Modulation of lectin-like oxidized low-density lipoprotein receptor-1 by Porphyromonas gingivalis promoting progression of atherosclerosis in apolipoprotein E-/- mice
Porphyromonas gingivalis (P. gingivalis), the primary pathogenic bacterium in periodontitis, can infiltrate the cardiovascular system via the bloodstream and actively contribute to various pathological processes associated with atherosclerosis. The scavenger receptor lectin-like oxidized low-density...
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| Published in | Journal of dental sciences Vol. 20; no. 2; pp. 754 - 763 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.04.2025
Association for Dental Sciences of the Republic of China Elsevier |
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| Abstract | Porphyromonas gingivalis (P. gingivalis), the primary pathogenic bacterium in periodontitis, can infiltrate the cardiovascular system via the bloodstream and actively contribute to various pathological processes associated with atherosclerosis. The scavenger receptor lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) plays a crucial role in atherosclerosis pathogenesis. Previous studies have shown that LOX-1 is involved in endothelial cell activation injury, monocyte migration, and adhesion to endothelial cells induced by P. gingivalis. The objective of this study was to further investigate the potential role of LOX-1 in promoting P. gingivalis-induced atherosclerosis in mice.
Using apolipoprotein E (APOE)-/- mice fed with high-fat diet for an established model. Intravenous injection of P. gingivalis was performed to create P. gingivalis blood model while intraperitoneal injection of Polyinosinic-polycytidylic acid (Poly (I:C)) served as an inhibitor for LOX-1. After 12 weeks, plaques and blood lipids were examined.
Results showed that induction with P. gingivalis led to increased expression of LOX-1 in both the aortic root and blood samples, increased plaque area, reduced plaque stability, elevated expression levels of vascular adhesion molecule-1(VCAM-1), Interleukin-6(IL-6) and M1 macrophages. However, pretreatment with Poly (I:C) resulted in decreased plaque area improved plaque stability and reduced expression levels of VCAM-1 and IL-6.
These findings suggest that LOX-1 may serve as an intermediary factor promoting atherosclerosis associated with periodontitis. |
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| AbstractList | (
), the primary pathogenic bacterium in periodontitis, can infiltrate the cardiovascular system via the bloodstream and actively contribute to various pathological processes associated with atherosclerosis. The scavenger receptor lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) plays a crucial role in atherosclerosis pathogenesis. Previous studies have shown that LOX-1 is involved in endothelial cell activation injury, monocyte migration, and adhesion to endothelial cells induced by
. The objective of this study was to further investigate the potential role of LOX-1 in promoting
-induced atherosclerosis in mice.
Using apolipoprotein E (APOE)
mice fed with high-fat diet for an established model. Intravenous injection of
was performed to create
blood model while intraperitoneal injection of Polyinosinic-polycytidylic acid (Poly (I:C)) served as an inhibitor for LOX-1. After 12 weeks, plaques and blood lipids were examined.
Results showed that induction with
led to increased expression of LOX-1 in both the aortic root and blood samples, increased plaque area, reduced plaque stability, elevated expression levels of vascular adhesion molecule-1(VCAM-1), Interleukin-6(IL-6) and M1 macrophages. However, pretreatment with Poly (I:C) resulted in decreased plaque area improved plaque stability and reduced expression levels of VCAM-1 and IL-6.
These findings suggest that LOX-1 may serve as an intermediary factor promoting atherosclerosis associated with periodontitis. Background/Purpose: Porphyromonas gingivalis (P. gingivalis), the primary pathogenic bacterium in periodontitis, can infiltrate the cardiovascular system via the bloodstream and actively contribute to various pathological processes associated with atherosclerosis. The scavenger receptor lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) plays a crucial role in atherosclerosis pathogenesis. Previous studies have shown that LOX-1 is involved in endothelial cell activation injury, monocyte migration, and adhesion to endothelial cells induced by P. gingivalis. The objective of this study was to further investigate the potential role of LOX-1 in promoting P. gingivalis-induced atherosclerosis in mice. Materials and methods: Using apolipoprotein E (APOE)-/- mice fed with high-fat diet for an established model. Intravenous injection of P. gingivalis was performed to create P. gingivalis blood model while intraperitoneal injection of Polyinosinic-polycytidylic acid (Poly (I:C)) served as an inhibitor for LOX-1. After 12 weeks, plaques and blood lipids were examined. Results: Results showed that induction with P. gingivalis led to increased expression of LOX-1 in both the aortic root and blood samples, increased plaque area, reduced plaque stability, elevated expression levels of vascular adhesion molecule-1(VCAM-1), Interleukin-6(IL-6) and M1 macrophages. However, pretreatment with Poly (I:C) resulted in decreased plaque area improved plaque stability and reduced expression levels of VCAM-1 and IL-6. Conclusion: These findings suggest that LOX-1 may serve as an intermediary factor promoting atherosclerosis associated with periodontitis. Porphyromonas gingivalis (P. gingivalis), the primary pathogenic bacterium in periodontitis, can infiltrate the cardiovascular system via the bloodstream and actively contribute to various pathological processes associated with atherosclerosis. The scavenger receptor lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) plays a crucial role in atherosclerosis pathogenesis. Previous studies have shown that LOX-1 is involved in endothelial cell activation injury, monocyte migration, and adhesion to endothelial cells induced by P. gingivalis. The objective of this study was to further investigate the potential role of LOX-1 in promoting P. gingivalis-induced atherosclerosis in mice. Using apolipoprotein E (APOE)-/- mice fed with high-fat diet for an established model. Intravenous injection of P. gingivalis was performed to create P. gingivalis blood model while intraperitoneal injection of Polyinosinic-polycytidylic acid (Poly (I:C)) served as an inhibitor for LOX-1. After 12 weeks, plaques and blood lipids were examined. Results showed that induction with P. gingivalis led to increased expression of LOX-1 in both the aortic root and blood samples, increased plaque area, reduced plaque stability, elevated expression levels of vascular adhesion molecule-1(VCAM-1), Interleukin-6(IL-6) and M1 macrophages. However, pretreatment with Poly (I:C) resulted in decreased plaque area improved plaque stability and reduced expression levels of VCAM-1 and IL-6. These findings suggest that LOX-1 may serve as an intermediary factor promoting atherosclerosis associated with periodontitis. AbstractBackground/PurposePorphyromonas gingivalis ( P. gingivalis), the primary pathogenic bacterium in periodontitis, can infiltrate the cardiovascular system via the bloodstream and actively contribute to various pathological processes associated with atherosclerosis. The scavenger receptor lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) plays a crucial role in atherosclerosis pathogenesis. Previous studies have shown that LOX-1 is involved in endothelial cell activation injury, monocyte migration, and adhesion to endothelial cells induced by P. gingivalis. The objective of this study was to further investigate the potential role of LOX-1 in promoting P. gingivalis-induced atherosclerosis in mice. Materials and methodsUsing apolipoprotein E (APOE) -/- mice fed with high-fat diet for an established model. Intravenous injection of P. gingivalis was performed to create P. gingivalis blood model while intraperitoneal injection of Polyinosinic-polycytidylic acid (Poly (I:C)) served as an inhibitor for LOX-1. After 12 weeks, plaques and blood lipids were examined. ResultsResults showed that induction with P. gingivalis led to increased expression of LOX-1 in both the aortic root and blood samples, increased plaque area, reduced plaque stability, elevated expression levels of vascular adhesion molecule-1(VCAM-1), Interleukin-6(IL-6) and M1 macrophages. However, pretreatment with Poly (I:C) resulted in decreased plaque area improved plaque stability and reduced expression levels of VCAM-1 and IL-6. ConclusionThese findings suggest that LOX-1 may serve as an intermediary factor promoting atherosclerosis associated with periodontitis. |
| Author | Zhang, Shengnan Liu, Jianru Ouyang, Xiangying Lyu, Peiying Wang, Yuanbo Zhong, Jinsheng |
| Author_xml | – sequence: 1 givenname: Shengnan surname: Zhang fullname: Zhang, Shengnan organization: Department of Periodontology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China – sequence: 2 givenname: Jianru surname: Liu fullname: Liu, Jianru organization: Department of Periodontology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China – sequence: 3 givenname: Xiangying orcidid: 0000-0003-3703-0847 surname: Ouyang fullname: Ouyang, Xiangying email: kqouyangxy@bjmu.edu.cn organization: Department of Periodontology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China – sequence: 4 givenname: Peiying surname: Lyu fullname: Lyu, Peiying organization: Department of Periodontology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China – sequence: 5 givenname: Yuanbo surname: Wang fullname: Wang, Yuanbo organization: Department of Periodontology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China – sequence: 6 givenname: Jinsheng surname: Zhong fullname: Zhong, Jinsheng organization: Department of Periodontology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China |
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| Cites_doi | 10.1111/prd.12429 10.1177/10760296211059500 10.1093/eurheartj/ehac173 10.1007/s12265-015-9655-z 10.1093/eurheartj/ehi339 10.3892/etm.2021.11094 10.1016/j.jds.2016.10.003 10.4049/jimmunol.166.8.5108 10.3390/antiox8070218 10.1093/bbb/zbac132 10.1080/02713683.2021.1948063 10.1093/eurheartj/ehac143 10.1111/jcpe.13864 10.1042/BSR20180071 10.3389/fmicb.2018.02470 10.1111/jre.12702 10.1016/j.archoralbio.2014.07.012 10.1902/jop.2000.71.10.1554 10.1016/j.jacc.2018.08.1043 10.1007/s11626-017-0164-z 10.1093/femspd/ftv011 10.3389/fcell.2020.00596 10.1053/j.semvascsurg.2017.04.008 10.1007/s00109-017-1575-8 10.1016/j.micinf.2011.08.003 10.3390/ijms231710011 10.1016/j.micinf.2023.105177 10.1038/s41368-022-00215-y 10.1016/j.micinf.2023.105181 10.1038/386073a0 10.1111/prd.12221 10.1038/35025203 10.1016/j.cyto.2017.07.011 10.1172/jci.insight.149955 10.1155/2015/364391 |
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| Copyright | 2025 Association for Dental Sciences of the Republic of China Association for Dental Sciences of the Republic of China 2025 Association for Dental Sciences of the Republic of China. Publishing services by Elsevier B.Vé. 2025 Association for Dental Sciences of the Republic of China. Publishing services by Elsevier B.Vé. 2025 Association for Dental Sciences of the Republic of China |
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| Keywords | Porphyromonas gingivalis Poly(I:C) LOX-1 Atherosclerosis Plaque Macrophage |
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| References | Truthe, Klassert, Schmelz, Jonigk, Blankenfeldt, Slevogt (bib19) 2024; 16 Kraler, Wenzl, Georgiopoulos (bib31) 2022; 43 Liu, Yang, Zhou, Wu, Zhao (bib42) 2021; 56 Lei, Li, Yu (bib16) 2023; 15 Slots (bib1) 2000 2017; 75 Sawamura, Kume, Aoyama (bib6) 1997; 386 Campbell, Puolakkainen, Lee, Rosenfeld, Garrigues, Kuo (bib22) 2012; 14 Miura, Oyanagi, Watanabe (bib14) 2022; 86 Jiang, Li, Cui (bib24) 2019; 12 Lin, Chen, Lei (bib18) 2015; 2015 Jungbauer, Stähli, Zhu, Auber Alberi, Sculean, Eick (bib2) 2000 2022; 89 Libby, Loscalzo, Ridker (bib5) 2018; 72 Shimaoka, Kume, Minami (bib21) 2001; 166 Du, Zhu, Lai (bib35) 2023; 25 Campbell, Lee, Rosenfeld, Kuo (bib23) 2013; 69 Yang, Wu, Zhang (bib36) 2017; 12 Hou, Yu, Liu (bib37) 2017; 53 Yamaguchi, Kurita-Ochiai, Kobayashi, Suzuki, Ando (bib40) 2015; 73 Kattoor, Goel, Mehta (bib7) 2019; 8 Xuan, Yu, Ni, Congcong, Lixin, Qingxian (bib17) 2023; 25 Veloso, Fernández, Astorga (bib41) 2022; 23 Zhang, Liu, Ma, Bai, Xu (bib26) 2020; 55 Speidl, Exner, Amighi (bib38) 2005; 26 Chistiakov, Melnichenko, Myasoedova, Grechko, Orekhov (bib39) 2017; 95 Lu, Peng, Xiang (bib8) 2018; 38 Haraszthy, Zambon, Trevisan, Zeid, Genco (bib3) 2000; 71 Zhang, Xu, Bai, Tan, Zhao, Liu (bib25) 2022; 23 Li, Liu, Liu (bib12) 2020; 8 Kolodgie, Yahagi, Mori (bib32) 2017; 30 Sasaki, Katagiri, Komazaki (bib15) 2018; 9 Sposito (bib30) 2022; 43 Wang, Zhang (bib11) 2017; 99 Huang, Shih, Tsao (bib27) 2016; 8 De, Abdul Zani, Russell, Wheatcroft, Ponnambalam, Homer-Vanniasinkam (bib29) 2015; 8 Li, C, Wang, Liu (bib13) 2016; 20 Yang, Hou, Liu (bib28) 2021; 27 Lusis (bib4) 2000; 407 Li, He, Yin (bib9) 2021; 46 Korkmaz, Shenoy, Symer (bib20) 2022; 7 Park, Kim, Han (bib34) 2023; 50 Cai, Kobayashi, Hashizume-Takizawa, Kurita-Ochiai (bib33) 2014; 59 Anfray, Varela, Ummarino (bib10) 2023; 14 Jungbauer (10.1016/j.jds.2024.10.015_bib2) 2000; 89 Li (10.1016/j.jds.2024.10.015_bib13) 2016; 20 Hou (10.1016/j.jds.2024.10.015_bib37) 2017; 53 De (10.1016/j.jds.2024.10.015_bib29) 2015; 8 Sposito (10.1016/j.jds.2024.10.015_bib30) 2022; 43 Li (10.1016/j.jds.2024.10.015_bib12) 2020; 8 Shimaoka (10.1016/j.jds.2024.10.015_bib21) 2001; 166 Wang (10.1016/j.jds.2024.10.015_bib11) 2017; 99 Sasaki (10.1016/j.jds.2024.10.015_bib15) 2018; 9 Slots (10.1016/j.jds.2024.10.015_bib1) 2000; 75 Xuan (10.1016/j.jds.2024.10.015_bib17) 2023; 25 Haraszthy (10.1016/j.jds.2024.10.015_bib3) 2000; 71 Yang (10.1016/j.jds.2024.10.015_bib36) 2017; 12 Lin (10.1016/j.jds.2024.10.015_bib18) 2015; 2015 Campbell (10.1016/j.jds.2024.10.015_bib22) 2012; 14 Liu (10.1016/j.jds.2024.10.015_bib42) 2021; 56 Anfray (10.1016/j.jds.2024.10.015_bib10) 2023; 14 Sawamura (10.1016/j.jds.2024.10.015_bib6) 1997; 386 Kattoor (10.1016/j.jds.2024.10.015_bib7) 2019; 8 Lusis (10.1016/j.jds.2024.10.015_bib4) 2000; 407 Jiang (10.1016/j.jds.2024.10.015_bib24) 2019; 12 Lei (10.1016/j.jds.2024.10.015_bib16) 2023; 15 Miura (10.1016/j.jds.2024.10.015_bib14) 2022; 86 Campbell (10.1016/j.jds.2024.10.015_bib23) 2013; 69 Kraler (10.1016/j.jds.2024.10.015_bib31) 2022; 43 Zhang (10.1016/j.jds.2024.10.015_bib26) 2020; 55 Li (10.1016/j.jds.2024.10.015_bib9) 2021; 46 Libby (10.1016/j.jds.2024.10.015_bib5) 2018; 72 Yang (10.1016/j.jds.2024.10.015_bib28) 2021; 27 Park (10.1016/j.jds.2024.10.015_bib34) 2023; 50 Chistiakov (10.1016/j.jds.2024.10.015_bib39) 2017; 95 Korkmaz (10.1016/j.jds.2024.10.015_bib20) 2022; 7 Huang (10.1016/j.jds.2024.10.015_bib27) 2016; 8 Truthe (10.1016/j.jds.2024.10.015_bib19) 2024; 16 Lu (10.1016/j.jds.2024.10.015_bib8) 2018; 38 Speidl (10.1016/j.jds.2024.10.015_bib38) 2005; 26 Zhang (10.1016/j.jds.2024.10.015_bib25) 2022; 23 Veloso (10.1016/j.jds.2024.10.015_bib41) 2022; 23 Yamaguchi (10.1016/j.jds.2024.10.015_bib40) 2015; 73 Kolodgie (10.1016/j.jds.2024.10.015_bib32) 2017; 30 Du (10.1016/j.jds.2024.10.015_bib35) 2023; 25 Cai (10.1016/j.jds.2024.10.015_bib33) 2014; 59 |
| References_xml | – volume: 26 start-page: 2294 year: 2005 end-page: 2299 ident: bib38 article-title: Complement component C5a predicts future cardiovascular events in patients with advanced atherosclerosis publication-title: Eur Heart J – volume: 50 start-page: 1553 year: 2023 end-page: 1567 ident: bib34 article-title: Oral Porphyromonas gingivalis infection affects intestinal microbiota and promotes atherosclerosis publication-title: J Clin Periodontol – volume: 89 start-page: 59 year: 2000 2022 end-page: 82 ident: bib2 article-title: Periodontal microorganisms and Alzheimer disease - a causative relationship? publication-title: Periodontol – volume: 14 start-page: 43 year: 2012 end-page: 49 ident: bib22 article-title: Chlamydia pneumoniae binds to the lectin-like oxidized LDL receptor for infection of endothelial cells publication-title: Microb Infect – volume: 38 year: 2018 ident: bib8 article-title: Trichosanthes kirilowii lectin alleviates diabetic nephropathy by inhibiting the LOX1/NF-κB/caspase-9 signaling pathway publication-title: Biosci Rep – volume: 59 start-page: 1183 year: 2014 end-page: 1191 ident: bib33 article-title: Porphyromonas gingivalis infection enhances Th17 responses for development of atherosclerosis publication-title: Arch Oral Biol – volume: 43 start-page: 1861 year: 2022 end-page: 1863 ident: bib30 article-title: Soluble LOX-1 levels during acute coronary syndrome: a potent and multifaceted warning sign for cardiovascular risk publication-title: Eur Heart J – volume: 56 start-page: 175 year: 2021 end-page: 181 ident: bib42 article-title: Porphyromonas gingivalis lipopolysaccharide regulates macrophage polarization via triggering receptors expressed on myeloid cells-1 publication-title: Zhonghua Kou Qiang Yi Xue Za Zhi – volume: 407 start-page: 233 year: 2000 end-page: 241 ident: bib4 article-title: Atherosclerosis publication-title: Nature – volume: 386 start-page: 73 year: 1997 end-page: 77 ident: bib6 article-title: An endothelial receptor for oxidized low-density lipoprotein publication-title: Nature – volume: 95 start-page: 1153 year: 2017 end-page: 1165 ident: bib39 article-title: Mechanisms of foam cell formation in atherosclerosis publication-title: J Mol Med (Berl) – volume: 7 year: 2022 ident: bib20 article-title: Lectin-like oxidized low-density lipoprotein receptor 1 attenuates pneumonia-induced lung injury publication-title: JCI Insight – volume: 25 year: 2023 ident: bib35 article-title: Imbalance of helper T cell subtypes and adipokine secretion in perivascular adipose tissue as a trigger of atherosclerosis in chronic Porphyromonas gingivalis W83 infection publication-title: Microb Infect – volume: 73 year: 2015 ident: bib40 article-title: Activation of the NLRP3 inflammasome in Porphyromonas gingivalis-accelerated atherosclerosis publication-title: Pathog Dis – volume: 14 year: 2023 ident: bib10 article-title: Polymeric nanocapsules loaded with poly(I:C) and resiquimod to reprogram tumor-associated macrophages for the treatment of solid tumors publication-title: Front Immunol – volume: 2015 year: 2015 ident: bib18 article-title: Effects of intravenous injection of Porphyromonas gingivalis on rabbit inflammatory immune response and atherosclerosis publication-title: Mediat Inflamm – volume: 75 start-page: 7 year: 2000 2017 end-page: 23 ident: bib1 article-title: Periodontitis: facts, fallacies and the future publication-title: Periodontology – volume: 166 start-page: 5108 year: 2001 end-page: 5114 ident: bib21 article-title: LOX-1 supports adhesion of Gram-positive and Gram-negative bacteria publication-title: J Immunol – volume: 43 start-page: 1849 year: 2022 end-page: 1860 ident: bib31 article-title: Soluble lectin-like oxidized low-density lipoprotein receptor-1 predicts premature death in acute coronary syndromes publication-title: Eur Heart J – volume: 27 year: 2021 ident: bib28 article-title: Soluble lectin-like oxidized low-density lipoprotein receptor-1 level is related to clinical prognosis in patients with acute atherosclerosis-related ischemic stroke publication-title: Clin Appl Thromb Hemost – volume: 16 start-page: 105 year: 2024 end-page: 132 ident: bib19 article-title: Role of lectin-like oxidized low-density lipoprotein receptor-1 in inflammation and pathogen-associated interactions publication-title: J Innate Immun – volume: 8 start-page: 596 year: 2020 ident: bib12 article-title: LOX-1 regulates P. gingivalis-induced monocyte migration and adhesion to human umbilical vein endothelial cells publication-title: Front Cell Dev Biol – volume: 25 year: 2023 ident: bib17 article-title: Protective effects of tanshinone IIA on Porphyromonas gingivalis-induced atherosclerosis via the downregulation of the NOX2/NOX4-ROS mediation of NF-κB signaling pathway publication-title: Microb Infect – volume: 15 start-page: 3 year: 2023 ident: bib16 article-title: Porphyromonas gingivalis bacteremia increases the permeability of the blood-brain barrier via the Mfsd2a/Caveolin-1 mediated transcytosis pathway publication-title: Int J Oral Sci – volume: 72 start-page: 2071 year: 2018 end-page: 2081 ident: bib5 article-title: Inflammation, immunity, and infection in atherothrombosis: JACC review topic of the week publication-title: J Am Coll Cardiol – volume: 8 start-page: 218 year: 2019 ident: bib7 article-title: LOX-1: regulation, signaling and its role in atherosclerosis publication-title: Antioxidants – volume: 8 start-page: 384 year: 2016 end-page: 404 ident: bib27 article-title: The GroEL protein of Porphyromonas gingivalis regulates atherogenic phenomena in endothelial cells mediated by upregulating toll-like receptor 4 expression publication-title: Am J Transl Res – volume: 12 start-page: 898 year: 2019 end-page: 903 ident: bib24 article-title: Inhibition of LOX-1 alleviates the proinflammatory effects of high-mobility group box 1 in Aspergillus fumigatus keratitis publication-title: Int J Ophthalmol – volume: 69 start-page: 1 year: 2013 end-page: 6 ident: bib23 article-title: Chlamydia pneumoniae induces expression of pro-atherogenic factors through activation of the lectin-like oxidized LDL receptor-1 publication-title: Pathog Dis – volume: 12 start-page: 60 year: 2017 end-page: 69 ident: bib36 article-title: Porphyromonas gingivalis oral infection promote T helper 17/Treg imbalance in the development of atherosclerosis publication-title: J Dent Sci – volume: 30 start-page: 31 year: 2017 end-page: 43 ident: bib32 article-title: High-risk carotid plaque: lessons learned from histopathology publication-title: Semin Vasc Surg – volume: 23 year: 2022 ident: bib41 article-title: Lipopolysaccharide from Porphyromonas gingivalis, but not from Porphyromonas endodontalis, induces macrophage M1 Profile publication-title: Int J Mol Sci – volume: 46 start-page: 1800 year: 2021 end-page: 1811 ident: bib9 article-title: LOX-1 regulates neutrophil apoptosis and fungal load in A. fumigatus keratitis publication-title: Curr Eye Res – volume: 99 start-page: 225 year: 2017 end-page: 232 ident: bib11 article-title: Poly (I:C) alleviates obesity related pro-inflammatory status and promotes glucose homeostasis publication-title: Cytokine – volume: 8 start-page: 458 year: 2015 end-page: 465 ident: bib29 article-title: Clinical and preclinical use of LOX-1-specific antibodies in diagnostics and therapeutics publication-title: J Cardiovasc Transl Res – volume: 71 start-page: 1554 year: 2000 end-page: 1560 ident: bib3 article-title: Identification of periodontal pathogens in atheromatous plaques publication-title: J Periodontol – volume: 9 start-page: 2470 year: 2018 ident: bib15 article-title: Endotoxemia by Porphyromonas gingivalis injection aggravates non-alcoholic fatty liver disease, disrupts glucose/lipid metabolism, and alters gut microbiota in mice publication-title: Front Microbiol – volume: 23 start-page: 171 year: 2022 ident: bib25 article-title: Lectin-type oxidized LDL receptor 1 modulates matrix metalloproteinase 2 production in peri-implantitis publication-title: Exp Ther Med – volume: 53 start-page: 593 year: 2017 end-page: 603 ident: bib37 article-title: Gingipain of Porphyromonas gingivalis manipulates M1 macrophage polarization through C5a pathway publication-title: In Vitro Cell Dev Biol Anim – volume: 20 start-page: 3863 year: 2016 end-page: 3867 ident: bib13 article-title: Progression of atherosclerosis in ApoE-knockout mice fed on a high-fat diet publication-title: Eur Rev Med Pharmacol Sci – volume: 86 start-page: 1423 year: 2022 end-page: 1430 ident: bib14 article-title: Acetyl-L-carnitine attenuates Poly I:C-induced sickness behavior in mice publication-title: Biosci Biotechnol Biochem – volume: 55 start-page: 199 year: 2020 end-page: 208 ident: bib26 article-title: Wnt5a is involved in LOX-1 and TLR4 induced host inflammatory response in peri-implantitis publication-title: J Periodontal Res – volume: 89 start-page: 59 year: 2000 ident: 10.1016/j.jds.2024.10.015_bib2 article-title: Periodontal microorganisms and Alzheimer disease - a causative relationship? publication-title: Periodontol doi: 10.1111/prd.12429 – volume: 27 year: 2021 ident: 10.1016/j.jds.2024.10.015_bib28 article-title: Soluble lectin-like oxidized low-density lipoprotein receptor-1 level is related to clinical prognosis in patients with acute atherosclerosis-related ischemic stroke publication-title: Clin Appl Thromb Hemost doi: 10.1177/10760296211059500 – volume: 43 start-page: 1861 year: 2022 ident: 10.1016/j.jds.2024.10.015_bib30 article-title: Soluble LOX-1 levels during acute coronary syndrome: a potent and multifaceted warning sign for cardiovascular risk publication-title: Eur Heart J doi: 10.1093/eurheartj/ehac173 – volume: 8 start-page: 458 year: 2015 ident: 10.1016/j.jds.2024.10.015_bib29 article-title: Clinical and preclinical use of LOX-1-specific antibodies in diagnostics and therapeutics publication-title: J Cardiovasc Transl Res doi: 10.1007/s12265-015-9655-z – volume: 16 start-page: 105 year: 2024 ident: 10.1016/j.jds.2024.10.015_bib19 article-title: Role of lectin-like oxidized low-density lipoprotein receptor-1 in inflammation and pathogen-associated interactions publication-title: J Innate Immun – volume: 26 start-page: 2294 year: 2005 ident: 10.1016/j.jds.2024.10.015_bib38 article-title: Complement component C5a predicts future cardiovascular events in patients with advanced atherosclerosis publication-title: Eur Heart J doi: 10.1093/eurheartj/ehi339 – volume: 69 start-page: 1 year: 2013 ident: 10.1016/j.jds.2024.10.015_bib23 article-title: Chlamydia pneumoniae induces expression of pro-atherogenic factors through activation of the lectin-like oxidized LDL receptor-1 publication-title: Pathog Dis – volume: 23 start-page: 171 year: 2022 ident: 10.1016/j.jds.2024.10.015_bib25 article-title: Lectin-type oxidized LDL receptor 1 modulates matrix metalloproteinase 2 production in peri-implantitis publication-title: Exp Ther Med doi: 10.3892/etm.2021.11094 – volume: 12 start-page: 60 year: 2017 ident: 10.1016/j.jds.2024.10.015_bib36 article-title: Porphyromonas gingivalis oral infection promote T helper 17/Treg imbalance in the development of atherosclerosis publication-title: J Dent Sci doi: 10.1016/j.jds.2016.10.003 – volume: 14 year: 2023 ident: 10.1016/j.jds.2024.10.015_bib10 article-title: Polymeric nanocapsules loaded with poly(I:C) and resiquimod to reprogram tumor-associated macrophages for the treatment of solid tumors publication-title: Front Immunol – volume: 166 start-page: 5108 year: 2001 ident: 10.1016/j.jds.2024.10.015_bib21 article-title: LOX-1 supports adhesion of Gram-positive and Gram-negative bacteria publication-title: J Immunol doi: 10.4049/jimmunol.166.8.5108 – volume: 12 start-page: 898 year: 2019 ident: 10.1016/j.jds.2024.10.015_bib24 article-title: Inhibition of LOX-1 alleviates the proinflammatory effects of high-mobility group box 1 in Aspergillus fumigatus keratitis publication-title: Int J Ophthalmol – volume: 8 start-page: 218 year: 2019 ident: 10.1016/j.jds.2024.10.015_bib7 article-title: LOX-1: regulation, signaling and its role in atherosclerosis publication-title: Antioxidants doi: 10.3390/antiox8070218 – volume: 86 start-page: 1423 year: 2022 ident: 10.1016/j.jds.2024.10.015_bib14 article-title: Acetyl-L-carnitine attenuates Poly I:C-induced sickness behavior in mice publication-title: Biosci Biotechnol Biochem doi: 10.1093/bbb/zbac132 – volume: 46 start-page: 1800 year: 2021 ident: 10.1016/j.jds.2024.10.015_bib9 article-title: LOX-1 regulates neutrophil apoptosis and fungal load in A. fumigatus keratitis publication-title: Curr Eye Res doi: 10.1080/02713683.2021.1948063 – volume: 43 start-page: 1849 year: 2022 ident: 10.1016/j.jds.2024.10.015_bib31 article-title: Soluble lectin-like oxidized low-density lipoprotein receptor-1 predicts premature death in acute coronary syndromes publication-title: Eur Heart J doi: 10.1093/eurheartj/ehac143 – volume: 50 start-page: 1553 year: 2023 ident: 10.1016/j.jds.2024.10.015_bib34 article-title: Oral Porphyromonas gingivalis infection affects intestinal microbiota and promotes atherosclerosis publication-title: J Clin Periodontol doi: 10.1111/jcpe.13864 – volume: 38 year: 2018 ident: 10.1016/j.jds.2024.10.015_bib8 article-title: Trichosanthes kirilowii lectin alleviates diabetic nephropathy by inhibiting the LOX1/NF-κB/caspase-9 signaling pathway publication-title: Biosci Rep doi: 10.1042/BSR20180071 – volume: 9 start-page: 2470 year: 2018 ident: 10.1016/j.jds.2024.10.015_bib15 article-title: Endotoxemia by Porphyromonas gingivalis injection aggravates non-alcoholic fatty liver disease, disrupts glucose/lipid metabolism, and alters gut microbiota in mice publication-title: Front Microbiol doi: 10.3389/fmicb.2018.02470 – volume: 55 start-page: 199 year: 2020 ident: 10.1016/j.jds.2024.10.015_bib26 article-title: Wnt5a is involved in LOX-1 and TLR4 induced host inflammatory response in peri-implantitis publication-title: J Periodontal Res doi: 10.1111/jre.12702 – volume: 20 start-page: 3863 year: 2016 ident: 10.1016/j.jds.2024.10.015_bib13 article-title: Progression of atherosclerosis in ApoE-knockout mice fed on a high-fat diet publication-title: Eur Rev Med Pharmacol Sci – volume: 59 start-page: 1183 year: 2014 ident: 10.1016/j.jds.2024.10.015_bib33 article-title: Porphyromonas gingivalis infection enhances Th17 responses for development of atherosclerosis publication-title: Arch Oral Biol doi: 10.1016/j.archoralbio.2014.07.012 – volume: 71 start-page: 1554 year: 2000 ident: 10.1016/j.jds.2024.10.015_bib3 article-title: Identification of periodontal pathogens in atheromatous plaques publication-title: J Periodontol doi: 10.1902/jop.2000.71.10.1554 – volume: 72 start-page: 2071 year: 2018 ident: 10.1016/j.jds.2024.10.015_bib5 article-title: Inflammation, immunity, and infection in atherothrombosis: JACC review topic of the week publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2018.08.1043 – volume: 53 start-page: 593 year: 2017 ident: 10.1016/j.jds.2024.10.015_bib37 article-title: Gingipain of Porphyromonas gingivalis manipulates M1 macrophage polarization through C5a pathway publication-title: In Vitro Cell Dev Biol Anim doi: 10.1007/s11626-017-0164-z – volume: 73 year: 2015 ident: 10.1016/j.jds.2024.10.015_bib40 article-title: Activation of the NLRP3 inflammasome in Porphyromonas gingivalis-accelerated atherosclerosis publication-title: Pathog Dis doi: 10.1093/femspd/ftv011 – volume: 8 start-page: 596 year: 2020 ident: 10.1016/j.jds.2024.10.015_bib12 article-title: LOX-1 regulates P. gingivalis-induced monocyte migration and adhesion to human umbilical vein endothelial cells publication-title: Front Cell Dev Biol doi: 10.3389/fcell.2020.00596 – volume: 56 start-page: 175 year: 2021 ident: 10.1016/j.jds.2024.10.015_bib42 article-title: Porphyromonas gingivalis lipopolysaccharide regulates macrophage polarization via triggering receptors expressed on myeloid cells-1 publication-title: Zhonghua Kou Qiang Yi Xue Za Zhi – volume: 30 start-page: 31 year: 2017 ident: 10.1016/j.jds.2024.10.015_bib32 article-title: High-risk carotid plaque: lessons learned from histopathology publication-title: Semin Vasc Surg doi: 10.1053/j.semvascsurg.2017.04.008 – volume: 95 start-page: 1153 year: 2017 ident: 10.1016/j.jds.2024.10.015_bib39 article-title: Mechanisms of foam cell formation in atherosclerosis publication-title: J Mol Med (Berl) doi: 10.1007/s00109-017-1575-8 – volume: 14 start-page: 43 year: 2012 ident: 10.1016/j.jds.2024.10.015_bib22 article-title: Chlamydia pneumoniae binds to the lectin-like oxidized LDL receptor for infection of endothelial cells publication-title: Microb Infect doi: 10.1016/j.micinf.2011.08.003 – volume: 23 year: 2022 ident: 10.1016/j.jds.2024.10.015_bib41 article-title: Lipopolysaccharide from Porphyromonas gingivalis, but not from Porphyromonas endodontalis, induces macrophage M1 Profile publication-title: Int J Mol Sci doi: 10.3390/ijms231710011 – volume: 25 year: 2023 ident: 10.1016/j.jds.2024.10.015_bib17 article-title: Protective effects of tanshinone IIA on Porphyromonas gingivalis-induced atherosclerosis via the downregulation of the NOX2/NOX4-ROS mediation of NF-κB signaling pathway publication-title: Microb Infect doi: 10.1016/j.micinf.2023.105177 – volume: 15 start-page: 3 year: 2023 ident: 10.1016/j.jds.2024.10.015_bib16 article-title: Porphyromonas gingivalis bacteremia increases the permeability of the blood-brain barrier via the Mfsd2a/Caveolin-1 mediated transcytosis pathway publication-title: Int J Oral Sci doi: 10.1038/s41368-022-00215-y – volume: 25 year: 2023 ident: 10.1016/j.jds.2024.10.015_bib35 article-title: Imbalance of helper T cell subtypes and adipokine secretion in perivascular adipose tissue as a trigger of atherosclerosis in chronic Porphyromonas gingivalis W83 infection publication-title: Microb Infect doi: 10.1016/j.micinf.2023.105181 – volume: 386 start-page: 73 year: 1997 ident: 10.1016/j.jds.2024.10.015_bib6 article-title: An endothelial receptor for oxidized low-density lipoprotein publication-title: Nature doi: 10.1038/386073a0 – volume: 75 start-page: 7 year: 2000 ident: 10.1016/j.jds.2024.10.015_bib1 article-title: Periodontitis: facts, fallacies and the future publication-title: Periodontology doi: 10.1111/prd.12221 – volume: 407 start-page: 233 year: 2000 ident: 10.1016/j.jds.2024.10.015_bib4 article-title: Atherosclerosis publication-title: Nature doi: 10.1038/35025203 – volume: 8 start-page: 384 year: 2016 ident: 10.1016/j.jds.2024.10.015_bib27 article-title: The GroEL protein of Porphyromonas gingivalis regulates atherogenic phenomena in endothelial cells mediated by upregulating toll-like receptor 4 expression publication-title: Am J Transl Res – volume: 99 start-page: 225 year: 2017 ident: 10.1016/j.jds.2024.10.015_bib11 article-title: Poly (I:C) alleviates obesity related pro-inflammatory status and promotes glucose homeostasis publication-title: Cytokine doi: 10.1016/j.cyto.2017.07.011 – volume: 7 year: 2022 ident: 10.1016/j.jds.2024.10.015_bib20 article-title: Lectin-like oxidized low-density lipoprotein receptor 1 attenuates pneumonia-induced lung injury publication-title: JCI Insight doi: 10.1172/jci.insight.149955 – volume: 2015 year: 2015 ident: 10.1016/j.jds.2024.10.015_bib18 article-title: Effects of intravenous injection of Porphyromonas gingivalis on rabbit inflammatory immune response and atherosclerosis publication-title: Mediat Inflamm doi: 10.1155/2015/364391 |
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| Snippet | Porphyromonas gingivalis (P. gingivalis), the primary pathogenic bacterium in periodontitis, can infiltrate the cardiovascular system via the bloodstream and... AbstractBackground/PurposePorphyromonas gingivalis ( P. gingivalis), the primary pathogenic bacterium in periodontitis, can infiltrate the cardiovascular... ( ), the primary pathogenic bacterium in periodontitis, can infiltrate the cardiovascular system via the bloodstream and actively contribute to various... Background/Purpose: Porphyromonas gingivalis (P. gingivalis), the primary pathogenic bacterium in periodontitis, can infiltrate the cardiovascular system via... |
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| SubjectTerms | Advanced Basic Science Atherosclerosis Dentistry LOX-1 Macrophage Original Plaque Poly(I:C) Porphyromonas gingivalis |
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| Title | Modulation of lectin-like oxidized low-density lipoprotein receptor-1 by Porphyromonas gingivalis promoting progression of atherosclerosis in apolipoprotein E-/- mice |
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