The Effect of Intracerebroventricular Dopamine Administration on the Respiratory Response to Hypoxia

• Published in: The Tohoku Journal of Experimental Medicine Vol. 196; no. 4; pp. 219 - 230
• Main Authors: GÜNER, IBRAHIM, YELMEN, NERMIN, SAHIN, GÜLDEREN, ORUÇ, TÜLIN
• Format: Journal Article
• Language: English
• Published: Japan Tohoku University Medical Press 2002
• Subjects: Animals; central respiratory pattern; Cerebrovascular Circulation; domperidone; Domperidone - pharmacology; dopamine; Dopamine - administration & dosage; Dopamine - pharmacology; Dopamine Antagonists - pharmacology; haloperidol; Haloperidol - pharmacology; Hypoxia; Rabbits; Respiratory Function Tests; Respiratory Physiological Phenomena - drug effects

Acute hypoxia produces an increase in ventilation. When the hypoxia is sustained, the initial increase in ventilation is followed a decrease in ventilation. The precise mechanism of this decline in ventilation during sustained hypoxia is unknown. Recent studies hypothesized that the accumulation of...