Disruptions of the olfactory and default mode networks in Alzheimer's disease

• Published in: Brain and behavior Vol. 9; no. 7; pp. e01296 - n/a
• Main Authors: Lu, Jiaming, Yang, Qing X., Zhang, Han, Eslinger, Paul J., Zhang, Xin, Wu, Sichu, Zhang, Bing, Zhu, Bin, Karunanayaka, Prasanna R.
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.07.2019; John Wiley and Sons Inc; Wiley
• Subjects: Age; Aged; Alzheimer Disease - physiopathology; Alzheimer Disease - psychology; Alzheimer's disease; Atrophy; Behavior; Brain research; Cognition - physiology; Correlation of Data; default mode network; Dementia; Female; Humans; Identification; Magnetic Resonance Imaging - methods; Male; Memory; Memory - physiology; mild cognitive impairment; Nerve Net - diagnostic imaging; Nerve Net - physiopathology; Neurodegeneration; NMR; Nuclear magnetic resonance; Olfactory Cortex - diagnostic imaging; Olfactory Cortex - physiopathology; olfactory fMRI; olfactory network; Olfactory Perception - physiology; Original Research; Pathology; United States > US; Pennsylvania; mild cognitive impairment; default mode network; olfactory network; Alzheimer's disease; olfactory fMRI

Introduction Olfactory deficits are prevalent in early Alzheimer's disease (AD) and are predictive of progressive memory loss and dementia. However, direct neural evidence to relate AD neurodegeneration to deficits in olfaction and memory is limited. Methods We combined the University of Pennsy...