CYP19A1 promotes gastric cancer as part of a lipid metabolism-related gene signature related to the response of immunotherapy and prognosis

• Published in: BMC medical genomics Vol. 16; no. 1; pp. 1 - 17
• Main Authors: Zhou, Xinyi, Meng, Fanyu, Xiao, Linmei, Shen, Hua
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 02.10.2023; BioMed Central; BMC
• Subjects: Algorithms; Analysis; Antibodies; Biomarkers; Cancer; Cancer therapies; Cell growth; Cholecystokinin; CYP19A1; Development and progression; DNA methylation; Drug therapy; Gastric cancer; Genes; Genetic aspects; Genetic research; Genomes; Genomics; Health aspects; Immune checkpoint inhibitors; Immunotherapy; Lipid metabolism; Lipids; Medical prognosis; Medical research; Medicine, Experimental; Membranes; Metabolism; Metastasis; Mutation; Patients; Physiological aspects; Plasmids; Prognosis; Regression analysis; Risk assessment; Risk groups; Stomach cancer; Transcriptomes; Tumor cell lines; Western blotting; Wound healing; China; United States > US

Increasing evidence suggests that the metabolism of lipids plays a crucial role in the progression of gastric cancer. However, the expression of lipid metabolism-related genes (LMGs) still does not serve as a prognostic biomarker in gastric cancer. We obtained transcriptome data for 751 LMGs and div...