Macro view of microRNA function in osteoarthritis

• Published in: Nature reviews. Rheumatology Vol. 8; no. 9; pp. 543 - 552
• Main Authors: Miyaki, Shigeru, Asahara, Hiroshi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2012; Nature Publishing Group
• Subjects: 631/208/200; 631/337/384/331; 631/80/304; 692/699/1670/407; Animals; Arthritis; Biomarkers - metabolism; Cartilage; Cartilage, Articular - metabolism; Cartilage, Articular - pathology; Cell death; Chondrocytes - metabolism; Development and progression; Disease; Disease Models, Animal; Enzymes; Gene Expression Regulation - physiology; Genes; Genetic aspects; Genetic engineering; Health aspects; Hepatitis C; Homeostasis; Homeostasis - genetics; Humans; Medicine; Medicine & Public Health; Mice; MicroRNA; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; MicroRNAs - therapeutic use; Osteoarthritis; Osteoarthritis - genetics; Osteoarthritis - metabolism; Osteoarthritis - pathology; Osteoarthritis - physiopathology; Pathogenesis; review-article; Rheumatology; RNA-Induced Silencing Complex - genetics; Signal Transduction; United States; Japan

MicroRNAs (miRNAs) function in several chronic diseases—miRNA-mediated fine control of genetic networks involved in tissue development and homeostasis becomes disrupted. Participating in production and maintenance of articular chondrocytes and skeletogenesis, miRNA are increasingly implicated in the...