Necroptosis molecular mechanisms: Recent findings regarding novel necroptosis regulators

Necroptosis is a form of programmed necrosis that is mediated by various cytokines and pattern recognition receptors (PRRs). Cells dying by necroptosis show necrotic phenotypes, including swelling and membrane rupture, and release damage-associated molecular patterns (DAMPs), inflammatory cytokines,...

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Published inExperimental & molecular medicine Vol. 53; no. 6; pp. 1007 - 1017
Main Authors Seo, Jinho, Nam, Young Woo, Kim, Seongmi, Oh, Doo-Byoung, Song, Jaewhan
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.06.2021
Springer Nature B.V
생화학분자생물학회
Subjects
631/337/458/1524
631/337/458/1733
631/337/458/582
631/80/82/23
631/80/82/2344
Animal models
Animals
Apoptosis
Biomedical and Life Sciences
Biomedicine
Cell death
Chemokines
Cytokines
Glycosylation
Immune response
Inflammation
Inflammatory diseases
Kinases
MAP kinase
Medical Biochemistry
Molecular Medicine
Molecular modelling
Necroptosis
Necrosis
Oligomerization
Pattern recognition receptors
Phenotypes
Phosphorylation
Protein interaction
Protein kinase
Protein Kinases - genetics
Protein Kinases - metabolism
Proteins
Psoriasis
Review
Review Article
Signal transduction
Stem Cells
Ubiquitination
생화학
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Abstract Necroptosis is a form of programmed necrosis that is mediated by various cytokines and pattern recognition receptors (PRRs). Cells dying by necroptosis show necrotic phenotypes, including swelling and membrane rupture, and release damage-associated molecular patterns (DAMPs), inflammatory cytokines, and chemokines, thereby mediating extreme inflammatory responses. Studies on gene knockout or necroptosis-specific inhibitor treatment in animal models have provided extensive evidence regarding the important roles of necroptosis in inflammatory diseases. The necroptosis signaling pathway is primarily modulated by activation of receptor-interacting protein kinase 3 (RIPK3), which phosphorylates mixed-lineage kinase domain-like protein (MLKL), mediating MLKL oligomerization. In the necroptosis process, these proteins are fine-tuned by posttranslational regulation via phosphorylation, ubiquitination, glycosylation, and protein–protein interactions. Herein, we review recent findings on the molecular regulatory mechanisms of necroptosis. Inflammation: Understanding cell death opens therapeutic possibilities A better understanding of the signaling pathways that drive an inflammatory mode of cell death known as necroptosis could lead to new therapies for autoimmune and neuroinflammatory conditions. Necroptosis is a regulated form of cell death often triggered by infections, tissue injuries, and chronic inflammatory conditions. It leads cells to rupture and disperse their contents, which in turn spurs an inflammatory immune response that can sometimes fuel disease. A team from South Korea led by Jaewhan Song of Yonsei University in Seoul discusses the molecular mechanisms of this process. They focus on several key mediators of the necroptosis signaling pathway and how those proteins in turn are modified to regulate their function. Several drug inhibitors of these proteins are already in clinical development for the treatment of psoriasis and other inflammatory disorders.
AbstractList Abstract Necroptosis is a form of programmed necrosis that is mediated by various cytokines and pattern recognition receptors (PRRs). Cells dying by necroptosis show necrotic phenotypes, including swelling and membrane rupture, and release damage-associated molecular patterns (DAMPs), inflammatory cytokines, and chemokines, thereby mediating extreme inflammatory responses. Studies on gene knockout or necroptosis-specific inhibitor treatment in animal models have provided extensive evidence regarding the important roles of necroptosis in inflammatory diseases. The necroptosis signaling pathway is primarily modulated by activation of receptor-interacting protein kinase 3 (RIPK3), which phosphorylates mixed-lineage kinase domain-like protein (MLKL), mediating MLKL oligomerization. In the necroptosis process, these proteins are fine-tuned by posttranslational regulation via phosphorylation, ubiquitination, glycosylation, and protein–protein interactions. Herein, we review recent findings on the molecular regulatory mechanisms of necroptosis.
Necroptosis is a form of programmed necrosis that is mediated by various cytokines and pattern recognition receptors (PRRs). Cells dying by necroptosis show necrotic phenotypes, including swelling and membrane rupture, and release damage-associated molecular patterns (DAMPs), inflammatory cytokines, and chemokines, thereby mediating extreme inflammatory responses. Studies on gene knockout or necroptosis-specific inhibitor treatment in animal models have provided extensive evidence regarding the important roles of necroptosis in inflammatory diseases. The necroptosis signaling pathway is primarily modulated by activation of receptor-interacting protein kinase 3 (RIPK3), which phosphorylates mixed-lineage kinase domain-like protein (MLKL), mediating MLKL oligomerization. In the necroptosis process, these proteins are fine-tuned by posttranslational regulation via phosphorylation, ubiquitination, glycosylation, and protein–protein interactions. Herein, we review recent findings on the molecular regulatory mechanisms of necroptosis. KCI Citation Count: 0
Necroptosis is a form of programmed necrosis that is mediated by various cytokines and pattern recognition receptors (PRRs). Cells dying by necroptosis show necrotic phenotypes, including swelling and membrane rupture, and release damage-associated molecular patterns (DAMPs), inflammatory cytokines, and chemokines, thereby mediating extreme inflammatory responses. Studies on gene knockout or necroptosis-specific inhibitor treatment in animal models have provided extensive evidence regarding the important roles of necroptosis in inflammatory diseases. The necroptosis signaling pathway is primarily modulated by activation of receptor-interacting protein kinase 3 (RIPK3), which phosphorylates mixed-lineage kinase domain-like protein (MLKL), mediating MLKL oligomerization. In the necroptosis process, these proteins are fine-tuned by posttranslational regulation via phosphorylation, ubiquitination, glycosylation, and protein–protein interactions. Herein, we review recent findings on the molecular regulatory mechanisms of necroptosis. Inflammation: Understanding cell death opens therapeutic possibilities A better understanding of the signaling pathways that drive an inflammatory mode of cell death known as necroptosis could lead to new therapies for autoimmune and neuroinflammatory conditions. Necroptosis is a regulated form of cell death often triggered by infections, tissue injuries, and chronic inflammatory conditions. It leads cells to rupture and disperse their contents, which in turn spurs an inflammatory immune response that can sometimes fuel disease. A team from South Korea led by Jaewhan Song of Yonsei University in Seoul discusses the molecular mechanisms of this process. They focus on several key mediators of the necroptosis signaling pathway and how those proteins in turn are modified to regulate their function. Several drug inhibitors of these proteins are already in clinical development for the treatment of psoriasis and other inflammatory disorders.
Necroptosis is a form of programmed necrosis that is mediated by various cytokines and pattern recognition receptors (PRRs). Cells dying by necroptosis show necrotic phenotypes, including swelling and membrane rupture, and release damage-associated molecular patterns (DAMPs), inflammatory cytokines, and chemokines, thereby mediating extreme inflammatory responses. Studies on gene knockout or necroptosis-specific inhibitor treatment in animal models have provided extensive evidence regarding the important roles of necroptosis in inflammatory diseases. The necroptosis signaling pathway is primarily modulated by activation of receptor-interacting protein kinase 3 (RIPK3), which phosphorylates mixed-lineage kinase domain-like protein (MLKL), mediating MLKL oligomerization. In the necroptosis process, these proteins are fine-tuned by posttranslational regulation via phosphorylation, ubiquitination, glycosylation, and protein–protein interactions. Herein, we review recent findings on the molecular regulatory mechanisms of necroptosis.Inflammation: Understanding cell death opens therapeutic possibilitiesA better understanding of the signaling pathways that drive an inflammatory mode of cell death known as necroptosis could lead to new therapies for autoimmune and neuroinflammatory conditions. Necroptosis is a regulated form of cell death often triggered by infections, tissue injuries, and chronic inflammatory conditions. It leads cells to rupture and disperse their contents, which in turn spurs an inflammatory immune response that can sometimes fuel disease. A team from South Korea led by Jaewhan Song of Yonsei University in Seoul discusses the molecular mechanisms of this process. They focus on several key mediators of the necroptosis signaling pathway and how those proteins in turn are modified to regulate their function. Several drug inhibitors of these proteins are already in clinical development for the treatment of psoriasis and other inflammatory disorders.
Necroptosis is a form of programmed necrosis that is mediated by various cytokines and pattern recognition receptors (PRRs). Cells dying by necroptosis show necrotic phenotypes, including swelling and membrane rupture, and release damage-associated molecular patterns (DAMPs), inflammatory cytokines, and chemokines, thereby mediating extreme inflammatory responses. Studies on gene knockout or necroptosis-specific inhibitor treatment in animal models have provided extensive evidence regarding the important roles of necroptosis in inflammatory diseases. The necroptosis signaling pathway is primarily modulated by activation of receptor-interacting protein kinase 3 (RIPK3), which phosphorylates mixed-lineage kinase domain-like protein (MLKL), mediating MLKL oligomerization. In the necroptosis process, these proteins are fine-tuned by posttranslational regulation via phosphorylation, ubiquitination, glycosylation, and protein–protein interactions. Herein, we review recent findings on the molecular regulatory mechanisms of necroptosis. A better understanding of the signaling pathways that drive an inflammatory mode of cell death known as necroptosis could lead to new therapies for autoimmune and neuroinflammatory conditions. Necroptosis is a regulated form of cell death often triggered by infections, tissue injuries, and chronic inflammatory conditions. It leads cells to rupture and disperse their contents, which in turn spurs an inflammatory immune response that can sometimes fuel disease. A team from South Korea led by Jaewhan Song of Yonsei University in Seoul discusses the molecular mechanisms of this process. They focus on several key mediators of the necroptosis signaling pathway and how those proteins in turn are modified to regulate their function. Several drug inhibitors of these proteins are already in clinical development for the treatment of psoriasis and other inflammatory disorders.
Necroptosis is a form of programmed necrosis that is mediated by various cytokines and pattern recognition receptors (PRRs). Cells dying by necroptosis show necrotic phenotypes, including swelling and membrane rupture, and release damage-associated molecular patterns (DAMPs), inflammatory cytokines, and chemokines, thereby mediating extreme inflammatory responses. Studies on gene knockout or necroptosis-specific inhibitor treatment in animal models have provided extensive evidence regarding the important roles of necroptosis in inflammatory diseases. The necroptosis signaling pathway is primarily modulated by activation of receptor-interacting protein kinase 3 (RIPK3), which phosphorylates mixed-lineage kinase domain-like protein (MLKL), mediating MLKL oligomerization. In the necroptosis process, these proteins are fine-tuned by posttranslational regulation via phosphorylation, ubiquitination, glycosylation, and protein-protein interactions. Herein, we review recent findings on the molecular regulatory mechanisms of necroptosis.
Author Kim, Seongmi
Oh, Doo-Byoung
Seo, Jinho
Song, Jaewhan
Nam, Young Woo
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  givenname: Jinho
  surname: Seo
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  surname: Nam
  fullname: Nam, Young Woo
  organization: Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University
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  surname: Kim
  fullname: Kim, Seongmi
  organization: Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University
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  givenname: Doo-Byoung
  surname: Oh
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Snippet Necroptosis is a form of programmed necrosis that is mediated by various cytokines and pattern recognition receptors (PRRs). Cells dying by necroptosis show...
Abstract Necroptosis is a form of programmed necrosis that is mediated by various cytokines and pattern recognition receptors (PRRs). Cells dying by...
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proquest
crossref
pubmed
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SubjectTerms 631/337/458/1524
631/337/458/1733
631/337/458/582
631/80/82/23
631/80/82/2344
Animal models
Animals
Apoptosis
Biomedical and Life Sciences
Biomedicine
Cell death
Chemokines
Cytokines
Glycosylation
Immune response
Inflammation
Inflammatory diseases
Kinases
MAP kinase
Medical Biochemistry
Molecular Medicine
Molecular modelling
Necroptosis
Necrosis
Oligomerization
Pattern recognition receptors
Phenotypes
Phosphorylation
Protein interaction
Protein kinase
Protein Kinases - genetics
Protein Kinases - metabolism
Proteins
Psoriasis
Review
Review Article
Signal transduction
Stem Cells
Ubiquitination
생화학
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Title Necroptosis molecular mechanisms: Recent findings regarding novel necroptosis regulators
URI https://link.springer.com/article/10.1038/s12276-021-00634-7
https://www.ncbi.nlm.nih.gov/pubmed/34075202
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https://pubmed.ncbi.nlm.nih.gov/PMC8166896
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Volume 53
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