Comprehensive Phenotyping in Inflammatory Bowel Disease: Search for Biomarker Algorithms in the Transkingdom Interactions Context

Inflammatory bowel disease (IBD) is the most common form of intestinal inflammation associated with a dysregulated immune system response to the commensal microbiota in a genetically susceptible host. IBD includes ulcerative colitis (UC) and Crohn's disease (CD), both of which are remarkably he...

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Published inMicroorganisms (Basel) Vol. 10; no. 11; p. 2190
Main Authors Rosso, Ayelén D, Aguilera, Pablo, Quesada, Sofía, Mascardi, Florencia, Mascuka, Sebastian N, Cimolai, María C, Cerezo, Jimena, Spiazzi, Renata, Conlon, Carolina, Milano, Claudia, Iraola, Gregorio M, Penas-Steinhardt, Alberto, Belforte, Fiorella S
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.11.2022
MDPI
Subjects
Algorithms
Biological markers
Biomarkers
Body mass index
Colon
Communication
comprehensive-phenotyping
Context
Crohn's disease
crohn-disease
Crohns disease
Data analysis
Developing countries
Diagnosis
Digestive system
Endoscopy
Epigenetics
Erythema
Feces
Gastrointestinal surgery
Gastrointestinal tract
gut-microbiota
Health aspects
Health services
Hospitals
Immune system
Inflammatory bowel disease
Inflammatory bowel diseases
Intestinal microflora
Intestine
Irritable bowel syndrome
LDCs
Metropolitan areas
Microbiota
Microorganisms
Patients
Phenotypes
Phenotyping
Qualitative analysis
Serology
Ulcerative colitis
Argentina
South America
gut-microbiota
comprehensive-phenotyping
crohn-disease
ulcerative-colitis
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Abstract Inflammatory bowel disease (IBD) is the most common form of intestinal inflammation associated with a dysregulated immune system response to the commensal microbiota in a genetically susceptible host. IBD includes ulcerative colitis (UC) and Crohn's disease (CD), both of which are remarkably heterogeneous in their clinical presentation and response to treatment. This translates into a notable diagnostic challenge, especially in underdeveloped countries where IBD is on the rise and access to diagnosis or treatment is not always accessible for chronic diseases. The present work characterized, for the first time in our region, epigenetic biomarkers and gut microbial profiles associated with UC and CD patients in the Buenos Aires Metropolitan area and revealed differences between non-IBD controls and IBD patients. General metabolic functions associated with the gut microbiota, as well as core microorganisms within groups, were also analyzed. Additionally, the gut microbiota analysis was integrated with relevant clinical, biochemical and epigenetic markers considered in the follow-up of patients with IBD, with the aim of generating more powerful diagnostic tools to discriminate phenotypes. Overall, our study provides new insights into data analysis algorithms to promote comprehensive phenotyping tools using quantitative and qualitative analysis in a transkingdom interactions network context.
AbstractList Inflammatory bowel disease (IBD) is the most common form of intestinal inflammation associated with a dysregulated immune system response to the commensal microbiota in a genetically susceptible host. IBD includes ulcerative colitis (UC) and Crohn's disease (CD), both of which are remarkably heterogeneous in their clinical presentation and response to treatment. This translates into a notable diagnostic challenge, especially in underdeveloped countries where IBD is on the rise and access to diagnosis or treatment is not always accessible for chronic diseases. The present work characterized, for the first time in our region, epigenetic biomarkers and gut microbial profiles associated with UC and CD patients in the Buenos Aires Metropolitan area and revealed differences between non-IBD controls and IBD patients. General metabolic functions associated with the gut microbiota, as well as core microorganisms within groups, were also analyzed. Additionally, the gut microbiota analysis was integrated with relevant clinical, biochemical and epigenetic markers considered in the follow-up of patients with IBD, with the aim of generating more powerful diagnostic tools to discriminate phenotypes. Overall, our study provides new insights into data analysis algorithms to promote comprehensive phenotyping tools using quantitative and qualitative analysis in a transkingdom interactions network context.
Inflammatory bowel disease (IBD) is the most common form of intestinal inflammation associated with a dysregulated immune system response to the commensal microbiota in a genetically susceptible host. IBD includes ulcerative colitis (UC) and Crohn's disease (CD), both of which are remarkably heterogeneous in their clinical presentation and response to treatment. This translates into a notable diagnostic challenge, especially in underdeveloped countries where IBD is on the rise and access to diagnosis or treatment is not always accessible for chronic diseases. The present work characterized, for the first time in our region, epigenetic biomarkers and gut microbial profiles associated with UC and CD patients in the Buenos Aires Metropolitan area and revealed differences between non-IBD controls and IBD patients. General metabolic functions associated with the gut microbiota, as well as core microorganisms within groups, were also analyzed. Additionally, the gut microbiota analysis was integrated with relevant clinical, biochemical and epigenetic markers considered in the follow-up of patients with IBD, with the aim of generating more powerful diagnostic tools to discriminate phenotypes. Overall, our study provides new insights into data analysis algorithms to promote comprehensive phenotyping tools using quantitative and qualitative analysis in a transkingdom interactions network context.Inflammatory bowel disease (IBD) is the most common form of intestinal inflammation associated with a dysregulated immune system response to the commensal microbiota in a genetically susceptible host. IBD includes ulcerative colitis (UC) and Crohn's disease (CD), both of which are remarkably heterogeneous in their clinical presentation and response to treatment. This translates into a notable diagnostic challenge, especially in underdeveloped countries where IBD is on the rise and access to diagnosis or treatment is not always accessible for chronic diseases. The present work characterized, for the first time in our region, epigenetic biomarkers and gut microbial profiles associated with UC and CD patients in the Buenos Aires Metropolitan area and revealed differences between non-IBD controls and IBD patients. General metabolic functions associated with the gut microbiota, as well as core microorganisms within groups, were also analyzed. Additionally, the gut microbiota analysis was integrated with relevant clinical, biochemical and epigenetic markers considered in the follow-up of patients with IBD, with the aim of generating more powerful diagnostic tools to discriminate phenotypes. Overall, our study provides new insights into data analysis algorithms to promote comprehensive phenotyping tools using quantitative and qualitative analysis in a transkingdom interactions network context.
Audience Academic
Author Penas-Steinhardt, Alberto
Mascuka, Sebastian N
Belforte, Fiorella S
Rosso, Ayelén D
Spiazzi, Renata
Quesada, Sofía
Aguilera, Pablo
Iraola, Gregorio M
Cimolai, María C
Cerezo, Jimena
Milano, Claudia
Conlon, Carolina
Mascardi, Florencia
AuthorAffiliation 7 Laboratorio de Genómica Microbiana, Institut Pasteur Montevideo, Montevideo 11400, Uruguay
6 Servicio de Gastroenterología, Hospital Nacional Prof. Alejandro Posadas, Ciudad Autónoma de Buenos Aires 1704, Argentina
9 Wellcome Sanger Institute, Wellcome Genome Campus, Cambridgeshire CB10 1SA, UK
4 Instituto de Ecología y Desarrollo Sustentable (INEDES-CONICET-UNLu), Departamento de Ciencias Básicas, Universidad Nacional de Luján, Luján 6700, Argentina
10 Instituto Universitario de Ciencias de la Salud, Fundación H.A. Barceló, Ciudad Autónoma de Buenos Aires 1127, Argentina
1 Laboratorio de Genómica Computacional (GeC-UNLu), Departamento de Ciencias Básicas, Universidad Nacional de Luján, Luján 6700, Argentina
2 Programa del Estudio de Comunicación y Señalización Interreino (PECSI-UNLu), Departamento de Ciencias Básicas, Universidad Nacional de Luján, Luján 6700, Argentina
5 Instituto de Medicina Traslacional e Ingeniería Biomédica (IMTIB), CONICET, Instituto Universitario del Hospital Italia
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CitedBy_id crossref_primary_10_1016_j_heliyon_2023_e23439
crossref_primary_10_1016_j_molimm_2024_05_004
Cites_doi 10.4049/jimmunol.0901518
10.1038/s41598-017-10034-5
10.3748/wjg.v25.i47.6866
10.1186/s12938-021-00857-9
10.1293/tox.2017-0051
10.1038/nmeth.f.303
10.1002/JLB.3MR0218-079R
10.1016/j.chom.2020.12.003
10.1101/gr.1239303
10.3389/fmed.2020.615858
10.1073/pnas.2104429118
10.1186/s13099-019-0341-6
10.1016/S0016-5107(04)01878-4
10.1038/s41598-021-87925-1
10.1128/mSystems.00021-18
10.3389/fnut.2021.615064
10.3389/fmicb.2019.00965
10.1093/ecco-jcc/jjx008
10.3748/wjg.v24.i1.5
10.1053/j.gastro.2016.10.020
10.1038/nature08821
10.1002/0471142727.mb1510s95
10.1016/j.bbrc.2018.06.174
10.1016/j.cca.2021.01.008
10.1038/nmeth.3869
10.1038/s41598-020-75702-5
10.1371/journal.pone.0061217
10.1016/S0016-5085(76)80163-1
10.1038/s41587-020-0548-6
10.1002/j.1538-7305.1948.tb00917.x
10.1038/nrgastro.2017.88
10.1056/NEJMra0804647
10.1097/QCO.0000000000000300
10.1159/000199983
10.1007/s00134-006-0488-8
10.3389/fmicb.2022.803121
10.1186/s12915-014-0087-z
10.1038/s41598-020-69537-3
10.2174/2211536611302010007
10.1007/s00198-008-0764-2
10.3389/fmicb.2017.01221
10.1371/journal.pone.0097876
10.1101/2020.10.05.326504
10.1038/s41598-021-96942-z
10.3748/wjg.v23.i25.4624
10.3389/fphys.2021.695019
10.3389/fmicb.2019.02346
10.1093/nar/gkv1164
10.1038/emm.2015.21
10.1101/610394
10.1111/j.1462-2920.2011.02585.x
10.3389/978-2-88919-740-8
10.1136/gut.2010.223263
10.1016/j.tem.2020.02.012
10.1007/s12088-017-0652-6
10.1016/j.tim.2016.11.008
10.1016/j.cell.2014.08.006
10.3390/ijms23147991
10.1371/journal.pone.0052078
10.1093/ibd/izaa001
10.1056/NEJM198712243172603
10.1186/s13059-016-0901-8
10.1016/j.cell.2007.04.040
10.1371/journal.pone.0006386
10.1186/s12950-020-00246-4
10.1007/978-981-16-3398-0
10.1007/s11306-021-01810-6
10.1111/j.1538-7836.2009.03586.x
10.1515/biol-2018-0057
10.1093/nar/gks1219
10.1016/j.crohns.2012.02.006
10.1053/j.gastro.2006.12.038
10.6061/clinics/2020/e1596
10.1038/32588
10.3389/fmicb.2017.00768
10.3748/wjg.v23.i25.4548
10.1016/j.trsl.2012.01.001
10.3748/wjg.v22.i26.6027
10.1128/JCM.01500-13
10.1109/COMST.2015.2476474
10.1136/bmj.k2179
10.3389/fmicb.2017.00846
10.3389/fgene.2014.00168
10.1038/s41598-019-47688-2
10.1128/mSystems.00984-20
10.1097/MIB.0000000000000687
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Keywords gut-microbiota
comprehensive-phenotyping
crohn-disease
ulcerative-colitis
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References Daperno (ref_22) 2004; 60
Truelove (ref_18) 1954; 81
Yuan (ref_57) 2018; 104
Anderson (ref_33) 2001; 26
Bajer (ref_61) 2017; 23
Ichii (ref_54) 2018; 31
Aguilera (ref_15) 2022; 13
Quast (ref_32) 2013; 41
Iskandar (ref_51) 2012; 159
Zhou (ref_8) 2017; 8
Belforte (ref_14) 2019; 10
Cognasse (ref_88) 2007; 33
ref_17
Valdes (ref_5) 2018; 361
Caspi (ref_34) 2016; 44
Qiu (ref_83) 2017; 57
Magro (ref_3) 2017; 11
Ni (ref_92) 2017; 14
Magne (ref_13) 2016; 29
Janssen (ref_30) 2018; 3
Alam (ref_71) 2020; 12
Liu (ref_91) 2021; 12
Fedorak (ref_65) 2010; 6
Shen (ref_9) 2018; 24
Smyth (ref_89) 2009; 7
Shannon (ref_40) 2003; 13
Best (ref_21) 1976; 70
Shade (ref_77) 2012; 14
Pathak (ref_53) 2015; 17
Wang (ref_64) 2014; 52
Singh (ref_67) 2020; 10
Selvaratnam (ref_50) 2019; 25
Okuda (ref_46) 2021; 11
Vasquez (ref_11) 2017; 8
ref_29
Ji (ref_6) 2018; 503
ref_28
ref_27
ref_26
Amos (ref_72) 2021; 11
Douglas (ref_35) 2020; 38
Shapiro (ref_82) 2021; 29
Banchereau (ref_90) 1998; 392
Kaplan (ref_2) 2017; 152
Wang (ref_59) 2016; 17
Chen (ref_62) 2017; 23
Joossens (ref_81) 2011; 60
Layeghifard (ref_42) 2017; 25
Liu (ref_73) 2020; 31
ref_76
ref_31
ref_75
ref_74
Morais (ref_45) 2021; 20
Kocsis (ref_7) 2016; 22
Kramer (ref_23) 2011; 95
ref_39
ref_38
Pathak (ref_55) 2015; 47
ref_37
Linares (ref_66) 2017; 8
Mazzini (ref_93) 2021; 17
Kaur (ref_4) 2020; 17
Sandborn (ref_19) 2007; 132
Mandal (ref_36) 2015; 26
Wu (ref_44) 2021; 516
Li (ref_86) 2020; 75
Kumar (ref_12) 2019; 9
Schroeder (ref_20) 1987; 317
ref_47
Landgraf (ref_60) 2007; 129
Kushkevych (ref_79) 2019; 13
Qin (ref_85) 2010; 464
Paraskevi (ref_52) 2012; 6
Kuwabara (ref_68) 2009; 20
ref_43
Soen (ref_63) 2014; 5
ref_87
ref_41
Palm (ref_80) 2014; 158
Neu (ref_78) 2021; 118
Rokonay (ref_56) 2016; 22
Carpenter (ref_58) 2009; 183
Jones (ref_84) 2020; 26
Callahan (ref_25) 2016; 13
Zhou (ref_70) 2021; 8
Zhuang (ref_69) 2020; 7
Caporaso (ref_24) 2010; 7
Shannon (ref_49) 1948; 27
Giliberto (ref_16) 2020; 10
Abraham (ref_1) 2009; 361
Medina (ref_10) 2019; 10
Mi (ref_48) 2013; 2
References_xml – volume: 183
  start-page: 3989
  year: 2009
  ident: ref_58
  article-title: TRIL, a Functional Component of the TLR4 Signaling Complex, Highly Expressed in Brain
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0901518
  contributor:
    fullname: Carpenter
– ident: ref_75
  doi: 10.1038/s41598-017-10034-5
– volume: 25
  start-page: 6866
  year: 2019
  ident: ref_50
  article-title: Epidemiology of inflammatory bowel disease in South America: A systematic review
  publication-title: World J. Gastroenterol.
  doi: 10.3748/wjg.v25.i47.6866
  contributor:
    fullname: Selvaratnam
– volume: 20
  start-page: 21
  year: 2021
  ident: ref_45
  article-title: miRNAs as biomarkers for early cancer detection and their application in the development of new diagnostic tools
  publication-title: Biomed. Eng. Online
  doi: 10.1186/s12938-021-00857-9
  contributor:
    fullname: Morais
– volume: 31
  start-page: 23
  year: 2018
  ident: ref_54
  article-title: MicroRNAs associated with the development of kidney diseases in humans and animals
  publication-title: J. Toxicol. Pathol.
  doi: 10.1293/tox.2017-0051
  contributor:
    fullname: Ichii
– volume: 7
  start-page: 335
  year: 2010
  ident: ref_24
  article-title: QIIME allows analysis of high-throughput community sequencing data
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.f.303
  contributor:
    fullname: Caporaso
– volume: 104
  start-page: 515
  year: 2018
  ident: ref_57
  article-title: MicroRNA miR-223 as Regulator of Innate Immunity
  publication-title: J. Leukoc. Biol.
  doi: 10.1002/JLB.3MR0218-079R
  contributor:
    fullname: Yuan
– volume: 29
  start-page: 83
  year: 2021
  ident: ref_82
  article-title: Immunoglobulin A Targets a Unique Subset of the Microbiota in Inflammatory Bowel Disease
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2020.12.003
  contributor:
    fullname: Shapiro
– volume: 13
  start-page: 2498
  year: 2003
  ident: ref_40
  article-title: Cytoscape: A software environment for integrated models of biomolecular interaction networks
  publication-title: Genome Res.
  doi: 10.1101/gr.1239303
  contributor:
    fullname: Shannon
– volume: 7
  start-page: 615858
  year: 2020
  ident: ref_69
  article-title: Gut Microbiota Profiles and Microbial-Based Therapies in Post-Operative Crohn’s Disease: A Systematic Review
  publication-title: Front. Med.
  doi: 10.3389/fmed.2020.615858
  contributor:
    fullname: Zhuang
– volume: 118
  start-page: e2104429118
  year: 2021
  ident: ref_78
  article-title: Defining and Quantifying the Core Microbiome: Challenges and Prospects
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.2104429118
  contributor:
    fullname: Neu
– volume: 12
  start-page: 1
  year: 2020
  ident: ref_71
  article-title: Microbial Imbalance in Inflammatory Bowel Disease Patients at Different Taxonomic Levels
  publication-title: Gut Pathog.
  doi: 10.1186/s13099-019-0341-6
  contributor:
    fullname: Alam
– volume: 60
  start-page: 505
  year: 2004
  ident: ref_22
  article-title: Development and validation of a new, simplified endoscopic activity score for Crohn’s disease: The SES-CD
  publication-title: Gastrointest. Endosc.
  doi: 10.1016/S0016-5107(04)01878-4
  contributor:
    fullname: Daperno
– ident: ref_39
– volume: 11
  start-page: 8508
  year: 2021
  ident: ref_46
  article-title: Urinary microRNA biomarkers for detecting the presence of esophageal cancer
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-021-87925-1
  contributor:
    fullname: Okuda
– volume: 3
  start-page: e00021-18
  year: 2018
  ident: ref_30
  article-title: Phylogenetic Placement of Exact Amplicon Sequences Improves Associations with Clinical Information
  publication-title: mSystems
  doi: 10.1128/mSystems.00021-18
  contributor:
    fullname: Janssen
– volume: 8
  start-page: 615064
  year: 2021
  ident: ref_70
  article-title: Alterations in Gut Microbial Communities Across Anatomical Locations in Inflammatory Bowel Diseases
  publication-title: Front. Nutr.
  doi: 10.3389/fnut.2021.615064
  contributor:
    fullname: Zhou
– volume: 10
  start-page: 965
  year: 2019
  ident: ref_14
  article-title: Getting to Know the Gut Microbial Diversity of Metropolitan Buenos Aires Inhabitants
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2019.00965
  contributor:
    fullname: Belforte
– volume: 11
  start-page: 649
  year: 2017
  ident: ref_3
  article-title: Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 1: Definitions, Diagnosis, Extra-intestinal Manifestations, Pregnancy, Cancer Surveillance, Surgery, and Ileo-anal Pouch Disorders
  publication-title: J. Crohn’s Colitis
  doi: 10.1093/ecco-jcc/jjx008
  contributor:
    fullname: Magro
– volume: 24
  start-page: 5
  year: 2018
  ident: ref_9
  article-title: Relationship between intestinal microbiota and ulcerative colitis: Mechanisms and clinical application of probiotics and fecal microbiota transplantation
  publication-title: World J. Gastroenterol.
  doi: 10.3748/wjg.v24.i1.5
  contributor:
    fullname: Shen
– volume: 152
  start-page: 313
  year: 2017
  ident: ref_2
  article-title: Understanding and Preventing the Global Increase of Inflammatory Bowel Disease
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2016.10.020
  contributor:
    fullname: Kaplan
– volume: 464
  start-page: 59
  year: 2010
  ident: ref_85
  article-title: A Human Gut Microbial Gene Catalogue Established by Metagenomic Sequencing
  publication-title: Nature
  doi: 10.1038/nature08821
  contributor:
    fullname: Qin
– volume: 95
  start-page: 1
  year: 2011
  ident: ref_23
  article-title: Stem-loop RT-qPCR for miRNAs
  publication-title: Curr. Protoc. Mol. Biol.
  doi: 10.1002/0471142727.mb1510s95
  contributor:
    fullname: Kramer
– volume: 503
  start-page: 2443
  year: 2018
  ident: ref_6
  article-title: Faecal microRNA as a biomarker of the activity and prognosis of inflammatory bowel diseases
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2018.06.174
  contributor:
    fullname: Ji
– volume: 516
  start-page: 46
  year: 2021
  ident: ref_44
  article-title: Circulating microRNAs: Biomarkers of disease
  publication-title: Clin. Chim. Acta
  doi: 10.1016/j.cca.2021.01.008
  contributor:
    fullname: Wu
– volume: 13
  start-page: 581
  year: 2016
  ident: ref_25
  article-title: DADA2: High-resolution sample inference from Illumina amplicon data
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.3869
  contributor:
    fullname: Callahan
– volume: 10
  start-page: 18597
  year: 2020
  ident: ref_67
  article-title: Anti-Inflammatory Bifidobacterium Strains Prevent Dextran Sodium Sulfate Induced Colitis and Associated Gut Microbial Dysbiosis in Mice
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-020-75702-5
  contributor:
    fullname: Singh
– ident: ref_37
  doi: 10.1371/journal.pone.0061217
– volume: 70
  start-page: 439
  year: 1976
  ident: ref_21
  article-title: Development of a Crohn’s disease activity index. National Cooperative Crohn’s Disease Study
  publication-title: Gastroenterology
  doi: 10.1016/S0016-5085(76)80163-1
  contributor:
    fullname: Best
– volume: 38
  start-page: 685
  year: 2020
  ident: ref_35
  article-title: PICRUSt2 for prediction of metagenome functions
  publication-title: Nat. Biotechnol.
  doi: 10.1038/s41587-020-0548-6
  contributor:
    fullname: Douglas
– volume: 27
  start-page: 623
  year: 1948
  ident: ref_49
  article-title: A Mathematical Theory of Communication
  publication-title: Bell Syst. Tech. J.
  doi: 10.1002/j.1538-7305.1948.tb00917.x
  contributor:
    fullname: Shannon
– volume: 14
  start-page: 573
  year: 2017
  ident: ref_92
  article-title: Gut Microbiota and IBD: Causation or Correlation?
  publication-title: Nat. Rev. Gastroenterol. Hepatol.
  doi: 10.1038/nrgastro.2017.88
  contributor:
    fullname: Ni
– volume: 361
  start-page: 2066
  year: 2009
  ident: ref_1
  article-title: Inflammatory bowel disease
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMra0804647
  contributor:
    fullname: Abraham
– volume: 29
  start-page: 528
  year: 2016
  ident: ref_13
  article-title: The human gut microbiome of Latin America populations: A landscape to be discovered
  publication-title: Curr. Opin. Infect. Dis.
  doi: 10.1097/QCO.0000000000000300
  contributor:
    fullname: Magne
– volume: 81
  start-page: 86
  year: 1954
  ident: ref_18
  article-title: Cortisone in Ulcerative Colitis Preliminary Report on a Therapeutic Trial
  publication-title: Digestion
  doi: 10.1159/000199983
  contributor:
    fullname: Truelove
– volume: 33
  start-page: 382
  year: 2007
  ident: ref_88
  article-title: Lipopolysaccharide Induces sCD40L Release through Human Platelets TLR4, but Not TLR2 and TLR9
  publication-title: Intensive Care Med.
  doi: 10.1007/s00134-006-0488-8
  contributor:
    fullname: Cognasse
– volume: 6
  start-page: 688
  year: 2010
  ident: ref_65
  article-title: Probiotics in the Management of Ulcerative Colitis
  publication-title: Gastroenterol. Hepatol.
  contributor:
    fullname: Fedorak
– volume: 13
  start-page: 803121
  year: 2022
  ident: ref_15
  article-title: A Two-Time Point Analysis of Gut Microbiota in the General Population of Buenos Aires and Its Variation Due to Preventive and Compulsory Social Isolation during the COVID-19 Pandemic
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2022.803121
  contributor:
    fullname: Aguilera
– ident: ref_28
  doi: 10.1186/s12915-014-0087-z
– volume: 10
  start-page: 12754
  year: 2020
  ident: ref_16
  article-title: Metagenomic analysis of gut microbiota in non-treated plaque psoriasis patients stratified by disease severity: Development of a new Psoriasis-Microbiome Index
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-020-69537-3
  contributor:
    fullname: Giliberto
– ident: ref_38
– volume: 2
  start-page: 63
  year: 2013
  ident: ref_48
  article-title: Circulating microRNAs as biomarkers for inflammatory diseases
  publication-title: Microrna
  doi: 10.2174/2211536611302010007
  contributor:
    fullname: Mi
– volume: 20
  start-page: 935
  year: 2009
  ident: ref_68
  article-title: High Prevalence of Vitamin K and D Deficiency and Decreased BMD in Inflammatory Bowel Disease
  publication-title: Osteoporos. Int.
  doi: 10.1007/s00198-008-0764-2
  contributor:
    fullname: Kuwabara
– volume: 8
  start-page: 1221
  year: 2017
  ident: ref_11
  article-title: The Gut Microbiota of Healthy Chilean Subjects Reveals a High Abundance of the Phylum Verrucomicrobia
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2017.01221
  contributor:
    fullname: Vasquez
– ident: ref_27
  doi: 10.1371/journal.pone.0097876
– ident: ref_31
  doi: 10.1101/2020.10.05.326504
– volume: 11
  start-page: 18699
  year: 2021
  ident: ref_72
  article-title: Exploring How Microbiome Signatures Change across Inflammatory Bowel Disease Conditions and Disease Locations
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-021-96942-z
  contributor:
    fullname: Amos
– volume: 23
  start-page: 4624
  year: 2017
  ident: ref_62
  article-title: Partners of Patients with Ulcerative Colitis Exhibit a Biologically Relevant Dysbiosis in Fecal Microbial Metacommunities
  publication-title: World J. Gastroenterol.
  doi: 10.3748/wjg.v23.i25.4624
  contributor:
    fullname: Chen
– volume: 12
  start-page: 695019
  year: 2021
  ident: ref_91
  article-title: Mechanism of Ulcerative Colitis-Aggravated Liver Fibrosis: The Activation of Hepatic Stellate Cells and TLR4 Signaling through Gut-Liver Axis
  publication-title: Front. Physiol.
  doi: 10.3389/fphys.2021.695019
  contributor:
    fullname: Liu
– volume: 10
  start-page: 2346
  year: 2019
  ident: ref_10
  article-title: Cross-Regional View of Functional and Taxonomic Microbiota Composition in Obesity and Post-obesity Treatment Shows Country Specific Microbial Contribution
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2019.02346
  contributor:
    fullname: Medina
– volume: 44
  start-page: D471
  year: 2016
  ident: ref_34
  article-title: The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkv1164
  contributor:
    fullname: Caspi
– volume: 47
  start-page: e164
  year: 2015
  ident: ref_55
  article-title: MiR-155 Modulates the Inflammatory Phenotype of Intestinal Myofibroblasts by Targeting SOCS1 in Ulcerative Colitis
  publication-title: Exp. Mol. Med.
  doi: 10.1038/emm.2015.21
  contributor:
    fullname: Pathak
– ident: ref_26
  doi: 10.1101/610394
– volume: 14
  start-page: 4
  year: 2012
  ident: ref_77
  article-title: Beyond the Venn Diagram: The Hunt for a Core Microbiome
  publication-title: Environ. Microbiol.
  doi: 10.1111/j.1462-2920.2011.02585.x
  contributor:
    fullname: Shade
– ident: ref_87
  doi: 10.3389/978-2-88919-740-8
– volume: 60
  start-page: 631
  year: 2011
  ident: ref_81
  article-title: Dysbiosis of the Faecal Microbiota in Patients with Crohn’s Disease and Their Unaffected Relatives
  publication-title: Gut
  doi: 10.1136/gut.2010.223263
  contributor:
    fullname: Joossens
– volume: 31
  start-page: 818
  year: 2020
  ident: ref_73
  article-title: Gut Microbial Metabolites of Aromatic Amino Acids as Signals in Host-Microbe Interplay
  publication-title: Trends Endocrinol. Metab.
  doi: 10.1016/j.tem.2020.02.012
  contributor:
    fullname: Liu
– volume: 57
  start-page: 307
  year: 2017
  ident: ref_83
  article-title: Targeted Metagenome Based Analyses Show Gut Microbial Diversity of Inflammatory Bowel Disease Patients
  publication-title: Indian J. Microbiol.
  doi: 10.1007/s12088-017-0652-6
  contributor:
    fullname: Qiu
– volume: 25
  start-page: 217
  year: 2017
  ident: ref_42
  article-title: Disentangling Interactions in the Microbiome: A Network Perspective
  publication-title: Trends Microbiol.
  doi: 10.1016/j.tim.2016.11.008
  contributor:
    fullname: Layeghifard
– volume: 26
  start-page: 27663
  year: 2015
  ident: ref_36
  article-title: Analysis of composition of microbiomes: A novel method for studying microbial composition
  publication-title: Microb. Ecol. Health Dis.
  contributor:
    fullname: Mandal
– volume: 158
  start-page: 1000
  year: 2014
  ident: ref_80
  article-title: Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease
  publication-title: Cell
  doi: 10.1016/j.cell.2014.08.006
  contributor:
    fullname: Palm
– ident: ref_47
  doi: 10.3390/ijms23147991
– ident: ref_17
  doi: 10.1371/journal.pone.0052078
– volume: 26
  start-page: 1026
  year: 2020
  ident: ref_84
  article-title: Bacterial Taxa and Functions Are Predictive of Sustained Remission Following Exclusive Enteral Nutrition in Pediatric Crohn’s Disease
  publication-title: Inflamm. Bowel Dis.
  doi: 10.1093/ibd/izaa001
  contributor:
    fullname: Jones
– volume: 317
  start-page: 1625
  year: 1987
  ident: ref_20
  article-title: Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJM198712243172603
  contributor:
    fullname: Schroeder
– volume: 17
  start-page: 58
  year: 2016
  ident: ref_59
  article-title: Pro-Inflammatory miR-223 Mediates the Cross-Talk between the IL23 Pathway and the Intestinal Barrier in Inflammatory Bowel Disease
  publication-title: Genome Biol.
  doi: 10.1186/s13059-016-0901-8
  contributor:
    fullname: Wang
– volume: 129
  start-page: 1401
  year: 2007
  ident: ref_60
  article-title: A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing
  publication-title: Cell
  doi: 10.1016/j.cell.2007.04.040
  contributor:
    fullname: Landgraf
– ident: ref_76
  doi: 10.1371/journal.pone.0006386
– volume: 17
  start-page: 15
  year: 2020
  ident: ref_4
  article-title: Ulcerative colitis: Understanding its cellular pathology could provide insights into novel therapies
  publication-title: J. Inflamm.
  doi: 10.1186/s12950-020-00246-4
  contributor:
    fullname: Kaur
– ident: ref_29
– ident: ref_41
  doi: 10.1007/978-981-16-3398-0
– volume: 17
  start-page: 58
  year: 2021
  ident: ref_93
  article-title: Plasma and Stool Metabolomics to Identify Microbiota Derived-Biomarkers of Metabolic Dysfunction-Associated Fatty Liver Disease: Effect of PNPLA3 Genotype
  publication-title: Metabolomics
  doi: 10.1007/s11306-021-01810-6
  contributor:
    fullname: Mazzini
– volume: 7
  start-page: 1759
  year: 2009
  ident: ref_89
  article-title: Platelet functions beyond hemostasis
  publication-title: J. Thromb. Haemost.
  doi: 10.1111/j.1538-7836.2009.03586.x
  contributor:
    fullname: Smyth
– volume: 13
  start-page: 481
  year: 2019
  ident: ref_79
  article-title: Analysis of Physiological Parameters of Desulfovibrio Strains from Individuals with Colitis
  publication-title: Open Life Sci.
  doi: 10.1515/biol-2018-0057
  contributor:
    fullname: Kushkevych
– volume: 41
  start-page: D590
  year: 2013
  ident: ref_32
  article-title: The SILVA ribosomal RNA gene database project: Improved data processing and web-based tools
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gks1219
  contributor:
    fullname: Quast
– volume: 6
  start-page: 900
  year: 2012
  ident: ref_52
  article-title: Circulating MicroRNA in inflammatory bowel disease
  publication-title: J. Crohns Colitis.
  doi: 10.1016/j.crohns.2012.02.006
  contributor:
    fullname: Paraskevi
– volume: 132
  start-page: 763
  year: 2007
  ident: ref_19
  article-title: A Review of Activity Indices and Efficacy End Points for Clinical Trials of Medical Therapy in Adults with Ulcerative Colitis
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2006.12.038
  contributor:
    fullname: Sandborn
– volume: 75
  start-page: e1596
  year: 2020
  ident: ref_86
  article-title: Platelets Can Reflect the Severity of Crohn’s Disease without the Effect of Anemia
  publication-title: Clinics
  doi: 10.6061/clinics/2020/e1596
  contributor:
    fullname: Li
– volume: 392
  start-page: 245
  year: 1998
  ident: ref_90
  article-title: Dendritic Cells and the Control of Immunity
  publication-title: Nature
  doi: 10.1038/32588
  contributor:
    fullname: Banchereau
– volume: 8
  start-page: 768
  year: 2017
  ident: ref_8
  article-title: New Insight into Inter-kingdom Communication: Horizontal Transfer of Mobile Small RNAs
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2017.00768
  contributor:
    fullname: Zhou
– volume: 26
  start-page: 32
  year: 2001
  ident: ref_33
  article-title: A new method for non-parametric multivariate analysis of variance
  publication-title: Austral Ecol.
  contributor:
    fullname: Anderson
– volume: 23
  start-page: 4548
  year: 2017
  ident: ref_61
  article-title: Distinct Gut Microbiota Profiles in Patients with Primary Sclerosing Cholangitis and Ulcerative Colitis
  publication-title: World J. Gastroenterol.
  doi: 10.3748/wjg.v23.i25.4548
  contributor:
    fullname: Bajer
– volume: 159
  start-page: 313
  year: 2012
  ident: ref_51
  article-title: Biomarkers in inflammatory bowel disease: Current practices and recent advances
  publication-title: Transl Res.
  doi: 10.1016/j.trsl.2012.01.001
  contributor:
    fullname: Iskandar
– volume: 22
  start-page: 6027
  year: 2016
  ident: ref_56
  article-title: Increased Duodenal Expression of miR-146a and -155 in Pediatric Crohn’s Disease
  publication-title: World J. Gastroenterol.
  doi: 10.3748/wjg.v22.i26.6027
  contributor:
    fullname: Rokonay
– volume: 52
  start-page: 398
  year: 2014
  ident: ref_64
  article-title: Increased Proportions of Bifidobacterium and the Lactobacillus Group and Loss of Butyrate-Producing Bacteria in Inflammatory Bowel Disease
  publication-title: J. Clin. Microbiol.
  doi: 10.1128/JCM.01500-13
  contributor:
    fullname: Wang
– volume: 17
  start-page: 2047
  year: 2015
  ident: ref_53
  article-title: Visible Light Communication, Networking, and Sensing: A Survey, Potential and Challenges
  publication-title: IEEE Commun. Surv. Tutor.
  doi: 10.1109/COMST.2015.2476474
  contributor:
    fullname: Pathak
– volume: 361
  start-page: k2179
  year: 2018
  ident: ref_5
  article-title: Role of the gut microbiota in nutrition and health
  publication-title: BMJ
  doi: 10.1136/bmj.k2179
  contributor:
    fullname: Valdes
– ident: ref_43
– volume: 8
  start-page: 846
  year: 2017
  ident: ref_66
  article-title: Lactic Acid Bacteria and Bifidobacteria with Potential to Design Natural Biofunctional Health-Promoting Dairy Foods
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2017.00846
  contributor:
    fullname: Linares
– volume: 5
  start-page: 168
  year: 2014
  ident: ref_63
  article-title: Environmental Disruption of Host-Microbe Co-Adaptation as a Potential Driving Force in Evolution
  publication-title: Front. Genet.
  doi: 10.3389/fgene.2014.00168
  contributor:
    fullname: Soen
– volume: 9
  start-page: 11293
  year: 2019
  ident: ref_12
  article-title: Integrated genomic epidemiology and phenotypic profiling of Clostridium difficile across intra-hospital and community populations in Colombia
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-019-47688-2
  contributor:
    fullname: Kumar
– ident: ref_74
  doi: 10.1128/mSystems.00984-20
– volume: 22
  start-page: 327
  year: 2016
  ident: ref_7
  article-title: Role of Altered Expression of miR-146a, miR-155, and miR-122 in Pediatric Patients with Inflammatory Bowel Disease
  publication-title: Inflamm. Bowel Dis.
  doi: 10.1097/MIB.0000000000000687
  contributor:
    fullname: Kocsis
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Snippet Inflammatory bowel disease (IBD) is the most common form of intestinal inflammation associated with a dysregulated immune system response to the commensal...
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SubjectTerms Algorithms
Biological markers
Biomarkers
Body mass index
Colon
Communication
comprehensive-phenotyping
Context
Crohn's disease
crohn-disease
Crohns disease
Data analysis
Developing countries
Diagnosis
Digestive system
Endoscopy
Epigenetics
Erythema
Feces
Gastrointestinal surgery
Gastrointestinal tract
gut-microbiota
Health aspects
Health services
Hospitals
Immune system
Inflammatory bowel disease
Inflammatory bowel diseases
Intestinal microflora
Intestine
Irritable bowel syndrome
LDCs
Metropolitan areas
Microbiota
Microorganisms
Patients
Phenotypes
Phenotyping
Qualitative analysis
Serology
Ulcerative colitis
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Title Comprehensive Phenotyping in Inflammatory Bowel Disease: Search for Biomarker Algorithms in the Transkingdom Interactions Context
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Volume 10
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