Angiotensin 1‐7 protects against ventilator‐induced diaphragm dysfunction

• Published in: Clinical and translational science Vol. 14; no. 4; pp. 1512 - 1523
• Main Authors: Yoshihara, Toshinori, Deminice, Rafael, Hyatt, Hayden W., Ozdemir, Mustafa, Nguyen, Branden L., Powers, Scott K.
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.07.2021; John Wiley and Sons Inc; Wiley
• Subjects: Angiotensin; Angiotensin I - administration & dosage; Animal models; Animals; Atrophy; Blood pressure; Catheters; Diaphragm; Diaphragm (Anatomy); Diaphragm - drug effects; Diaphragm - physiopathology; Disease Models, Animal; Endocrine system; Experiments; Female; Force; Humans; Infusions, Intravenous; Mechanical ventilation; Mitochondria; Muscle contraction; Muscle Contraction - drug effects; Muscle Contraction - physiology; Muscle Weakness - etiology; Muscle Weakness - physiopathology; Muscle Weakness - prevention & control; Muscular Disorders, Atrophic - etiology; Muscular Disorders, Atrophic - physiopathology; Muscular Disorders, Atrophic - prevention & control; Oxidative stress; Oxidative Stress - drug effects; Patients; Peptide Fragments - administration & dosage; Proteinase; Proteolysis; Rats; Renin; Respiration; Respiration, Artificial - adverse effects; Signal transduction; Ventilators; Weaning

Mechanical ventilation (MV) is a life‐saving instrument used to provide ventilatory support for critically ill patients and patients undergoing surgery. Unfortunately, an unintended consequence of prolonged MV is the development of inspiratory weakness due to both diaphragmatic atrophy and contracti...