Sex Differences in Neuropathology and Cognitive Behavior in APP/PS1/tau Triple-Transgenic Mouse Model of Alzheimer’s Disease

• Published in: Neuroscience bulletin Vol. 34; no. 5; pp. 736 - 746
• Main Authors: Yang, Jun-Ting, Wang, Zhao-Jun, Cai, Hong-Yan, Yuan, Li, Hu, Meng-Ming, Wu, Mei-Na, Qi, Jin-Shun
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.10.2018; Springer
• Subjects: Advertising executives; Alzheimer's disease; Analysis; Anatomy; Anesthesiology; Behavior; Biomedical and Life Sciences; Biomedicine; Genetic engineering; Human Physiology; Neurology; Neurosciences; Original; Original Article; Pain Medicine; Protein binding; Protein kinases; Target marketing; 3×Tg-AD mouse; Amyloid plaque; Neuroinflammation; Neurofibrillary tangle; Sex difference; Spatial memory

Alzheimer’s disease (AD) is the most common form of dementia among the elderly, characterized by amyloid plaques, neurofibrillary tangles, and neuroinflammation in the brain, as well as impaired cognitive behaviors. A sex difference in the prevalence of AD has been noted, while sex differences in th...