Two Kinesins Transport Cargo Primarily via the Action of One Motor: Implications for Intracellular Transport

• Published in: Biophysical journal Vol. 99; no. 9; pp. 2967 - 2977
• Main Authors: Jamison, D. Kenneth, Driver, Jonathan W., Rogers, Arthur R., Constantinou, Pamela E., Diehl, Michael R.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 03.11.2010; Biophysical Society; The Biophysical Society
• Subjects: Assemblies; Binding sites; Biological Transport, Active; Biophysical Phenomena; Biophysics; Cells; Commodities; Elasticity; Filaments; Humans; In Vitro Techniques; Kinesin - chemistry; Kinesin - genetics; Kinesin - metabolism; Kinetics; Loads (forces); Microtubules - metabolism; Models, Biological; Molecular Motor Proteins - chemistry; Molecular Motor Proteins - genetics; Molecular Motor Proteins - metabolism; Molecules; Motors; Muscle, Motility, and Motor Proteins; Optical Tweezers; Protein Multimerization; Recombinant Proteins - chemistry; Recombinant Proteins - genetics; Recombinant Proteins - metabolism; Studies; Transport; Tuning

The number of microtubule motors attached to vesicles, organelles, and other subcellular commodities is widely believed to influence their motile properties. There is also evidence that cells regulate intracellular transport by tuning the number and/or ratio of motor types on cargos. Yet, the number...