Modulation of lectin-like oxidized low-density lipoprotein receptor-1 by Porphyromonas gingivalis promoting progression of atherosclerosis in apolipoprotein E-/- mice

• Published in: Journal of dental sciences Vol. 20; no. 2; pp. 754 - 763
• Main Authors: Zhang, Shengnan, Liu, Jianru, Ouyang, Xiangying, Lyu, Peiying, Wang, Yuanbo, Zhong, Jinsheng
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2025; Association for Dental Sciences of the Republic of China; Elsevier
• Subjects: Advanced Basic Science; Atherosclerosis; Dentistry; LOX-1; Macrophage; Original; Plaque; Poly(I:C); Porphyromonas gingivalis; Porphyromonas gingivalis; Poly(I:C); LOX-1; Atherosclerosis; Plaque; Macrophage

Porphyromonas gingivalis (P. gingivalis), the primary pathogenic bacterium in periodontitis, can infiltrate the cardiovascular system via the bloodstream and actively contribute to various pathological processes associated with atherosclerosis. The scavenger receptor lectin-like oxidized low-density...