New improved radiometabolite analysis method for [18F]FTHA from human plasma: a test-retest study with postprandial and fasting state

• Published in: EJNMMI research Vol. 14; no. 1; pp. 53 - 9
• Main Authors: Aarnio, Richard, Kirjavainen, Anna, Rajander, Johan, Forsback, Sarita, Kalliokoski, Kari, Nuutila, Pirjo, Milicevic, Zvonko, Coskun, Tamer, Haupt, Axel, Laitinen, Iina, Haaparanta-Solin, Merja
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 13.06.2024; Springer Nature B.V; SpringerOpen
• Subjects: [18F]FTHA; Blood plasma; Cardiac Imaging; Fasting; Imaging; Medicine; Medicine & Public Health; Metabolic imaging; Nuclear Medicine; Oncology; Original Research; Orthopedics; Parent fraction; Plasma; Radio-TLC; Radioactivity; Radiology; Radiometabolite analysis; Reproducibility; Thin layer chromatography; Parent fraction; Radio-TLC; Metabolic imaging; [; F]FTHA; Radiometabolite analysis; [18F]FTHA

Background Fatty acid uptake can be measured using PET and 14-( R,S )‐[ 18 F]fluoro‐6‐thia‐heptadecanoic acid ([ 18 F]FTHA). However, the relatively rapid rate of [ 18 F]FTHA metabolism significantly affects kinetic modeling of tissue uptake. Thus, there is a need for accurate chromatographic method...