Estrogen attenuates physical and psychological stress‐induced cognitive impairments in ovariectomized rats

Introduction Women are more vulnerable to stress‐related disorders than men, which is counterintuitive as female sex hormones, especially estrogen, have been shown to be protective against stress disorders. Methods In this study, we investigated whether two different models of stress act differently...

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Published inBrain and behavior Vol. 11; no. 5; pp. e02139 - n/a
Main Authors Khaleghi, Mina, Rajizadeh, Mohammad Amin, Bashiri, Hamideh, Kohlmeier, Kristi Anne, Mohammadi, Fatemeh, Khaksari, Mohammad, Shabani, Mohammad
Format Journal Article
LanguageEnglish
Published United States John Wiley & Sons, Inc 01.05.2021
John Wiley and Sons Inc
Wiley
Subjects
Anxiety
anxiety‐like behavior
Behavior
Cognition & reasoning
cognitive impairments
estrogen
Estrogens
Laboratory animals
Memory
Original Research
Ovaries
OVX rats
Stress
Swimming
Womens health
stress
estrogen
OVX rats
anxiety-like behavior
cognitive impairments
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Abstract Introduction Women are more vulnerable to stress‐related disorders than men, which is counterintuitive as female sex hormones, especially estrogen, have been shown to be protective against stress disorders. Methods In this study, we investigated whether two different models of stress act differently on ovariectomized (OVX) rats and the impact of estrogen on physical or psychological stress‐induced impairments in cognitive‐behaviors. Adult female Wistar rats at 21–22 weeks of age were utilized for this investigation. Sham and OVX rats were subjected to physical and psychological stress for 1 hr/day for 7 days, and cognitive performance was assessed using morris water maze (MWM) and passive avoidance (PA) tests. The open field and elevated plus maze tests (EPM) evaluated exploratory and anxiety‐like behaviors. Results In sham and OVX rats, both physical and psychological stressors were associated with an increase in EPM‐determined anxiety‐like behavior. OVX rats exhibited decreased explorative behavior in comparison with nonstressed sham rats (p < .05). Both physical stress and psychological stress resulted in disrupted spatial cognition as assayed in the MWM (p < .05) and impaired learning and memory as determined by the PA test when the OVX and sham groups were compared with the nonstressed sham group. Estrogen increased explorative behavior, learning and memory (p < .05), and decreased anxiety‐like behavior compared with vehicle in OVX rats exposed to either type of stressor. Conclusions When taken together, estrogen and both stressors had opposite effects on memory, anxiety, and PA performance in a rat model of menopause, which has important implications for potential protective effects of estrogen in postmenopausal women exposed to chronic stress. Findings from the current study delineated that exposure to both physical stress and psychological stress can cause cognitive disorders and increase anxiety‐like behaviors. These findings suggest that female rats are vulnerable to both stressor types, and effects impact motor and cognitive behaviors of the animals.
AbstractList INTRODUCTIONWomen are more vulnerable to stress-related disorders than men, which is counterintuitive as female sex hormones, especially estrogen, have been shown to be protective against stress disorders. METHODSIn this study, we investigated whether two different models of stress act differently on ovariectomized (OVX) rats and the impact of estrogen on physical or psychological stress-induced impairments in cognitive-behaviors. Adult female Wistar rats at 21-22 weeks of age were utilized for this investigation. Sham and OVX rats were subjected to physical and psychological stress for 1 hr/day for 7 days, and cognitive performance was assessed using morris water maze (MWM) and passive avoidance (PA) tests. The open field and elevated plus maze tests (EPM) evaluated exploratory and anxiety-like behaviors. RESULTSIn sham and OVX rats, both physical and psychological stressors were associated with an increase in EPM-determined anxiety-like behavior. OVX rats exhibited decreased explorative behavior in comparison with nonstressed sham rats (p < .05). Both physical stress and psychological stress resulted in disrupted spatial cognition as assayed in the MWM (p < .05) and impaired learning and memory as determined by the PA test when the OVX and sham groups were compared with the nonstressed sham group. Estrogen increased explorative behavior, learning and memory (p < .05), and decreased anxiety-like behavior compared with vehicle in OVX rats exposed to either type of stressor. CONCLUSIONSWhen taken together, estrogen and both stressors had opposite effects on memory, anxiety, and PA performance in a rat model of menopause, which has important implications for potential protective effects of estrogen in postmenopausal women exposed to chronic stress.
Introduction Women are more vulnerable to stress‐related disorders than men, which is counterintuitive as female sex hormones, especially estrogen, have been shown to be protective against stress disorders. Methods In this study, we investigated whether two different models of stress act differently on ovariectomized (OVX) rats and the impact of estrogen on physical or psychological stress‐induced impairments in cognitive‐behaviors. Adult female Wistar rats at 21–22 weeks of age were utilized for this investigation. Sham and OVX rats were subjected to physical and psychological stress for 1 hr/day for 7 days, and cognitive performance was assessed using morris water maze (MWM) and passive avoidance (PA) tests. The open field and elevated plus maze tests (EPM) evaluated exploratory and anxiety‐like behaviors. Results In sham and OVX rats, both physical and psychological stressors were associated with an increase in EPM‐determined anxiety‐like behavior. OVX rats exhibited decreased explorative behavior in comparison with nonstressed sham rats (p < .05). Both physical stress and psychological stress resulted in disrupted spatial cognition as assayed in the MWM (p < .05) and impaired learning and memory as determined by the PA test when the OVX and sham groups were compared with the nonstressed sham group. Estrogen increased explorative behavior, learning and memory (p < .05), and decreased anxiety‐like behavior compared with vehicle in OVX rats exposed to either type of stressor. Conclusions When taken together, estrogen and both stressors had opposite effects on memory, anxiety, and PA performance in a rat model of menopause, which has important implications for potential protective effects of estrogen in postmenopausal women exposed to chronic stress. Findings from the current study delineated that exposure to both physical stress and psychological stress can cause cognitive disorders and increase anxiety‐like behaviors. These findings suggest that female rats are vulnerable to both stressor types, and effects impact motor and cognitive behaviors of the animals.
Abstract Introduction Women are more vulnerable to stress‐related disorders than men, which is counterintuitive as female sex hormones, especially estrogen, have been shown to be protective against stress disorders. Methods In this study, we investigated whether two different models of stress act differently on ovariectomized (OVX) rats and the impact of estrogen on physical or psychological stress‐induced impairments in cognitive‐behaviors. Adult female Wistar rats at 21–22 weeks of age were utilized for this investigation. Sham and OVX rats were subjected to physical and psychological stress for 1 hr/day for 7 days, and cognitive performance was assessed using morris water maze (MWM) and passive avoidance (PA) tests. The open field and elevated plus maze tests (EPM) evaluated exploratory and anxiety‐like behaviors. Results In sham and OVX rats, both physical and psychological stressors were associated with an increase in EPM‐determined anxiety‐like behavior. OVX rats exhibited decreased explorative behavior in comparison with nonstressed sham rats ( p  < .05). Both physical stress and psychological stress resulted in disrupted spatial cognition as assayed in the MWM ( p  < .05) and impaired learning and memory as determined by the PA test when the OVX and sham groups were compared with the nonstressed sham group. Estrogen increased explorative behavior, learning and memory ( p  < .05), and decreased anxiety‐like behavior compared with vehicle in OVX rats exposed to either type of stressor. Conclusions When taken together, estrogen and both stressors had opposite effects on memory, anxiety, and PA performance in a rat model of menopause, which has important implications for potential protective effects of estrogen in postmenopausal women exposed to chronic stress.
Women are more vulnerable to stress-related disorders than men, which is counterintuitive as female sex hormones, especially estrogen, have been shown to be protective against stress disorders. In this study, we investigated whether two different models of stress act differently on ovariectomized (OVX) rats and the impact of estrogen on physical or psychological stress-induced impairments in cognitive-behaviors. Adult female Wistar rats at 21-22 weeks of age were utilized for this investigation. Sham and OVX rats were subjected to physical and psychological stress for 1 hr/day for 7 days, and cognitive performance was assessed using morris water maze (MWM) and passive avoidance (PA) tests. The open field and elevated plus maze tests (EPM) evaluated exploratory and anxiety-like behaviors. In sham and OVX rats, both physical and psychological stressors were associated with an increase in EPM-determined anxiety-like behavior. OVX rats exhibited decreased explorative behavior in comparison with nonstressed sham rats (p < .05). Both physical stress and psychological stress resulted in disrupted spatial cognition as assayed in the MWM (p < .05) and impaired learning and memory as determined by the PA test when the OVX and sham groups were compared with the nonstressed sham group. Estrogen increased explorative behavior, learning and memory (p < .05), and decreased anxiety-like behavior compared with vehicle in OVX rats exposed to either type of stressor. When taken together, estrogen and both stressors had opposite effects on memory, anxiety, and PA performance in a rat model of menopause, which has important implications for potential protective effects of estrogen in postmenopausal women exposed to chronic stress.
Abstract Introduction Women are more vulnerable to stress‐related disorders than men, which is counterintuitive as female sex hormones, especially estrogen, have been shown to be protective against stress disorders. Methods In this study, we investigated whether two different models of stress act differently on ovariectomized (OVX) rats and the impact of estrogen on physical or psychological stress‐induced impairments in cognitive‐behaviors. Adult female Wistar rats at 21–22 weeks of age were utilized for this investigation. Sham and OVX rats were subjected to physical and psychological stress for 1 hr/day for 7 days, and cognitive performance was assessed using morris water maze (MWM) and passive avoidance (PA) tests. The open field and elevated plus maze tests (EPM) evaluated exploratory and anxiety‐like behaviors. Results In sham and OVX rats, both physical and psychological stressors were associated with an increase in EPM‐determined anxiety‐like behavior. OVX rats exhibited decreased explorative behavior in comparison with nonstressed sham rats (p < .05). Both physical stress and psychological stress resulted in disrupted spatial cognition as assayed in the MWM (p < .05) and impaired learning and memory as determined by the PA test when the OVX and sham groups were compared with the nonstressed sham group. Estrogen increased explorative behavior, learning and memory (p < .05), and decreased anxiety‐like behavior compared with vehicle in OVX rats exposed to either type of stressor. Conclusions When taken together, estrogen and both stressors had opposite effects on memory, anxiety, and PA performance in a rat model of menopause, which has important implications for potential protective effects of estrogen in postmenopausal women exposed to chronic stress.
Findings from the current study delineated that exposure to both physical stress and psychological stress can cause cognitive disorders and increase anxiety‐like behaviors. These findings suggest that female rats are vulnerable to both stressor types, and effects impact motor and cognitive behaviors of the animals.
Author Kohlmeier, Kristi Anne
Mohammadi, Fatemeh
Rajizadeh, Mohammad Amin
Khaleghi, Mina
Khaksari, Mohammad
Bashiri, Hamideh
Shabani, Mohammad
AuthorAffiliation 1 Department of Physiology and Pharmacology Kerman University of Medical Sciences Kerman Iran
3 Department of Drug Design and Pharmacology Faculty of Health Sciences University of Copenhagen Copenhagen Denmark
2 Department of Physiology and Pharmacology Kerman University of Medical Science, Kerman Iran and Sirjan School of Medical Sciences Sirjan Iran
4 Neuroscience Research Center Neuropharmacology Institute Kerman University of Medical Sciences Kerman Iran
5 Endocrinology and Metabolism Research Center Kerman University of Medical Sciences Kerman Iran
AuthorAffiliation_xml – name: 2 Department of Physiology and Pharmacology Kerman University of Medical Science, Kerman Iran and Sirjan School of Medical Sciences Sirjan Iran
– name: 1 Department of Physiology and Pharmacology Kerman University of Medical Sciences Kerman Iran
– name: 3 Department of Drug Design and Pharmacology Faculty of Health Sciences University of Copenhagen Copenhagen Denmark
– name: 5 Endocrinology and Metabolism Research Center Kerman University of Medical Sciences Kerman Iran
– name: 4 Neuroscience Research Center Neuropharmacology Institute Kerman University of Medical Sciences Kerman Iran
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  fullname: Khaleghi, Mina
  organization: Kerman University of Medical Sciences
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/33811472$$D View this record in MEDLINE/PubMed
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Issue 5
Keywords stress
estrogen
OVX rats
anxiety-like behavior
cognitive impairments
Language English
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Snippet Introduction Women are more vulnerable to stress‐related disorders than men, which is counterintuitive as female sex hormones, especially estrogen, have been...
Women are more vulnerable to stress-related disorders than men, which is counterintuitive as female sex hormones, especially estrogen, have been shown to be...
Abstract Introduction Women are more vulnerable to stress‐related disorders than men, which is counterintuitive as female sex hormones, especially estrogen,...
IntroductionWomen are more vulnerable to stress‐related disorders than men, which is counterintuitive as female sex hormones, especially estrogen, have been...
INTRODUCTIONWomen are more vulnerable to stress-related disorders than men, which is counterintuitive as female sex hormones, especially estrogen, have been...
Findings from the current study delineated that exposure to both physical stress and psychological stress can cause cognitive disorders and increase...
Abstract Introduction Women are more vulnerable to stress‐related disorders than men, which is counterintuitive as female sex hormones, especially estrogen,...
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StartPage e02139
SubjectTerms Anxiety
anxiety‐like behavior
Behavior
Cognition & reasoning
cognitive impairments
estrogen
Estrogens
Laboratory animals
Memory
Original Research
Ovaries
OVX rats
Stress
Swimming
Womens health
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Title Estrogen attenuates physical and psychological stress‐induced cognitive impairments in ovariectomized rats
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fbrb3.2139
https://www.ncbi.nlm.nih.gov/pubmed/33811472
https://www.proquest.com/docview/2526502790
https://search.proquest.com/docview/2508579927
https://pubmed.ncbi.nlm.nih.gov/PMC8119870
https://doaj.org/article/cd286fa8df5f4f598f5e928eb9a3ddda
Volume 11
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