Surface plasmon resonance biosensor for detection of pregnancy associated plasma protein A2 in clinical samples

Pregnancy associated plasma protein A2 (PAPP-A2) is a metalloproteinase that plays multiple roles in fetal development and post-natal growth. Here we present a novel surface plasmon resonance (SPR) biosensor for the rapid and quantitative detection of PAPP-A2 in blood samples. This biosensor uses a...

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Published inAnalytical and bioanalytical chemistry Vol. 408; no. 26; pp. 7265 - 7269
Main Authors Bocková, Markéta, Chadtová Song, Xue, Gedeonová, Erika, Levová, Kateřina, Kalousová, Marta, Zima, Tomáš, Homola, Jiří
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2016
Springer
Springer Nature B.V
Subjects
Analytical Chemistry
Antibodies
Biochemistry
Biosensors
Blood
blood proteins
blood sampling
blood serum
Buffers
Characterization and Evaluation of Materials
Chemical Sensing Systems
Chemistry
Chemistry and Materials Science
cross reaction
Equipment and supplies
Female
fetal development
Food Science
Gold - chemistry
Humans
Laboratory Medicine
Limit of Detection
Male
Mathematical analysis
Membrane proteins
men
Metal Nanoparticles - chemistry
Methods
Monitoring/Environmental Analysis
nanogold
Nanoparticles
Paper in Forefront
Photonics
Physiological aspects
Plasma
Plasmons
Preeclampsia
Pregnancy
pregnancy diagnosis
Pregnancy-Associated Plasma Protein-A - analysis
pregnant women
Proteins
Referencing
Resonance
Sensors
surface plasmon resonance
Surface Plasmon Resonance - methods
Surface plasmon resonance spectroscopy
Women
United States > US
Czech Republic
Blood sample
Nanoparticles
Surface plasmon resonance
Pregnancy associated plasma protein A2
Online AccessGet full text
ISSN1618-2642
1618-2650
1618-2650
DOI10.1007/s00216-016-9664-z

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Abstract Pregnancy associated plasma protein A2 (PAPP-A2) is a metalloproteinase that plays multiple roles in fetal development and post-natal growth. Here we present a novel surface plasmon resonance (SPR) biosensor for the rapid and quantitative detection of PAPP-A2 in blood samples. This biosensor uses a single surface referencing approach and a sandwich assay with functionalized gold nanoparticles for signal enhancement. We demonstrate that this SPR biosensor enables the detection of PAPP-A2 in 30 % blood plasma at levels as low as 3.6 ng/mL. We also characterize the performance of the biosensor and evaluate its cross-reactivity to a PAPP-A analogue. Finally, we utilize this SPR biosensor for the detection of PAPP-A2 in blood serum from two groups of subjects: pregnant women and healthy non-pregnant women and men. Graphical Abstract Temporal sensor response corresponding to respective steps of the assay for detection of PAPP-A2 in buffer
AbstractList Pregnancy associated plasma protein A2 (PAPP-A2) is a metalloproteinase that plays multiple roles in fetal development and post-natal growth. Here we present a novel surface plasmon resonance (SPR) biosensor for the rapid and quantitative detection of PAPP-A2 in blood samples. This biosensor uses a single surface referencing approach and a sandwich assay with functionalized gold nanoparticles for signal enhancement. We demonstrate that this SPR biosensor enables the detection of PAPP-A2 in 30 % blood plasma at levels as low as 3.6 ng/mL. We also characterize the performance of the biosensor and evaluate its cross-reactivity to a PAPP-A analogue. Finally, we utilize this SPR biosensor for the detection of PAPP-A2 in blood serum from two groups of subjects: pregnant women and healthy non-pregnant women and men. Graphical Abstract Temporal sensor response corresponding to respective steps of the assay for detection of PAPP-A2 in buffer.Pregnancy associated plasma protein A2 (PAPP-A2) is a metalloproteinase that plays multiple roles in fetal development and post-natal growth. Here we present a novel surface plasmon resonance (SPR) biosensor for the rapid and quantitative detection of PAPP-A2 in blood samples. This biosensor uses a single surface referencing approach and a sandwich assay with functionalized gold nanoparticles for signal enhancement. We demonstrate that this SPR biosensor enables the detection of PAPP-A2 in 30 % blood plasma at levels as low as 3.6 ng/mL. We also characterize the performance of the biosensor and evaluate its cross-reactivity to a PAPP-A analogue. Finally, we utilize this SPR biosensor for the detection of PAPP-A2 in blood serum from two groups of subjects: pregnant women and healthy non-pregnant women and men. Graphical Abstract Temporal sensor response corresponding to respective steps of the assay for detection of PAPP-A2 in buffer.
Pregnancy associated plasma protein A2 (PAPP-A2) is a metalloproteinase that plays multiple roles in fetal development and post-natal growth. Here we present a novel surface plasmon resonance (SPR) biosensor for the rapid and quantitative detection of PAPP-A2 in blood samples. This biosensor uses a single surface referencing approach and a sandwich assay with functionalized gold nanoparticles for signal enhancement. We demonstrate that this SPR biosensor enables the detection of PAPP-A2 in 30 % blood plasma at levels as low as 3.6 ng/mL. We also characterize the performance of the biosensor and evaluate its cross-reactivity to a PAPP-A analogue. Finally, we utilize this SPR biosensor for the detection of PAPP-A2 in blood serum from two groups of subjects: pregnant women and healthy non-pregnant women and men. Graphical Abstract Temporal sensor response corresponding to respective steps of the assay for detection of PAPP-A2 in buffer
Pregnancy associated plasma protein A2 (PAPP-A2) is a metalloproteinase that plays multiple roles in fetal development and post-natal growth. Here we present a novel surface plasmon resonance (SPR) biosensor for the rapid and quantitative detection of PAPP-A2 in blood samples. This biosensor uses a single surface referencing approach and a sandwich assay with functionalized gold nanoparticles for signal enhancement. We demonstrate that this SPR biosensor enables the detection of PAPP-A2 in 30 % blood plasma at levels as low as 3.6 ng/mL. We also characterize the performance of the biosensor and evaluate its cross-reactivity to a PAPP-A analogue. Finally, we utilize this SPR biosensor for the detection of PAPP-A2 in blood serum from two groups of subjects: pregnant women and healthy non-pregnant women and men. Graphical Abstract Temporal sensor response corresponding to respective steps of the assay for detection of PAPP-A2 in buffer
Pregnancy associated plasma protein A2 (PAPP-A2) is a metalloproteinase that plays multiple roles in fetal development and post-natal growth. Here we present a novel surface plasmon resonance (SPR) biosensor for the rapid and quantitative detection of PAPP-A2 in blood samples. This biosensor uses a single surface referencing approach and a sandwich assay with functionalized gold nanoparticles for signal enhancement. We demonstrate that this SPR biosensor enables the detection of PAPP-A2 in 30 % blood plasma at levels as low as 3.6 ng/mL. We also characterize the performance of the biosensor and evaluate its cross-reactivity to a PAPP-A analogue. Finally, we utilize this SPR biosensor for the detection of PAPP-A2 in blood serum from two groups of subjects: pregnant women and healthy non-pregnant women and men. [Figure not available: see fulltext.]
Pregnancy associated plasma protein A2 (PAPP-A2) is a metalloproteinase that plays multiple roles in fetal development and post-natal growth. Here we present a novel surface plasmon resonance (SPR) biosensor for the rapid and quantitative detection of PAPP-A2 in blood samples. This biosensor uses a single surface referencing approach and a sandwich assay with functionalized gold nanoparticles for signal enhancement. We demonstrate that this SPR biosensor enables the detection of PAPP-A2 in 30 % blood plasma at levels as low as 3.6 ng/mL. We also characterize the performance of the biosensor and evaluate its cross-reactivity to a PAPP-A analogue. Finally, we utilize this SPR biosensor for the detection of PAPP-A2 in blood serum from two groups of subjects: pregnant women and healthy non-pregnant women and men. Graphical Abstract Temporal sensor response corresponding to respective steps of the assay for detection of PAPP-A2 in buffer.
Pregnancy associated plasma protein A2 (PAPP-A2) is a metalloproteinase that plays multiple roles in fetal development and post-natal growth. Here we present a novel surface plasmon resonance (SPR) biosensor for the rapid and quantitative detection of PAPP-A2 in blood samples. This biosensor uses a single surface referencing approach and a sandwich assay with functionalized gold nanoparticles for signal enhancement. We demonstrate that this SPR biosensor enables the detection of PAPP-A2 in 30 % blood plasma at levels as low as 3.6 ng/mL. We also characterize the performance of the biosensor and evaluate its cross-reactivity to a PAPP-A analogue. Finally, we utilize this SPR biosensor for the detection of PAPP-A2 in blood serum from two groups of subjects: pregnant women and healthy non-pregnant women and men.
Audience Academic
Author Kalousová, Marta
Levová, Kateřina
Chadtová Song, Xue
Zima, Tomáš
Bocková, Markéta
Gedeonová, Erika
Homola, Jiří
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  surname: Homola
  fullname: Homola, Jiří
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  organization: Department of Optical Sensors, Institute of Photonics and Electronics of the CAS
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27299774$$D View this record in MEDLINE/PubMed
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Issue 26
Keywords Blood sample
Nanoparticles
Surface plasmon resonance
Pregnancy associated plasma protein A2
Language English
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PublicationTitle Analytical and bioanalytical chemistry
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Nishizawa, Pryor-Koishi, Suzuki, Kato, Kogo, Sekiya (CR2) 2008; 14
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Kloverpris, Gaidamauskas, Rasmussen, Overgaard, Kronborg, Knudsen (CR1) 2013; 19
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  start-page: 595
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  year: 2008
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  article-title: Increased levels of pregnancy-associated plasma protein-A2 in the serum of pre-eclamptic patients
  publication-title: Mol Hum Reprod
  doi: 10.1093/molehr/gan054
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– year: 2006
  ident: CR4
  publication-title: Surface plasmon resonance based sensors
  doi: 10.1007/b100321
– volume: 19
  start-page: 756
  issue: 11
  year: 2013
  end-page: 63
  ident: CR1
  article-title: A robust immunoassay for pregnancy-associated plasma protein-A2 based on analysis of circulating antigen: establishment of normal ranges in pregnancy
  publication-title: Mol Hum Reprod
  doi: 10.1093/molehr/gat047
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  doi: 10.1007/s00216-012-6308-9
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  doi: 10.1007/s00216-011-5395-3
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  doi: 10.1021/ac401062m
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Snippet Pregnancy associated plasma protein A2 (PAPP-A2) is a metalloproteinase that plays multiple roles in fetal development and post-natal growth. Here we present a...
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SubjectTerms Analytical Chemistry
Antibodies
Biochemistry
Biosensors
Blood
blood proteins
blood sampling
blood serum
Buffers
Characterization and Evaluation of Materials
Chemical Sensing Systems
Chemistry
Chemistry and Materials Science
cross reaction
Equipment and supplies
Female
fetal development
Food Science
Gold - chemistry
Humans
Laboratory Medicine
Limit of Detection
Male
Mathematical analysis
Membrane proteins
men
Metal Nanoparticles - chemistry
Methods
Monitoring/Environmental Analysis
nanogold
Nanoparticles
Paper in Forefront
Photonics
Physiological aspects
Plasma
Plasmons
Preeclampsia
Pregnancy
pregnancy diagnosis
Pregnancy-Associated Plasma Protein-A - analysis
pregnant women
Proteins
Referencing
Resonance
Sensors
surface plasmon resonance
Surface Plasmon Resonance - methods
Surface plasmon resonance spectroscopy
Women
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Title Surface plasmon resonance biosensor for detection of pregnancy associated plasma protein A2 in clinical samples
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