Amyloidogenic Nanoplaques in Blood Serum of Patients with Alzheimer’s Disease Revealed by Time-Resolved Thioflavin T Fluorescence Intensity Fluctuation Analysis

• Published in: Journal of Alzheimer's disease Vol. 68; no. 2; pp. 571 - 582
• Main Authors: Tiiman, Ann, Jelić, Vesna, Jarvet, Jüri, Järemo, Petter, Bogdanović, Nenad, Rigler, Rudolf, Terenius, Lars, Gräslund, Astrid, Vukojević, Vladana
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.01.2019
• Subjects: early diagnosis; Thioflavin T; Alzheimer’s disease; fluorescence correlation spectroscopy; blood serum; amyloidogenic aggregates; β-pleated sheet; florescence intensity fluctuation analysis; single-molecule sensitivity

Background: Biomarkers are central to current research on molecular mechanisms underlying Alzheimer’s disease (AD). Their further development is of paramount importance for understanding pathophysiological processes that eventually lead to disease onset. Biomarkers are also crucial for early disease...