Quiescence unveils a novel mutational force in fission yeast

• Published in: eLife Vol. 6
• Main Authors: Gangloff, Serge, Achaz, Guillaume, Francesconi, Stefania, Villain, Adrien, Miled, Samia, Denis, Claire, Arcangioli, Benoit
• Format: Journal Article
• Language: English
• Published: England eLife Sciences Publications Ltd 18.12.2017; eLife Sciences Publication; eLife Sciences Publications, Ltd
• Subjects: Biological Variation, Population; Cell cycle; Cell division; Clonal deletion; Deoxyribonucleic acid; DNA; DNA repair; Evolution; Gene deletion; Genetics and Genomics; Genomes; Genotype & phenotype; Insertion; Life Sciences; molecular clock; Mutation; mutations; Natural selection; Nitrogen; Phenotypic variations; Population; postmitotic; Schizosaccharomyces - genetics; Schizosaccharomyces - physiology; Selection, Genetic; stem cells; Time Factors; Yeast; postmitotic; stem cells; evolutionary biology; molecular clock; mutations; S. pombe; genomics; evolution

To maintain life across a fluctuating environment, cells alternate between phases of cell division and quiescence. During cell division, the spontaneous mutation rate is expressed as the probability of mutations per generation (Luria and Delbrück, 1943; Lea and Coulson, 1949), whereas during quiesce...