Cirsiliol regulates mitophagy in colon cancer cells via STAT3 signaling

• Published in: Cancer cell international Vol. 22; no. 1; pp. 1 - 12
• Main Authors: Jiang, Tao, Peng, Lulu, Wang, Qian, Huang, Bingyu, Peng, Dewei, Men, Lintong, Jiang, Yue, Zhu, Mengying, Wang, Moran, Lin, Li, Lv, Jiagao, Li, Sheng
• Format: Journal Article
• Language: English
• Published: London BioMed Central 07.10.2022; BMC
• Subjects: Autophagy; Biotechnology; BNIP3 protein; Cancer therapies; Cell proliferation; Cell viability; Cirsiliol; Colon cancer; Colonies; Colorectal cancer; Cytology; Flavonoids; Immunofluorescence; Medical prognosis; Membrane potential; Mitochondria; Mitophagy; Morphology; Natural products; Nuclear transport; Phosphorylation; Protein transport; Proteins; PTEN-induced putative kinase; Reactive oxygen species; ROS; Software; STAT3; Stat3 protein; Statistical analysis; Tumorigenesis; Variance analysis; Wound healing; United States > US; China; Fiji

Background Mitophagy is a type of selective autophagy for dysfunctional mitochondria and plays a key role in tumorigenesis and cancer progression. However, whether mitophagy plays a role in colon cancer remains unclear. Cirsiliol is a natural product and has been found to exert anti-cancer effects i...