The spectral exponent of the resting EEG indexes the presence of consciousness during unresponsiveness induced by propofol, xenon, and ketamine

• Published in: NeuroImage (Orlando, Fla.) Vol. 189; pp. 631 - 644
• Main Authors: Colombo, Michele Angelo, Napolitani, Martino, Boly, Melanie, Gosseries, Olivia, Casarotto, Silvia, Rosanova, Mario, Brichant, Jean-Francois, Boveroux, Pierre, Rex, Steffen, Laureys, Steven, Massimini, Marcello, Chieregato, Arturo, Sarasso, Simone
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2019; Elsevier Limited
• Subjects: 1/F; Adolescent; Adult; Anesthesia; Anesthetics, General - pharmacology; Brain; Brain Waves - drug effects; Consciousness; Consciousness - drug effects; E/I; EEG; Electroencephalography; Electroencephalography - drug effects; Female; Humans; Ketamine; Ketamine - pharmacology; Male; NCC; Preservation; Propofol; Propofol - pharmacology; Sleep; Sleep and wakefulness; Unconsciousness; Unconsciousness - chemically induced; Unconsciousness - physiopathology; Xenon; Xenon - pharmacology; Young Adult; Belgium; United States > US; Italy; 1/F; Anesthesia; Consciousness; EEG; E/I; NCC

Despite the absence of responsiveness during anesthesia, conscious experience may persist. However, reliable, easily acquirable and interpretable neurophysiological markers of the presence of consciousness in unresponsive states are still missing. A promising marker is based on the decay-rate of the...