Quiescence unveils a novel mutational force in fission yeast

To maintain life across a fluctuating environment, cells alternate between phases of cell division and quiescence. During cell division, the spontaneous mutation rate is expressed as the probability of mutations per generation (Luria and Delbrück, 1943; Lea and Coulson, 1949), whereas during quiesce...

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Published ineLife Vol. 6
Main Authors Gangloff, Serge, Achaz, Guillaume, Francesconi, Stefania, Villain, Adrien, Miled, Samia, Denis, Claire, Arcangioli, Benoit
Format Journal Article
LanguageEnglish
Published England eLife Sciences Publications Ltd 18.12.2017
eLife Sciences Publication
eLife Sciences Publications, Ltd
Subjects
Biological Variation, Population
Cell cycle
Cell division
Clonal deletion
Deoxyribonucleic acid
DNA
DNA repair
Evolution
Gene deletion
Genetics and Genomics
Genomes
Genotype & phenotype
Insertion
Life Sciences
molecular clock
Mutation
mutations
Natural selection
Nitrogen
Phenotypic variations
Population
postmitotic
Schizosaccharomyces - genetics
Schizosaccharomyces - physiology
Selection, Genetic
stem cells
Time Factors
Yeast
postmitotic
stem cells
evolutionary biology
molecular clock
mutations
S. pombe
genomics
evolution
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Abstract To maintain life across a fluctuating environment, cells alternate between phases of cell division and quiescence. During cell division, the spontaneous mutation rate is expressed as the probability of mutations per generation (Luria and Delbrück, 1943; Lea and Coulson, 1949), whereas during quiescence it will be expressed per unit of time. In this study, we report that during quiescence, the unicellular haploid fission yeast accumulates mutations as a linear function of time. The novel mutational landscape of quiescence is characterized by insertion/deletion (indels) accumulating as fast as single nucleotide variants (SNVs), and elevated amounts of deletions. When we extended the study to 3 months of quiescence, we confirmed the replication-independent mutational spectrum at the whole-genome level of a clonally aged population and uncovered phenotypic variations that subject the cells to natural selection. Thus, our results support the idea that genomes continuously evolve under two alternating phases that will impact on their size and composition.
AbstractList To maintain life across a fluctuating environment, cells alternate between phases of cell division and quiescence. During cell division, the spontaneous mutation rate is expressed as the probability of mutations per generation (Luria and Delbrück, 1943; Lea and Coulson, 1949), whereas during quiescence it will be expressed per unit of time. In this study, we report that during quiescence, the unicellular haploid fission yeast accumulates mutations as a linear function of time. The novel mutational landscape of quiescence is characterized by insertion/deletion (indels) accumulating as fast as single nucleotide variants (SNVs), and elevated amounts of deletions. When we extended the study to 3 months of quiescence, we confirmed the replication-independent mutational spectrum at the whole-genome level of a clonally aged population and uncovered phenotypic variations that subject the cells to natural selection. Thus, our results support the idea that genomes continuously evolve under two alternating phases that will impact on their size and composition.
To maintain life across a fluctuating environment, cells alternate between phases of cell division and quiescence. During cell division, the spontaneous mutation rate is expressed as the probability of mutations generation (Luria and Delbrück, 1943; Lea and Coulson, 1949), whereas during quiescence it will be expressed unit of time. In this study, we report that during quiescence, the unicellular haploid fission yeast accumulates mutations as a linear function of time. The novel mutational landscape of quiescence is characterized by insertion/deletion (indels) accumulating as fast as single nucleotide variants (SNVs), and elevated amounts of deletions. When we extended the study to 3 months of quiescence, we confirmed the replication-independent mutational spectrum at the whole-genome level of a clonally aged population and uncovered phenotypic variations that subject the cells to natural selection. Thus, our results support the idea that genomes continuously evolve under two alternating phases that will impact on their size and composition.
To maintain life across a fluctuating environment, cells alternate between phases of cell division and quiescence. During cell division, the spontaneous mutation rate is expressed as the probability of mutations per generation (Luria and Delbrück, 1943; Lea and Coulson, 1949), whereas during quiescence it will be expressed per unit of time. In this study, we report that during quiescence, the unicellular haploid fission yeast accumulates mutations as a linear function of time. The novel mutational landscape of quiescence is characterized by insertion/deletion (indels) accumulating as fast as single nucleotide variants (SNVs), and elevated amounts of deletions. When we extended the study to 3 months of quiescence, we confirmed the replication-independent mutational spectrum at the whole-genome level of a clonally aged population and uncovered phenotypic variations that subject the cells to natural selection. Thus, our results support the idea that genomes continuously evolve under two alternating phases that will impact on their size and composition.To maintain life across a fluctuating environment, cells alternate between phases of cell division and quiescence. During cell division, the spontaneous mutation rate is expressed as the probability of mutations per generation (Luria and Delbrück, 1943; Lea and Coulson, 1949), whereas during quiescence it will be expressed per unit of time. In this study, we report that during quiescence, the unicellular haploid fission yeast accumulates mutations as a linear function of time. The novel mutational landscape of quiescence is characterized by insertion/deletion (indels) accumulating as fast as single nucleotide variants (SNVs), and elevated amounts of deletions. When we extended the study to 3 months of quiescence, we confirmed the replication-independent mutational spectrum at the whole-genome level of a clonally aged population and uncovered phenotypic variations that subject the cells to natural selection. Thus, our results support the idea that genomes continuously evolve under two alternating phases that will impact on their size and composition.
To maintain life across a fluctuating environment, cells alternate between phases of cell division and quiescence. During cell division, the spontaneous mutation rate is expressed as the probability of mutations per generation (Luria and Delbrück, 1943; Lea and Coulson, 1949), whereas during quiescence it will be expressed per unit of time. In this study, we report that during quiescence, the unicellular haploid fission yeast accumulates mutations as a linear function of time. The novel mutational landscape of quiescence is characterized by insertion/deletion (indels) accumulating as fast as single nucleotide variants (SNVs), and elevated amounts of deletions. When we extended the study to 3 months of quiescence, we confirmed the replication-independent mutational spectrum at the whole-genome level of a clonally aged population and uncovered phenotypic variations that subject the cells to natural selection. Thus, our results support the idea that genomes continuously evolve under two alternating phases that will impact on their size and composition.
To maintain life across a fluctuating environment, cells alternate between phases of cell division and quiescence. During cell division, the spontaneous mutation rate is expressed as the probability of mutations per generation (Luria and Delbrü ck, 1943; Lea and Coulson, 1949), whereas during quiescence it will be expressed per unit of time. In this study, we report that during quiescence, the unicellular haploid fission yeast accumulates mutations as a linear function of time. The novel mutational landscape of quiescence is characterized by insertion/deletion (indels) accumulating as fast as single nucleotide variants (SNVs), and elevated amounts of deletions. When we extended the study to 3 months of quiescence, we confirmed the replication-independent mutational spectrum at the whole-genome level of a clonally aged population and uncovered phenotypic variations that subject the cells to natural selection. Thus, our results support the idea that genomes continuously evolve under two alternating phases that will impact on their size and composition.
Author Achaz, Guillaume
Francesconi, Stefania
Denis, Claire
Villain, Adrien
Gangloff, Serge
Miled, Samia
Arcangioli, Benoit
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Keywords postmitotic
stem cells
evolutionary biology
molecular clock
mutations
S. pombe
genomics
evolution
Language English
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Snippet To maintain life across a fluctuating environment, cells alternate between phases of cell division and quiescence. During cell division, the spontaneous...
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SubjectTerms Biological Variation, Population
Cell cycle
Cell division
Clonal deletion
Deoxyribonucleic acid
DNA
DNA repair
Evolution
Gene deletion
Genetics and Genomics
Genomes
Genotype & phenotype
Insertion
Life Sciences
molecular clock
Mutation
mutations
Natural selection
Nitrogen
Phenotypic variations
Population
postmitotic
Schizosaccharomyces - genetics
Schizosaccharomyces - physiology
Selection, Genetic
stem cells
Time Factors
Yeast
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Title Quiescence unveils a novel mutational force in fission yeast
URI https://www.ncbi.nlm.nih.gov/pubmed/29252184
https://www.proquest.com/docview/1982817775
https://www.proquest.com/docview/1978722311
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https://pubmed.ncbi.nlm.nih.gov/PMC5734874
https://doaj.org/article/8a73c21b2e5447b5a927da0f8b32716d
Volume 6
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