SARS-CoV-2 primed platelets–derived microRNAs enhance NETs formation by extracellular vesicle transmission and TLR7/8 activation

• Published in: Cell communication and signaling Vol. 21; no. 1; pp. 1 - 21
• Main Authors: Liao, Tsai-Ling, Liu, Hung-Jen, Chen, Der-Yuan, Tang, Kuo-Tung, Chen, Yi-Ming, Liu, Po-Yu
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 30.10.2023; BioMed Central; BMC
• Subjects: Analysis; Anticoagulants; Asymptomatic; Blood platelets; Cell activation; Cell interactions; Communication; COVID-19; Disease transmission; Electric vehicles; Endocytosis; extracellular vesicles; Flow cytometry; Genetic transcription; Health aspects; Hospitals; Immunoblotting; Immunofluorescence; Infections; Invoices; Leukocytes (neutrophilic); MicroRNA; MicroRNAs; miRNA; NAD(P)H oxidase; Neutrophils; Next-generation sequencing; NF-κB protein; Oxidases; Phosphorylation; Platelets; Platelets, NETs; Proteins; Reverse transcription; Scientific equipment and supplies industry; Severe acute respiratory syndrome coronavirus 2; Spike protein; Therapeutic targets; Thrombosis; TLR7 protein; TLR8; Toll-like receptors; Up-regulation; Ventilators; United States; Taiwan; United States > US; Germany

Hyperactive neutrophil extracellular traps (NETs) formation plays a key role in the pathogenesis of severe COVID-19. Extracellular vesicles (EVs) are vehicles which carry cellular components for intercellular communication. The association between COVID-19 patients-derived EVs and NETs formation rem...