Safety and efficacy of adzuki bean extract in subjects with moderate to high LDL-C: a randomized trial

• Published in: Bioscience, biotechnology, and biochemistry Vol. 83; no. 5; pp. 933 - 941
• Main Authors: Kitano-Okada, Tomoko, Nagata, Ryuji, Han, Kyu-Ho, Mikami, Nana, Satoh, Koji, Nishihira, Jun, Sasaki, Keiko, Ohba, Kiyoshi, Fukusima, Michihiro
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.05.2019; Oxford University Press
• Subjects: Adiponectin - metabolism; Adult; Adzuki bean; Aged; biotechnology; Blood Glucose - analysis; Blood Pressure; Body Mass Index; Body Weight; Cholesterol, HDL - blood; Cholesterol, LDL - blood; clinical trials; Cohort Studies; Double-Blind Method; Female; Glycated Hemoglobin A - metabolism; Humans; LDL-cholesterol; lipid metabolism; Male; Middle Aged; Oxidative Stress - drug effects; Placebos; Plant Extracts - adverse effects; Plant Extracts - chemistry; Plant Extracts - pharmacology; Polyphenols - analysis; triglycerides; Vigna - chemistry; Vigna angularis; Adzuki bean; LDL-cholesterol; triglycerides
• ISSN: 0916-8451; 1347-6947; 1347-6947
• DOI: 10.1080/09168451.2019.1574553

The safety and efficacy of polyphenol-containing adzuki bean extract on lipid metabolism were evaluated in human subjects in an 8-week, randomized, double-blind, placebo-controlled, parallel intervention study. No adverse effects were observed in the participants receiving adzuki bean extract. The adzuki bean group showed a significant increase in the ΔHDL-C concentration compared with the placebo group after 4 weeks of intervention (3.76 ± 7.79 mg/dL vs. −0.08 ± 6.03 mg/dL), respectively, and both groups showed reduced ∆HDL-C concentrations, with the adzuki bean extract group showing a return to the baseline levels (0.36 ± 5.36 mg/dL) and the placebo group showing a decrease to below the baseline levels (−3.17 ± 7.79 mg/dL) at week 8. This short-term study represents the first step in establishing the practicality, safety, and plausibility of HDL-C maintaining effects of adzuki bean extract in human subjects. The safety and efficacy of polyphenol-containing adzuki bean extract were examined in human subjects using a 8-week, randomized, double-blind, placebo-controlled, parallel intervention study.