Analysis of altered gait cycle duration in amyotrophic lateral sclerosis based on nonparametric probability density function estimation

• Published in: Medical engineering & physics Vol. 33; no. 3; pp. 347 - 355
• Main Authors: Wu, Yunfeng, Shi, Lei
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.04.2011; Elsevier
• Subjects: Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - physiopathology; Biological and medical sciences; Case-Control Studies; Central nervous system; Cerebrospinal fluid. Meninges. Spinal cord; Classification; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Female; Foot; gait; Gait - physiology; Gait analysis; Humans; Kernels; Locomotion; Male; Medical sciences; Middle Aged; Movement disorders; Nervous system (semeiology, syndromes); Neurology; Nonlinear Dynamics; Parzen window; Probability density function; Probability Theory; Radiology; Rhythms; ROC Curve; Statistics; Statistics, Nonparametric; Support vector machine; Probability density function; Amyotrophic lateral sclerosis; Parzen window; Support vector machine; Gait analysis; Movement disorders; Human; Nervous system diseases; Modeling; Abnormal movement; Locomotion; Walking; Statistical model; Central nervous system disease; Body movement; Degenerative disease; Spinal cord disease; Biomedical engineering

Human locomotion is regulated by the central nervous system (CNS). The neurophysiological changes in the CNS due to amyotrophic lateral sclerosis (ALS) may cause altered gait cycle duration (stride interval) or other gait rhythm. This article used a statistical method to analyze the altered stride i...