The ubiquitin ligase Huwe1 regulates the maintenance and lymphoid commitment of hematopoietic stem cells

• Published in: Nature immunology Vol. 17; no. 11; pp. 1312 - 1321
• Main Authors: King, Bryan, Boccalatte, Francesco, Moran-Crusio, Kelly, Wolf, Elmar, Wang, Jingjing, Kayembe, Clarisse, Lazaris, Charalampos, Yu, Xiaofeng, Aranda-Orgilles, Beatriz, Lasorella, Anna, Aifantis, Iannis
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.11.2016; Nature Publishing Group
• Subjects: 13/100; 13/106; 13/31; 13/89; 38/35; 38/39; 38/47; 631/250/232/2058; 631/532/1542; 64/60; Animals; Biomedicine; Bone marrow; Cell Cycle - genetics; Cell Differentiation - genetics; Cell Line; Cell Lineage - genetics; Cell Self Renewal - genetics; Cluster Analysis; Gene Expression Profiling; Genes, myc; Genetic aspects; Genetic regulation; Growth; Hematopoietic stem cells; Hematopoietic Stem Cells - cytology; Hematopoietic Stem Cells - metabolism; Homeostasis; Identification and classification; Immunology; Infectious Diseases; Ligases; Lymphocytes - cytology; Lymphocytes - metabolism; Mice; Mice, Knockout; Mice, Transgenic; Observations; Protein Stability; Proto-Oncogene Proteins c-myc - genetics; Proto-Oncogene Proteins c-myc - metabolism; Stem cells; Stress, Physiological; Transcription, Genetic; Ubiquitin-Protein Ligases - deficiency; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism

The longevity of hematopoietic stem cells requires strict regulation to prevent their exhaustion. Aifantis and colleagues show that the ubiquitin E3 ligase Huwe1 is needed to suppress the activity of the transcription factor N-myc and maintain the quiescence and function of these cells. Hematopoieti...