Serum prostate-specific antigen but not testosterone levels decrease in a randomized soy intervention among men

• Published in: European journal of clinical nutrition Vol. 60; no. 12; pp. 1423 - 1429
• Main Authors: Maskarinec, G, Morimoto, Y, Hebshi, S, Sharma, S, Franke, A.A, Stanczyk, F.Z
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing 01.12.2006; Nature Publishing Group
• Subjects: anticarcinogenic activity; Antigens; Biological and medical sciences; Biomarkers, Tumor - blood; Blood; blood chemistry; Calendars; Clinical trials; Cross-Over Studies; Diet; Dietary intake; Diseases of the digestive system; Evaluation; Excretion; Feasibility studies; Food; Food intake; General aspects; High performance liquid chromatography; human nutrition; Humans; Isoflavones; Isoflavones - urine; Liquid chromatography; Male; Medical sciences; Men; Metabolic diseases; Middle Aged; Nutrient deficiency; nutritional intervention; Patient Compliance; Photodiodes; Pilot Projects; Prostate cancer; prostate gland; Prostate-specific antigen; Prostate-Specific Antigen - blood; Prostatic Neoplasms - blood; Prostatic Neoplasms - epidemiology; Prostatic Neoplasms - prevention & control; Radioimmunoassay; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); randomized clinical trials; Soy Foods; Soy products; soybean products; Testosterone; Testosterone - blood; Human; Androgen; androgens; Male; Tumoral marker; Soybean; Feeding; Prostate specific antigen; Testosterone; Randomization; Diet therapy; men; Serum; Testicular hormone; Biological effect; Sex steroid hormone; soy; Urogenital system; Prostate; dietary intervention; prostate-specific antigen

Background: Low prostate cancer incidence and high soy intake in Asian countries suggest a possible protective effect of soy foods against prostate cancer. The goal of this pilot study was to evaluate the feasibility of a randomized, crossover soy trial among men and to investigate the effects of da...