The complex interplay between endoplasmic reticulum stress and the NLRP3 inflammasome: a potential therapeutic target for inflammatory disorders

• Published in: Clinical & translational immunology Vol. 10; no. 2; pp. e1247 - n/a
• Main Authors: Chong, Wai Chin, Shastri, Madhur D, Peterson, Gregory M, Patel, Rahul P, Pathinayake, Prabuddha S, Dua, Kamal, Hansbro, Nicole G, Hsu, Alan C, Wark, Peter A, Shukla, Shakti Dhar, Johansen, Matt D, Schroder, Kate, Hansbro, Philip M
• Format: Journal Article
• Language: English
• Published: Australia John Wiley & Sons, Inc 2021; John Wiley and Sons Inc; Wiley
• Subjects: Allergens; Alzheimer's disease; Arteriosclerosis; Asthma; Atherosclerosis; Binding sites; Biosynthesis; Chronic obstructive pulmonary disease; Diabetes; Endoplasmic reticulum; endoplasmic reticulum stress; Homeostasis; Immune system; Infections; inflammasome; Inflammasomes; Inflammation; Inflammatory bowel disease; Inflammatory bowel diseases; Inflammatory diseases; inflammatory disorder; Intestine; Kinases; Lung diseases; Metabolism; NLRP3; Obstructive lung disease; Pathogenesis; Pathogens; Physiology; Protein folding; Protein synthesis; Quality control; Review; Rheumatoid arthritis; Sarcoidosis; Therapeutic targets; Transcription factors; NLRP3; inflammatory disorder; inflammasome; endoplasmic reticulum stress

Inflammation is the result of a complex network of cellular and molecular interactions and mechanisms that facilitate immune protection against intrinsic and extrinsic stimuli, particularly pathogens, to maintain homeostasis and promote tissue healing. However, dysregulation in the immune system eli...