A comparative study of the gut microbiota in immune-mediated inflammatory diseases—does a common dysbiosis exist?

• Published in: Microbiome Vol. 6; no. 1; pp. 221 - 15
• Main Authors: Forbes, Jessica D., Chen, Chih-yu, Knox, Natalie C., Marrie, Ruth-Ann, El-Gabalawy, Hani, de Kievit, Teresa, Alfa, Michelle, Bernstein, Charles N., Van Domselaar, Gary
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 13.12.2018; BioMed Central; BMC
• Subjects: 16S rRNA gene amplicon sequencing; Abundance; Adult; Ambulatory care; Arthritis; Arthritis, Rheumatoid - microbiology; Artificial intelligence; Bacteria; Bacteria - classification; Bacteria - genetics; Bacteria - isolation & purification; Biological markers; Biomarkers; Case-Control Studies; Colitis; Colitis, Ulcerative - microbiology; Comparative literature; Crohn Disease - microbiology; Crohn's disease; Diagnosis; DNA, Bacterial - genetics; DNA, Ribosomal - genetics; Dysbacteriosis; Dysbiosis; Dysbiosis - diagnosis; Etiology; Etiology (Medicine); Female; Gastrointestinal Microbiome; Genes; Genetic aspects; Genetic research; Gut microbiota; Health; Humans; Immune-mediated inflammatory disease; Immunologic diseases; Inflammation; Inflammatory bowel disease; Inflammatory bowel diseases; Inflammatory Bowel Diseases - microbiology; Inflammatory diseases; Intestinal microflora; Learning algorithms; Machine Learning; Male; Metagenomics - methods; Microbiomes; Microbiota; Microbiota (Symbiotic organisms); Middle Aged; Multiple sclerosis; Multiple Sclerosis - microbiology; Pathogenesis; Phylogeny; Rheumatoid arthritis; Rheumatoid factor; Risk factors; RNA; RNA, Ribosomal, 16S - genetics; rRNA 16S; Sequence Analysis, DNA - methods; Studies; Taxonomy; Ulcerative colitis; 16S rRNA gene amplicon sequencing; Gut microbiota; Inflammatory bowel disease; Multiple sclerosis; Immune-mediated inflammatory disease; Machine learning classifiers; Rheumatoid arthritis; Bacteria; Taxonomic biomarkers

Immune-mediated inflammatory disease (IMID) represents a substantial health concern. It is widely recognized that IMID patients are at a higher risk for developing secondary inflammation-related conditions. While an ambiguous etiology is common to all IMIDs, in recent years, considerable knowledge h...