Cortical interneurons in autism

• Published in: Nature neuroscience Vol. 24; no. 12; pp. 1648 - 1659
• Main Authors: Contractor, Anis, Ethell, Iryna M., Portera-Cailliau, Carlos
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.12.2021; Nature Publishing Group
• Subjects: 13/51; 14; 14/69; 38/43; 38/91; 631/378/1689/1373; 631/378/2571/1696; 64/60; 9/74; Animal Genetics and Genomics; Animal models; Autism; Autistic Disorder; Behavioral Sciences; Biological Techniques; Biomedical and Life Sciences; Biomedicine; Brain research; Cerebral cortex; Circuits; Development and progression; Environmental risk; Genetic aspects; Health aspects; Humans; Interneurons; Interneurons - physiology; Neural circuitry; Neural networks; Neurobiology; Neurosciences; Parvalbumin; Parvalbumins - physiology; Phenotype; Phenotypes; Physiological aspects; Review Article; Risk analysis; Risk factors; United States

The mechanistic underpinnings of autism remain a subject of debate and controversy. Why do individuals with autism share an overlapping set of atypical behaviors and symptoms, despite having different genetic and environmental risk factors? A major challenge in developing new therapies for autism ha...