Genome-wide in vivo screen identifies novel host regulators of metastatic colonization

• Published in: Nature (London) Vol. 541; no. 7636; pp. 233 - 236
• Main Authors: van der Weyden, Louise, Arends, Mark J, Campbell, Andrew D, Bald, Tobias, Wardle-Jones, Hannah, Griggs, Nicola, Velasco-Herrera, Martin Del Castillo, Tüting, Thomas, Sansom, Owen J, Karp, Natasha A, Clare, Simon, Gleeson, Diane, Ryder, Edward, Galli, Antonella, Tuck, Elizabeth, Cambridge, Emma L, Voet, Thierry, Macaulay, Iain C, Wong, Kim, Spiegel, Sarah, Speak, Anneliese O, Adams, David J
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 12.01.2017
• Subjects: Animals; Anion Transport Proteins - deficiency; Anion Transport Proteins - genetics; Anion Transport Proteins - metabolism; Cancer; Cancer metastasis; Cell Line, Tumor; Cell Movement; Colonization; Disease Models, Animal; Female; Genetic aspects; Genome - genetics; Genome-wide association studies; Genomics; Genotype & phenotype; Immune system; Killer Cells, Natural - cytology; Killer Cells, Natural - immunology; Kinases; Lung Neoplasms - genetics; Lung Neoplasms - immunology; Lung Neoplasms - pathology; Lung Neoplasms - secondary; Lungs; Lymphocytes; Lymphopenia - genetics; Lymphopenia - pathology; Lysophospholipids - metabolism; Male; Melanoma; Metastasis; Mice; Neoplasm Metastasis - genetics; Neoplasm Metastasis - pathology; Regulation; Rodents; Sphingosine - analogs & derivatives; Sphingosine - metabolism; T-Lymphocytes - cytology; T-Lymphocytes - immunology; Tumor Microenvironment; Tumors; Veins & arteries

Metastasis is the leading cause of death for cancer patients. This multi-stage process requires tumour cells to survive in the circulation, extravasate at distant sites, then proliferate; it involves contributions from both the tumour cell and tumour microenvironment ('host', which include...