Inferring the genetic relationship between brain imaging-derived phenotypes and risk of complex diseases by Mendelian randomization and genome-wide colocalization

• Published in: NeuroImage (Orlando, Fla.) Vol. 279; p. 120325
• Main Authors: Lin, Siying, Zhang, Haoyang, Qi, Mengling, Cooper, David N., Yang, Yuedong, Yang, Yuanhao, Zhao, Huiying
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2023; Elsevier Limited; Elsevier
• Subjects: Alzheimer's disease; Amyotrophic lateral sclerosis; Angina pectoris; Autism; Biomarkers; Brain disorders; Brain imaging-derived phenotypes; Cardiovascular disease; Cardiovascular diseases; Causal relationships; Consortia; Genetic correlation; Genetic relationship; Genome-wide association studies; Genomes; Genomic analysis; Genomics; Hypertension; Insomnia; Magnetic resonance imaging; Medical imaging; Mental depression; Mental disorders; Neuroimaging; Neurological disorders; Phenotypes; Schizophrenia; Single-nucleotide polymorphism; Sleep; Statistical analysis; Statistics; Temporal lobe; PP; ADHD; GWAS; Brain disorders; Genetic correlation; ALS; WTE; IVW; SCZ; MDD; STM; SA; TFA; INS; STR; ASD; HBP; KEGG; BID; MAGMA; MI; CA; AD; CH; MR; MS; GO; LDSC; AN; UKB; AP; PTSD; PAD; MAF; PD; rg; Brain imaging-derived phenotypes; Cardiovascular diseases; Causal relationships; HF; NAR; EPI

•We found the first evidence for significant putative causal effects of multiple brain region-specific IDPs on the increased risks of ALS, MDD, ASD, and SCZ.•The brain IDPs from temporal lobe were identified as a putatively causal consequence of hypertension.•We identified causal SNPs, rs853676, rs1...