Deficient Inhibitory Cortical Networks in Antipsychotic-Naive Subjects at Risk of Developing First-Episode Psychosis and First-Episode Schizophrenia Patients: A Cross-Sectional Study
Impaired cortical inhibition is a well-established finding in schizophrenia patients and has been linked to dysfunctional gamma-aminobutyric acid (GABA)ergic transmission. However, there have been no previous studies investigating cortical excitability with particular regard to intracortical inhibit...
Saved in:
| Published in | Biological psychiatry (1969) Vol. 72; no. 9; pp. 744 - 751 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York, NY
Elsevier Inc
01.11.2012
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0006-3223 1873-2402 1873-2402 |
| DOI | 10.1016/j.biopsych.2012.03.005 |
Cover
Loading…
| Abstract | Impaired cortical inhibition is a well-established finding in schizophrenia patients and has been linked to dysfunctional gamma-aminobutyric acid (GABA)ergic transmission. However, there have been no previous studies investigating cortical excitability with particular regard to intracortical inhibitory networks in antipsychotic-naive subjects at risk of developing first-episode psychosis.
A total of 18 subjects at risk, 18 first-episode schizophrenia patients, and 18 healthy control subjects were included in this study. Transcranial magnetic stimulation over the left primary motor cortex was used to determine short-latency intracortical inhibition, intracortical facilitation, and the contralateral silent period (CSP). Short-latency intracortical inhibition can be considered as a parameter of GABA type A (GABAA)-mediated inhibition and it has been proposed that CSP can test GABA type B (GABAB)-mediated inhibitory intracortical networks.
Subjects at risk and first-episode patients showed a reduced short-latency intracortical inhibition compared with healthy control subjects, suggesting reduced GABAA-mediated inhibition. First-episode patients had a prolonged CSP duration compared with the other two groups, implying a GABAB imbalance only in patients with full-blown psychosis. Analyses did not reveal group differences for intracortical facilitation.
These results indicate specific alterations in inhibitory cortical networks in subjects at risk and in first-episode patients. It appears that there is already a cortical inhibitory deficit in at-risk individuals. These results suggest a possible GABAA dysfunction early in the disease course, whereas alterations in GABAB functionality seem to occur later in the disease's progression. Future longitudinal studies will be needed to clarify this inhibitory deficit and its relation to the transition to psychosis. |
|---|---|
| AbstractList | Impaired cortical inhibition is a well-established finding in schizophrenia patients and has been linked to dysfunctional gamma-aminobutyric acid (GABA)ergic transmission. However, there have been no previous studies investigating cortical excitability with particular regard to intracortical inhibitory networks in antipsychotic-naive subjects at risk of developing first-episode psychosis.
A total of 18 subjects at risk, 18 first-episode schizophrenia patients, and 18 healthy control subjects were included in this study. Transcranial magnetic stimulation over the left primary motor cortex was used to determine short-latency intracortical inhibition, intracortical facilitation, and the contralateral silent period (CSP). Short-latency intracortical inhibition can be considered as a parameter of GABA type A (GABA(A))-mediated inhibition and it has been proposed that CSP can test GABA type B (GABA(B))-mediated inhibitory intracortical networks.
Subjects at risk and first-episode patients showed a reduced short-latency intracortical inhibition compared with healthy control subjects, suggesting reduced GABA(A)-mediated inhibition. First-episode patients had a prolonged CSP duration compared with the other two groups, implying a GABA(B) imbalance only in patients with full-blown psychosis. Analyses did not reveal group differences for intracortical facilitation.
These results indicate specific alterations in inhibitory cortical networks in subjects at risk and in first-episode patients. It appears that there is already a cortical inhibitory deficit in at-risk individuals. These results suggest a possible GABA(A) dysfunction early in the disease course, whereas alterations in GABA(B) functionality seem to occur later in the disease's progression. Future longitudinal studies will be needed to clarify this inhibitory deficit and its relation to the transition to psychosis. Impaired cortical inhibition is a well-established finding in schizophrenia patients and has been linked to dysfunctional gamma-aminobutyric acid (GABA)ergic transmission. However, there have been no previous studies investigating cortical excitability with particular regard to intracortical inhibitory networks in antipsychotic-naive subjects at risk of developing first-episode psychosis.BACKGROUNDImpaired cortical inhibition is a well-established finding in schizophrenia patients and has been linked to dysfunctional gamma-aminobutyric acid (GABA)ergic transmission. However, there have been no previous studies investigating cortical excitability with particular regard to intracortical inhibitory networks in antipsychotic-naive subjects at risk of developing first-episode psychosis.A total of 18 subjects at risk, 18 first-episode schizophrenia patients, and 18 healthy control subjects were included in this study. Transcranial magnetic stimulation over the left primary motor cortex was used to determine short-latency intracortical inhibition, intracortical facilitation, and the contralateral silent period (CSP). Short-latency intracortical inhibition can be considered as a parameter of GABA type A (GABA(A))-mediated inhibition and it has been proposed that CSP can test GABA type B (GABA(B))-mediated inhibitory intracortical networks.METHODSA total of 18 subjects at risk, 18 first-episode schizophrenia patients, and 18 healthy control subjects were included in this study. Transcranial magnetic stimulation over the left primary motor cortex was used to determine short-latency intracortical inhibition, intracortical facilitation, and the contralateral silent period (CSP). Short-latency intracortical inhibition can be considered as a parameter of GABA type A (GABA(A))-mediated inhibition and it has been proposed that CSP can test GABA type B (GABA(B))-mediated inhibitory intracortical networks.Subjects at risk and first-episode patients showed a reduced short-latency intracortical inhibition compared with healthy control subjects, suggesting reduced GABA(A)-mediated inhibition. First-episode patients had a prolonged CSP duration compared with the other two groups, implying a GABA(B) imbalance only in patients with full-blown psychosis. Analyses did not reveal group differences for intracortical facilitation.RESULTSSubjects at risk and first-episode patients showed a reduced short-latency intracortical inhibition compared with healthy control subjects, suggesting reduced GABA(A)-mediated inhibition. First-episode patients had a prolonged CSP duration compared with the other two groups, implying a GABA(B) imbalance only in patients with full-blown psychosis. Analyses did not reveal group differences for intracortical facilitation.These results indicate specific alterations in inhibitory cortical networks in subjects at risk and in first-episode patients. It appears that there is already a cortical inhibitory deficit in at-risk individuals. These results suggest a possible GABA(A) dysfunction early in the disease course, whereas alterations in GABA(B) functionality seem to occur later in the disease's progression. Future longitudinal studies will be needed to clarify this inhibitory deficit and its relation to the transition to psychosis.CONCLUSIONSThese results indicate specific alterations in inhibitory cortical networks in subjects at risk and in first-episode patients. It appears that there is already a cortical inhibitory deficit in at-risk individuals. These results suggest a possible GABA(A) dysfunction early in the disease course, whereas alterations in GABA(B) functionality seem to occur later in the disease's progression. Future longitudinal studies will be needed to clarify this inhibitory deficit and its relation to the transition to psychosis. BackgroundImpaired cortical inhibition is a well-established finding in schizophrenia patients and has been linked to dysfunctional gamma-aminobutyric acid (GABA)ergic transmission. However, there have been no previous studies investigating cortical excitability with particular regard to intracortical inhibitory networks in antipsychotic-naive subjects at risk of developing first-episode psychosis. MethodsA total of 18 subjects at risk, 18 first-episode schizophrenia patients, and 18 healthy control subjects were included in this study. Transcranial magnetic stimulation over the left primary motor cortex was used to determine short-latency intracortical inhibition, intracortical facilitation, and the contralateral silent period (CSP). Short-latency intracortical inhibition can be considered as a parameter of GABA type A (GABA A)-mediated inhibition and it has been proposed that CSP can test GABA type B (GABA B)-mediated inhibitory intracortical networks. ResultsSubjects at risk and first-episode patients showed a reduced short-latency intracortical inhibition compared with healthy control subjects, suggesting reduced GABA A-mediated inhibition. First-episode patients had a prolonged CSP duration compared with the other two groups, implying a GABA B imbalance only in patients with full-blown psychosis. Analyses did not reveal group differences for intracortical facilitation. ConclusionsThese results indicate specific alterations in inhibitory cortical networks in subjects at risk and in first-episode patients. It appears that there is already a cortical inhibitory deficit in at-risk individuals. These results suggest a possible GABA A dysfunction early in the disease course, whereas alterations in GABA B functionality seem to occur later in the disease's progression. Future longitudinal studies will be needed to clarify this inhibitory deficit and its relation to the transition to psychosis. Impaired cortical inhibition is a well-established finding in schizophrenia patients and has been linked to dysfunctional gamma-aminobutyric acid (GABA)ergic transmission. However, there have been no previous studies investigating cortical excitability with particular regard to intracortical inhibitory networks in antipsychotic-naive subjects at risk of developing first-episode psychosis. A total of 18 subjects at risk, 18 first-episode schizophrenia patients, and 18 healthy control subjects were included in this study. Transcranial magnetic stimulation over the left primary motor cortex was used to determine short-latency intracortical inhibition, intracortical facilitation, and the contralateral silent period (CSP). Short-latency intracortical inhibition can be considered as a parameter of GABA type A (GABAA)-mediated inhibition and it has been proposed that CSP can test GABA type B (GABAB)-mediated inhibitory intracortical networks. Subjects at risk and first-episode patients showed a reduced short-latency intracortical inhibition compared with healthy control subjects, suggesting reduced GABAA-mediated inhibition. First-episode patients had a prolonged CSP duration compared with the other two groups, implying a GABAB imbalance only in patients with full-blown psychosis. Analyses did not reveal group differences for intracortical facilitation. These results indicate specific alterations in inhibitory cortical networks in subjects at risk and in first-episode patients. It appears that there is already a cortical inhibitory deficit in at-risk individuals. These results suggest a possible GABAA dysfunction early in the disease course, whereas alterations in GABAB functionality seem to occur later in the disease's progression. Future longitudinal studies will be needed to clarify this inhibitory deficit and its relation to the transition to psychosis. |
| Author | Bechdolf, Andreas Hasan, Alkomiet Schneider-Axmann, Thomas Levold, Katrin Falkai, Peter Müller, Hendrik Labusga, Marcin Grefkes, Christian Klosterkötter, Joachim Wobrock, Thomas |
| Author_xml | – sequence: 1 givenname: Alkomiet surname: Hasan fullname: Hasan, Alkomiet organization: Department of Psychiatry and Psychotherapy, Georg-August University, Goettingen, Germany – sequence: 2 givenname: Thomas surname: Wobrock fullname: Wobrock, Thomas email: twobroc@gwdg.de organization: Department of Psychiatry and Psychotherapy, Georg-August University, Goettingen, Germany – sequence: 3 givenname: Christian surname: Grefkes fullname: Grefkes, Christian organization: Max Planck Institute for Neurological Research and Department of Neurology, University of Cologne, Cologne, Germany – sequence: 4 givenname: Marcin surname: Labusga fullname: Labusga, Marcin organization: Department of Psychiatry and Psychotherapy, Georg-August University, Goettingen, Germany – sequence: 5 givenname: Katrin surname: Levold fullname: Levold, Katrin organization: Department of Psychiatry and Psychotherapy, Georg-August University, Goettingen, Germany – sequence: 6 givenname: Thomas surname: Schneider-Axmann fullname: Schneider-Axmann, Thomas organization: Department of Psychiatry and Psychotherapy, Georg-August University, Goettingen, Germany – sequence: 7 givenname: Peter surname: Falkai fullname: Falkai, Peter organization: Department of Psychiatry and Psychotherapy, Georg-August University, Goettingen, Germany – sequence: 8 givenname: Hendrik surname: Müller fullname: Müller, Hendrik organization: Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany – sequence: 9 givenname: Joachim surname: Klosterkötter fullname: Klosterkötter, Joachim organization: Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany – sequence: 10 givenname: Andreas surname: Bechdolf fullname: Bechdolf, Andreas organization: Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26544271$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/22502988$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkl1v0zAUhiM0xLrBX5h8g8RNiuN8OEUIreo2mDSNicK15Tgn9LSpHWynqPwwfh_O2gqpF4wry_Lzno_X71l0oo2GKLpI6DihSfF2Oa7QdG6rFmNGEzam6ZjS_Fk0Skqexiyj7CQaUUqLOGUsPY3OnFuGK2cseRGdMpZTNinLUfT7ChpUCNqTW73ACr2xWzIz1qOSLbkH_9PYlSOoyVR7fOxowlt8L3EDZN5XS1DeEenJF3QrYhpyBRtoTYf6O7lB63x83aEzNZCHR7HDQOv66G2uFvjLdAsLGiV5kH4Yyb0jUzKzxrl4Hrqg0WGkue_r7cvoeSNbB6_253n07eb66-xTfPf54-1sehernGc-bnidy6puoKFllTQlb_KyyHgKaVmlnHPZZMHMKuMyZwUt1KSYSGCU5Szhss6q9Dx6s6vbWfOjB-fFGp2CtpUaTO9EQidpgGlZBPRij_bVGmrRWVxLuxUHrwPweg9IF7xtrNQK3V-uyLOM8SRw73ecGja30AiFXg7beyuxDT3FEAGxFIcIiCECgqYiRCDIiyP5ocOTwsudEIKhGwQr3BAMBTXa4L6oDT5d4sNRCdWiHpK0gi24pelt-MJgm3BBI-ZDQId8JoxSFs5_F_ifCf4Aydr8WA |
| CODEN | BIPCBF |
| CitedBy_id | crossref_primary_10_1093_brain_awad395 crossref_primary_10_3389_fpsyt_2023_1200864 crossref_primary_10_1016_j_bbr_2014_01_041 crossref_primary_10_1016_j_brs_2016_11_006 crossref_primary_10_1016_j_clinph_2024_11_015 crossref_primary_10_1016_j_neuroimage_2014_09_028 crossref_primary_10_1016_j_psychres_2018_06_014 crossref_primary_10_3109_15622975_2015_1050061 crossref_primary_10_1016_j_neuroimage_2017_11_026 crossref_primary_10_1016_j_brs_2013_08_009 crossref_primary_10_1016_j_biopsych_2018_06_007 crossref_primary_10_1016_j_schres_2014_03_028 crossref_primary_10_1016_j_schres_2014_10_011 crossref_primary_10_1111_cns_12261 crossref_primary_10_1007_s00406_013_0446_8 crossref_primary_10_1093_ijnp_pyu040 crossref_primary_10_1016_j_neubiorev_2016_01_007 crossref_primary_10_1177_0269881116662650 crossref_primary_10_15252_emmm_201505677 crossref_primary_10_1177_02698811221078751 crossref_primary_10_1016_j_schres_2013_12_017 crossref_primary_10_3389_fnbeh_2014_00308 crossref_primary_10_1016_j_schres_2015_05_023 crossref_primary_10_1007_s00115_016_0169_y crossref_primary_10_1016_j_clinph_2013_01_014 crossref_primary_10_1038_s41598_017_17052_3 crossref_primary_10_1155_2021_5585951 crossref_primary_10_25259_IJPP_90_2020 crossref_primary_10_1016_j_schres_2014_10_004 crossref_primary_10_1016_j_schres_2021_12_012 crossref_primary_10_1016_j_jpsychires_2024_11_055 crossref_primary_10_1093_schbul_sbt078 crossref_primary_10_1109_TBME_2014_2313575 crossref_primary_10_3389_fnhum_2020_00241 crossref_primary_10_1038_s41537_024_00476_y crossref_primary_10_1016_j_schres_2017_04_045 crossref_primary_10_1093_brain_awz127 crossref_primary_10_1016_j_biopsych_2012_08_010 crossref_primary_10_1155_2016_3915703 crossref_primary_10_1002_ccr3_1240 crossref_primary_10_1097_JCP_0000000000001793 crossref_primary_10_1016_j_brs_2013_03_001 |
| Cites_doi | 10.1016/j.schres.2005.04.024 10.4088/JCP.v64n0607 10.1002/(SICI)1097-4598(199809)21:9<1209::AID-MUS15>3.0.CO;2-M 10.1016/j.neubiorev.2006.11.006 10.1016/j.clinph.2004.03.006 10.1055/s-2004-815529 10.1016/j.schres.2008.05.017 10.1016/j.biopsych.2006.08.009 10.1016/j.biopsych.2008.02.006 10.1176/appi.ajp.163.10.1829 10.1093/schbul/13.2.261 10.1007/s00213-002-1068-4 10.1113/jphysiol.1993.sp019912 10.1016/j.brs.2011.08.004 10.1001/archgenpsychiatry.2011.42 10.1093/schbul/20.3.453 10.1016/j.biopsych.2010.09.057 10.1038/nrn1648 10.1016/j.psychres.2009.04.003 10.1016/S0924-980X(98)00038-1 10.1007/s00213-009-1736-8 10.1001/archgenpsychiatry.2010.77 10.1016/j.neuropharm.2010.12.011 10.1016/S0920-9964(01)00222-5 10.1093/schbul/sbr083 10.1192/bjp.169.6.690 10.1111/j.1600-0447.2009.01524.x 10.1016/S0140-6736(03)12323-9 10.1016/j.neubiorev.2010.12.005 10.1016/j.biopsych.2008.09.012 10.4088/JCP.v68n0310 10.1093/oxfordjournals.schbul.a033322 10.1176/appi.ajp.159.5.863 10.1001/archpsyc.59.4.347 10.1017/S1461145705005456 10.1016/j.clinph.2005.10.029 10.1007/s00221-003-1684-1 10.1093/cercor/bhq169 10.1016/j.eurpsy.2011.06.006 10.1007/s00213-003-1548-1 10.1016/0028-3932(71)90067-4 10.1016/j.schres.2003.09.017 10.1001/archpsyc.1976.01770060086012 10.1055/s-0029-1224137 10.2174/138920112800784763 10.4088/JCP.08r04808yel 10.1177/0269881107084002 10.1016/j.biopsych.2004.08.023 10.1016/j.neubiorev.2010.01.016 10.1016/j.ijpsycho.2008.07.003 10.1016/j.clinph.2003.12.025 10.1007/s00213-007-1000-z 10.1097/WNR.0b013e328349739b 10.1001/archgenpsychiatry.2009.206 10.1176/appi.ajp.2007.07081223 10.1176/appi.ajp.158.2.256 10.1016/j.schres.2011.08.021 10.1038/mp.2009.108 10.1001/archgenpsychiatry.2011.46 10.1016/S0920-9964(03)00223-8 10.1016/j.schres.2008.06.001 10.1113/jphysiol.2006.114694 10.1073/pnas.0703806104 10.1016/S0925-4927(02)00002-1 10.1093/schbul/sbp006 10.1093/schbul/sbn176 10.1001/archgenpsychiatry.2007.3 10.1001/archpsyc.65.4.378 10.1093/cercor/bhm151 10.1016/j.bbr.2011.05.017 10.1007/s00406-011-0242-2 |
| ContentType | Journal Article |
| Copyright | 2012 Society of Biological Psychiatry Society of Biological Psychiatry 2015 INIST-CNRS Copyright © 2012 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved. |
| Copyright_xml | – notice: 2012 Society of Biological Psychiatry – notice: Society of Biological Psychiatry – notice: 2015 INIST-CNRS – notice: Copyright © 2012 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved. |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/j.biopsych.2012.03.005 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Chemistry Biology |
| EISSN | 1873-2402 |
| EndPage | 751 |
| ExternalDocumentID | 22502988 26544271 10_1016_j_biopsych_2012_03_005 S0006322312002223 1_s2_0_S0006322312002223 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- --K --M -DZ .1- .FO .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 23N 4.4 457 4G. 5GY 5RE 5VS 6J9 7-5 71M 8P~ 9JM AABNK AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AATTM AAXKI AAXLA AAXUO AAYWO ABBQC ABCQJ ABCQX ABFNM ABFRF ABIVO ABJNI ABLJU ABMAC ABWVN ABXDB ACDAQ ACGFO ACIEU ACIUM ACNCT ACRLP ACRPL ACVFH ADBBV ADCNI ADEZE ADMUD ADNMO AEBSH AEFWE AEIPS AEKER AENEX AEUPX AEVXI AFPUW AFRHN AFTJW AFXIZ AGCQF AGHFR AGUBO AGWIK AGYEJ AHHHB AIEXJ AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX AXJTR BKOJK BLXMC BNPGV CS3 DU5 EBS EFJIC EFKBS EJD EO8 EO9 EP2 EP3 F5P FDB FIRID FNPLU FYGXN G-Q GBLVA HZ~ IHE J1W KOM L7B M29 M2V M39 M41 MO0 MOBAO N9A O-L O9- OAUVE OH0 OU- OZT P-8 P-9 P2P PC. Q38 ROL RPZ SAE SCC SDF SDG SDP SEL SES SPCBC SSH SSN SSZ T5K UNMZH UPT UV1 WH7 Z5R ZCA ~G- .GJ 3O- 53G AACTN AAQXK ABDPE ABMZM AFCTW AFFNX AFJKZ AFKWA AJOXV AMFUW ASPBG AVWKF AZFZN FEDTE FGOYB G-2 HEG HMK HMO HMQ HVGLF H~9 PKN R2- RIG SNS UAP WUQ XJT XOL ZGI ZKB ZXP AADPK AAIAV ABLVK ABYKQ AJBFU EFLBG LCYCR ZA5 AAYXX AGQPQ AGRNS AIGII APXCP CITATION 08R ABPIF ABPTK G8K IQODW CGR CUY CVF ECM EIF NPM 7X8 |
| ID | FETCH-LOGICAL-c574t-f7d5abdfef08b1f87f586473e38b3777af4016b47a52606c969ae2025217ad4b3 |
| IEDL.DBID | .~1 |
| ISSN | 0006-3223 1873-2402 |
| IngestDate | Thu Sep 04 18:49:25 EDT 2025 Mon Jul 21 05:22:31 EDT 2025 Sun Oct 22 16:06:10 EDT 2023 Thu Apr 24 23:01:29 EDT 2025 Tue Jul 01 03:38:08 EDT 2025 Fri Feb 23 02:26:55 EST 2024 Sun Feb 23 10:19:40 EST 2025 Tue Aug 26 16:31:54 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 9 |
| Keywords | GABA Cortical inhibition schizophrenia transcranial magnetic stimulation prodrome first-episode schizophrenia Human Cerebral cortex Transcranial magnetic stimulation Central nervous system Schizophrenia Prodrome Neural network Encephalon Psychosis First episode Cross sectional study Risk factor Neurotransmitter Development Inhibition |
| Language | English |
| License | https://www.elsevier.com/tdm/userlicense/1.0 CC BY 4.0 Copyright © 2012 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c574t-f7d5abdfef08b1f87f586473e38b3777af4016b47a52606c969ae2025217ad4b3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 22502988 |
| PQID | 1093521086 |
| PQPubID | 23479 |
| PageCount | 8 |
| ParticipantIDs | proquest_miscellaneous_1093521086 pubmed_primary_22502988 pascalfrancis_primary_26544271 crossref_citationtrail_10_1016_j_biopsych_2012_03_005 crossref_primary_10_1016_j_biopsych_2012_03_005 elsevier_sciencedirect_doi_10_1016_j_biopsych_2012_03_005 elsevier_clinicalkeyesjournals_1_s2_0_S0006322312002223 elsevier_clinicalkey_doi_10_1016_j_biopsych_2012_03_005 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2012-11-01 |
| PublicationDateYYYYMMDD | 2012-11-01 |
| PublicationDate_xml | – month: 11 year: 2012 text: 2012-11-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | New York, NY |
| PublicationPlace_xml | – name: New York, NY – name: United States |
| PublicationTitle | Biological psychiatry (1969) |
| PublicationTitleAlternate | Biol Psychiatry |
| PublicationYear | 2012 |
| Publisher | Elsevier Inc Elsevier |
| Publisher_xml | – name: Elsevier Inc – name: Elsevier |
| References | Fusar-Poli, Perez, Broome, Borgwardt, Placentino, Caverzasi (bib13) 2007; 31 Fitzgerald, Brown, Daskalakis, deCastella, Kulkarni (bib60) 2002; 56 Daskalakis, Christensen, Fitzgerald, Moller, Fountain, Chen (bib63) 2008; 22 Smieskova, Fusar-Poli, Allen, Bendfeldt, Stieglitz, Drewe (bib8) 2010; 34 Di Lazzaro, Pilato, Dileone, Ranieri, Ricci, Profice (bib54) 2006; 575 Daskalakis, Christensen, Fitzgerald, Chen (bib69) 2008; 65 Howes, Kapur (bib2) 2009; 35 Ruhrmann, Schultze-Lutter, Salokangas, Heinimaa, Linszen, Dingemans (bib5) 2010; 67 Fitzgerald, Brown, Daskalakis, Kulkarni (bib30) 2002; 114 (bib42) 2004 Fusar-Poli, Howes, Allen, Broome, Valli, Asselin (bib58) 2011; 16 van der Stelt, Lieberman, Belger (bib19) 2005; 77 Frommann, Brinkmeyer, Ruhrmann, Hack, Brockhaus-Dumke, Bechdolf (bib18) 2008; 70 Hashimoto, Bazmi, Mirnics, Wu, Sampson, Lewis (bib24) 2008; 165 Borgwardt, Riecher-Rossler, Dazzan, Chitnis, Aston, Drewe (bib9) 2007; 61 Frantseva, Fitzgerald, Chen, Moller, Daigle, Daskalakis (bib70) 2008; 18 Stephan, Friston, Frith (bib1) 2009; 35 Cannon, Cadenhead, Cornblatt, Woods, Addington, Walker (bib6) 2008; 65 Fusar-Poli, Borgwardt, Crescini, Deste, Kempton, Lawrie (bib14) 2011; 35 Wobrock, Schneider, Kadovic, Schneider-Axmann, Ecker, Retz (bib32) 2008; 105 Lewis, Hashimoto, Volk (bib23) 2005; 6 Benes (bib22) 2011; 60 Guy (bib39) 1976 Puri, Davey, Ellaway, Lewis (bib62) 1996; 169 Eichhammer, Wiegand, Kharraz, Langguth, Binder, Hajak (bib27) 2004; 67 Wobrock, Schneider-Axmann, Retz, Rosler, Kadovic, Falkai, Schneider (bib33) 2009; 42 Bechdolf, Muller, Stutzer, Wagner, Maier, Lautenschlager (bib36) 2011; 37 Saka, Atbasoglu, Ozguven, Sener, Ozay (bib52) 2005; 8 Mechelli, Riecher-Rossler, Meisenzahl, Tognin, Wood, Borgwardt (bib11) 2011; 68 Ozgurdal, Gudlowski, Witthaus, Kawohl, Uhl, Hauser (bib17) 2008; 105 Dlabac-de Lange, Knegtering, Aleman (bib74) 2010; 71 Siebner, Dressnandt, Auer, Conrad (bib48) 1998; 21 Wobrock, Hasan, Malchow, Wolff-Menzler, Guse, Lang (bib67) 2010; 208 Fitzgerald, Brown, Daskalakis, Kulkarni (bib29) 2002; 162 Beneyto, Abbott, Hashimoto, Lewis (bib25) 2011; 21 Clinton, Meador-Woodruff (bib57) 2004; 69 Endicott, Spitzer, Fleiss, Cohen (bib40) 1976; 33 Di Lazzaro, Oliviero, Profice, Saturno, Pilato, Insola (bib45) 1998; 109 Langguth, Eichhammer, Spranz, Landgrebe, Frick, Sand, Hajak (bib65) 2008; 196 Soubasi, Chroni, Gourzis, Zisis, Beratis, Papathanasopoulos (bib34) 2010; 176 Hasan, Nitsche, Herrmann, Schneider-Axmann, Marshall, Gruber (bib44) 2012 Daskalakis, Christensen, Chen, Fitzgerald, Zipursky, Kapur (bib47) 2003; 170 Paz, Andreasen, Daoud, Conley, Roberts, Bustillo, Perrone-Bizzozero (bib26) 2006; 163 Fusar-Poli, McGuire, Borgwardt (bib7) 2011; 27 Miller, McGlashan, Rosen, Somjee, Markovich, Stein, Woods (bib41) 2002; 159 Walker (bib53) 1994; 20 Oldfield (bib37) 1971; 9 Fusar-Poli, Stone, Broome, Valli, Mechelli, McLean (bib56) 2011; 68 Oxley, Fitzgerald, Brown, de Castella, Daskalakis, Kulkarni (bib71) 2004; 56 Ziemann (bib35) 2004; 115 Kujirai, Caramia, Rothwell, Day, Thompson, Ferbert (bib46) 1993; 471 Broome, Matthiasson, Fusar-Poli, Woolley, Johns, Tabraham (bib51) 2010; 122 Woods (bib43) 2003; 64 Orth, Rothwell (bib50) 2004; 115 Pantelis, Velakoulis, McGorry, Wood, Suckling, Phillips (bib10) 2003; 361 Borgwardt, McGuire, Fusar-Poli (bib12) 2011; 133 Benes, Lim, Matzilevich, Walsh, Subburaju, Minns (bib21) 2007; 104 Wobrock, Hasan, Falkai (bib72) 2012 Chen (bib66) 2004; 154 Kay, Fiszbein, Opler (bib38) 1987; 13 Benes (bib20) 1998; 24 Aleman, Sommer, Kahn (bib73) 2007; 68 Krystall, Moghaddam (bib3) 2011 Hasan, Nitsche, Rein, Schneider-Axmann, Guse, Gruber (bib68) 2011; 224 Sommer, Alfaro, Rummel, Speck, Lang, Tings, Paulus (bib49) 2006; 117 Bajbouj, Gallinat, Niehaus, Lang, Roricht, Meyer (bib61) 2004; 37 Liu, Fitzgerald, Daigle, Chen, Daskalakis (bib31) 2009; 65 Schmitt, Hasan, Gruber, Falkai (bib4) 2011; 261 Bodatsch, Ruhrmann, Wagner, Muller, Schultze-Lutter, Frommann (bib16) 2011; 69 Wu, Blichowski, Daskalakis, Wu, Liu, Cortez, Snead (bib64) 2011; 22 Brockhaus-Dumke, Schultze-Lutter, Mueller, Tendolkar, Bechdolf, Pukrop (bib15) 2008; 64 Fusar-Poli, Howes, Allen, Broome, Valli, Asselin (bib59) 2010; 67 Daskalakis, Christensen, Chen, Fitzgerald, Zipursky, Kapur (bib28) 2002; 59 Volk, Austin, Pierri, Sampson, Lewis (bib55) 2001; 158 Eichhammer (10.1016/j.biopsych.2012.03.005_bib27) 2004; 67 Guy (10.1016/j.biopsych.2012.03.005_bib39) 1976 Stephan (10.1016/j.biopsych.2012.03.005_bib1) 2009; 35 Borgwardt (10.1016/j.biopsych.2012.03.005_bib12) 2011; 133 Daskalakis (10.1016/j.biopsych.2012.03.005_bib28) 2002; 59 Clinton (10.1016/j.biopsych.2012.03.005_bib57) 2004; 69 Borgwardt (10.1016/j.biopsych.2012.03.005_bib9) 2007; 61 Bechdolf (10.1016/j.biopsych.2012.03.005_bib36) 2011; 37 Oxley (10.1016/j.biopsych.2012.03.005_bib71) 2004; 56 Ziemann (10.1016/j.biopsych.2012.03.005_bib35) 2004; 115 Aleman (10.1016/j.biopsych.2012.03.005_bib73) 2007; 68 Sommer (10.1016/j.biopsych.2012.03.005_bib49) 2006; 117 Smieskova (10.1016/j.biopsych.2012.03.005_bib8) 2010; 34 Schmitt (10.1016/j.biopsych.2012.03.005_bib4) 2011; 261 Howes (10.1016/j.biopsych.2012.03.005_bib2) 2009; 35 Broome (10.1016/j.biopsych.2012.03.005_bib51) 2010; 122 Di Lazzaro (10.1016/j.biopsych.2012.03.005_bib54) 2006; 575 Krystall (10.1016/j.biopsych.2012.03.005_bib3) 2011 Langguth (10.1016/j.biopsych.2012.03.005_bib65) 2008; 196 Wobrock (10.1016/j.biopsych.2012.03.005_bib72) 2012 Bodatsch (10.1016/j.biopsych.2012.03.005_bib16) 2011; 69 Wu (10.1016/j.biopsych.2012.03.005_bib64) 2011; 22 Dlabac-de Lange (10.1016/j.biopsych.2012.03.005_bib74) 2010; 71 Beneyto (10.1016/j.biopsych.2012.03.005_bib25) 2011; 21 Puri (10.1016/j.biopsych.2012.03.005_bib62) 1996; 169 Benes (10.1016/j.biopsych.2012.03.005_bib21) 2007; 104 Benes (10.1016/j.biopsych.2012.03.005_bib22) 2011; 60 Frantseva (10.1016/j.biopsych.2012.03.005_bib70) 2008; 18 Hasan (10.1016/j.biopsych.2012.03.005_bib68) 2011; 224 Pantelis (10.1016/j.biopsych.2012.03.005_bib10) 2003; 361 van der Stelt (10.1016/j.biopsych.2012.03.005_bib19) 2005; 77 (10.1016/j.biopsych.2012.03.005_bib42) 2004 Mechelli (10.1016/j.biopsych.2012.03.005_bib11) 2011; 68 Soubasi (10.1016/j.biopsych.2012.03.005_bib34) 2010; 176 Chen (10.1016/j.biopsych.2012.03.005_bib66) 2004; 154 Ruhrmann (10.1016/j.biopsych.2012.03.005_bib5) 2010; 67 Fusar-Poli (10.1016/j.biopsych.2012.03.005_bib13) 2007; 31 Woods (10.1016/j.biopsych.2012.03.005_bib43) 2003; 64 Hashimoto (10.1016/j.biopsych.2012.03.005_bib24) 2008; 165 Hasan (10.1016/j.biopsych.2012.03.005_bib44) 2012 Siebner (10.1016/j.biopsych.2012.03.005_bib48) 1998; 21 Frommann (10.1016/j.biopsych.2012.03.005_bib18) 2008; 70 Wobrock (10.1016/j.biopsych.2012.03.005_bib32) 2008; 105 Fusar-Poli (10.1016/j.biopsych.2012.03.005_bib59) 2010; 67 Kujirai (10.1016/j.biopsych.2012.03.005_bib46) 1993; 471 Volk (10.1016/j.biopsych.2012.03.005_bib55) 2001; 158 Walker (10.1016/j.biopsych.2012.03.005_bib53) 1994; 20 Fusar-Poli (10.1016/j.biopsych.2012.03.005_bib58) 2011; 16 Orth (10.1016/j.biopsych.2012.03.005_bib50) 2004; 115 Daskalakis (10.1016/j.biopsych.2012.03.005_bib63) 2008; 22 Kay (10.1016/j.biopsych.2012.03.005_bib38) 1987; 13 Fusar-Poli (10.1016/j.biopsych.2012.03.005_bib14) 2011; 35 Paz (10.1016/j.biopsych.2012.03.005_bib26) 2006; 163 Miller (10.1016/j.biopsych.2012.03.005_bib41) 2002; 159 Fitzgerald (10.1016/j.biopsych.2012.03.005_bib29) 2002; 162 Wobrock (10.1016/j.biopsych.2012.03.005_bib33) 2009; 42 Di Lazzaro (10.1016/j.biopsych.2012.03.005_bib45) 1998; 109 Fitzgerald (10.1016/j.biopsych.2012.03.005_bib30) 2002; 114 Saka (10.1016/j.biopsych.2012.03.005_bib52) 2005; 8 Fusar-Poli (10.1016/j.biopsych.2012.03.005_bib7) 2011; 27 Daskalakis (10.1016/j.biopsych.2012.03.005_bib47) 2003; 170 Daskalakis (10.1016/j.biopsych.2012.03.005_bib69) 2008; 65 Cannon (10.1016/j.biopsych.2012.03.005_bib6) 2008; 65 Bajbouj (10.1016/j.biopsych.2012.03.005_bib61) 2004; 37 Fusar-Poli (10.1016/j.biopsych.2012.03.005_bib56) 2011; 68 Oldfield (10.1016/j.biopsych.2012.03.005_bib37) 1971; 9 Ozgurdal (10.1016/j.biopsych.2012.03.005_bib17) 2008; 105 Liu (10.1016/j.biopsych.2012.03.005_bib31) 2009; 65 Wobrock (10.1016/j.biopsych.2012.03.005_bib67) 2010; 208 Brockhaus-Dumke (10.1016/j.biopsych.2012.03.005_bib15) 2008; 64 Benes (10.1016/j.biopsych.2012.03.005_bib20) 1998; 24 Lewis (10.1016/j.biopsych.2012.03.005_bib23) 2005; 6 Endicott (10.1016/j.biopsych.2012.03.005_bib40) 1976; 33 Fitzgerald (10.1016/j.biopsych.2012.03.005_bib60) 2002; 56 23036506 - Biol Psychiatry. 2012 Nov 1;72(9):714-5 |
| References_xml | – volume: 159 start-page: 863 year: 2002 end-page: 865 ident: bib41 article-title: Prospective diagnosis of the initial prodrome for schizophrenia based on the Structured Interview for Prodromal Syndromes: Preliminary evidence of interrater reliability and predictive validity publication-title: Am J Psychiatry – volume: 35 start-page: 509 year: 2009 end-page: 527 ident: bib1 article-title: Dysconnection in schizophrenia: From abnormal synaptic plasticity to failures of self-monitoring publication-title: Schizophr Bull – volume: 162 start-page: 74 year: 2002 end-page: 81 ident: bib29 article-title: A transcranial magnetic stimulation study of the effects of olanzapine and risperidone on motor cortical excitability in patients with schizophrenia publication-title: Psychopharmacology (Berl) – year: 2012 ident: bib72 article-title: Innovative treatment approaches in schizophrenia enhancing neuroplasticity: Aerobic exercise, erythropoetin and repetitive transcranial magnetic stimulation [published online ahead of print January 26] publication-title: Curr Pharm Biotechnol – volume: 133 start-page: 63 year: 2011 end-page: 67 ident: bib12 article-title: Gray matters! Mapping the transition to psychosis publication-title: Schizophr Res – volume: 65 start-page: 378 year: 2008 end-page: 385 ident: bib69 article-title: Dysfunctional neural plasticity in patients with schizophrenia publication-title: Arch Gen Psychiatry – volume: 68 start-page: 881 year: 2011 end-page: 890 ident: bib56 article-title: Thalamic glutamate levels as a predictor of cortical response during executive functioning in subjects at high risk for psychosis publication-title: Arch Gen Psychiatry – volume: 70 start-page: 192 year: 2008 end-page: 205 ident: bib18 article-title: Auditory P300 in individuals clinically at risk for psychosis publication-title: Int J Psychophysiol – volume: 42 start-page: 194 year: 2009 end-page: 201 ident: bib33 article-title: Motor circuit abnormalities in first-episode schizophrenia assessed with transcranial magnetic stimulation publication-title: Pharmacopsychiatry – volume: 117 start-page: 838 year: 2006 end-page: 844 ident: bib49 article-title: Half sine, monophasic and biphasic transcranial magnetic stimulation of the human motor cortex publication-title: Clin Neurophysiol – volume: 18 start-page: 990 year: 2008 end-page: 996 ident: bib70 article-title: Evidence for impaired long-term potentiation in schizophrenia and its relationship to motor skill learning publication-title: Cereb Cortex – start-page: 433 year: 2011 end-page: 461 ident: bib3 article-title: Contributions of glutmate and GABA systems to the neurobiology and treatment of schizophrenia publication-title: Schizophrenia – volume: 22 start-page: 637 year: 2011 end-page: 641 ident: bib64 article-title: Evidence that clozapine directly interacts on the GABAB receptor publication-title: Neuroreport – volume: 16 start-page: 67 year: 2011 end-page: 75 ident: bib58 article-title: Abnormal prefrontal activation directly related to pre-synaptic striatal dopamine dysfunction in people at clinical high risk for psychosis publication-title: Mol Psychiatry – volume: 27 start-page: 181 year: 2011 end-page: 191 ident: bib7 article-title: Mapping prodromal psychosis: A critical review of neuroimaging studies publication-title: Eur Psychiatry – volume: 165 start-page: 479 year: 2008 end-page: 489 ident: bib24 article-title: Conserved regional patterns of GABA-related transcript expression in the neocortex of subjects with schizophrenia publication-title: Am J Psychiatry – volume: 59 start-page: 347 year: 2002 end-page: 354 ident: bib28 article-title: Evidence for impaired cortical inhibition in schizophrenia using transcranial magnetic stimulation publication-title: Arch Gen Psychiatry – volume: 37 start-page: 74 year: 2004 end-page: 80 ident: bib61 article-title: Abnormalities of inhibitory neuronal mechanisms in the motor cortex of patients with schizophrenia publication-title: Pharmacopsychiatry – year: 2012 ident: bib44 article-title: Impaired long-term depression in schizophrenia: A cathodal tDCS pilot study [published online ahead of print September 5] publication-title: Brain Stimul – volume: 8 start-page: 595 year: 2005 end-page: 599 ident: bib52 article-title: Cortical inhibition in first-degree relatives of schizophrenic patients assessed with transcranial magnetic stimulation publication-title: Int J Neuropsychopharmacol – volume: 575 start-page: 721 year: 2006 end-page: 726 ident: bib54 article-title: GABAA receptor subtype specific enhancement of inhibition in human motor cortex publication-title: J Physiol – volume: 154 start-page: 1 year: 2004 end-page: 10 ident: bib66 article-title: Interactions between inhibitory and excitatory circuits in the human motor cortex publication-title: Exp Brain Res – volume: 61 start-page: 1148 year: 2007 end-page: 1156 ident: bib9 article-title: Regional gray matter volume abnormalities in the at risk mental state publication-title: Biol Psychiatry – volume: 471 start-page: 501 year: 1993 end-page: 519 ident: bib46 article-title: Corticocortical inhibition in human motor cortex publication-title: J Physiol – volume: 60 start-page: 1232 year: 2011 end-page: 1242 ident: bib22 article-title: Regulation of cell cycle and DNA repair in post-mitotic GABA neurons in psychotic disorders publication-title: Neuropharmacology – volume: 65 start-page: 28 year: 2008 end-page: 37 ident: bib6 article-title: Prediction of psychosis in youth at high clinical risk: A multisite longitudinal study in North America publication-title: Arch Gen Psychiatry – volume: 105 start-page: 252 year: 2008 end-page: 261 ident: bib32 article-title: Reduced cortical inhibition in first-episode schizophrenia publication-title: Schizophr Res – volume: 37 start-page: S111 year: 2011 end-page: S121 ident: bib36 article-title: Rationale and baseline characteristics of PREVENT: A second-generation intervention trial in subjects at-risk (prodromal) of developing first-episode psychosis evaluating cognitive behavior therapy, aripiprazole, and placebo for the prevention of psychosis publication-title: Schizophr Bull – volume: 104 start-page: 10164 year: 2007 end-page: 10169 ident: bib21 article-title: Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars publication-title: Proc Natl Acad Sci U S A – volume: 77 start-page: 309 year: 2005 end-page: 320 ident: bib19 article-title: Auditory P300 in high-risk, recent-onset and chronic schizophrenia publication-title: Schizophr Res – volume: 65 start-page: 503 year: 2009 end-page: 509 ident: bib31 article-title: The relationship between cortical inhibition, antipsychotic treatment, and the symptoms of schizophrenia publication-title: Biol Psychiatry – volume: 163 start-page: 1829 year: 2006 end-page: 1831 ident: bib26 article-title: Increased expression of activity-dependent genes in cerebellar glutamatergic neurons of patients with schizophrenia publication-title: Am J Psychiatry – volume: 208 start-page: 353 year: 2010 end-page: 363 ident: bib67 article-title: Increased cortical inhibition deficits in first-episode schizophrenia with comorbid cannabis abuse publication-title: Psychopharmacology (Berl) – volume: 34 start-page: 1207 year: 2010 end-page: 1222 ident: bib8 article-title: Neuroimaging predictors of transition to psychosis--a systematic review and meta-analysis publication-title: Neurosci Biobehav Rev – volume: 64 start-page: 663 year: 2003 end-page: 667 ident: bib43 article-title: Chlorpromazine equivalent doses for the newer atypical antipsychotics publication-title: J Clin Psychiatry – volume: 21 start-page: 999 year: 2011 end-page: 1011 ident: bib25 article-title: Lamina-specific alterations in cortical GABAA receptor subunit expression in schizophrenia publication-title: Cereb Cortex – volume: 21 start-page: 1209 year: 1998 end-page: 1212 ident: bib48 article-title: Continuous intrathecal baclofen infusions induced a marked increase of the transcranially evoked silent period in a patient with generalized dystonia publication-title: Muscle Nerve – volume: 35 start-page: 1175 year: 2011 end-page: 1185 ident: bib14 article-title: Neuroanatomy of vulnerability to psychosis: A voxel-based meta-analysis publication-title: Neurosci Biobehav Rev – volume: 196 start-page: 623 year: 2008 end-page: 629 ident: bib65 article-title: Modulation of human motor cortex excitability by quetiapine publication-title: Psychopharmacology (Berl) – volume: 6 start-page: 312 year: 2005 end-page: 324 ident: bib23 article-title: Cortical inhibitory neurons and schizophrenia publication-title: Nat Rev Neurosci – volume: 122 start-page: 295 year: 2010 end-page: 301 ident: bib51 article-title: Neural correlates of movement generation in the 'at-risk mental state' publication-title: Acta Psychiatr Scand – volume: 68 start-page: 489 year: 2011 end-page: 495 ident: bib11 article-title: Neuroanatomical abnormalities that predate the onset of psychosis: A multicenter study publication-title: Arch Gen Psychiatry – volume: 224 start-page: 15 year: 2011 end-page: 22 ident: bib68 article-title: Dysfunctional long-term potentiation-like plasticity in schizophrenia revealed by transcranial direct current stimulation publication-title: Behav Brain Res – volume: 56 start-page: 628 year: 2004 end-page: 633 ident: bib71 article-title: Repetitive transcranial magnetic stimulation reveals abnormal plastic response to premotor cortex stimulation in schizophrenia publication-title: Biol Psychiatry – volume: 64 start-page: 376 year: 2008 end-page: 384 ident: bib15 article-title: Sensory gating in schizophrenia: P50 and N100 gating in antipsychotic-free subjects at risk, first-episode, and chronic patients publication-title: Biol Psychiatry – volume: 33 start-page: 766 year: 1976 end-page: 771 ident: bib40 article-title: The Global Assessment Scale publication-title: Arch Gen Psychiatry – volume: 68 start-page: 416 year: 2007 end-page: 421 ident: bib73 article-title: Efficacy of slow repetitive transcranial magnetic stimulation in the treatment of resistant auditory hallucinations in schizophrenia: A meta-analysis publication-title: J Clin Psychiatry – volume: 169 start-page: 690 year: 1996 end-page: 695 ident: bib62 article-title: An investigation of motor function in schizophrenia using transcranial magnetic stimulation of the motor cortex publication-title: Br J Psychiatry – volume: 114 start-page: 11 year: 2002 end-page: 22 ident: bib30 article-title: A transcranial magnetic stimulation study of inhibitory deficits in the motor cortex in patients with schizophrenia publication-title: Psychiatry Res – year: 2004 ident: bib42 publication-title: Diagnostic and Statistical Manual of Mental Disorders – volume: 115 start-page: 1076 year: 2004 end-page: 1082 ident: bib50 article-title: The cortical silent period: Intrinsic variability and relation to the waveform of the transcranial magnetic stimulation pulse publication-title: Clin Neurophysiol – volume: 176 start-page: 132 year: 2010 end-page: 136 ident: bib34 article-title: Cortical motor neurophysiology of patients with schizophrenia: A study using transcranial magnetic stimulation publication-title: Psychiatry Res – volume: 115 start-page: 1717 year: 2004 end-page: 1729 ident: bib35 article-title: TMS and drugs publication-title: Clin Neurophysiol – volume: 35 start-page: 549 year: 2009 end-page: 562 ident: bib2 article-title: The dopamine hypothesis of schizophrenia: Version III--the final common pathway publication-title: Schizophr Bull – volume: 67 start-page: 253 year: 2004 end-page: 259 ident: bib27 article-title: Cortical excitability in neuroleptic-naive first-episode schizophrenic patients publication-title: Schizophr Res – volume: 22 start-page: 203 year: 2008 end-page: 209 ident: bib63 article-title: Increased cortical inhibition in persons with schizophrenia treated with clozapine publication-title: J Psychopharmacol – volume: 13 start-page: 261 year: 1987 end-page: 276 ident: bib38 article-title: The Positive and Negative Syndrome Scale (PANSS) for schizophrenia publication-title: Schizophr Bull – volume: 20 start-page: 453 year: 1994 end-page: 480 ident: bib53 article-title: Developmentally moderated expressions of the neuropathology underlying schizophrenia publication-title: Schizophr Bull – volume: 105 start-page: 272 year: 2008 end-page: 278 ident: bib17 article-title: Reduction of auditory event-related P300 amplitude in subjects with at-risk mental state for schizophrenia publication-title: Schizophr Res – volume: 170 start-page: 255 year: 2003 end-page: 262 ident: bib47 article-title: Effect of antipsychotics on cortical inhibition using transcranial magnetic stimulation publication-title: Psychopharmacology (Berl) – volume: 158 start-page: 256 year: 2001 end-page: 265 ident: bib55 article-title: GABA transporter-1 mRNA in the prefrontal cortex in schizophrenia: Decreased expression in a subset of neurons publication-title: Am J Psychiatry – year: 1976 ident: bib39 publication-title: CGI: Clinical Global Impressions – volume: 109 start-page: 397 year: 1998 end-page: 401 ident: bib45 article-title: Comparison of descending volleys evoked by transcranial magnetic and electric stimulation in conscious humans publication-title: Electroencephalogr Clin Neurophysiol – volume: 261 start-page: 150 year: 2011 end-page: 154 ident: bib4 article-title: Schizophrenia as a disorder of disconnectivity publication-title: Eur Arch Psychiatry Clin Neurosci – volume: 69 start-page: 237 year: 2004 end-page: 253 ident: bib57 article-title: Thalamic dysfunction in schizophrenia: Neurochemical, neuropathological, and in vivo imaging abnormalities publication-title: Schizophr Res – volume: 361 start-page: 281 year: 2003 end-page: 288 ident: bib10 article-title: Neuroanatomical abnormalities before and after onset of psychosis: A cross-sectional and longitudinal MRI comparison publication-title: Lancet – volume: 9 start-page: 97 year: 1971 end-page: 113 ident: bib37 article-title: The assessment and analysis of handedness: The Edinburgh inventory publication-title: Neuropsychologia – volume: 71 start-page: 411 year: 2010 end-page: 418 ident: bib74 article-title: Repetitive transcranial magnetic stimulation for negative symptoms of schizophrenia: Review and meta-analysis publication-title: J Clin Psychiatry – volume: 67 start-page: 241 year: 2010 end-page: 251 ident: bib5 article-title: Prediction of psychosis in adolescents and young adults at high risk: Results from the prospective European prediction of psychosis study publication-title: Arch Gen Psychiatry – volume: 69 start-page: 959 year: 2011 end-page: 966 ident: bib16 article-title: Prediction of psychosis by mismatch negativity publication-title: Biol Psychiatry – volume: 31 start-page: 465 year: 2007 end-page: 484 ident: bib13 article-title: Neurofunctional correlates of vulnerability to psychosis: A systematic review and meta-analysis publication-title: Neurosci Biobehav Rev – volume: 24 start-page: 219 year: 1998 end-page: 230 ident: bib20 article-title: Model generation and testing to probe neural circuitry in the cingulate cortex of postmortem schizophrenic brain publication-title: Schizophr Bull – volume: 56 start-page: 199 year: 2002 end-page: 209 ident: bib60 article-title: A study of transcallosal inhibition in schizophrenia using transcranial magnetic stimulation publication-title: Schizophr Res – volume: 67 start-page: 683 year: 2010 end-page: 691 ident: bib59 article-title: Abnormal frontostriatal interactions in people with prodromal signs of psychosis: A multimodal imaging study publication-title: Arch Gen Psychiatry – volume: 77 start-page: 309 year: 2005 ident: 10.1016/j.biopsych.2012.03.005_bib19 article-title: Auditory P300 in high-risk, recent-onset and chronic schizophrenia publication-title: Schizophr Res doi: 10.1016/j.schres.2005.04.024 – volume: 64 start-page: 663 year: 2003 ident: 10.1016/j.biopsych.2012.03.005_bib43 article-title: Chlorpromazine equivalent doses for the newer atypical antipsychotics publication-title: J Clin Psychiatry doi: 10.4088/JCP.v64n0607 – volume: 21 start-page: 1209 year: 1998 ident: 10.1016/j.biopsych.2012.03.005_bib48 article-title: Continuous intrathecal baclofen infusions induced a marked increase of the transcranially evoked silent period in a patient with generalized dystonia publication-title: Muscle Nerve doi: 10.1002/(SICI)1097-4598(199809)21:9<1209::AID-MUS15>3.0.CO;2-M – volume: 31 start-page: 465 year: 2007 ident: 10.1016/j.biopsych.2012.03.005_bib13 article-title: Neurofunctional correlates of vulnerability to psychosis: A systematic review and meta-analysis publication-title: Neurosci Biobehav Rev doi: 10.1016/j.neubiorev.2006.11.006 – volume: 115 start-page: 1717 year: 2004 ident: 10.1016/j.biopsych.2012.03.005_bib35 article-title: TMS and drugs publication-title: Clin Neurophysiol doi: 10.1016/j.clinph.2004.03.006 – volume: 37 start-page: 74 year: 2004 ident: 10.1016/j.biopsych.2012.03.005_bib61 article-title: Abnormalities of inhibitory neuronal mechanisms in the motor cortex of patients with schizophrenia publication-title: Pharmacopsychiatry doi: 10.1055/s-2004-815529 – volume: 105 start-page: 272 year: 2008 ident: 10.1016/j.biopsych.2012.03.005_bib17 article-title: Reduction of auditory event-related P300 amplitude in subjects with at-risk mental state for schizophrenia publication-title: Schizophr Res doi: 10.1016/j.schres.2008.05.017 – volume: 61 start-page: 1148 year: 2007 ident: 10.1016/j.biopsych.2012.03.005_bib9 article-title: Regional gray matter volume abnormalities in the at risk mental state publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2006.08.009 – volume: 64 start-page: 376 year: 2008 ident: 10.1016/j.biopsych.2012.03.005_bib15 article-title: Sensory gating in schizophrenia: P50 and N100 gating in antipsychotic-free subjects at risk, first-episode, and chronic patients publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2008.02.006 – volume: 163 start-page: 1829 year: 2006 ident: 10.1016/j.biopsych.2012.03.005_bib26 article-title: Increased expression of activity-dependent genes in cerebellar glutamatergic neurons of patients with schizophrenia publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.163.10.1829 – volume: 13 start-page: 261 year: 1987 ident: 10.1016/j.biopsych.2012.03.005_bib38 article-title: The Positive and Negative Syndrome Scale (PANSS) for schizophrenia publication-title: Schizophr Bull doi: 10.1093/schbul/13.2.261 – volume: 162 start-page: 74 year: 2002 ident: 10.1016/j.biopsych.2012.03.005_bib29 article-title: A transcranial magnetic stimulation study of the effects of olanzapine and risperidone on motor cortical excitability in patients with schizophrenia publication-title: Psychopharmacology (Berl) doi: 10.1007/s00213-002-1068-4 – volume: 471 start-page: 501 year: 1993 ident: 10.1016/j.biopsych.2012.03.005_bib46 article-title: Corticocortical inhibition in human motor cortex publication-title: J Physiol doi: 10.1113/jphysiol.1993.sp019912 – year: 2012 ident: 10.1016/j.biopsych.2012.03.005_bib44 article-title: Impaired long-term depression in schizophrenia: A cathodal tDCS pilot study [published online ahead of print September 5] publication-title: Brain Stimul doi: 10.1016/j.brs.2011.08.004 – volume: 68 start-page: 489 year: 2011 ident: 10.1016/j.biopsych.2012.03.005_bib11 article-title: Neuroanatomical abnormalities that predate the onset of psychosis: A multicenter study publication-title: Arch Gen Psychiatry doi: 10.1001/archgenpsychiatry.2011.42 – volume: 20 start-page: 453 year: 1994 ident: 10.1016/j.biopsych.2012.03.005_bib53 article-title: Developmentally moderated expressions of the neuropathology underlying schizophrenia publication-title: Schizophr Bull doi: 10.1093/schbul/20.3.453 – volume: 69 start-page: 959 year: 2011 ident: 10.1016/j.biopsych.2012.03.005_bib16 article-title: Prediction of psychosis by mismatch negativity publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2010.09.057 – volume: 6 start-page: 312 year: 2005 ident: 10.1016/j.biopsych.2012.03.005_bib23 article-title: Cortical inhibitory neurons and schizophrenia publication-title: Nat Rev Neurosci doi: 10.1038/nrn1648 – year: 1976 ident: 10.1016/j.biopsych.2012.03.005_bib39 – volume: 176 start-page: 132 year: 2010 ident: 10.1016/j.biopsych.2012.03.005_bib34 article-title: Cortical motor neurophysiology of patients with schizophrenia: A study using transcranial magnetic stimulation publication-title: Psychiatry Res doi: 10.1016/j.psychres.2009.04.003 – volume: 109 start-page: 397 year: 1998 ident: 10.1016/j.biopsych.2012.03.005_bib45 article-title: Comparison of descending volleys evoked by transcranial magnetic and electric stimulation in conscious humans publication-title: Electroencephalogr Clin Neurophysiol doi: 10.1016/S0924-980X(98)00038-1 – year: 2004 ident: 10.1016/j.biopsych.2012.03.005_bib42 – volume: 208 start-page: 353 year: 2010 ident: 10.1016/j.biopsych.2012.03.005_bib67 article-title: Increased cortical inhibition deficits in first-episode schizophrenia with comorbid cannabis abuse publication-title: Psychopharmacology (Berl) doi: 10.1007/s00213-009-1736-8 – volume: 67 start-page: 683 year: 2010 ident: 10.1016/j.biopsych.2012.03.005_bib59 article-title: Abnormal frontostriatal interactions in people with prodromal signs of psychosis: A multimodal imaging study publication-title: Arch Gen Psychiatry doi: 10.1001/archgenpsychiatry.2010.77 – volume: 60 start-page: 1232 year: 2011 ident: 10.1016/j.biopsych.2012.03.005_bib22 article-title: Regulation of cell cycle and DNA repair in post-mitotic GABA neurons in psychotic disorders publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2010.12.011 – volume: 56 start-page: 199 year: 2002 ident: 10.1016/j.biopsych.2012.03.005_bib60 article-title: A study of transcallosal inhibition in schizophrenia using transcranial magnetic stimulation publication-title: Schizophr Res doi: 10.1016/S0920-9964(01)00222-5 – volume: 37 start-page: S111 issue: suppl 2 year: 2011 ident: 10.1016/j.biopsych.2012.03.005_bib36 article-title: Rationale and baseline characteristics of PREVENT: A second-generation intervention trial in subjects at-risk (prodromal) of developing first-episode psychosis evaluating cognitive behavior therapy, aripiprazole, and placebo for the prevention of psychosis publication-title: Schizophr Bull doi: 10.1093/schbul/sbr083 – volume: 169 start-page: 690 year: 1996 ident: 10.1016/j.biopsych.2012.03.005_bib62 article-title: An investigation of motor function in schizophrenia using transcranial magnetic stimulation of the motor cortex publication-title: Br J Psychiatry doi: 10.1192/bjp.169.6.690 – volume: 122 start-page: 295 year: 2010 ident: 10.1016/j.biopsych.2012.03.005_bib51 article-title: Neural correlates of movement generation in the 'at-risk mental state' publication-title: Acta Psychiatr Scand doi: 10.1111/j.1600-0447.2009.01524.x – volume: 361 start-page: 281 year: 2003 ident: 10.1016/j.biopsych.2012.03.005_bib10 article-title: Neuroanatomical abnormalities before and after onset of psychosis: A cross-sectional and longitudinal MRI comparison publication-title: Lancet doi: 10.1016/S0140-6736(03)12323-9 – volume: 35 start-page: 1175 year: 2011 ident: 10.1016/j.biopsych.2012.03.005_bib14 article-title: Neuroanatomy of vulnerability to psychosis: A voxel-based meta-analysis publication-title: Neurosci Biobehav Rev doi: 10.1016/j.neubiorev.2010.12.005 – volume: 65 start-page: 503 year: 2009 ident: 10.1016/j.biopsych.2012.03.005_bib31 article-title: The relationship between cortical inhibition, antipsychotic treatment, and the symptoms of schizophrenia publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2008.09.012 – volume: 68 start-page: 416 year: 2007 ident: 10.1016/j.biopsych.2012.03.005_bib73 article-title: Efficacy of slow repetitive transcranial magnetic stimulation in the treatment of resistant auditory hallucinations in schizophrenia: A meta-analysis publication-title: J Clin Psychiatry doi: 10.4088/JCP.v68n0310 – volume: 24 start-page: 219 year: 1998 ident: 10.1016/j.biopsych.2012.03.005_bib20 article-title: Model generation and testing to probe neural circuitry in the cingulate cortex of postmortem schizophrenic brain publication-title: Schizophr Bull doi: 10.1093/oxfordjournals.schbul.a033322 – volume: 159 start-page: 863 year: 2002 ident: 10.1016/j.biopsych.2012.03.005_bib41 article-title: Prospective diagnosis of the initial prodrome for schizophrenia based on the Structured Interview for Prodromal Syndromes: Preliminary evidence of interrater reliability and predictive validity publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.159.5.863 – volume: 59 start-page: 347 year: 2002 ident: 10.1016/j.biopsych.2012.03.005_bib28 article-title: Evidence for impaired cortical inhibition in schizophrenia using transcranial magnetic stimulation publication-title: Arch Gen Psychiatry doi: 10.1001/archpsyc.59.4.347 – volume: 8 start-page: 595 year: 2005 ident: 10.1016/j.biopsych.2012.03.005_bib52 article-title: Cortical inhibition in first-degree relatives of schizophrenic patients assessed with transcranial magnetic stimulation publication-title: Int J Neuropsychopharmacol doi: 10.1017/S1461145705005456 – volume: 117 start-page: 838 year: 2006 ident: 10.1016/j.biopsych.2012.03.005_bib49 article-title: Half sine, monophasic and biphasic transcranial magnetic stimulation of the human motor cortex publication-title: Clin Neurophysiol doi: 10.1016/j.clinph.2005.10.029 – volume: 154 start-page: 1 year: 2004 ident: 10.1016/j.biopsych.2012.03.005_bib66 article-title: Interactions between inhibitory and excitatory circuits in the human motor cortex publication-title: Exp Brain Res doi: 10.1007/s00221-003-1684-1 – volume: 21 start-page: 999 year: 2011 ident: 10.1016/j.biopsych.2012.03.005_bib25 article-title: Lamina-specific alterations in cortical GABAA receptor subunit expression in schizophrenia publication-title: Cereb Cortex doi: 10.1093/cercor/bhq169 – volume: 27 start-page: 181 year: 2011 ident: 10.1016/j.biopsych.2012.03.005_bib7 article-title: Mapping prodromal psychosis: A critical review of neuroimaging studies publication-title: Eur Psychiatry doi: 10.1016/j.eurpsy.2011.06.006 – volume: 170 start-page: 255 year: 2003 ident: 10.1016/j.biopsych.2012.03.005_bib47 article-title: Effect of antipsychotics on cortical inhibition using transcranial magnetic stimulation publication-title: Psychopharmacology (Berl) doi: 10.1007/s00213-003-1548-1 – volume: 9 start-page: 97 year: 1971 ident: 10.1016/j.biopsych.2012.03.005_bib37 article-title: The assessment and analysis of handedness: The Edinburgh inventory publication-title: Neuropsychologia doi: 10.1016/0028-3932(71)90067-4 – volume: 69 start-page: 237 year: 2004 ident: 10.1016/j.biopsych.2012.03.005_bib57 article-title: Thalamic dysfunction in schizophrenia: Neurochemical, neuropathological, and in vivo imaging abnormalities publication-title: Schizophr Res doi: 10.1016/j.schres.2003.09.017 – volume: 33 start-page: 766 year: 1976 ident: 10.1016/j.biopsych.2012.03.005_bib40 article-title: The Global Assessment Scale publication-title: Arch Gen Psychiatry doi: 10.1001/archpsyc.1976.01770060086012 – volume: 42 start-page: 194 year: 2009 ident: 10.1016/j.biopsych.2012.03.005_bib33 article-title: Motor circuit abnormalities in first-episode schizophrenia assessed with transcranial magnetic stimulation publication-title: Pharmacopsychiatry doi: 10.1055/s-0029-1224137 – start-page: 433 year: 2011 ident: 10.1016/j.biopsych.2012.03.005_bib3 article-title: Contributions of glutmate and GABA systems to the neurobiology and treatment of schizophrenia – year: 2012 ident: 10.1016/j.biopsych.2012.03.005_bib72 article-title: Innovative treatment approaches in schizophrenia enhancing neuroplasticity: Aerobic exercise, erythropoetin and repetitive transcranial magnetic stimulation [published online ahead of print January 26] publication-title: Curr Pharm Biotechnol doi: 10.2174/138920112800784763 – volume: 71 start-page: 411 year: 2010 ident: 10.1016/j.biopsych.2012.03.005_bib74 article-title: Repetitive transcranial magnetic stimulation for negative symptoms of schizophrenia: Review and meta-analysis publication-title: J Clin Psychiatry doi: 10.4088/JCP.08r04808yel – volume: 22 start-page: 203 year: 2008 ident: 10.1016/j.biopsych.2012.03.005_bib63 article-title: Increased cortical inhibition in persons with schizophrenia treated with clozapine publication-title: J Psychopharmacol doi: 10.1177/0269881107084002 – volume: 56 start-page: 628 year: 2004 ident: 10.1016/j.biopsych.2012.03.005_bib71 article-title: Repetitive transcranial magnetic stimulation reveals abnormal plastic response to premotor cortex stimulation in schizophrenia publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2004.08.023 – volume: 34 start-page: 1207 year: 2010 ident: 10.1016/j.biopsych.2012.03.005_bib8 article-title: Neuroimaging predictors of transition to psychosis--a systematic review and meta-analysis publication-title: Neurosci Biobehav Rev doi: 10.1016/j.neubiorev.2010.01.016 – volume: 70 start-page: 192 year: 2008 ident: 10.1016/j.biopsych.2012.03.005_bib18 article-title: Auditory P300 in individuals clinically at risk for psychosis publication-title: Int J Psychophysiol doi: 10.1016/j.ijpsycho.2008.07.003 – volume: 115 start-page: 1076 year: 2004 ident: 10.1016/j.biopsych.2012.03.005_bib50 article-title: The cortical silent period: Intrinsic variability and relation to the waveform of the transcranial magnetic stimulation pulse publication-title: Clin Neurophysiol doi: 10.1016/j.clinph.2003.12.025 – volume: 196 start-page: 623 year: 2008 ident: 10.1016/j.biopsych.2012.03.005_bib65 article-title: Modulation of human motor cortex excitability by quetiapine publication-title: Psychopharmacology (Berl) doi: 10.1007/s00213-007-1000-z – volume: 22 start-page: 637 year: 2011 ident: 10.1016/j.biopsych.2012.03.005_bib64 article-title: Evidence that clozapine directly interacts on the GABAB receptor publication-title: Neuroreport doi: 10.1097/WNR.0b013e328349739b – volume: 67 start-page: 241 year: 2010 ident: 10.1016/j.biopsych.2012.03.005_bib5 article-title: Prediction of psychosis in adolescents and young adults at high risk: Results from the prospective European prediction of psychosis study publication-title: Arch Gen Psychiatry doi: 10.1001/archgenpsychiatry.2009.206 – volume: 165 start-page: 479 year: 2008 ident: 10.1016/j.biopsych.2012.03.005_bib24 article-title: Conserved regional patterns of GABA-related transcript expression in the neocortex of subjects with schizophrenia publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.2007.07081223 – volume: 158 start-page: 256 year: 2001 ident: 10.1016/j.biopsych.2012.03.005_bib55 article-title: GABA transporter-1 mRNA in the prefrontal cortex in schizophrenia: Decreased expression in a subset of neurons publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.158.2.256 – volume: 133 start-page: 63 year: 2011 ident: 10.1016/j.biopsych.2012.03.005_bib12 article-title: Gray matters! Mapping the transition to psychosis publication-title: Schizophr Res doi: 10.1016/j.schres.2011.08.021 – volume: 16 start-page: 67 year: 2011 ident: 10.1016/j.biopsych.2012.03.005_bib58 article-title: Abnormal prefrontal activation directly related to pre-synaptic striatal dopamine dysfunction in people at clinical high risk for psychosis publication-title: Mol Psychiatry doi: 10.1038/mp.2009.108 – volume: 68 start-page: 881 year: 2011 ident: 10.1016/j.biopsych.2012.03.005_bib56 article-title: Thalamic glutamate levels as a predictor of cortical response during executive functioning in subjects at high risk for psychosis publication-title: Arch Gen Psychiatry doi: 10.1001/archgenpsychiatry.2011.46 – volume: 67 start-page: 253 year: 2004 ident: 10.1016/j.biopsych.2012.03.005_bib27 article-title: Cortical excitability in neuroleptic-naive first-episode schizophrenic patients publication-title: Schizophr Res doi: 10.1016/S0920-9964(03)00223-8 – volume: 105 start-page: 252 year: 2008 ident: 10.1016/j.biopsych.2012.03.005_bib32 article-title: Reduced cortical inhibition in first-episode schizophrenia publication-title: Schizophr Res doi: 10.1016/j.schres.2008.06.001 – volume: 575 start-page: 721 year: 2006 ident: 10.1016/j.biopsych.2012.03.005_bib54 article-title: GABAA receptor subtype specific enhancement of inhibition in human motor cortex publication-title: J Physiol doi: 10.1113/jphysiol.2006.114694 – volume: 104 start-page: 10164 year: 2007 ident: 10.1016/j.biopsych.2012.03.005_bib21 article-title: Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0703806104 – volume: 114 start-page: 11 year: 2002 ident: 10.1016/j.biopsych.2012.03.005_bib30 article-title: A transcranial magnetic stimulation study of inhibitory deficits in the motor cortex in patients with schizophrenia publication-title: Psychiatry Res doi: 10.1016/S0925-4927(02)00002-1 – volume: 35 start-page: 549 year: 2009 ident: 10.1016/j.biopsych.2012.03.005_bib2 article-title: The dopamine hypothesis of schizophrenia: Version III--the final common pathway publication-title: Schizophr Bull doi: 10.1093/schbul/sbp006 – volume: 35 start-page: 509 year: 2009 ident: 10.1016/j.biopsych.2012.03.005_bib1 article-title: Dysconnection in schizophrenia: From abnormal synaptic plasticity to failures of self-monitoring publication-title: Schizophr Bull doi: 10.1093/schbul/sbn176 – volume: 65 start-page: 28 year: 2008 ident: 10.1016/j.biopsych.2012.03.005_bib6 article-title: Prediction of psychosis in youth at high clinical risk: A multisite longitudinal study in North America publication-title: Arch Gen Psychiatry doi: 10.1001/archgenpsychiatry.2007.3 – volume: 65 start-page: 378 year: 2008 ident: 10.1016/j.biopsych.2012.03.005_bib69 article-title: Dysfunctional neural plasticity in patients with schizophrenia publication-title: Arch Gen Psychiatry doi: 10.1001/archpsyc.65.4.378 – volume: 18 start-page: 990 year: 2008 ident: 10.1016/j.biopsych.2012.03.005_bib70 article-title: Evidence for impaired long-term potentiation in schizophrenia and its relationship to motor skill learning publication-title: Cereb Cortex doi: 10.1093/cercor/bhm151 – volume: 224 start-page: 15 year: 2011 ident: 10.1016/j.biopsych.2012.03.005_bib68 article-title: Dysfunctional long-term potentiation-like plasticity in schizophrenia revealed by transcranial direct current stimulation publication-title: Behav Brain Res doi: 10.1016/j.bbr.2011.05.017 – volume: 261 start-page: 150 issue: suppl 2 year: 2011 ident: 10.1016/j.biopsych.2012.03.005_bib4 article-title: Schizophrenia as a disorder of disconnectivity publication-title: Eur Arch Psychiatry Clin Neurosci doi: 10.1007/s00406-011-0242-2 – reference: 23036506 - Biol Psychiatry. 2012 Nov 1;72(9):714-5 |
| SSID | ssj0007221 |
| Score | 2.2880943 |
| Snippet | Impaired cortical inhibition is a well-established finding in schizophrenia patients and has been linked to dysfunctional gamma-aminobutyric acid (GABA)ergic... BackgroundImpaired cortical inhibition is a well-established finding in schizophrenia patients and has been linked to dysfunctional gamma-aminobutyric acid... |
| SourceID | proquest pubmed pascalfrancis crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 744 |
| SubjectTerms | Adult Adult and adolescent clinical studies Antipsychotic Agents - pharmacology Antipsychotic Agents - therapeutic use Biological and medical sciences Case-Control Studies Cerebral Cortex - drug effects Cerebral Cortex - physiopathology Cortical inhibition Cross-Sectional Studies Electromyography - methods Evoked Potentials, Motor - drug effects Evoked Potentials, Motor - physiology Female first-episode schizophrenia GABA Humans Male Medical sciences Neural Inhibition - drug effects Neural Inhibition - physiology prodrome Psychiatric/Mental Health Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Psychotic Disorders - drug therapy Psychotic Disorders - physiopathology Schizophrenia Schizophrenia - drug therapy Schizophrenia - physiopathology transcranial magnetic stimulation Transcranial Magnetic Stimulation - methods |
| Title | Deficient Inhibitory Cortical Networks in Antipsychotic-Naive Subjects at Risk of Developing First-Episode Psychosis and First-Episode Schizophrenia Patients: A Cross-Sectional Study |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0006322312002223 https://www.clinicalkey.es/playcontent/1-s2.0-S0006322312002223 https://dx.doi.org/10.1016/j.biopsych.2012.03.005 https://www.ncbi.nlm.nih.gov/pubmed/22502988 https://www.proquest.com/docview/1093521086 |
| Volume | 72 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELaqIqASQrBACY-Vkbi6m4cdO9xWaVdbUFeIUqk3Kw9buKBkVaeHXvhZ_D7GcbJtQRUIjkk8SmKPZz7b38wg9JYDJE5hDhEmQkFoxDXJFEsJQHtWgf_SrHInukerdHlC35-y0y2Uj7EwjlY52H5v03trPdyZDb05WxvjYnzBvYJ3i-I-otNl_KSUu_z5e9-vaB48joeqeSlxra9FCZ_tlabtScWO4hX7ZKfsNgf1YF1Y6Dbt613cDkh7x7R4hB4OiBLP_Uc_RluqmaC7vsbk5QTdz8eSbhN072g4SX-CfuwrlzsCXA4-bL6Y0rjDdpy35_3eNl55drjFpsHzpjNDsJapyKoA-4jB3rgNHIuLDn8y9ituNd7fxF_hhQFQSQ7Wxra1wt7IWgOtm_qXZ8fXSX_4o8_yat_hOc5d95DjnirmftAxHi-fopPFwed8SYYaDqRinHZE85oVZa2VDkUZacE1EynliUpEmXDOCw0LvLSkvGCwskqrLM0KFQMQg6VSUdMyeYa2m7ZRzxGuGGOFoGVdC03B0IhKhXWoS85DziNWBYiNAyerIcG5q7PxTY5MtjM5Drh0Ay7DRMKAB2i2kVv7FB9_lOCjXsgxgBVMrgQv9G-Syg6Ww8pIWmgsf9PuAGUbyRsT5K_eOr2hvJvfjFNGacyjAL0ZtVmCSrozo6JR7YV1BAWA6K4cV4B2vZpfSQN8jjMhXvzHp71EO-7KR3e-Qtvd-YV6DTCvK6f9PJ6iO_PDD8vVTykvU5c |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwED-NTTAkhKAMKB_DSLyaJmkcu7xV3aaWrRVim7Q3Kx-28EBJNXcP-8f4-zjHTtlAEwhek5yS-M6_O9u_uwN4xzEkznAOUSYiQdOYazpSLKMY2rMS_ZdmpTvRnS-y6Wn68YydbcCky4VxtMqA_R7TW7QOVwZhNAdLY1yOL7pX9G5x0mZ0Du_AlqtOhca-NZ4dThdrQOZJEhrnZdQJXEsUPn9fmKblFTuWV-LrnbLbfNSDZW5x5LRveXF7TNr6poNH8DAElWTsv_sxbKi6B3d9m8mrHmxPuq5uPbg3D4fpT-D7nnLlI9DrkFn9xRTGnbeTSXPRbm-ThSeIW2JqMq5XJuRrmZIucoRIgpDj9nAsyVfks7FfSaPJ3joFixwYjCvp_tLYplLE46w1-HRd_XLv-Drvj3zyhV7tBzImEzc89Lhli7kfdKTHqx04Pdg_mUxpaONAS8bTFdW8YnlRaaUjUcRacM1EhnpSQ1EMOee5xjVeVqQ8Z7i4yspRNspVgrEYrpbyKi2GT2Gzbmr1HEjJGMtFWlSV0ClijShVVEW64DziPGZlH1inOFmGGueu1cY32ZHZzmWncOkULqOhRIX3YbCWW_oqH3-U4J1dyC6HFVFXoiP6N0llA3hYGUuLD8vfDLwPo7XkjTnyV2_dvWG8699MMpamCY_78LazZokm6Y6N8lo1l9ZxFDBKdx25-vDMm_lPaYygk5EQL_7j097A9vRkfiSPZovDl3Df3fHJnq9gc3VxqV5j1LcqdsOs_gGYblZI |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Deficient+Inhibitory+Cortical+Networks+in+Antipsychotic-Naive+Subjects+at+Risk+of+Developing+First-Episode+Psychosis+and+First-Episode+Schizophrenia+Patients%3A+A+Cross-Sectional+Study&rft.jtitle=Biological+psychiatry+%281969%29&rft.au=Hasan%2C+Alkomiet&rft.au=Wobrock%2C+Thomas&rft.au=Grefkes%2C+Christian&rft.au=Labusga%2C+Marcin&rft.date=2012-11-01&rft.issn=0006-3223&rft.volume=72&rft.issue=9&rft.spage=744&rft.epage=751&rft_id=info:doi/10.1016%2Fj.biopsych.2012.03.005&rft.externalDBID=ECK1-s2.0-S0006322312002223&rft.externalDocID=1_s2_0_S0006322312002223 |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F00063223%2FS0006322311X00434%2Fcov150h.gif |