Effect of DTPP-mediated photodynamic therapy on cell morphology, viability, cell cycle, and cytotoxicity in a murine lung adenocarcinoma cell line

• Published in: Lasers in medical science Vol. 30; no. 1; pp. 181 - 191
• Main Authors: Liu, Jianhua, Zheng, Liqing, Li, Yingxin, Zhang, Zhihua, Zhang, Li, Shen, Lixia, Zhang, Xiulong, Qiao, Haixia
• Format: Journal Article
• Language: English
• Published: London Springer London 01.01.2015; Springer Nature B.V
• Subjects: Adenocarcinoma - drug therapy; Adenocarcinoma - pathology; Adenocarcinoma of Lung; Animals; Apoptosis; Apoptosis - drug effects; Biotechnology; Cell Cycle; Cell Line, Tumor; Cell Membrane - drug effects; Cell Membrane - physiology; Cell Nucleus Shape - drug effects; Cell Shape - drug effects; Cell Survival - drug effects; Cytotoxicity; Density; Dentistry; Flow cytometry; Humans; Lasers; Lung cancer; Lung Neoplasms - drug therapy; Lung Neoplasms - pathology; Lungs; Medicine; Medicine & Public Health; Mice; Morphology; Optical Devices; Optics; Organophosphorus Compounds; Original Article; Photochemotherapy - methods; Photodynamic therapy; Photonics; Photosensitizing Agents - metabolism; Photosensitizing Agents - therapeutic use; Porphyrins - metabolism; Porphyrins - therapeutic use; Quantum Optics; Scanning microscopy; Viability; DTPP; Photodynamic therapy; LA795; Cell death; Cell cycle; Apoptosis

Photodynamic therapy (PDT) involves the administration and activation of photosensitizing reagents in cancer tissues to induce cytotoxicity. Here we examined the effects of 5-5- (4- N , N -diacetoxylphenyl)-10,15,20- tetraphenylporphyrin (DTPP) -mediated PDT on cell morphology, viability, cell cycle...