Florent
  surname: Colin
  fullname: Colin, Florent
  organization: Tumor Biomechanics, INSERM UMR_S1109, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Equipe Labellisée Ligue Contre le Cancer
– sequence: 10
  givenname: Marina
  surname: Peralta
  fullname: Peralta, Marina
  organization: Tumor Biomechanics, INSERM UMR_S1109, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Equipe Labellisée Ligue Contre le Cancer
– sequence: 11
  givenname: Naël
  surname: Osmani
  fullname: Osmani, Naël
  organization: Tumor Biomechanics, INSERM UMR_S1109, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Equipe Labellisée Ligue Contre le Cancer
– sequence: 12
  givenname: Valentin
  surname: Gensbittel
  fullname: Gensbittel, Valentin
  organization: Tumor Biomechanics, INSERM UMR_S1109, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Equipe Labellisée Ligue Contre le Cancer
– sequence: 13
  givenname: Catherine
  surname: Bourdon
  fullname: Bourdon, Catherine
  organization: UMR_S 1255, INSERM, Etablissement Français du Sang-Alsace, Université de Strasbourg
– sequence: 14
  givenname: Rafael
  surname: Samaniego
  fullname: Samaniego, Rafael
  organization: Instituto de Investigación Sanitaria Gregorio Marañón (IISGM), Unidad de Microscopía Confocal
– sequence: 15
  givenname: Angélique
  orcidid: 0000-0003-2515-5538
  surname: Pichot
  fullname: Pichot, Angélique
  organization: Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Laboratoire d’ImmunoRhumatologie Moléculaire, Plateforme GENOMAX, Institut national de la santé et de la recherche médicale (INSERM) UMR_S 1109, Institut thématique interdisciplinaire (ITI) de Médecine de Précision de Strasbourg Transplantex NG
– sequence: 16
  givenname: Nicodème
  orcidid: 0000-0003-4680-3012
  surname: Paul
  fullname: Paul, Nicodème
  organization: Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Laboratoire d’ImmunoRhumatologie Moléculaire, Plateforme GENOMAX, Institut national de la santé et de la recherche médicale (INSERM) UMR_S 1109, Institut thématique interdisciplinaire (ITI) de Médecine de Précision de Strasbourg Transplantex NG
– sequence: 17
  givenname: Anne
  surname: Molitor
  fullname: Molitor, Anne
  organization: Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Laboratoire d’ImmunoRhumatologie Moléculaire, Plateforme GENOMAX, Institut national de la santé et de la recherche médicale (INSERM) UMR_S 1109, Institut thématique interdisciplinaire (ITI) de Médecine de Précision de Strasbourg Transplantex NG
– sequence: 18
  givenname: Raphaël
  orcidid: 0000-0002-7036-442X
  surname: Carapito
  fullname: Carapito, Raphaël
  organization: Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Laboratoire d’ImmunoRhumatologie Moléculaire, Plateforme GENOMAX, Institut national de la santé et de la recherche médicale (INSERM) UMR_S 1109, Institut thématique interdisciplinaire (ITI) de Médecine de Précision de Strasbourg Transplantex NG, Service d’Immunologie Biologique, Plateau Technique de Biologie, Pôle de Biologie, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, 1 Place de l’Hôpital
– sequence: 19
  givenname: Martine
  orcidid: 0000-0002-8450-9247
  surname: Jandrot-Perrus
  fullname: Jandrot-Perrus, Martine
  organization: UMR_S 1148, INSERM, Université Paris-Cité
– sequence: 20
  givenname: Olivier
  orcidid: 0000-0001-9130-9174
  surname: Lefebvre
  fullname: Lefebvre, Olivier
  organization: Tumor Biomechanics, INSERM UMR_S1109, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Equipe Labellisée Ligue Contre le Cancer
– sequence: 21
  givenname: Pierre H.
  orcidid: 0000-0001-9522-6261
  surname: Mangin
  fullname: Mangin, Pierre H.
  email: Pierre.Mangin@efs.sante.fr
  organization: UMR_S 1255, INSERM, Etablissement Français du Sang-Alsace, Université de Strasbourg
– sequence: 22
  givenname: Jacky G.
  orcidid: 0000-0003-2842-8116
  surname: Goetz
  fullname: Goetz, Jacky G.
  email: jacky.goetz@inserm.fr
  organization: Tumor Biomechanics, INSERM UMR_S1109, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Equipe Labellisée Ligue Contre le Cancer
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38740748$$D View this record in MEDLINE/PubMed
https://hal.science/hal-04974164$$DView record in HAL
BookMark eNp9Uktv1DAQjlARLaV_gAOKxAUOAT_GsXNCVQW00kpwgLPlOOPdrLJxsZ1d9d_j3ZTS7qG-2B5_j9HneV2cjH7EonhLySdKuPocgUItK8KgAiloXe1eFGeMAK2oZPzk0fm0uIhxTfLiDVUAr4pTriQQCeqskD8Hk3DAFEtntj6UaYWln9Iy-F1ald6VGJNphz6usCs3mEy-RoxvipfODBEv7vfz4ve3r7-urqvFj-83V5eLygopUqVapEDQGGGoNQwU7SSj6LpWurpxjWm7xjghBOQ6Koe8bixzBkRHoHGSnxc3s27nzVrfhn5jwp32pteHgg9LbULq7YCadUYw1tZdWxMAZVtS15blM6eqtR3NWl9mrdup3WBncUzBDE9En76M_Uov_VZTShpK6yYrfJwVVke868uF3tdy0xJoDdu924d7t-D_TDlFvemjxWEwI_opak4EKCCiYRn6_gi69lMYc64HFCccxD6Kd4_bf_D_95kZwGaADT7GgO4BQoneD42eh0bnodGHodG7TFJHJNsnk3q_j6AfnqfymRqzz7jE8L_tZ1h_AXEL1X0
CitedBy_id crossref_primary_10_3390_nu16213717
crossref_primary_10_1016_S1773_035X_24_00248_X
crossref_primary_10_1016_j_jbc_2025_108330
crossref_primary_10_1007_s10147_024_02646_5
crossref_primary_10_1126_sciadv_adq4416
crossref_primary_10_1038_s41580_024_00777_1
crossref_primary_10_3390_bios15020091
crossref_primary_10_1002_mef2_70000
crossref_primary_10_1186_s12964_024_01973_4
crossref_primary_10_1016_j_heliyon_2024_e38831
crossref_primary_10_1016_j_jmoldx_2025_02_006
Cites_doi 10.1038/jid.2009.278
10.1182/blood.2018877043
10.1158/1055-9965.EPI-14-0146
10.1158/1078-0432.CCR-05-1698
10.1016/j.ccell.2022.08.004
10.1016/j.celrep.2014.01.032
10.1111/j.1538-7836.2009.03559.x
10.1016/j.coi.2015.10.009
10.3389/fimmu.2021.640578
10.1084/jem.20140654
10.1093/bioinformatics/btv566
10.1038/nature16985
10.1038/nature12807
10.1073/pnas.0700625104
10.1038/sj.bjp.0705606
10.1073/pnas.1411082111
10.1016/j.cell.2014.07.013
10.1182/bloodadvances.2018026161
10.1124/jpet.111.189050
10.1073/pnas.61.1.46
10.1016/j.ccell.2018.03.002
10.1038/s41568-022-00520-y
10.1038/s41588-019-0423-x
10.1016/j.cell.2017.11.001
10.1016/j.devcel.2018.02.015
10.1016/j.ccr.2011.09.009
10.1158/0008-5472.CAN-11-1872
10.1182/blood-2007-09-113837
10.1093/bioinformatics/bts635
10.1056/NEJMoa1110352
10.18632/oncotarget.14921
10.1097/HS9.0000000000000750
10.1186/s13059-014-0550-8
10.1158/2159-8290.CD-12-0329
10.1016/j.phrs.2022.106301
10.1016/j.bbamcr.2020.118886
10.1172/JCI85086
10.1016/j.devcel.2019.01.014
10.1038/s41586-019-0915-y
10.3389/fonc.2020.01350
10.1161/ATVBAHA.118.312314
10.1038/s41568-019-0221-x
10.1016/j.ccr.2007.12.003
10.1182/blood.2019003977
10.1111/j.1538-7836.2005.01654.x
10.1016/j.celrep.2019.07.102
10.1038/nmeth.4197
10.1182/blood.2020005710
10.1016/j.cell.2018.11.046
10.1186/1471-2407-14-167
10.18632/oncotarget.1524
10.1038/jid.2013.88
10.1371/journal.pone.0172788
10.1016/S0140-6736(05)75597-5
10.1007/s10555-017-9673-1
10.1016/j.tmrv.2014.11.006
10.2217/bmm-2016-0214
10.1136/bmjopen-2023-074874
10.1111/j.1538-7836.2007.02435.x
10.1160/TH15-01-0077
10.1038/sj.bjp.0706013
10.1038/s41467-019-09234-6
10.1016/j.bbrc.2020.04.065
10.1016/j.isci.2022.103969
10.1182/blood.2019004119
10.1242/jcs.069443
10.1016/j.ccr.2013.05.008
10.1080/19420862.2017.1336592
10.1182/blood.V96.5.1798
10.4049/jimmunol.179.5.2851
10.3324/haematol.2020.270439
10.1186/gb-2004-5-10-r80
10.1007/978-1-0716-1350-4_8
10.1126/sciimmunol.aai7911
10.1172/jci.insight.160978
ContentType Journal Article
Copyright The Author(s) 2024
2024. The Author(s).
The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Distributed under a Creative Commons Attribution 4.0 International License
Copyright_xml – notice: The Author(s) 2024
– notice: 2024. The Author(s).
– notice: The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: Distributed under a Creative Commons Attribution 4.0 International License
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7X7
7XB
88E
8AO
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
ARAPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7P
P5Z
P62
P64
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
RC3
SOI
7X8
1XC
VOOES
5PM
DOA
DOI 10.1038/s41467-024-47516-w
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Ecology Abstracts
Entomology Abstracts (Full archive)
Environment Abstracts
Immunology Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest One Sustainability
ProQuest Central UK/Ireland
Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Technology Collection
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Central
Engineering Research Database
ProQuest Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
ProQuest SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
Medical Database
Biological Science Database
Advanced Technologies & Aerospace Database
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Genetics Abstracts
Environment Abstracts
MEDLINE - Academic
Hyper Article en Ligne (HAL)
Hyper Article en Ligne (HAL) (Open Access)
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
Chemoreception Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Advanced Technologies & Aerospace Collection
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Entomology Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest One Academic (New)
Technology Collection
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
AIDS and Cancer Research Abstracts
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Immunology Abstracts
Environment Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
MEDLINE

MEDLINE - Academic

CrossRef
Publicly Available Content Database
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 4
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 5
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2041-1723
EndPage 19
ExternalDocumentID oai_doaj_org_article_2da522b6db60448cb066c2604318bcd1
PMC11091169
oai_HAL_hal_04974164v1
38740748
10_1038_s41467_024_47516_w
Genre Journal Article
GrantInformation_xml – fundername: Ligue Contre le Cancer
  funderid: https://doi.org/10.13039/501100004099
– fundername: Institut National Du Cancer (French National Cancer Institute)
  funderid: https://doi.org/10.13039/501100006364
GroupedDBID ---
0R~
39C
3V.
53G
5VS
70F
7X7
88E
8AO
8FE
8FG
8FH
8FI
8FJ
AAHBH
AAJSJ
ABUWG
ACGFO
ACGFS
ACIWK
ACMJI
ACPRK
ACSMW
ADBBV
ADFRT
ADMLS
ADRAZ
AENEX
AEUYN
AFKRA
AFRAH
AHMBA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMTXH
AOIJS
ARAPS
ASPBG
AVWKF
AZFZN
BBNVY
BCNDV
BENPR
BGLVJ
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
EBLON
EBS
EE.
EMOBN
F5P
FEDTE
FYUFA
GROUPED_DOAJ
HCIFZ
HMCUK
HVGLF
HYE
HZ~
KQ8
LGEZI
LK8
LOTEE
M1P
M48
M7P
M~E
NADUK
NAO
NXXTH
O9-
OK1
P2P
P62
PIMPY
PQQKQ
PROAC
PSQYO
RNS
RNT
RNTTT
RPM
SNYQT
SV3
TSG
UKHRP
AASML
AAYXX
CITATION
PHGZM
PHGZT
CGR
CUY
CVF
ECM
EIF
NPM
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7XB
8FD
8FK
AARCD
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
P64
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQUKI
PRINS
RC3
SOI
7X8
1XC
VOOES
5PM
PUEGO
ID FETCH-LOGICAL-c575t-8be140eaa5a1ca2481d721efdb7f69f9abd9af5554d72e8fe369c2fa45d049f73
IEDL.DBID M48
ISSN 2041-1723
IngestDate Wed Aug 27 01:22:25 EDT 2025
Thu Aug 21 18:35:41 EDT 2025
Tue Jul 01 06:33:00 EDT 2025
Fri Jul 11 02:02:22 EDT 2025
Wed Aug 13 09:29:03 EDT 2025
Thu Apr 03 06:51:55 EDT 2025
Tue Jul 01 02:11:07 EDT 2025
Thu Apr 24 22:58:47 EDT 2025
Fri Feb 21 02:37:38 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License 2024. The Author(s).
Distributed under a Creative Commons Attribution 4.0 International License: http://creativecommons.org/licenses/by/4.0
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c575t-8be140eaa5a1ca2481d721efdb7f69f9abd9af5554d72e8fe369c2fa45d049f73
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0003-4680-3012
0000-0002-8450-9247
0000-0002-7036-442X
0000-0003-0495-9529
0009-0003-7050-3287
0000-0002-2139-7794
0000-0001-9522-6261
0000-0003-2842-8116
0000-0003-2515-5538
0000-0001-9130-9174
0000-0003-1195-753X
0000-0001-7363-2218
0000-0003-1646-2325
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.1038/s41467-024-47516-w
PMID 38740748
PQID 3054303457
PQPubID 546298
PageCount 19
ParticipantIDs doaj_primary_oai_doaj_org_article_2da522b6db60448cb066c2604318bcd1
pubmedcentral_primary_oai_pubmedcentral_nih_gov_11091169
hal_primary_oai_HAL_hal_04974164v1
proquest_miscellaneous_3054840592
proquest_journals_3054303457
pubmed_primary_38740748
crossref_primary_10_1038_s41467_024_47516_w
crossref_citationtrail_10_1038_s41467_024_47516_w
springer_journals_10_1038_s41467_024_47516_w
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2024-05-13
PublicationDateYYYYMMDD 2024-05-13
PublicationDate_xml – month: 05
  year: 2024
  text: 2024-05-13
  day: 13
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Nature communications
PublicationTitleAbbrev Nat Commun
PublicationTitleAlternate Nat Commun
PublicationYear 2024
Publisher Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: Nature Portfolio
References Szczerba (CR8) 2019; 566
Senft (CR13) 2022; 22
Osmani (CR3) 2019; 28
Mammadova-Bach (CR59) 2020; 135
Schmied, Höglund, Meinke (CR36) 2021; 12
Baig (CR43) 2015; 212
Mangin (CR42) 2012; 341
Munn, Bronte (CR63) 2016; 39
Labelle, Begum, Hynes (CR9) 2014; 111
Stewart, Abrams (CR41) 2007; 179
Erpenbeck, Nieswandt, Schön, Pozgajova, Schön (CR23) 2010; 130
Allen (CR56) 2014; 5
Goetz (CR72) 2014; 6
CR76
Follain (CR1) 2020; 20
Roy (CR44) 2014; 505
Voors-Pette (CR70) 2019; 39
CR71
Li (CR33) 2014; 14
Hu (CR38) 2019; 51
Gaertner (CR58) 2017; 171
Labelle, Hynes (CR18) 2012; 2
Follain (CR2) 2018; 45
Qi (CR68) 2023; 13
Strassel (CR74) 2006; 4
CR4
Zhou (CR82) 2019; 10
Katagiri (CR50) 1991; 51
Hyenne (CR30) 2019; 48
Haemmerle (CR32) 2016; 126
Feinauer (CR20) 2021; 137
Monroe, Key (CR55) 2007; 5
Haemmerle, Stone, Menter, Afshar-Kharghan, Sood (CR10) 2018; 33
Wojtukiewicz, Sierko, Hempel, Tucker, Honn (CR54) 2017; 36
Liotta, Saidel, Kleinerman (CR31) 1976; 36
CR45
Johnson (CR35) 2019; 3
Sood (CR57) 2006; 12
Ma (CR12) 2022; 40
Placke (CR65) 2012; 72
Patro, Duggal, Love, Irizarry, Kingsford (CR79) 2017; 14
Falanga (CR28) 2022; 6
Samaniego (CR75) 2013; 133
Headley (CR29) 2016; 531
Jadoui (CR47) 2021; 106
Stoletov (CR73) 2010; 123
Aceto (CR5) 2014; 158
Jain (CR16) 2007; 104
Chaurasia, Kushwaha, Pandey, Dash (CR66) 2020; 527
Alonso-Escolano, Strongin, Chung, Deryugina, Radomski (CR49) 2004; 141
Dobin (CR78) 2013; 29
Jurasz, Alonso-Escolano, Radomski (CR26) 2004; 143
Hüsemann (CR37) 2008; 13
Italiano (CR61) 2008; 111
Mehta, Lawson, Ward, Kimura, Gee (CR22) 1987; 47
Gentleman (CR81) 2004; 5
Nieswandt, Hafner, Echtenacher, Männel (CR19) 1999; 59
Peralta, Osmani, Goetz (CR6) 2022; 25
Gkountela (CR7) 2019; 176
Lebozec, Jandrot-Perrus, Avenard, Favre-Bulle, Billiald (CR46) 2017; 9
Wang (CR52) 2017; 11
Tesfamariam, Wood (CR40) 2022; 182
Schwarz (CR53) 1999; 353
Lucotti, Muschel (CR25) 2020; 10
Gasic, Gasic, Stewart (CR14) 1968; 61
Jandrot-Perrus (CR39) 2000; 96
Tao, Tassi Yunga, Williams, McCarty (CR69) 2021; 137
Echtler (CR24) 2017; 12
McFadyen, Kaplan (CR27) 2015; 29
Schumacher, Strilic, Sivaraj, Wettschureck, Offermanns (CR21) 2013; 24
Jain, Russell, Ware (CR15) 2009; 7
Templeton (CR67) 2014; 23
Labelle, Begum, Hynes (CR34) 2011; 20
Love, Huber, Anders (CR80) 2014; 15
Vismara (CR62) 2021; 1868
Volz (CR17) 2019; 133
Okonechnikov, Conesa, García-Alcalde (CR77) 2016; 32
Serebruany, Cherepanov, Cabrera-Fuentes, Kim (CR48) 2015; 114
CR64
Lazar, Goldfinger (CR60) 2021; 137
Stone (CR11) 2012; 366
Gao, Zhang, Zhang, Zhang, Wang (CR51) 2017; 8
SN Chaurasia (47516_CR66) 2020; 527
N Aceto (47516_CR5) 2014; 158
KE Johnson (47516_CR35) 2019; 3
J Volz (47516_CR17) 2019; 133
JG Goetz (47516_CR72) 2014; 6
P Mehta (47516_CR22) 1987; 47
Y Hüsemann (47516_CR37) 2008; 13
B Nieswandt (47516_CR19) 1999; 59
R Samaniego (47516_CR75) 2013; 133
M Haemmerle (47516_CR32) 2016; 126
TJ Stewart (47516_CR41) 2007; 179
C Voors-Pette (47516_CR70) 2019; 39
R Li (47516_CR33) 2014; 14
L Schmied (47516_CR36) 2021; 12
Mangin (47516_CR42) 2012; 341
S Jain (47516_CR15) 2009; 7
Y Katagiri (47516_CR50) 1991; 51
L Erpenbeck (47516_CR23) 2010; 130
AK Sood (47516_CR57) 2006; 12
T Placke (47516_CR65) 2012; 72
K Echtler (47516_CR24) 2017; 12
DM Monroe (47516_CR55) 2007; 5
N Osmani (47516_CR3) 2019; 28
K Okonechnikov (47516_CR77) 2016; 32
MJ Feinauer (47516_CR20) 2021; 137
M Haemmerle (47516_CR10) 2018; 33
S Lazar (47516_CR60) 2021; 137
VL Serebruany (47516_CR48) 2015; 114
47516_CR4
JD McFadyen (47516_CR27) 2015; 29
RC Gentleman (47516_CR81) 2004; 5
MS Baig (47516_CR43) 2015; 212
M Labelle (47516_CR9) 2014; 111
P Jurasz (47516_CR26) 2004; 143
D Schumacher (47516_CR21) 2013; 24
X Qi (47516_CR68) 2023; 13
JE Allen (47516_CR56) 2014; 5
MZ Wojtukiewicz (47516_CR54) 2017; 36
MG Roy (47516_CR44) 2014; 505
LA Liotta (47516_CR31) 1976; 36
47516_CR64
K Stoletov (47516_CR73) 2010; 123
RL Stone (47516_CR11) 2012; 366
MB Headley (47516_CR29) 2016; 531
DH Munn (47516_CR63) 2016; 39
M Vismara (47516_CR62) 2021; 1868
M Peralta (47516_CR6) 2022; 25
GJ Gasic (47516_CR14) 1968; 61
S Lucotti (47516_CR25) 2020; 10
DL Tao (47516_CR69) 2021; 137
V Hyenne (47516_CR30) 2019; 48
B Tesfamariam (47516_CR40) 2022; 182
RE Schwarz (47516_CR53) 1999; 353
L Gao (47516_CR51) 2017; 8
A Dobin (47516_CR78) 2013; 29
BM Szczerba (47516_CR8) 2019; 566
M Labelle (47516_CR18) 2012; 2
S Jain (47516_CR16) 2007; 104
47516_CR76
E Mammadova-Bach (47516_CR59) 2020; 135
D Senft (47516_CR13) 2022; 22
Y-H Wang (47516_CR52) 2017; 11
47516_CR71
K Lebozec (47516_CR46) 2017; 9
D Alonso-Escolano (47516_CR49) 2004; 141
C Ma (47516_CR12) 2022; 40
F Gaertner (47516_CR58) 2017; 171
M Jandrot-Perrus (47516_CR39) 2000; 96
AJ Templeton (47516_CR67) 2014; 23
G Follain (47516_CR1) 2020; 20
S Jadoui (47516_CR47) 2021; 106
C Strassel (47516_CR74) 2006; 4
M Labelle (47516_CR34) 2011; 20
47516_CR45
JE Italiano (47516_CR61) 2008; 111
S Gkountela (47516_CR7) 2019; 176
A Falanga (47516_CR28) 2022; 6
Z Hu (47516_CR38) 2019; 51
R Patro (47516_CR79) 2017; 14
G Follain (47516_CR2) 2018; 45
MI Love (47516_CR80) 2014; 15
Y Zhou (47516_CR82) 2019; 10
References_xml – volume: 130
  start-page: 576
  year: 2010
  end-page: 586
  ident: CR23
  article-title: Inhibition of platelet GPIbα and promotion of melanoma metastasis
  publication-title: J. Invest. Dermatol.
  doi: 10.1038/jid.2009.278
– ident: CR45
– volume: 133
  start-page: 2696
  year: 2019
  end-page: 2706
  ident: CR17
  article-title: Inhibition of platelet GPVI induces intratumor hemorrhage and increases efficacy of chemotherapy in mice
  publication-title: Blood
  doi: 10.1182/blood.2018877043
– volume: 23
  start-page: 1204
  year: 2014
  end-page: 1212
  ident: CR67
  article-title: Prognostic role of platelet to lymphocyte ratio in solid tumors: a systematic review and meta-analysis
  publication-title: Cancer Epidemiol. Biomark. Prev.
  doi: 10.1158/1055-9965.EPI-14-0146
– ident: CR4
– volume: 12
  start-page: 369
  year: 2006
  end-page: 375
  ident: CR57
  article-title: Stress hormone–mediated invasion of ovarian cancer cells
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-05-1698
– volume: 51
  start-page: 1286
  year: 1991
  end-page: 1293
  ident: CR50
  article-title: Characterization of platelet aggregation induced by the human melanoma cell line HMV-I: roles of heparin, plasma adhesive proteins, and tumor cell membrane proteins
  publication-title: Cancer Res.
– volume: 135
  start-page: 1146
  year: 2020
  end-page: 1160
  ident: CR59
  article-title: Platelet glycoprotein VI promotes metastasis through interaction with cancer cell-derived Galectin-3
  publication-title: Blood
– volume: 40
  start-page: 986
  year: 2022
  end-page: 998.e5
  ident: CR12
  article-title: Platelets control liver tumor growth through P2Y12-dependent CD40L release in NAFLD
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2022.08.004
– volume: 6
  start-page: 799
  year: 2014
  end-page: 808
  ident: CR72
  article-title: Endothelial cilia mediate low flow sensing during zebrafish vascular development
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2014.01.032
– volume: 7
  start-page: 1713
  year: 2009
  end-page: 1717
  ident: CR15
  article-title: Platelet glycoprotein VI facilitates experimental lung metastasis in syngenic mouse models
  publication-title: J. Thromb. Haemost.
  doi: 10.1111/j.1538-7836.2009.03559.x
– volume: 39
  start-page: 1
  year: 2016
  end-page: 6
  ident: CR63
  article-title: Immune suppressive mechanisms in the tumor microenvironment
  publication-title: Curr. Opin. Immunol.
  doi: 10.1016/j.coi.2015.10.009
– volume: 12
  start-page: 640578
  year: 2021
  ident: CR36
  article-title: Platelet-mediated protection of cancer cells from immune surveillance - possible implications for cancer immunotherapy
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2021.640578
– volume: 212
  start-page: 1725
  year: 2015
  end-page: 1738
  ident: CR43
  article-title: NOS1-derived nitric oxide promotes NF-κB transcriptional activity through inhibition of suppressor of cytokine signaling-1
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20140654
– volume: 32
  start-page: 292
  year: 2016
  end-page: 294
  ident: CR77
  article-title: Qualimap 2: advanced multi-sample quality control for high-throughput sequencing data
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btv566
– volume: 531
  start-page: 513
  year: 2016
  end-page: 517
  ident: CR29
  article-title: Visualization of immediate immune responses to pioneer metastatic cells in the lung
  publication-title: Nature
  doi: 10.1038/nature16985
– volume: 505
  start-page: 412
  year: 2014
  end-page: 416
  ident: CR44
  article-title: Muc5b is required for airway defence
  publication-title: Nature
  doi: 10.1038/nature12807
– volume: 104
  start-page: 9024
  year: 2007
  end-page: 9028
  ident: CR16
  article-title: Platelet glycoprotein Ibα supports experimental lung metastasis
  publication-title: Proc. Natl Acad. Sci.
  doi: 10.1073/pnas.0700625104
– volume: 141
  start-page: 241
  year: 2004
  end-page: 252
  ident: CR49
  article-title: Membrane type-1 matrix metalloproteinase stimulates tumour cell-induced platelet aggregation: role of receptor glycoproteins
  publication-title: Br. J. Pharmacol.
  doi: 10.1038/sj.bjp.0705606
– volume: 111
  start-page: E3053
  year: 2014
  end-page: E3061
  ident: CR9
  article-title: Platelets guide the formation of early metastatic niches
  publication-title: Proc. Natl Acad. Sci.
  doi: 10.1073/pnas.1411082111
– volume: 59
  start-page: 1295
  year: 1999
  end-page: 1300
  ident: CR19
  article-title: Lysis of tumor cells by natural killer cells in mice is impeded by platelets
  publication-title: Cancer Res.
– ident: CR71
– volume: 158
  start-page: 1110
  year: 2014
  end-page: 1122
  ident: CR5
  article-title: Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis
  publication-title: Cell
  doi: 10.1016/j.cell.2014.07.013
– volume: 3
  start-page: 198
  year: 2019
  end-page: 211
  ident: CR35
  article-title: Aspirin inhibits platelets from reprogramming breast tumor cells and promoting metastasis
  publication-title: Blood Adv.
  doi: 10.1182/bloodadvances.2018026161
– volume: 341
  start-page: 156
  year: 2012
  end-page: 163
  ident: CR42
  article-title: A humanized glycoprotein VI (GPVI) mouse model to assess the antithrombotic efficacies of anti-GPVI agents
  publication-title: J. Pharmacol. Exp. Ther.
  doi: 10.1124/jpet.111.189050
– volume: 61
  start-page: 46
  year: 1968
  end-page: 52
  ident: CR14
  article-title: Antimetastatic effects associated with platelet reduction
  publication-title: Proc. Natl Acad. Sci.
  doi: 10.1073/pnas.61.1.46
– volume: 33
  start-page: 965
  year: 2018
  end-page: 983
  ident: CR10
  article-title: The platelet lifeline to cancer: challenges and opportunities
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2018.03.002
– volume: 22
  start-page: 608
  year: 2022
  end-page: 608
  ident: CR13
  article-title: Platelets limit liver tumours
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/s41568-022-00520-y
– volume: 51
  start-page: 1113
  year: 2019
  end-page: 1122
  ident: CR38
  article-title: Quantitative evidence for early metastatic seeding in colorectal cancer
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-019-0423-x
– volume: 171
  start-page: 1368
  year: 2017
  end-page: 1382.e23
  ident: CR58
  article-title: Migrating platelets are mechano-scavengers that collect and bundle bacteria
  publication-title: Cell
  doi: 10.1016/j.cell.2017.11.001
– volume: 45
  start-page: 33
  year: 2018
  end-page: 52.e12
  ident: CR2
  article-title: Hemodynamic forces tune the arrest, adhesion, and extravasation of circulating tumor cells
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2018.02.015
– volume: 20
  start-page: 576
  year: 2011
  end-page: 590
  ident: CR34
  article-title: Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2011.09.009
– volume: 72
  start-page: 440
  year: 2012
  end-page: 448
  ident: CR65
  article-title: Platelet-derived MHC class I confers a pseudonormal phenotype to cancer cells that subverts the antitumor reactivity of natural killer immune cells
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-11-1872
– volume: 111
  start-page: 1227
  year: 2008
  end-page: 1233
  ident: CR61
  article-title: Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet α granules and differentially released
  publication-title: Blood
  doi: 10.1182/blood-2007-09-113837
– volume: 29
  start-page: 15
  year: 2013
  end-page: 21
  ident: CR78
  article-title: STAR: ultrafast universal RNA-seq aligner
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bts635
– volume: 366
  start-page: 610
  year: 2012
  end-page: 618
  ident: CR11
  article-title: Paraneoplastic thrombocytosis in ovarian cancer
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1110352
– volume: 8
  start-page: 15632
  year: 2017
  end-page: 15641
  ident: CR51
  article-title: Prognostic value of combination of preoperative platelet count and mean platelet volume in patients with resectable non-small cell lung cancer
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.14921
– volume: 6
  start-page: e750
  year: 2022
  ident: CR28
  article-title: EHA guidelines on management of antithrombotic treatments in thrombocytopenic patients with cancer
  publication-title: HemaSphere
  doi: 10.1097/HS9.0000000000000750
– ident: CR64
– volume: 15
  year: 2014
  ident: CR80
  article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
  publication-title: Genome Biol.
  doi: 10.1186/s13059-014-0550-8
– volume: 2
  start-page: 1091
  year: 2012
  end-page: 1099
  ident: CR18
  article-title: The initial hours of metastasis: the importance of cooperative host–tumor cell interactions during hematogenous dissemination
  publication-title: Cancer Discov.
  doi: 10.1158/2159-8290.CD-12-0329
– volume: 182
  start-page: 106301
  year: 2022
  ident: CR40
  article-title: Targeting glycoprotein VI to disrupt platelet-mediated tumor cell extravasation
  publication-title: Pharmacol. Res.
  doi: 10.1016/j.phrs.2022.106301
– volume: 1868
  start-page: 118886
  year: 2021
  ident: CR62
  article-title: Platelet-derived extracellular vesicles regulate cell cycle progression and cell migration in breast cancer cells
  publication-title: Biochim. Biophys. Acta Mol. Cell Res.
  doi: 10.1016/j.bbamcr.2020.118886
– volume: 126
  start-page: 1885
  year: 2016
  end-page: 1896
  ident: CR32
  article-title: FAK regulates platelet extravasation and tumor growth after antiangiogenic therapy withdrawal
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI85086
– volume: 48
  start-page: 554
  year: 2019
  end-page: 572.e7
  ident: CR30
  article-title: Studying the fate of tumor extracellular vesicles at high spatiotemporal resolution using the zebrafish embryo
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2019.01.014
– volume: 566
  start-page: 553
  year: 2019
  end-page: 557
  ident: CR8
  article-title: Neutrophils escort circulating tumour cells to enable cell cycle progression
  publication-title: Nature
  doi: 10.1038/s41586-019-0915-y
– volume: 10
  start-page: 1350
  year: 2020
  ident: CR25
  article-title: Platelets and metastasis: new implications of an old interplay
  publication-title: Front. Oncol.
  doi: 10.3389/fonc.2020.01350
– volume: 39
  start-page: 956
  year: 2019
  end-page: 964
  ident: CR70
  article-title: Safety and tolerability, pharmacokinetics, and pharmacodynamics of ACT017, an antiplatelet GPVI (Glycoprotein VI) fab
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.118.312314
– volume: 20
  start-page: 107
  year: 2020
  end-page: 124
  ident: CR1
  article-title: Fluids and their mechanics in tumour transit: shaping metastasis
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/s41568-019-0221-x
– volume: 13
  start-page: 58
  year: 2008
  end-page: 68
  ident: CR37
  article-title: Systemic spread is an early step in breast cancer
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2007.12.003
– volume: 137
  start-page: 3201
  year: 2021
  end-page: 3211
  ident: CR69
  article-title: Aspirin and antiplatelet treatments in cancer
  publication-title: Blood
  doi: 10.1182/blood.2019003977
– volume: 4
  start-page: 217
  year: 2006
  end-page: 228
  ident: CR74
  article-title: Synthesis of GPIb beta with novel transmembrane and cytoplasmic sequences in a Bernard-Soulier patient resulting in GPIb-defective signaling in CHO cells
  publication-title: J. Thromb. Haemost.
  doi: 10.1111/j.1538-7836.2005.01654.x
– volume: 28
  start-page: 2491
  year: 2019
  end-page: 2500.e5
  ident: CR3
  article-title: Metastatic tumor cells exploit their adhesion repertoire to counteract shear forces during intravascular arrest
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2019.07.102
– volume: 14
  start-page: 417
  year: 2017
  end-page: 419
  ident: CR79
  article-title: Salmon provides fast and bias-aware quantification of transcript expression
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.4197
– volume: 137
  start-page: 1219
  year: 2021
  end-page: 1232
  ident: CR20
  article-title: Local blood coagulation drives cancer cell arrest and brain metastasis in a mouse model
  publication-title: Blood
  doi: 10.1182/blood.2020005710
– volume: 176
  start-page: 98
  year: 2019
  end-page: 112.e14
  ident: CR7
  article-title: Circulating tumor cell clustering shapes DNA methylation to enable metastasis seeding
  publication-title: Cell
  doi: 10.1016/j.cell.2018.11.046
– volume: 14
  year: 2014
  ident: CR33
  article-title: Presence of intratumoral platelets is associated with tumor vessel structure and metastasis
  publication-title: BMC Cancer
  doi: 10.1186/1471-2407-14-167
– volume: 5
  start-page: 1753
  year: 2014
  end-page: 1760
  ident: CR56
  article-title: Apoptotic circulating tumor cells (CTCs) in the peripheral blood of metastatic colorectal cancer patients are associated with liver metastasis but not CTCs
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.1524
– volume: 133
  start-page: 2255
  year: 2013
  end-page: 2264
  ident: CR75
  article-title: Mesenchymal contribution to recruitment, infiltration, and positioning of leukocytes in human melanoma tissues
  publication-title: J. Invest. Dermatol.
  doi: 10.1038/jid.2013.88
– volume: 12
  start-page: e0172788
  year: 2017
  ident: CR24
  article-title: Platelet GPIIb supports initial pulmonary retention but inhibits subsequent proliferation of melanoma cells during hematogenic metastasis
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0172788
– volume: 47
  start-page: 3115
  year: 1987
  end-page: 3117
  ident: CR22
  article-title: Effect of human tumor cells on platelet aggregation: potential relevance to pattern of metastasis
  publication-title: Cancer Res.
– volume: 353
  start-page: 2158
  year: 1999
  end-page: 2159
  ident: CR53
  article-title: Platelet counts and prognosis of pancreatic cancer
  publication-title: Lancet
  doi: 10.1016/S0140-6736(05)75597-5
– volume: 36
  start-page: 249
  year: 2017
  end-page: 262
  ident: CR54
  article-title: Platelets and cancer angiogenesis nexus
  publication-title: Cancer Metastasis Rev.
  doi: 10.1007/s10555-017-9673-1
– volume: 29
  start-page: 110
  year: 2015
  end-page: 119
  ident: CR27
  article-title: Platelets are not just for clots
  publication-title: Transfus. Med. Rev.
  doi: 10.1016/j.tmrv.2014.11.006
– volume: 11
  start-page: 195
  year: 2017
  end-page: 210
  ident: CR52
  article-title: The pretreatment thrombocytosis may predict prognosis of patients with colorectal cancer: a systematic review and meta-analysis
  publication-title: Biomark. Med.
  doi: 10.2217/bmm-2016-0214
– volume: 13
  start-page: e074874
  year: 2023
  ident: CR68
  article-title: Prognostic significance of platelet-to-lymphocyte ratio (PLR) in patients with breast cancer treated with neoadjuvant chemotherapy: a meta-analysis
  publication-title: BMJ Open
  doi: 10.1136/bmjopen-2023-074874
– volume: 5
  start-page: 1097
  year: 2007
  end-page: 1105
  ident: CR55
  article-title: The tissue factor-factor VIIa complex: procoagulant activity, regulation, and multitasking
  publication-title: J. Thromb. Haemost.
  doi: 10.1111/j.1538-7836.2007.02435.x
– volume: 114
  start-page: 1104
  year: 2015
  end-page: 1112
  ident: CR48
  article-title: Solid cancers after antiplatelet therapy: confirmations, controversies, and challenges
  publication-title: Thromb. Haemost.
  doi: 10.1160/TH15-01-0077
– volume: 143
  start-page: 819
  year: 2004
  end-page: 826
  ident: CR26
  article-title: Platelet-cancer interactions: mechanisms and pharmacology of tumour cell-induced platelet aggregation
  publication-title: Br. J. Pharmacol.
  doi: 10.1038/sj.bjp.0706013
– volume: 10
  year: 2019
  ident: CR82
  article-title: Metascape provides a biologist-oriented resource for the analysis of systems-level datasets
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-09234-6
– volume: 527
  start-page: 104
  year: 2020
  end-page: 109
  ident: CR66
  article-title: Human platelets express functional ectonucleotidases that restrict platelet activation signaling
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2020.04.065
– volume: 36
  start-page: 889
  year: 1976
  end-page: 894
  ident: CR31
  article-title: The significance of hematogenous tumor cell clumps in the metastatic process
  publication-title: Cancer Res.
– volume: 25
  start-page: 103969
  year: 2022
  ident: CR6
  article-title: Circulating tumor cells: towards mechanical phenotyping of metastasis
  publication-title: iScience
  doi: 10.1016/j.isci.2022.103969
– volume: 137
  start-page: 3192
  year: 2021
  end-page: 3200
  ident: CR60
  article-title: Platelets and extracellular vesicles and their cross talk with cancer
  publication-title: Blood
  doi: 10.1182/blood.2019004119
– volume: 123
  start-page: 2332
  year: 2010
  end-page: 2341
  ident: CR73
  article-title: Visualizing extravasation dynamics of metastatic tumor cells
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.069443
– volume: 24
  start-page: 130
  year: 2013
  end-page: 137
  ident: CR21
  article-title: Platelet-derived nucleotides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2013.05.008
– volume: 9
  start-page: 945
  year: 2017
  end-page: 958
  ident: CR46
  article-title: Design, development and characterization of ACT017, a humanized Fab that blocks platelet’s glycoprotein VI function without causing bleeding risks
  publication-title: MAbs
  doi: 10.1080/19420862.2017.1336592
– volume: 96
  start-page: 1798
  year: 2000
  end-page: 1807
  ident: CR39
  article-title: Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily
  publication-title: Blood
  doi: 10.1182/blood.V96.5.1798
– volume: 179
  start-page: 2851
  year: 2007
  end-page: 2859
  ident: CR41
  article-title: Altered immune function during long-term host-tumor interactions can be modulated to retard autochthonous neoplastic growth
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.179.5.2851
– volume: 106
  start-page: 2000
  year: 2021
  end-page: 2003
  ident: CR47
  article-title: Glenzocimab does not impact glycoprotein VI-dependent inflammatory haemostasis
  publication-title: Haematologica
  doi: 10.3324/haematol.2020.270439
– ident: CR76
– volume: 5
  start-page: 1
  year: 2004
  end-page: 16
  ident: CR81
  article-title: Bioconductor: open software development for computational biology and bioinformatics
  publication-title: Genome Biol.
  doi: 10.1186/gb-2004-5-10-r80
– volume: 158
  start-page: 1110
  year: 2014
  ident: 47516_CR5
  publication-title: Cell
  doi: 10.1016/j.cell.2014.07.013
– volume: 111
  start-page: E3053
  year: 2014
  ident: 47516_CR9
  publication-title: Proc. Natl Acad. Sci.
  doi: 10.1073/pnas.1411082111
– volume: 137
  start-page: 3192
  year: 2021
  ident: 47516_CR60
  publication-title: Blood
  doi: 10.1182/blood.2019004119
– volume: 28
  start-page: 2491
  year: 2019
  ident: 47516_CR3
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2019.07.102
– volume: 141
  start-page: 241
  year: 2004
  ident: 47516_CR49
  publication-title: Br. J. Pharmacol.
  doi: 10.1038/sj.bjp.0705606
– volume: 111
  start-page: 1227
  year: 2008
  ident: 47516_CR61
  publication-title: Blood
  doi: 10.1182/blood-2007-09-113837
– volume: 179
  start-page: 2851
  year: 2007
  ident: 47516_CR41
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.179.5.2851
– volume: 137
  start-page: 1219
  year: 2021
  ident: 47516_CR20
  publication-title: Blood
  doi: 10.1182/blood.2020005710
– volume: 143
  start-page: 819
  year: 2004
  ident: 47516_CR26
  publication-title: Br. J. Pharmacol.
  doi: 10.1038/sj.bjp.0706013
– volume: 36
  start-page: 889
  year: 1976
  ident: 47516_CR31
  publication-title: Cancer Res.
– volume: 341
  start-page: 156
  year: 2012
  ident: 47516_CR42
  publication-title: J. Pharmacol. Exp. Ther.
  doi: 10.1124/jpet.111.189050
– volume: 527
  start-page: 104
  year: 2020
  ident: 47516_CR66
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2020.04.065
– volume: 29
  start-page: 15
  year: 2013
  ident: 47516_CR78
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bts635
– volume: 40
  start-page: 986
  year: 2022
  ident: 47516_CR12
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2022.08.004
– volume: 10
  year: 2019
  ident: 47516_CR82
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-09234-6
– volume: 505
  start-page: 412
  year: 2014
  ident: 47516_CR44
  publication-title: Nature
  doi: 10.1038/nature12807
– ident: 47516_CR4
  doi: 10.1007/978-1-0716-1350-4_8
– volume: 14
  year: 2014
  ident: 47516_CR33
  publication-title: BMC Cancer
  doi: 10.1186/1471-2407-14-167
– volume: 130
  start-page: 576
  year: 2010
  ident: 47516_CR23
  publication-title: J. Invest. Dermatol.
  doi: 10.1038/jid.2009.278
– volume: 353
  start-page: 2158
  year: 1999
  ident: 47516_CR53
  publication-title: Lancet
  doi: 10.1016/S0140-6736(05)75597-5
– volume: 33
  start-page: 965
  year: 2018
  ident: 47516_CR10
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2018.03.002
– volume: 5
  start-page: 1753
  year: 2014
  ident: 47516_CR56
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.1524
– volume: 39
  start-page: 1
  year: 2016
  ident: 47516_CR63
  publication-title: Curr. Opin. Immunol.
  doi: 10.1016/j.coi.2015.10.009
– volume: 32
  start-page: 292
  year: 2016
  ident: 47516_CR77
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btv566
– volume: 135
  start-page: 1146
  year: 2020
  ident: 47516_CR59
  publication-title: Blood
– volume: 7
  start-page: 1713
  year: 2009
  ident: 47516_CR15
  publication-title: J. Thromb. Haemost.
  doi: 10.1111/j.1538-7836.2009.03559.x
– volume: 20
  start-page: 107
  year: 2020
  ident: 47516_CR1
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/s41568-019-0221-x
– volume: 126
  start-page: 1885
  year: 2016
  ident: 47516_CR32
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI85086
– volume: 13
  start-page: 58
  year: 2008
  ident: 47516_CR37
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2007.12.003
– volume: 137
  start-page: 3201
  year: 2021
  ident: 47516_CR69
  publication-title: Blood
  doi: 10.1182/blood.2019003977
– volume: 104
  start-page: 9024
  year: 2007
  ident: 47516_CR16
  publication-title: Proc. Natl Acad. Sci.
  doi: 10.1073/pnas.0700625104
– volume: 5
  start-page: 1097
  year: 2007
  ident: 47516_CR55
  publication-title: J. Thromb. Haemost.
  doi: 10.1111/j.1538-7836.2007.02435.x
– volume: 366
  start-page: 610
  year: 2012
  ident: 47516_CR11
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1110352
– volume: 11
  start-page: 195
  year: 2017
  ident: 47516_CR52
  publication-title: Biomark. Med.
  doi: 10.2217/bmm-2016-0214
– volume: 2
  start-page: 1091
  year: 2012
  ident: 47516_CR18
  publication-title: Cancer Discov.
  doi: 10.1158/2159-8290.CD-12-0329
– volume: 133
  start-page: 2255
  year: 2013
  ident: 47516_CR75
  publication-title: J. Invest. Dermatol.
  doi: 10.1038/jid.2013.88
– volume: 182
  start-page: 106301
  year: 2022
  ident: 47516_CR40
  publication-title: Pharmacol. Res.
  doi: 10.1016/j.phrs.2022.106301
– volume: 23
  start-page: 1204
  year: 2014
  ident: 47516_CR67
  publication-title: Cancer Epidemiol. Biomark. Prev.
  doi: 10.1158/1055-9965.EPI-14-0146
– volume: 3
  start-page: 198
  year: 2019
  ident: 47516_CR35
  publication-title: Blood Adv.
  doi: 10.1182/bloodadvances.2018026161
– volume: 47
  start-page: 3115
  year: 1987
  ident: 47516_CR22
  publication-title: Cancer Res.
– volume: 39
  start-page: 956
  year: 2019
  ident: 47516_CR70
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.118.312314
– volume: 12
  start-page: 369
  year: 2006
  ident: 47516_CR57
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-05-1698
– volume: 22
  start-page: 608
  year: 2022
  ident: 47516_CR13
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/s41568-022-00520-y
– volume: 114
  start-page: 1104
  year: 2015
  ident: 47516_CR48
  publication-title: Thromb. Haemost.
  doi: 10.1160/TH15-01-0077
– volume: 29
  start-page: 110
  year: 2015
  ident: 47516_CR27
  publication-title: Transfus. Med. Rev.
  doi: 10.1016/j.tmrv.2014.11.006
– volume: 72
  start-page: 440
  year: 2012
  ident: 47516_CR65
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-11-1872
– volume: 4
  start-page: 217
  year: 2006
  ident: 47516_CR74
  publication-title: J. Thromb. Haemost.
  doi: 10.1111/j.1538-7836.2005.01654.x
– volume: 9
  start-page: 945
  year: 2017
  ident: 47516_CR46
  publication-title: MAbs
  doi: 10.1080/19420862.2017.1336592
– volume: 45
  start-page: 33
  year: 2018
  ident: 47516_CR2
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2018.02.015
– volume: 96
  start-page: 1798
  year: 2000
  ident: 47516_CR39
  publication-title: Blood
  doi: 10.1182/blood.V96.5.1798
– ident: 47516_CR76
– volume: 15
  year: 2014
  ident: 47516_CR80
  publication-title: Genome Biol.
  doi: 10.1186/s13059-014-0550-8
– volume: 5
  start-page: 1
  year: 2004
  ident: 47516_CR81
  publication-title: Genome Biol.
  doi: 10.1186/gb-2004-5-10-r80
– volume: 123
  start-page: 2332
  year: 2010
  ident: 47516_CR73
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.069443
– volume: 24
  start-page: 130
  year: 2013
  ident: 47516_CR21
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2013.05.008
– volume: 25
  start-page: 103969
  year: 2022
  ident: 47516_CR6
  publication-title: iScience
  doi: 10.1016/j.isci.2022.103969
– volume: 6
  start-page: 799
  year: 2014
  ident: 47516_CR72
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2014.01.032
– volume: 12
  start-page: 640578
  year: 2021
  ident: 47516_CR36
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2021.640578
– volume: 171
  start-page: 1368
  year: 2017
  ident: 47516_CR58
  publication-title: Cell
  doi: 10.1016/j.cell.2017.11.001
– volume: 51
  start-page: 1286
  year: 1991
  ident: 47516_CR50
  publication-title: Cancer Res.
– volume: 13
  start-page: e074874
  year: 2023
  ident: 47516_CR68
  publication-title: BMJ Open
  doi: 10.1136/bmjopen-2023-074874
– volume: 10
  start-page: 1350
  year: 2020
  ident: 47516_CR25
  publication-title: Front. Oncol.
  doi: 10.3389/fonc.2020.01350
– volume: 20
  start-page: 576
  year: 2011
  ident: 47516_CR34
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2011.09.009
– volume: 6
  start-page: e750
  year: 2022
  ident: 47516_CR28
  publication-title: HemaSphere
  doi: 10.1097/HS9.0000000000000750
– ident: 47516_CR71
– volume: 106
  start-page: 2000
  year: 2021
  ident: 47516_CR47
  publication-title: Haematologica
  doi: 10.3324/haematol.2020.270439
– volume: 8
  start-page: 15632
  year: 2017
  ident: 47516_CR51
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.14921
– ident: 47516_CR64
  doi: 10.1126/sciimmunol.aai7911
– volume: 59
  start-page: 1295
  year: 1999
  ident: 47516_CR19
  publication-title: Cancer Res.
– ident: 47516_CR45
  doi: 10.1172/jci.insight.160978
– volume: 133
  start-page: 2696
  year: 2019
  ident: 47516_CR17
  publication-title: Blood
  doi: 10.1182/blood.2018877043
– volume: 531
  start-page: 513
  year: 2016
  ident: 47516_CR29
  publication-title: Nature
  doi: 10.1038/nature16985
– volume: 212
  start-page: 1725
  year: 2015
  ident: 47516_CR43
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20140654
– volume: 12
  start-page: e0172788
  year: 2017
  ident: 47516_CR24
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0172788
– volume: 61
  start-page: 46
  year: 1968
  ident: 47516_CR14
  publication-title: Proc. Natl Acad. Sci.
  doi: 10.1073/pnas.61.1.46
– volume: 36
  start-page: 249
  year: 2017
  ident: 47516_CR54
  publication-title: Cancer Metastasis Rev.
  doi: 10.1007/s10555-017-9673-1
– volume: 566
  start-page: 553
  year: 2019
  ident: 47516_CR8
  publication-title: Nature
  doi: 10.1038/s41586-019-0915-y
– volume: 48
  start-page: 554
  year: 2019
  ident: 47516_CR30
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2019.01.014
– volume: 176
  start-page: 98
  year: 2019
  ident: 47516_CR7
  publication-title: Cell
  doi: 10.1016/j.cell.2018.11.046
– volume: 51
  start-page: 1113
  year: 2019
  ident: 47516_CR38
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-019-0423-x
– volume: 1868
  start-page: 118886
  year: 2021
  ident: 47516_CR62
  publication-title: Biochim. Biophys. Acta Mol. Cell Res.
  doi: 10.1016/j.bbamcr.2020.118886
– volume: 14
  start-page: 417
  year: 2017
  ident: 47516_CR79
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.4197
SSID ssj0000391844
Score 2.5275352
Snippet Despite abundant evidence demonstrating that platelets foster metastasis, anti-platelet agents have low therapeutic potential due to the risk of hemorrhages....
Abstract Despite abundant evidence demonstrating that platelets foster metastasis, anti-platelet agents have low therapeutic potential due to the risk of...
SourceID doaj
pubmedcentral
hal
proquest
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 3297
SubjectTerms 13/1
13/51
14
14/19
14/5
45/91
631/67/1059
631/67/322
64/116
64/60
Animal models
Animals
Binding
Blood Platelets - drug effects
Blood Platelets - metabolism
Cell Line, Tumor
Female
Glycoprotein VI
Glycoproteins
Hematology
Hemorrhage
Human health and pathology
Humanities and Social Sciences
Humans
Life Sciences
Metastases
Metastasis
Mice
Mice, Inbred C57BL
multidisciplinary
Neoplasm Metastasis
Pharmacology
Platelet Membrane Glycoproteins - genetics
Platelet Membrane Glycoproteins - metabolism
Platelets
Receptors
Science
Science (multidisciplinary)
Tumor cells
Tumors
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Nb9QwEB2hSpW4IChfgYIC4gZRN7Zjx8eCqFYVIA5U6s3yJ4tUEtRkW_HvGdvZpaGiXDjGcRJnPPZ7T7ZnAF5RbhFmnKuQK7iKeScqabSoODPCBh0CdfGA88dPfHnCjk-b0yupvuKesBweOBvugDiNFMFwZ_gCpYQ1iJEWSTgCX2usS8IHMe-KmEpzMJUoXdh0SmZB24OBpTkBIalioql5dTlDohSwH_FlFbdDXuea17dM_rFumuDo6C7cmXhkeZjbfw9u-W4PdnNmyZ_3QXw-QxKJfTKUQV_05yXyvLJfj19RdY-rsg8lflfnHfGu_O5HjZeDHx7AydH7L--W1ZQjobJItMaqNR4lkte60bXVhCH9RE3ngzMicBmkNk7q0CBpwHLfBk-5tCRo1jjUBkHQh7DT9Z1_DKWJ6XAlJ54sAnNSGGJCII0LQVJLuS-g3thL2SmAeMxjcabSQjZtVbaxQhurZGN1WcDr7TM_cviMG2u_jd2wrRlDX6cCdAg1OYT6l0MU8BI7cfaO5eEHFcvwjyMBZRdYaX_Tx2oatIPCqY8horNGFPBiexuHW1xD0Z3v17kOauJGkgIeZZfYforG9IaCtQW0M2eZtWV-p_u2SiG9Y9zXuuaygDcbv_rdrr8b7Mn_MNhTuE3isIghaek-7Izna_8MmdZonqdB9QtUTCNf
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagCIkL4k2goIC4gdWN7djxCRVEtUKAOFBpb5afXaSSlE22Ff-emSSbKlT0GMd5zYw939iTbwh5w6UHNxMCBawQqIhBUe2solI45ZNNiQf8wfnrN7k8Fp9X5WpccGvHtMrdnNhP1KHxuEZ-AHYpYLoVpXp_9pti1SjcXR1LaNwkt5C6DFO61EpNayzIfl4JMf4rs-DVQSv6mQEcExWqLCS9mPmjnrYfvMwakyKvIs6riZP_7J72TunoHrk7osn8cFD_fXIj1g_I7aG-5J-HRH0_BSgJmmnzZM-bTQ5oL2-23QnE3t06b1IOz7VDXnzIf8XOwmEb20fk-OjTj49LOlZKoB7gVkcrFyFQitaWtvCWCQChENnFFJxKUidtXdA2lQAdoD1WKXKpPUtWlAEihKT4Y7JXN3V8SnKHRXG1ZJEtkghaOeZSYmVISXPPZcxIsZOX8SONOFazODX9djavzCBjAzI2vYzNRUbeTtecDSQa1_b-gGqYeiIBdt_QbE7MOJ4MCxaQo5PByQVEmN4BdPIQmwEeqpwPRUZegxJn91gefjHYBl-MMFScQ6f9nY7NOHRbc2loGXk1nYZBhzspto7NdugDkXGpWUaeDCYxPYpjkUMlqoxUM2OZvcv8TP1z3RN7I_trUUidkXc7u7p8r_8L7Nn1n_Gc3GFo8Eg5y_fJXrfZxheApDr3sh8ufwGPYBtK
  priority: 102
  providerName: ProQuest
– databaseName: Springer Nature OA Free Journals
  dbid: C6C
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwEB6VIiQuFW9SCgqIG0RsbMeOj2VFtUKAOFCpN8vPLlJJ0Cbbin_P2MkGhQISx3UmG-94JvPNevwNwEvKLYYZ5wrECq5g3olCGi0KzoywQYdAXTzg_PETX52y92fV2R6Q3VmYVLSfKC3Ta3pXHfamY8mlMaIUTFQlL65uwM1I3R6tesmX0_8qkfG8Zmw8H7Og9R9uncWgRNWPkWUdCyGvo8zrxZK_7ZimQHRyBw5GBJkfD3O-C3u-uQe3hp6SP-6D-HyB8BFXo8uDvmw3OSK8vN3255hv9-u8DTk-Vw-18C7_5nuNHzvfPYDTk3dflqti7I5QWIRYfVEbj8mR17rSpdWEIfDEbM4HZ0TgMkhtnNShQriA474OnnJpSdCscpgVBEEfwn7TNv4x5CY2wpWceLIIzElhiAmBVC4ESS3lPoNypy9lR-rw2MHiQqUtbFqrQccKdaySjtVVBq-me74PxBn_lH4bl2GSjKTXaaDdnKvRCBRxGtGi4c7wBWaV1iBcspiPIQaqjXVlBi9wEWffsTr-oOIY_uIIPdklCh3t1liN7topfOkxjOWsEhk8ny6jo8XdE934djvIYDZcSZLBo8EkpkfR2NhQsDqDemYss7nMrzRf14nMOzK-liWXGbze2dWvef1dYYf_J_4EbpPoAJF2lh7Bfr_Z-qeIpnrzLLnPT9NJGa4
  priority: 102
  providerName: Springer Nature
Title Platelets favor the outgrowth of established metastases
URI https://link.springer.com/article/10.1038/s41467-024-47516-w
https://www.ncbi.nlm.nih.gov/pubmed/38740748
https://www.proquest.com/docview/3054303457
https://www.proquest.com/docview/3054840592
https://hal.science/hal-04974164
https://pubmed.ncbi.nlm.nih.gov/PMC11091169
https://doaj.org/article/2da522b6db60448cb066c2604318bcd1
Volume 15
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwED_tQ6C9IL4JjCog3iCwJI4dPyDUVStVxaYJqNQ3y58rUkmgTTf233POR6Fs8MBLojhOnJzvcr9fbN8BvEipRjdjTIRYwUTEGhZxJVlEiWLaSedS4xc4H5_Q0YSMp9l0C7p0R60Al9dSO59ParKYv_7x_fIdGvzbZsl4_mZJanNHbxMRlsU0utiGXfRMzBvqcQv36y9zypHQkHbtzPWX7sHN1KepYz4j0G-uqo7ojw5o5udLXgWjV-dU_jGwWvur4W241QLNsN9oxh3YssVduNGknry8B-x0jigTO20ZOnleLkIEgmG5qs6QllezsHQhtiubKfMm_GoriYdLu7wPk-HR58EoapMoRBqRWBXlyiKHslJmMtYyIYhPkfRZZxRzlDsuleHSZYgqsNzmzqaU68RJkhkkD46lD2CnKAv7CELl8-VymtjkwBHDmUqUc0lmnOOpTqkNIO7kJXQbYdwnupiLeqQ7zUUjboHiFrW4xUUAL9fXfGvia_yz9qHvhnVNHxu7LigXZ6I1NZEYiaBSUaPoAZJPrRBVaaRtCJVypU0cwHPsxI17jPofhC_DN_YIlZxjpf2uj0WnlAK_jQRdPslYAM_Wp9Ee_SCLLGy5auogac54EsDDRiXWTXWKFUC-oSwbz7J5pvgyq2N--8CwcUx5AK86vfr1XH8X2OP_b-kJ7CXeLnyk2nQfdqrFyj5FAFapHmyzKcNtPnzfg91-f_xpjPvDo5PTj1g6oINe_WujV1vfT5dnMxc
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VIgQXxJtAgYDgBFE3jmMnB4TKo9rSbcWhlfbm-tlFKknZZLvqn-I3Ms6rWip66zGO8xp_M_NNbM8AvE2YRjdjTIRcwUTUGh7lSvKIUcW1k84lxm9w3ttn40P6fZpO1-BPvxfGL6vsbWJjqE2p_T_yTcQlRXNLU_7p9Hfkq0b52dW-hEYLi117vsSQrfq48xXH9x0h298OvoyjrqpApJGa1FGmLAYVVspUxloSioQNoyDrjOKO5S6XyuTSpehmsd1mziYs18RJmhpk044neN8bcBMd78hrFJ_y4Z-Oz7aeUdrtzRkl2WZFG0uEjjCiPI1ZtFzxf02ZAPRqM78I8zLDvbxQ85_Z2sYJbt-Dux17DbdauN2HNVs8gFttPcvzh8B_nCB1RSRUoZNn5TxEdhmWi_oYY_16FpYuxOfKdh2-CX_ZWuJhZatHcHgtMnwM60VZ2KcQKl-EN2fEkpGjJueKKOdIapzLE50wG0Dcy0voLm25r55xIprp8yQTrYwFylg0MhbLAN4P15y2STuu7P3ZD8PQ0yfcbhrK-bHo9FcQI5GpKmYUG2FEqxVSNY2xIMIgU9rEAbzBQVy5x3hrInwbfrGnvfQMO230Yyw6U1GJC2AH8Ho4jUruZ25kYctF2wcj8TQnATxpITE8KvFFFTnNAshWwLLyLqtnip-zJpG4zzYbxywP4EOPq4v3-r_Anl39Ga_g9vhgbyImO_u7z-EO8eD36W6TDViv5wv7AllcrV42qhPC0XXr6l8JL1nv
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VIhAXxJtAgYDgBFE3tmMnB4QKZbWlpeqBSntz_ewilU3ZZLvqX-PXMc5jq6Witx7jOE48nsc38XgG4C3lBs2MtQliBZswZ0VSaCUSzrQwXnlPbTjg_H2fjw7Zt3E2XoM__VmYEFbZ68RGUdvShH_km8iXDNUtQwfed2ERB9vDT6e_k1BBKuy09uU0WhbZdecLdN-qjzvbuNbvCBl-_fFllHQVBhKDMKVOcu3QwXBKZSo1ijAEb-gROW-18LzwhdK2UD5Dk4vtLveO8sIQr1hmEVl7QXHcG3BT0CwNMibGYvl_J2RezxnrzukMaL5ZsUYroVFMmMhSnixWbGFTMgAt3CQEZF5Gu5eDNv_ZuW0M4vAe3O2QbLzVst59WHPTB3CrrW15_hDEwQnCWOSKKvbqrJzFiDTjcl4fo99fT-LSx_he1cbk2_iXqxVeVq56BIfXQsPHsD4tp-4pxDoU5C04cWTgmS2EJtp7klnvC2oodxGkPb2k6VKYh0oaJ7LZSqe5bGkskcayobFcRPB--cxpm8Djyt6fwzIse4bk201DOTuWnSxLYhWiVs2t5gP0bo1G2GbQL0Qslmtj0wje4CKujDHa2pOhDWccIDA7w04b_RrLTm1U8oLJI3i9vI0CH3Zx1NSV87YPeuVZQSJ40rLE8lU0FFgULI8gX2GWlW9ZvTP9OWmSiofMs2nKiwg-9Hx18V3_J9izq6fxCm6jlMq9nf3d53CHBN4PmW_pBqzXs7l7gYCu1i8byYnh6LpF9S8xDV4l
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Platelets+favor+the+outgrowth+of+established+metastases&rft.jtitle=Nature+communications&rft.au=Garcia-Leon%2C+Maria+J.&rft.au=Liboni%2C+Cristina&rft.au=Mittelheisser%2C+Vincent&rft.au=Bochler%2C+Louis&rft.date=2024-05-13&rft.pub=Nature+Publishing+Group+UK&rft.eissn=2041-1723&rft.volume=15&rft_id=info:doi/10.1038%2Fs41467-024-47516-w&rft_id=info%3Apmid%2F38740748&rft.externalDocID=PMC11091169
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon