MKL1 cooperates with p38MAPK to promote vascular senescence, inflammation, and abdominal aortic aneurysm

• Published in: Redox biology Vol. 41; p. 101903
• Main Authors: Gao, Ping, Gao, Pan, Zhao, Jinjing, Shan, Shengshuai, Luo, Wei, Slivano, Orazio J., Zhang, Wei, Tabuchi, Akiko, LeMaire, Scott A., Maegdefessel, Lars, Shen, Ying H., Miano, Joseph M., Singer, Harold A., Long, Xiaochun
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2021; Elsevier
• Subjects: Angiotensin II; Animals; Aortic aneurysm; Aortic Aneurysm, Abdominal; Disease Models, Animal; Inflammation; Medicin och hälsovetenskap; Mice; Mice, Inbred C57BL; Mice, Knockout; MKL1; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; p38MAPK; Research Paper; Senescence; Trans-Activators; Senescence; Inflammation; Aortic aneurysm; p38MAPK; MKL1

Abdominal aortic aneurysm (AAA) is a catastrophic disease with little effective therapy. Myocardin related transcription factor A (MRTFA, MKL1) is a multifaceted transcription factor, regulating diverse biological processes. However, a detailed understanding of the mechanistic role of MKL1 in AAA ha...