Elite Suppressors Harbor Low Levels of Integrated HIV DNA and High Levels of 2-LTR Circular HIV DNA Compared to HIV+ Patients On and Off HAART

• Published in: PLoS pathogens Vol. 7; no. 2; p. e1001300
• Main Authors: Graf, Erin H., Mexas, Angela M., Yu, Jianqing J., Shaheen, Farida, Liszewski, Megan K., Di Mascio, Michele, Migueles, Stephen A., Connors, Mark, O'Doherty, Una
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.02.2011; Public Library of Science (PLoS)
• Subjects: Antiretroviral Therapy, Highly Active; CD4-Positive T-Lymphocytes - virology; Cohort Studies; Deoxyribonucleic acid; DNA; DNA, Circular - genetics; DNA, Viral - genetics; Drug therapy; Health aspects; Highly active antiretroviral therapy; HIV; HIV infection; HIV Infections - drug therapy; HIV Infections - virology; HIV Long Terminal Repeat - genetics; HIV patients; HIV-1 - genetics; Human immunodeficiency virus; Humans; Immune system; Immunology; Immunology/Immune Response; Immunology/Immunity to Infections; Methods; Patients; Physiological aspects; Viral Load; Virology; Virology/Host Antiviral Responses; Virology/Immunodeficiency Viruses; Virology/Mechanisms of Resistance and Susceptibility, including Host Genetics; Virology/Persistence and Latency; Virus Integration; United States

Elite suppressors (ES) are a rare population of HIV-infected individuals that are capable of naturally controlling the infection without the use of highly active anti-retroviral therapy (HAART). Patients on HAART often achieve viral control to similar (undetectable) levels. Accurate and sensitive me...