Pharmacokinetic and Pharmacodynamic Studies of Chlorpromazine in Rats : Effect of Chlorpromazine on Dopamine and Dopamine Metabolite Concentration in Rat Striatum

• Published in: Biological & pharmaceutical bulletin Vol. 18; no. 7; pp. 990 - 995
• Main Authors: SATO, Shinji, KOITABASHI, Toshinobu, KOSHIRO, Akira
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 1995; Maruzen
• Subjects: 3, 4-dihydroxyphenylacetic acid (DOPAC); 3,4-Dihydroxyphenylacetic Acid - metabolism; Animals; Biological and medical sciences; chlorpromazine; Chlorpromazine - pharmacokinetics; Chlorpromazine - pharmacology; Dopamine - metabolism; Dopamine Antagonists - pharmacokinetics; Dopamine Antagonists - pharmacology; dopamine metabolism model; homovanillic acid (HVA); Homovanillic Acid - metabolism; Least-Squares Analysis; Male; Medical sciences; Neostriatum - drug effects; Neostriatum - metabolism; Neuropharmacology; pharmacokinetic; Pharmacology. Drug treatments; Psycholeptics: tranquillizer, neuroleptic; Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Rats; Rats, Wistar; striatum; Pharmacokinetic pharmacodynamic relationship; Dopamine; Intravenous administration; Rat; Metabolite; Neuroleptic; Psychotropic; Rodentia; Central nervous system; Corpus striatum; Phenothiazine derivatives; Catecholamine; Normal; Vertebrata; Mammalia; Animal; Neurotransmitter; Models; Pharmacokinetics; Brain (vertebrata)

The concentrations of dopamine, 3, 4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in rat striatum were increased after the i. v. administration of chlorpromazine (CPZ). Assuming that the enhancement of dopamine concentration in the striatum after CPZ administration is caused by the...