Genetically Elevated C-Reactive Protein and Ischemic Vascular Disease
In a study of four cohorts of patients from Denmark, the subjects were typed for four single-nucleotide polymorphisms in the gene for C-reactive protein (CRP). The resulting genotypes were correlated with an increase in CRP levels of up to 64%, a result predicting significantly increased risks of is...
Saved in:
| Published in | The New England journal of medicine Vol. 359; no. 18; pp. 1897 - 1908 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Boston, MA
Massachusetts Medical Society
30.10.2008
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0028-4793 1533-4406 1533-4406 |
| DOI | 10.1056/NEJMoa0707402 |
Cover
Loading…
| Abstract | In a study of four cohorts of patients from Denmark, the subjects were typed for four single-nucleotide polymorphisms in the gene for C-reactive protein (CRP). The resulting genotypes were correlated with an increase in CRP levels of up to 64%, a result predicting significantly increased risks of ischemic heart disease and ischemic cerebrovascular disease. However, no such increase in risk was observed, a result suggesting that the known association between CRP levels and vascular risk is not causal.
Four cohorts of patients were typed for four single-nucleotide polymorphisms in the gene for C-reactive protein (CRP). Although the resulting genotypes were correlated with an increase in CRP levels of up to 64%, no increase in risk of ischemic heart disease or ischemic cerebrovascular disease was observed, suggesting that the association between CRP levels and vascular risk is not causal.
Elevated plasma levels of C-reactive protein (CRP) are associated with increased risks of ischemic heart disease and ischemic cerebrovascular disease.
1
–
5
However, whether CRP is simply a marker for ischemic vascular disease or whether elevated CRP levels actually contribute directly to causing such disorders is presently unknown. This question has clinical importance, since several drugs that specifically lower CRP levels are being developed,
6
with the ultimate aim of preventing ischemic vascular disease.
The random assortment of genes that occurs during gamete formation provides a relatively unbiased method of assessing whether risk factors that have a genetic component are in fact . . . |
|---|---|
| AbstractList | Elevated levels of C-reactive protein (CRP) are associated with increased risks of ischemic heart disease and ischemic cerebrovascular disease. We tested whether this is a causal association.
We studied 10,276 persons from a general population cohort, including 1786 in whom ischemic heart disease developed and 741 in whom ischemic cerebrovascular disease developed. We examined another 31,992 persons from a cross-sectional general population study, of whom 2521 had ischemic heart disease and 1483 had ischemic cerebrovascular disease. Finally, we compared 2238 patients with ischemic heart disease with 4474 control subjects and 612 patients with ischemic cerebrovascular disease with 1224 control subjects. We measured levels of high-sensitivity CRP and conducted genotyping for four CRP polymorphisms and two apolipoprotein E polymorphisms.
The risk of ischemic heart disease and ischemic cerebrovascular disease was increased by a factor of 1.6 and 1.3, respectively, in persons who had CRP levels above 3 mg per liter, as compared with persons who had CRP levels below 1 mg per liter. Genotype combinations of the four CRP polymorphisms were associated with an increase in CRP levels of up to 64%, resulting in a theoretically predicted increased risk of up to 32% for ischemic heart disease and up to 25% for ischemic cerebrovascular disease. However, these genotype combinations were not associated with an increased risk of ischemic vascular disease. In contrast, apolipoprotein E genotypes were associated with both elevated cholesterol levels and an increased risk of ischemic heart disease.
Polymorphisms in the CRP gene are associated with marked increases in CRP levels and thus with a theoretically predicted increase in the risk of ischemic vascular disease. However, these polymorphisms are not in themselves associated with an increased risk of ischemic vascular disease. Background Elevated levels of C-reactive protein (CRP) are associated with increased risks of ischemic heart disease and ischemic cerebrovascular disease. We tested whether this is a causal association. Methods We studied 10,276 persons from a general population cohort, including 1786 in whom ischemic heart disease developed and 741 in whom ischemic cerebrovascular disease developed. We examined another 31,992 persons from a cross-sectional general population study, of whom 2521 had ischemic heart disease and 1483 had ischemic cerebrovascular disease. Finally, we compared 2238 patients with ischemic heart disease with 4474 control subjects and 612 patients with ischemic cerebrovascular disease with 1224 control subjects. We measured levels of high-sensitivity CRP and conducted genotyping for four CRP polymorphisms and two apolipoprotein E polymorphisms. Results The risk of ischemic heart disease and ischemic cerebrovascular disease was increased by a factor of 1.6 and 1.3, respectively, in persons who had CRP levels above 3 mg per liter, as compared with persons who had CRP levels below 1 mg per liter. Genotype combinations of the four CRP polymorphisms were associated with an increase in CRP levels of up to 64%, resulting in a theoretically predicted increased risk of up to 32% for ischemic heart disease and up to 25% for ischemic cerebrovascular disease. However, these genotype combinations were not associated with an increased risk of ischemic vascular disease. In contrast, apolipoprotein E genotypes were associated with both elevated cholesterol levels and an increased risk of ischemic heart disease. Conclusions Polymorphisms in the CRP gene are associated with marked increases in CRP levels and thus with a theoretically predicted increase in the risk of ischemic vascular disease. However, these polymorphisms are not in themselves associated with an increased risk of ischemic vascular disease. Elevated levels of C-reactive protein (CRP) are associated with increased risks of ischemic heart disease and ischemic cerebrovascular disease. We tested whether this is a causal association.BACKGROUNDElevated levels of C-reactive protein (CRP) are associated with increased risks of ischemic heart disease and ischemic cerebrovascular disease. We tested whether this is a causal association.We studied 10,276 persons from a general population cohort, including 1786 in whom ischemic heart disease developed and 741 in whom ischemic cerebrovascular disease developed. We examined another 31,992 persons from a cross-sectional general population study, of whom 2521 had ischemic heart disease and 1483 had ischemic cerebrovascular disease. Finally, we compared 2238 patients with ischemic heart disease with 4474 control subjects and 612 patients with ischemic cerebrovascular disease with 1224 control subjects. We measured levels of high-sensitivity CRP and conducted genotyping for four CRP polymorphisms and two apolipoprotein E polymorphisms.METHODSWe studied 10,276 persons from a general population cohort, including 1786 in whom ischemic heart disease developed and 741 in whom ischemic cerebrovascular disease developed. We examined another 31,992 persons from a cross-sectional general population study, of whom 2521 had ischemic heart disease and 1483 had ischemic cerebrovascular disease. Finally, we compared 2238 patients with ischemic heart disease with 4474 control subjects and 612 patients with ischemic cerebrovascular disease with 1224 control subjects. We measured levels of high-sensitivity CRP and conducted genotyping for four CRP polymorphisms and two apolipoprotein E polymorphisms.The risk of ischemic heart disease and ischemic cerebrovascular disease was increased by a factor of 1.6 and 1.3, respectively, in persons who had CRP levels above 3 mg per liter, as compared with persons who had CRP levels below 1 mg per liter. Genotype combinations of the four CRP polymorphisms were associated with an increase in CRP levels of up to 64%, resulting in a theoretically predicted increased risk of up to 32% for ischemic heart disease and up to 25% for ischemic cerebrovascular disease. However, these genotype combinations were not associated with an increased risk of ischemic vascular disease. In contrast, apolipoprotein E genotypes were associated with both elevated cholesterol levels and an increased risk of ischemic heart disease.RESULTSThe risk of ischemic heart disease and ischemic cerebrovascular disease was increased by a factor of 1.6 and 1.3, respectively, in persons who had CRP levels above 3 mg per liter, as compared with persons who had CRP levels below 1 mg per liter. Genotype combinations of the four CRP polymorphisms were associated with an increase in CRP levels of up to 64%, resulting in a theoretically predicted increased risk of up to 32% for ischemic heart disease and up to 25% for ischemic cerebrovascular disease. However, these genotype combinations were not associated with an increased risk of ischemic vascular disease. In contrast, apolipoprotein E genotypes were associated with both elevated cholesterol levels and an increased risk of ischemic heart disease.Polymorphisms in the CRP gene are associated with marked increases in CRP levels and thus with a theoretically predicted increase in the risk of ischemic vascular disease. However, these polymorphisms are not in themselves associated with an increased risk of ischemic vascular disease.CONCLUSIONSPolymorphisms in the CRP gene are associated with marked increases in CRP levels and thus with a theoretically predicted increase in the risk of ischemic vascular disease. However, these polymorphisms are not in themselves associated with an increased risk of ischemic vascular disease. In a study of four cohorts of patients from Denmark, the subjects were typed for four single-nucleotide polymorphisms in the gene for C-reactive protein (CRP). The resulting genotypes were correlated with an increase in CRP levels of up to 64%, a result predicting significantly increased risks of ischemic heart disease and ischemic cerebrovascular disease. However, no such increase in risk was observed, a result suggesting that the known association between CRP levels and vascular risk is not causal. Four cohorts of patients were typed for four single-nucleotide polymorphisms in the gene for C-reactive protein (CRP). Although the resulting genotypes were correlated with an increase in CRP levels of up to 64%, no increase in risk of ischemic heart disease or ischemic cerebrovascular disease was observed, suggesting that the association between CRP levels and vascular risk is not causal. Elevated plasma levels of C-reactive protein (CRP) are associated with increased risks of ischemic heart disease and ischemic cerebrovascular disease. 1 – 5 However, whether CRP is simply a marker for ischemic vascular disease or whether elevated CRP levels actually contribute directly to causing such disorders is presently unknown. This question has clinical importance, since several drugs that specifically lower CRP levels are being developed, 6 with the ultimate aim of preventing ischemic vascular disease. The random assortment of genes that occurs during gamete formation provides a relatively unbiased method of assessing whether risk factors that have a genetic component are in fact . . . |
| Author | Tybjærg-Hansen, Anne Nordestgaard, Børge G Zacho, Jeppe Jensen, Jan Skov Sillesen, Henrik Grande, Peer |
| Author_xml | – sequence: 1 givenname: Jeppe surname: Zacho fullname: Zacho, Jeppe – sequence: 2 givenname: Anne surname: Tybjærg-Hansen fullname: Tybjærg-Hansen, Anne – sequence: 3 givenname: Jan Skov surname: Jensen fullname: Jensen, Jan Skov – sequence: 4 givenname: Peer surname: Grande fullname: Grande, Peer – sequence: 5 givenname: Henrik surname: Sillesen fullname: Sillesen, Henrik – sequence: 6 givenname: Børge G surname: Nordestgaard fullname: Nordestgaard, Børge G |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20811071$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/18971492$$D View this record in MEDLINE/PubMed |
| BookMark | eNp10c9PFTEQB_CGYOCBHr2aDQneVvtrt9sjeTwRg2CMem26s7OxL90utF0S_ntreJJIQi_Tw2cm33aOyH6YAxLyltEPjDbtx-vNl6-zpYoqSfkeWbFGiFpK2u6TFaW8q6XS4pAcpbSl5TCpD8gh67QqN74imwsMmB1Y7x-qjcd7m3Go1vV3tJDdPVbf4pzRhcqGobpM8BsnB9Uvm2DxNlbnLqFN-Jq8Gq1P-GZXj8nPT5sf68_11c3F5frsqoZGyVyjaMeWQg9DJwQwBCE6pVAjNgBMj4h9T0ekI8hBM-QoBw7Ycam16nnDxTF5_zj3Ns53C6ZsJpcAvbcB5yWZVqvCqCrw5BnczksMJZvhXGjeCqkLerdDSz_hYG6jm2x8MP9-p4DTHSjvtX6MNoBLT47TjjGqWHHi0UGcU4o4GnDZZjeHHK3zhlHzd1fmv12VrvpZ11OAF_wuzTQlE3A7veD-AH8Tnxk |
| CODEN | NEJMAG |
| CitedBy_id | crossref_primary_10_1111_eci_12067 crossref_primary_10_1161_CIRCULATIONAHA_110_951798 crossref_primary_10_1016_j_atherosclerosis_2015_12_038 crossref_primary_10_1016_j_ejim_2012_09_010 crossref_primary_10_1373_clinchem_2016_255190 crossref_primary_10_3390_biomedicines11092444 crossref_primary_10_1164_rccm_201206_1113OC crossref_primary_10_1016_j_sleep_2021_10_018 crossref_primary_10_1080_07853890_2018_1498118 crossref_primary_10_1016_j_atherosclerosis_2023_05_015 crossref_primary_10_1161_STROKEAHA_114_007657 crossref_primary_10_1007_s10689_013_9601_7 crossref_primary_10_1016_j_cca_2011_01_022 crossref_primary_10_3390_ijms21239128 crossref_primary_10_1093_eurheartj_ehv236 crossref_primary_10_1038_nrneurol_2016_125 crossref_primary_10_7554_eLife_51317 crossref_primary_10_1016_j_numecd_2019_03_010 crossref_primary_10_1021_ac9012122 crossref_primary_10_1111_j_1365_2265_2010_03879_x crossref_primary_10_1016_j_atherosclerosis_2023_05_010 crossref_primary_10_1161_ATVBAHA_111_223768 crossref_primary_10_1097_QAD_0000000000000283 crossref_primary_10_1111_bph_13805 crossref_primary_10_1016_j_thromres_2011_05_015 crossref_primary_10_1016_j_atherosclerosis_2017_07_001 crossref_primary_10_1016_S0140_6736_12_60361_4 crossref_primary_10_14260_Jemds_2017_1059 crossref_primary_10_5853_kjs_2011_13_2_57 crossref_primary_10_1177_039463201002300423 crossref_primary_10_1093_cid_cis933 crossref_primary_10_3899_jrheum_100689 crossref_primary_10_1016_j_ajog_2011_03_049 crossref_primary_10_1038_ejcn_2010_99 crossref_primary_10_1161_STROKEAHA_116_013647 crossref_primary_10_2174_1874306401610010001 crossref_primary_10_1007_s11033_011_1193_4 crossref_primary_10_1016_j_acmx_2014_11_005 crossref_primary_10_1200_JCO_2015_63_2133 crossref_primary_10_1373_clinchem_2018_287581 crossref_primary_10_1161_ATVBAHA_119_311392 crossref_primary_10_3899_jrheum_110006 crossref_primary_10_1016_j_jacc_2018_06_082 crossref_primary_10_1002_ijc_29638 crossref_primary_10_1371_journal_pone_0158608 crossref_primary_10_1373_clinchem_2016_258566 crossref_primary_10_1007_s12471_014_0534_z crossref_primary_10_1111_eci_12047 crossref_primary_10_1016_j_biopsych_2013_10_009 crossref_primary_10_1111_hiv_12143 crossref_primary_10_2337_dc22_1353 crossref_primary_10_1016_j_amjcard_2018_04_005 crossref_primary_10_1111_joim_12953 crossref_primary_10_1186_s40345_017_0109_1 crossref_primary_10_5507_bp_2017_002 crossref_primary_10_1373_clinchem_2008_115923 crossref_primary_10_1016_j_ijcard_2012_01_050 crossref_primary_10_1080_20786204_2011_10874070 crossref_primary_10_3892_br_2016_793 crossref_primary_10_1111_j_1365_2796_2012_02586_x crossref_primary_10_1371_journal_pone_0183706 crossref_primary_10_1093_eurheartj_ehad055 crossref_primary_10_1007_s10067_020_04992_x crossref_primary_10_1111_j_1525_139X_2010_00784_x crossref_primary_10_1097_FJC_0b013e31819d6188 crossref_primary_10_1111_j_1600_0897_2011_01076_x crossref_primary_10_1378_chest_11_2521 crossref_primary_10_1016_j_jalz_2018_07_223 crossref_primary_10_1093_ije_dyr233 crossref_primary_10_1093_jnci_djt016 crossref_primary_10_1007_s12170_010_0127_3 crossref_primary_10_1007_s11434_012_5591_3 crossref_primary_10_2337_dc09_1342 crossref_primary_10_1186_ar3145 crossref_primary_10_1164_rccm_200912_1951OC crossref_primary_10_1016_j_ijcard_2011_06_066 crossref_primary_10_3389_fcvm_2020_631398 crossref_primary_10_1093_cvr_cvs237 crossref_primary_10_1007_s11427_019_9537_4 crossref_primary_10_1016_j_exer_2010_02_008 crossref_primary_10_1371_journal_pone_0077741 crossref_primary_10_1007_s12035_015_9310_3 crossref_primary_10_1007_s13105_016_0505_5 crossref_primary_10_1155_2014_757123 crossref_primary_10_1177_0022034517720924 crossref_primary_10_1016_j_ijcard_2015_05_013 crossref_primary_10_1161_JAHA_118_008951 crossref_primary_10_1016_j_jadr_2022_100427 crossref_primary_10_1146_annurev_immunol_030409_101305 crossref_primary_10_1161_CIRCGENETICS_110_958801 crossref_primary_10_1016_S1773_035X_09_70121_2 crossref_primary_10_1097_YIC_0b013e32833643fd crossref_primary_10_1002_ana_24326 crossref_primary_10_1160_TH14_12_1007 crossref_primary_10_3390_molecules24112062 crossref_primary_10_1016_j_canep_2010_01_003 crossref_primary_10_1186_s12879_016_2026_9 crossref_primary_10_1097_HRP_0000000000000167 crossref_primary_10_4244_EIJY15M07_04 crossref_primary_10_1016_j_atherosclerosis_2022_04_013 crossref_primary_10_1089_met_2009_0116 crossref_primary_10_3389_fcvm_2021_734400 crossref_primary_10_4070_kcj_2023_0075 crossref_primary_10_1038_nrurol_2012_192 crossref_primary_10_1016_j_rmclc_2015_04_002 crossref_primary_10_1007_s11883_018_0715_0 crossref_primary_10_1016_j_cjca_2012_11_032 crossref_primary_10_1111_j_1749_6632_2010_05784_x crossref_primary_10_1038_tpj_2009_34 crossref_primary_10_1016_S0749_4041_08_79103_6 crossref_primary_10_1016_j_tcm_2021_04_002 crossref_primary_10_5853_jos_2013_15_1_27 crossref_primary_10_1164_rccm_200810_1540OC crossref_primary_10_2459_JCM_0000000000001396 crossref_primary_10_3109_10408363_2014_992063 crossref_primary_10_1186_s12881_019_0910_z crossref_primary_10_3109_0886022X_2012_696469 crossref_primary_10_1093_eurheartj_ehae557 crossref_primary_10_1093_eurheartj_ehw028 crossref_primary_10_1373_clinchem_2015_249680 crossref_primary_10_1111_joim_12862 crossref_primary_10_2337_db08_1788 crossref_primary_10_1016_j_jjcc_2018_04_007 crossref_primary_10_1007_s40471_017_0128_6 crossref_primary_10_1016_j_bcp_2011_01_021 crossref_primary_10_1210_jc_2012_1563 crossref_primary_10_1161_CIRCULATIONAHA_109_907212 crossref_primary_10_1007_s12265_012_9420_5 crossref_primary_10_1016_j_jacc_2012_02_043 crossref_primary_10_1111_j_1538_7836_2010_03903_x crossref_primary_10_1212_WNL_0b013e3181d7b45b crossref_primary_10_1007_s00125_010_1742_8 crossref_primary_10_1007_s12181_009_0159_4 crossref_primary_10_1186_s12882_020_01935_1 crossref_primary_10_3945_ajcn_115_118216 crossref_primary_10_1016_j_ijcard_2013_07_113 crossref_primary_10_1371_journal_pone_0194991 crossref_primary_10_23736_S2724_5683_24_06477_9 crossref_primary_10_1152_physrev_00047_2009 crossref_primary_10_2165_1153161_S0_000000000_00000 crossref_primary_10_1378_chest_09_1677 crossref_primary_10_1016_j_clinthera_2014_10_003 crossref_primary_10_1097_FPC_0b013e32833042cb crossref_primary_10_1161_CIRCULATIONAHA_115_018381 crossref_primary_10_1161_CIRCRESAHA_116_308398 crossref_primary_10_1093_humrep_des416 crossref_primary_10_1161_ATVBAHA_110_204669 crossref_primary_10_1007_s11886_022_01698_1 crossref_primary_10_1186_s12933_022_01585_7 crossref_primary_10_1093_ehjci_jeae314 crossref_primary_10_1016_S0716_8640_12_70366_8 crossref_primary_10_1016_S2213_8587_13_70200_6 crossref_primary_10_1161_ATVBAHA_115_306958 crossref_primary_10_1161_JAHA_117_007490 crossref_primary_10_1093_infdis_jiaa246 crossref_primary_10_1038_nrneph_2011_62 crossref_primary_10_1016_j_jacc_2009_02_047 crossref_primary_10_1161_CIRCGENETICS_110_958603 crossref_primary_10_1161_HYPERTENSIONAHA_110_155077 crossref_primary_10_3390_brainsci13040658 crossref_primary_10_1021_acs_biomac_1c00085 crossref_primary_10_1016_S0140_6736_09_61717_7 crossref_primary_10_1097_MCO_0000000000000999 crossref_primary_10_1016_j_cell_2012_03_001 crossref_primary_10_1039_C4IB00025K crossref_primary_10_1136_jmedgenet_2013_101908 crossref_primary_10_1016_j_atherosclerosis_2022_11_016 crossref_primary_10_1111_j_1755_5922_2009_00128_x crossref_primary_10_1002_acr_20052 crossref_primary_10_1016_j_jacc_2012_07_045 crossref_primary_10_1007_s10753_013_9604_4 crossref_primary_10_3390_jcm11071762 crossref_primary_10_1016_S0828_282X_10_71060_6 crossref_primary_10_1152_ajpendo_00351_2009 crossref_primary_10_1007_s00125_009_1486_5 crossref_primary_10_1371_journal_pone_0053030 crossref_primary_10_1038_labinvest_2011_42 crossref_primary_10_1158_1078_0432_CCR_10_1359 crossref_primary_10_3109_00365510903518191 crossref_primary_10_1016_j_cca_2009_05_024 crossref_primary_10_1111_j_1532_5415_2009_02625_x crossref_primary_10_1177_247553031117a00105 crossref_primary_10_1016_j_jacc_2009_12_047 crossref_primary_10_1093_eurheartj_ehz455 crossref_primary_10_1161_CIRCRESAHA_110_217992 crossref_primary_10_1177_247553031117a00103 crossref_primary_10_18502_sjms_v13i4_3641 crossref_primary_10_1016_S0145_4145_09_79525_5 crossref_primary_10_3390_jcm11071771 crossref_primary_10_1155_2021_3090120 crossref_primary_10_2169_internalmedicine_49_4211 crossref_primary_10_1210_clinem_dgaf106 crossref_primary_10_1007_s11883_009_0028_4 crossref_primary_10_1161_ATVBAHA_120_314983 crossref_primary_10_2174_1874192401004010038 crossref_primary_10_1111_j_1747_4949_2009_00284_x crossref_primary_10_1586_erc_11_159 crossref_primary_10_1097_SHK_0000000000001118 crossref_primary_10_1007_s10096_010_0978_z crossref_primary_10_1016_j_atherosclerosis_2014_01_049 crossref_primary_10_2215_CJN_03090509 crossref_primary_10_1192_bjp_bp_114_150870 crossref_primary_10_1016_S0828_282X_10_71061_8 crossref_primary_10_1093_ije_dyu215 crossref_primary_10_1194_jlr_R067314 crossref_primary_10_1152_ajprenal_00368_2017 crossref_primary_10_1016_j_jacc_2010_06_015 crossref_primary_10_1080_07853890_2016_1197413 crossref_primary_10_1016_j_jdiacomp_2019_107413 crossref_primary_10_1111_j_1365_2362_2010_02360_x crossref_primary_10_1038_s41598_020_62391_3 crossref_primary_10_1681_ASN_2010090987 crossref_primary_10_1016_j_preteyeres_2009_08_001 crossref_primary_10_1016_j_atherosclerosis_2014_01_054 crossref_primary_10_3109_07853890_2011_582511 crossref_primary_10_1016_j_ejphar_2015_04_010 crossref_primary_10_1164_rccm_201702_0405CP crossref_primary_10_4103_sjamf_sjamf_100_20 crossref_primary_10_1161_CIRCGENETICS_110_957431 crossref_primary_10_5551_jat_11999 crossref_primary_10_1002_alz_12568 crossref_primary_10_1002_alz_12688 crossref_primary_10_1016_j_atherosclerosis_2011_01_005 crossref_primary_10_3390_antibiotics12040738 crossref_primary_10_1016_j_amjcard_2010_07_044 crossref_primary_10_1016_j_cjca_2015_03_023 crossref_primary_10_1007_s10753_009_9178_3 crossref_primary_10_1016_j_atherosclerosis_2014_07_036 crossref_primary_10_1016_j_nlm_2017_10_008 crossref_primary_10_1016_j_jstrokecerebrovasdis_2015_06_039 crossref_primary_10_1155_2012_982683 crossref_primary_10_1007_s00441_010_1018_0 crossref_primary_10_2147_JIR_S466469 crossref_primary_10_2459_JCM_0000000000000229 crossref_primary_10_1016_j_cca_2018_02_025 crossref_primary_10_1161_HYPERTENSIONAHA_109_143982 crossref_primary_10_1164_rccm_200906_0963OC crossref_primary_10_1586_14789450_2014_933673 crossref_primary_10_1093_infdis_jiw173 crossref_primary_10_1016_j_atherosclerosis_2019_08_014 crossref_primary_10_1093_cvr_cvae034 crossref_primary_10_1038_nrneph_2011_2 crossref_primary_10_1016_S0749_4041_08_79107_3 crossref_primary_10_1093_eurheartj_ehp454 crossref_primary_10_1111_j_1525_139X_2009_00596_x crossref_primary_10_1373_clinchem_2009_139964 crossref_primary_10_1016_j_ghir_2010_02_002 crossref_primary_10_1016_j_ijcard_2012_03_040 crossref_primary_10_1016_j_jcin_2010_12_016 crossref_primary_10_1038_ijo_2010_137 crossref_primary_10_1016_j_amjcard_2018_01_004 crossref_primary_10_1038_s41598_017_08696_2 crossref_primary_10_1111_joim_13437 crossref_primary_10_1111_j_1365_2796_2012_02576_x crossref_primary_10_1136_bmjopen_2022_062352 crossref_primary_10_1016_j_rccar_2019_11_007 crossref_primary_10_2215_CJN_02720409 crossref_primary_10_1134_S2079086415040027 crossref_primary_10_1186_1471_2350_11_157 crossref_primary_10_1373_clinchem_2010_146530 crossref_primary_10_1186_s12916_018_1029_3 crossref_primary_10_1016_j_jacc_2010_06_045 crossref_primary_10_1093_gerona_glab190 crossref_primary_10_1161_JAHA_115_002497 crossref_primary_10_1097_CRD_0000000000000006 crossref_primary_10_2217_pme_12_34 crossref_primary_10_1161_CIRCGENETICS_109_880955 crossref_primary_10_3390_jcm12030965 crossref_primary_10_1179_1077352512Z_0000000008 crossref_primary_10_1016_j_amjcard_2014_04_048 crossref_primary_10_1016_j_cjca_2012_06_025 crossref_primary_10_5301_heartint_5000218 crossref_primary_10_1038_cr_2014_7 crossref_primary_10_1097_CM9_0000000000000530 crossref_primary_10_1016_j_jtho_2017_07_008 crossref_primary_10_1111_1756_185X_12356 crossref_primary_10_1038_nrcardio_2016_185 crossref_primary_10_1245_s10434_011_1575_9 crossref_primary_10_1016_j_atherosclerosis_2022_03_022 crossref_primary_10_1016_j_cmpb_2017_02_001 crossref_primary_10_1210_clinem_dgab095 crossref_primary_10_1111_j_1538_7836_2010_04110_x crossref_primary_10_1007_s00439_009_0654_5 crossref_primary_10_1016_j_hrtlng_2024_10_011 crossref_primary_10_1056_NEJMc1213688 crossref_primary_10_1093_ije_dyr036 crossref_primary_10_1016_j_jacc_2024_02_053 crossref_primary_10_2459_JCM_0b013e3283577170 crossref_primary_10_1016_j_jacc_2015_11_037 crossref_primary_10_1371_journal_pmed_1001976 crossref_primary_10_1371_journal_pone_0175507 crossref_primary_10_1210_jc_2014_3677 crossref_primary_10_1111_j_1365_2796_2011_02447_x crossref_primary_10_1093_hmg_ddt355 crossref_primary_10_1016_j_jacc_2010_02_066 crossref_primary_10_1586_erc_09_166 crossref_primary_10_4049_jimmunol_2200831 crossref_primary_10_1186_s12933_024_02207_0 crossref_primary_10_1093_eurheartj_ehq103 crossref_primary_10_1016_j_bbi_2017_08_022 crossref_primary_10_1007_s11883_011_0164_5 crossref_primary_10_1016_j_tcm_2009_12_003 crossref_primary_10_1371_journal_pmed_1001866 crossref_primary_10_1111_j_1365_2265_2011_04045_x crossref_primary_10_1007_s00281_017_0632_2 crossref_primary_10_1136_openhrt_2014_000152 crossref_primary_10_1007_s00296_011_2198_y crossref_primary_10_1007_s11883_024_01259_7 crossref_primary_10_1016_j_acvd_2010_03_001 crossref_primary_10_1161_ATVBAHA_110_205377 crossref_primary_10_1007_s11886_014_0513_4 crossref_primary_10_1016_j_cjca_2010_12_040 crossref_primary_10_1530_EJE_10_0277 crossref_primary_10_1007_s10620_020_06717_1 crossref_primary_10_1186_1471_2350_12_65 crossref_primary_10_1017_S0950268820000291 crossref_primary_10_1210_jc_2014_1161 crossref_primary_10_1016_j_jacc_2011_11_019 crossref_primary_10_1111_j_1742_7843_2010_00548_x crossref_primary_10_3109_10408363_2011_599831 crossref_primary_10_1016_j_yjmcc_2009_01_002 crossref_primary_10_1016_j_encep_2019_10_001 crossref_primary_10_2459_JCM_0b013e32834102ab crossref_primary_10_1253_circj_CJ_14_0985 crossref_primary_10_1053_j_ackd_2011_09_004 crossref_primary_10_1002_oby_21554 crossref_primary_10_1111_j_1365_2796_2009_02137_x crossref_primary_10_1111_sdi_12440 crossref_primary_10_1185_03007990802643557 crossref_primary_10_1007_s12072_010_9200_8 crossref_primary_10_1161_ATVBAHA_111_237271 crossref_primary_10_1590_s1679_45082011rw1953 crossref_primary_10_1016_j_trsl_2010_12_014 crossref_primary_10_1007_s11010_013_1828_y crossref_primary_10_1007_s00134_022_06778_y crossref_primary_10_1093_jnci_djp459 crossref_primary_10_1089_jir_2024_0163 crossref_primary_10_15252_emmm_201506174 crossref_primary_10_1074_jbc_M114_555318 crossref_primary_10_1161_CIRCGENETICS_111_959809 crossref_primary_10_1111_joim_13368 crossref_primary_10_1097_QAD_0000000000001954 crossref_primary_10_1210_clinem_dgac146 crossref_primary_10_2174_1568026623666230718141235 crossref_primary_10_3945_ajcn_114_104497 crossref_primary_10_1016_j_eprac_2022_08_002 crossref_primary_10_1016_j_jacc_2008_12_047 crossref_primary_10_1200_JCO_2010_32_9870 crossref_primary_10_1053_j_ajkd_2013_11_010 crossref_primary_10_1155_2014_561428 crossref_primary_10_1002_jbmr_3937 crossref_primary_10_1093_eurheartj_ehq238 crossref_primary_10_1111_j_1399_5448_2010_00660_x crossref_primary_10_1093_hmg_ddu450 crossref_primary_10_1093_eurjpc_zwad116 crossref_primary_10_1371_journal_pone_0151636 crossref_primary_10_1038_s41598_020_63051_2 crossref_primary_10_17116_jnevro202112108211 crossref_primary_10_1002_art_27325 crossref_primary_10_1161_CIRCRESAHA_115_306566 crossref_primary_10_1161_CIRCGENETICS_110_957399 crossref_primary_10_1111_ane_12180 crossref_primary_10_1155_2011_180729 crossref_primary_10_1016_j_metabol_2022_155179 crossref_primary_10_1016_j_jacc_2008_11_050 crossref_primary_10_1016_j_atherosclerosis_2021_04_013 crossref_primary_10_14336_AD_2018_0329 crossref_primary_10_1002_hep_26563 crossref_primary_10_1039_b925612a crossref_primary_10_1038_ncpcardio1425 crossref_primary_10_1093_ije_dyu119 crossref_primary_10_1371_journal_pone_0023890 crossref_primary_10_3760_cma_j_issn_0366_6999_20131485 crossref_primary_10_1097_MOL_0b013e3283307bfe crossref_primary_10_1177_0003319713502719 crossref_primary_10_1007_s12170_010_0099_3 crossref_primary_10_1371_journal_pone_0022318 crossref_primary_10_1007_s00395_009_0026_2 crossref_primary_10_1146_annurev_genom_082509_141637 crossref_primary_10_1093_eurheartj_ehq022 crossref_primary_10_1038_ncpendmet1029 crossref_primary_10_1016_j_atherosclerosis_2009_01_013 crossref_primary_10_1161_ATVBAHA_111_238030 crossref_primary_10_3389_fimmu_2024_1410871 crossref_primary_10_3109_10253890_2010_515273 crossref_primary_10_1007_s11883_012_0308_2 crossref_primary_10_3390_antiox13101180 crossref_primary_10_1183_09031936_00176811 crossref_primary_10_1093_eurjpc_zwab089 crossref_primary_10_1093_ndt_gfp237 crossref_primary_10_1161_CIRCGENETICS_116_001530 crossref_primary_10_4065_mcp_2010_0708 crossref_primary_10_2214_AJR_12_9773 crossref_primary_10_1038_ncomms8060 crossref_primary_10_1016_j_humimm_2010_01_008 crossref_primary_10_1016_j_jhep_2012_08_013 crossref_primary_10_1016_j_sciaf_2024_e02204 crossref_primary_10_1093_ajh_hpu029 crossref_primary_10_1155_2014_979132 crossref_primary_10_1159_000447558 crossref_primary_10_1093_eurjpc_zwaf110 crossref_primary_10_1681_ASN_2016010098 crossref_primary_10_1002_hep_24046 crossref_primary_10_1016_j_repc_2021_11_009 crossref_primary_10_1126_scitranslmed_aad3744 crossref_primary_10_1161_ATVBAHA_110_219329 crossref_primary_10_1161_CIRCRESAHA_121_319077 crossref_primary_10_1016_j_thromres_2009_04_008 crossref_primary_10_1093_ije_dyv108 crossref_primary_10_1093_ije_dyw325 crossref_primary_10_1093_schbul_sbt120 crossref_primary_10_1080_00365510903056015 crossref_primary_10_3389_fimmu_2018_00511 crossref_primary_10_1586_erc_09_93 crossref_primary_10_3109_10641963_2010_531837 crossref_primary_10_1371_journal_pmed_1000356 crossref_primary_10_1371_journal_pone_0112279 crossref_primary_10_2337_dc12_0082 crossref_primary_10_1089_jir_2011_0022 crossref_primary_10_1161_STROKEAHA_110_588954 crossref_primary_10_1097_MOL_0b013e32832b7154 crossref_primary_10_1016_j_jacasi_2021_11_014 crossref_primary_10_1373_clinchem_2014_229096 crossref_primary_10_1161_CIRCRESAHA_118_311362 crossref_primary_10_1038_nri_2016_63 crossref_primary_10_1093_ije_dyu153 crossref_primary_10_1186_s12263_017_0587_x crossref_primary_10_1093_ije_dyw330 crossref_primary_10_1016_j_atherosclerosis_2011_01_049 crossref_primary_10_2217_bmm_09_57 crossref_primary_10_1371_journal_pmed_1001212 crossref_primary_10_1016_j_numecd_2010_11_003 crossref_primary_10_1016_j_cjca_2012_09_014 crossref_primary_10_1093_cvr_cvy045 crossref_primary_10_1016_j_berh_2024_101967 crossref_primary_10_1371_journal_pone_0077913 crossref_primary_10_1586_ecp_10_51 crossref_primary_10_1093_ndt_gfq098 crossref_primary_10_3389_fcvm_2019_00016 crossref_primary_10_1038_oby_2011_164 crossref_primary_10_1042_CS20100504 crossref_primary_10_1002_clc_20681 crossref_primary_10_1016_j_psyneuen_2020_104654 crossref_primary_10_1111_1756_185X_13180 crossref_primary_10_1161_ATVBAHA_109_198473 crossref_primary_10_3389_fcvm_2018_00057 crossref_primary_10_1016_j_atherosclerosis_2017_09_019 crossref_primary_10_1161_CIRCULATIONAHA_109_912568 crossref_primary_10_1186_s12882_017_0624_4 crossref_primary_10_1097_QAI_0000000000001795 crossref_primary_10_1210_jc_2009_1887 crossref_primary_10_1016_j_atherosclerosis_2024_117461 crossref_primary_10_1155_2013_379040 crossref_primary_10_1097_HCO_0000000000000625 crossref_primary_10_4070_kcj_2012_42_3_151 crossref_primary_10_1007_s40572_019_0226_3 crossref_primary_10_1371_journal_pgen_1003063 crossref_primary_10_1016_S0300_8932_10_70140_8 crossref_primary_10_1530_EJE_11_1009 crossref_primary_10_1186_s12944_015_0054_x crossref_primary_10_1111_prd_12299 crossref_primary_10_1038_ng_2566 crossref_primary_10_1186_1471_2377_9_18 crossref_primary_10_1038_ijir_2014_26 crossref_primary_10_1016_j_gene_2012_09_107 crossref_primary_10_2217_fca_09_8 crossref_primary_10_1016_j_clim_2024_110281 crossref_primary_10_1111_bjh_12099 crossref_primary_10_1016_j_ymgme_2011_11_198 crossref_primary_10_1161_ATVBAHA_112_251306 crossref_primary_10_1016_j_jpainsymman_2015_11_025 crossref_primary_10_1148_radiol_14130772 crossref_primary_10_1177_1741826710394274 crossref_primary_10_1016_j_jalz_2015_04_006 crossref_primary_10_1016_j_jad_2011_06_033 crossref_primary_10_1016_S0992_5945_09_70010_8 crossref_primary_10_1371_journal_pone_0102418 crossref_primary_10_1373_clinchem_2008_119214 crossref_primary_10_1161_JAHA_116_005077 crossref_primary_10_1016_S0140_6736_09_61227_7 crossref_primary_10_1093_aje_kwr235 crossref_primary_10_1200_JCO_2009_27_0454 crossref_primary_10_3389_fneur_2021_662510 crossref_primary_10_1373_clinchem_2013_219881 crossref_primary_10_1371_journal_pone_0190528 crossref_primary_10_1016_j_gene_2015_05_052 crossref_primary_10_1097_MD_0000000000030221 crossref_primary_10_31083_j_rcm2401010 crossref_primary_10_1093_jnci_djr008 crossref_primary_10_1016_j_eururo_2013_01_028 crossref_primary_10_1111_j_1538_7836_2010_04086_x crossref_primary_10_1111_ene_14113 crossref_primary_10_1016_j_diabet_2011_11_006 crossref_primary_10_1016_j_amjcard_2010_01_352 crossref_primary_10_1186_bcr2891 crossref_primary_10_1161_CIRCRESAHA_116_304846 crossref_primary_10_17116_jnevro202212212212 crossref_primary_10_1111_j_1365_2796_2010_02232_x crossref_primary_10_1016_j_numecd_2009_07_005 crossref_primary_10_1186_s12872_024_03870_7 crossref_primary_10_3109_1354750X_2011_651158 crossref_primary_10_25005_2074_0581_2020_22_2_241_245 crossref_primary_10_1371_journal_pmed_1000286 crossref_primary_10_1373_clinchem_2011_165712 crossref_primary_10_1016_S1131_3587_09_71502_X crossref_primary_10_1002_art_42236 crossref_primary_10_1016_j_atherosclerosis_2010_07_049 crossref_primary_10_1161_JAHA_115_002823 crossref_primary_10_1164_rccm_201206_1013OC crossref_primary_10_3390_cells12131775 crossref_primary_10_1212_WNL_0000000000009631 crossref_primary_10_1007_s11936_013_0268_z crossref_primary_10_1016_j_atherosclerosis_2011_06_001 crossref_primary_10_1515_jom_2021_0103 crossref_primary_10_1136_thoraxjnl_2015_207561 crossref_primary_10_1371_journal_pone_0006590 crossref_primary_10_1111_eci_12027 crossref_primary_10_1590_S0100_69912014000300006 crossref_primary_10_1016_j_dib_2016_01_060 crossref_primary_10_1093_ije_dyw147 crossref_primary_10_1038_hr_2012_126 crossref_primary_10_1093_eurheartj_ehs168 crossref_primary_10_1016_j_ijcard_2016_07_061 crossref_primary_10_1016_j_eurpsy_2011_07_003 crossref_primary_10_1007_s00391_011_0198_x crossref_primary_10_1016_j_jns_2009_04_018 crossref_primary_10_1016_j_acmx_2013_08_004 crossref_primary_10_1038_nrcardio_2010_223 crossref_primary_10_4070_kcj_2013_43_10_664 crossref_primary_10_1016_j_ijcard_2018_01_046 crossref_primary_10_1177_0003319710398010 crossref_primary_10_3389_fonc_2024_1450326 crossref_primary_10_1007_s00059_009_3305_7 crossref_primary_10_1056_NEJMe0807235 crossref_primary_10_1016_j_amjcard_2014_08_013 crossref_primary_10_1007_s11886_009_0065_1 crossref_primary_10_1177_2047487320937491 crossref_primary_10_1007_s00198_013_2578_0 crossref_primary_10_1111_j_1365_2125_2012_04219_x crossref_primary_10_1161_STROKEAHA_109_567768 crossref_primary_10_1093_eurheartj_eht481 crossref_primary_10_1161_CIRCULATIONAHA_109_872796 crossref_primary_10_1016_j_jacc_2024_12_033 crossref_primary_10_1161_CIRCHEARTFAILURE_119_006414 crossref_primary_10_1111_eci_12002 crossref_primary_10_4061_2011_529061 crossref_primary_10_1161_CIRCULATIONAHA_109_934620 crossref_primary_10_1007_s10753_014_9897_y crossref_primary_10_1161_STROKEAHA_116_012901 crossref_primary_10_1016_j_eclinm_2020_100280 crossref_primary_10_1097_MOL_0b013e32834477d2 crossref_primary_10_1146_annurev_med_080819_044918 crossref_primary_10_2215_CJN_01900309 crossref_primary_10_1515_CCLM_2009_257 crossref_primary_10_1111_tri_13425 crossref_primary_10_1089_ars_2008_2381 crossref_primary_10_1161_CIRCRESAHA_115_306656 crossref_primary_10_1093_eurheartj_ehv213 crossref_primary_10_1093_ije_dyv078 crossref_primary_10_1097_MAJ_0b013e31828aab45 crossref_primary_10_1016_j_jacc_2013_05_016 crossref_primary_10_1586_erc_10_18 crossref_primary_10_1161_ATVBAHA_111_223867 crossref_primary_10_1056_NEJMc082413 crossref_primary_10_1002_ijc_25375 crossref_primary_10_1097_HCO_0b013e3283398e53 crossref_primary_10_1371_journal_pone_0135894 crossref_primary_10_31744_einstein_journal_2019AO4399 crossref_primary_10_1093_eurheartj_ehad649 crossref_primary_10_1007_s00125_019_05024_3 crossref_primary_10_1017_S0007114515000902 crossref_primary_10_1093_ije_dyn353 crossref_primary_10_1161_ATVBAHA_112_300350 crossref_primary_10_1007_s40620_014_0116_6 crossref_primary_10_1038_s41398_020_0696_y crossref_primary_10_1093_cvr_cvab337 crossref_primary_10_1161_ATVBAHA_113_301736 crossref_primary_10_1038_nrd3444 crossref_primary_10_1093_ije_dyx147 crossref_primary_10_1093_ije_dyv083 crossref_primary_10_1155_2022_7480579 crossref_primary_10_1001_jamacardio_2023_4115 crossref_primary_10_1093_ntr_nty077 crossref_primary_10_4330_wjc_v2_i11_365 crossref_primary_10_1016_j_eururo_2011_11_007 crossref_primary_10_1016_j_jim_2019_04_009 crossref_primary_10_1038_nrcardio_2017_78 crossref_primary_10_1161_CIRCULATIONAHA_113_003008 |
| Cites_doi | 10.1161/01.CIR.0000053730.47739.3C 10.1056/NEJMoa032804 10.1007/0-387-21645-6_9 10.1093/ije/dyl041 10.1016/0140-6736(90)90878-9 10.1007/s00109-005-0658-0 10.1161/STROKEAHA.107.482661 10.1161/01.STR.0000231872.86071.68 10.1093/rheumatology/keh613 10.1038/ng.76 10.1001/jama.299.21.2524 10.1001/archinte.165.21.2479 10.1007/s11883-006-0040-x 10.1152/ajpheart.01164.2005 10.1093/eurheartj/ehl018 10.1038/ng.75 10.1093/oxfordjournals.aje.a010013 10.1086/431366 10.1001/jama.296.22.2703 10.1001/jama.298.3.309 10.1001/jama.298.3.299 10.1196/annals.1354.036 10.1016/j.atherosclerosis.2004.08.018 10.1161/CIRCULATIONAHA.106.643114 10.1053/euhj.2001.2842 10.1016/j.atherosclerosis.2007.09.031 10.1016/S0021-9150(01)00703-1 10.1161/01.STR.0000140740.19421.fe 10.1016/j.jacc.2006.09.030 10.1111/j.1529-8817.2005.00210.x 10.1093/ije/dyg070 10.1016/S0735-1097(00)00520-9 10.1093/ije/dyh132 10.1161/CIRCULATIONAHA.105.591271 10.1093/aje/kwj062 10.7326/0003-4819-127-5-199709010-00002 |
| ContentType | Journal Article |
| Copyright | Copyright © 2008 Massachusetts Medical Society. All rights reserved. 2008 INIST-CNRS 2008 Massachusetts Medical Society |
| Copyright_xml | – notice: Copyright © 2008 Massachusetts Medical Society. All rights reserved. – notice: 2008 INIST-CNRS – notice: 2008 Massachusetts Medical Society |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7RV 7X7 7XB 8AO 8C1 8FE 8FH 8FI ABUWG AFKRA AN0 AZQEC BBNVY BEC BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ GUQSH HCIFZ K0Y LK8 M0R M0T M1P M2M M2O M2P M7P MBDVC NAPCQ PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PSYQQ Q9U 7X8 |
| DOI | 10.1056/NEJMoa0707402 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Nursing & Allied Health Database Health & Medical Collection ProQuest Central (purchase pre-March 2016) ProQuest Pharma Collection Public Health Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection ProQuest Central (Alumni) ProQuest Central UK/Ireland British Nursing Database ProQuest Central Essentials - QC Biological Science Collection eLibrary ProQuest Central Natural Science Collection ProQuest One ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Research Library SciTech Premium Collection New England Journal of Medicine ProQuest Biological Science Collection Consumer Health Database Healthcare Administration Database Medical Database Psychology Database Research Library Science Database Biological Science Database Research Library (Corporate) Nursing & Allied Health Premium ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology ProQuest Central Basic MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest One Psychology Research Library Prep ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials elibrary ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing New England Journal of Medicine ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Health Research Premium Collection Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Research Library ProQuest Central (New) ProQuest Public Health ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest Family Health ProQuest One Academic Eastern Edition British Nursing Index with Full Text ProQuest Health Management ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest Medical Library ProQuest Psychology Journals ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE ProQuest One Psychology MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1533-4406 |
| EndPage | 1908 |
| ExternalDocumentID | 1586781111 18971492 20811071 10_1056_NEJMoa0707402 NJ200810303591807 |
| Genre | Original Article Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | - 0R 0WA 123 186 1AW 1KJ 1VV 29N 2KS 2WC 34G 39C 3O- 3V. 4 4.4 53G 55 5D0 5RE 68V 7FN 7RV 7X7 85S 8AO 8C1 8FE 8FH 8FI 8RP AACLI AAEJM AAIKC AALRV AAPBV AAQQT AARDX AASXA AAWTL ABACO ABEFU ABEHJ ABFLS ABIVO ABOCM ABPPZ ABPTK ABQES ABQIJ ABUFD ABUWG ABWJO ACDCL ACGFS ACGOD ACJLH ACNCT ACPRK ACRZS ACVYA ADBBV ADCBC AENEX AETEA AFDAS AFFNX AFKRA AFMIJ AGNAY AHMBA AHVBC AIKQT AJJEV AJUXI AJYGW ALMA_UNASSIGNED_HOLDINGS AN0 AQUVI AZQEC BBAFP BBNVY BCR BCU BENPR BES BHPHI BKEYQ BKNYI BLC BNQBC BPHCQ BVXVI C45 CJ0 CO CS3 DCD DU5 DWQXO DZ EBS EJD ET EX3 F20 F5P FD8 FM. FYUFA G8K GJ GNUQQ GUQSH H13 HCIFZ HZ IH2 J5H K-O K78 KM KOO L7B LK8 M0R M0T M1P M2M M2O M2P M7P MBDVC MVM N9A NEJ O0- O9- OHM OHT OK1 OMK OVD P-O P2P PADUT PCD PEA PQEST PQQKQ PQUKI PRINS PROAC PSQYO QJJ RHI RWL RXW S6N SJFOW SJN SKT TAE TAF TN5 TWZ U1N UCV UKR UMD UQL VQA W2G WH7 WOQ WOW X X7M XJT XYN XZL YCJ YNT YZZ ZA5 ZGI ZHY ZKB ZKG ZXP --- -DZ -ET -~X .-4 .55 .CO .GJ 0R~ 36B 6TJ AAMNW AAYOK AAYXX ABBLC ABCQX ABDPE ABDQB ABJNI ACKOT ACPFK ADRHT ADUKH ADXHL AERZD AFOSN AGFXO AGHSJ ALIPV BYPQX CCPQU CITATION HF~ HMCUK HZ~ N4W NAPCQ PHGZM PHGZT PSYQQ TEORI TUQ UKHRP XOL YFH YR2 YR5 YYP ZCA ZR0 ZVN ~KM 1CY 41~ 8WZ 9M8 A6W AAQOH AAUTI ACPVT ACTDY AFFDN AFHKK D0S FA8 IQODW LPU MQT NHB PJZUB PPXIY PQGLB QZG S10 UBX WHG YHZ YQI YQJ YRY YYQ CGR CUY CVF ECM EIF NPM UIG 7XB BEC K0Y PKEHL Q9U 7X8 |
| ID | FETCH-LOGICAL-c574t-e36f60cbcd833c1ec33877e9ee5cc19feebb0fe0fc4d91e2e4d2ce824997b2523 |
| IEDL.DBID | 7X7 |
| ISSN | 0028-4793 1533-4406 |
| IngestDate | Fri Jul 11 01:55:45 EDT 2025 Sat Aug 23 13:03:52 EDT 2025 Thu Apr 03 06:59:11 EDT 2025 Mon Jul 21 09:13:01 EDT 2025 Tue Jul 01 04:06:25 EDT 2025 Thu Apr 24 23:08:45 EDT 2025 Wed Nov 11 00:33:07 EST 2020 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 18 |
| Keywords | Medicine Vascular disease Acute phase protein Ischemia Cardiovascular disease Genetics C reactive protein |
| Language | English |
| License | CC BY 4.0 2008 Massachusetts Medical Society |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c574t-e36f60cbcd833c1ec33877e9ee5cc19feebb0fe0fc4d91e2e4d2ce824997b2523 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-General Information-1 content type line 14 ObjectType-Feature-3 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://www.nejm.org/doi/pdf/10.1056/NEJMoa0707402?articleTools=true |
| PMID | 18971492 |
| PQID | 223926349 |
| PQPubID | 40644 |
| PageCount | 12 |
| ParticipantIDs | proquest_miscellaneous_69725207 proquest_journals_223926349 pubmed_primary_18971492 pascalfrancis_primary_20811071 crossref_citationtrail_10_1056_NEJMoa0707402 crossref_primary_10_1056_NEJMoa0707402 mms_nejm_10_1056_NEJMoa0707402 |
| ProviderPackageCode | DCD 7FN CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2008-10-30 |
| PublicationDateYYYYMMDD | 2008-10-30 |
| PublicationDate_xml | – month: 10 year: 2008 text: 2008-10-30 day: 30 |
| PublicationDecade | 2000 |
| PublicationPlace | Boston, MA |
| PublicationPlace_xml | – name: Boston, MA – name: United States – name: Boston |
| PublicationTitle | The New England journal of medicine |
| PublicationTitleAlternate | N Engl J Med |
| PublicationYear | 2008 |
| Publisher | Massachusetts Medical Society |
| Publisher_xml | – name: Massachusetts Medical Society |
| References | Szalai, AJ, Alarcon, GS, Calvo-Alen, J (r030) 2005; 44 Agerholm-Larsen, B, Tybjaerg-Hansen, A, Frikke-Schmidt, R, Gronholdt, ML, Jensen, G, Nordestgaard, BG (r013) 1997; 127 Zee, RY, Ridker, PM (r022) 2002; 162 Kathiresan, S, Melander, O, Guiducci, C (r031) 2008; 40 Nordestgaard, BG, Benn, M, Schnohr, P, Tybjaerg-Hansen, A (r010) 2007; 298 Clarke, R, Shipley, M, Lewington, S (r016) 1999; 150 Lowe, GD, Pepys, MB (r006) 2006; 8 Flex, A, Gaetani, E, Papaleo, P (r026) 2004; 35 Lange, LA, Carlson, CS, Hindorff, LA (r028) 2006; 296 Frikke-Schmidt, R, Nordestgaard, BG, Stene, MC (r012) 2008; 299 Bis, JC, Heckbert, SR, Smith, NL (r027) 2008; 198 Ladenvall, C, Jood, K, Blomstrand, C, Nilsson, S, Jern, C, Ladenvall, P (r025) 2006; 37 Szalai, AJ, Wu, J, Lange, EM (r034) 2005; 83 Frikke-Schmidt, R, Tybjaerg-Hansen, A, Steffensen, R, Jensen, G, Nordestgaard, BG (r014) 2000; 35 MacMahon, S, Peto, R, Cutler, J (r017) 1990; 335 Wang, Q, Hunt, SC, Xu, Q (r019) 2006; 291 Refinements of the semiparametric proportional hazards model. In: Klein JP, Moeschberger ML. Survival analysis: techniques for censored and truncated data. 2nd ed. New York: Springer-Verlag, 2003:295-325. Miller, DT, Zee, RY, Suk, DJ (r008) 2005; 69 Reitz, C, Berger, K, de Maat, MP (r024) 2007; 38 Everett, BM, Kurth, T, Buring, JE, Ridker, PM (r003) 2006; 48 Danesh, J, Wheeler, JG, Hirschfield, GM (r002) 2004; 350 Ballantyne, CM, Hoogeveen, RC, Bang, H (r004) 2005; 165 Smith, GD, Ebrahim, S (r007) 2004; 33 Kovacs, A, Green, F, Hansson, LO (r021) 2005; 178 Carlson, CS, Aldred, SF, Lee, PK (r009) 2005; 77 Balistreri, CR, Vasto, S, Listi, F (r029) 2006; 1067 Nitsch, D, Molokhia, M, Smeeth, L, DeStavola, BL, Whittaker, JC, Leon, DA (r036) 2006; 163 Sattar, N, Murray, HM, McConnachie, A (r005) 2007; 115 Willer, CJ, Sanna, S, Jackson, AU (r032) 2008; 40 Ridker, PM (r001) 2003; 107 Kardys, I, de Maat, MP, Uitterlinden, AG, Hofman, A, Witteman, JC (r020) 2006; 27 Casas, JP, Shah, T, Cooper, J (r018) 2006; 35 Bansal, S, Buring, JE, Rifai, N, Mora, S, Sacks, FM, Ridker, PM (r033) 2007; 298 Davey Smith, G, Ebrahim, S (r035) 2003; 32 Schnohr, P, Jensen, JS, Scharling, H, Nordestgaard, BG (r011) 2002; 23 Kathiresan, S, Larson, MG, Vasan, RS (r023) 2006; 113 r020 r021 r022 r001 r023 r017 r018 r019 r035 r014 r036 r015 Clarke R (r016) 1999; 150 r031 r010 r032 r011 r033 r012 r034 r030 r006 r028 r007 r029 r008 r009 r002 r024 r003 r025 r004 r026 r005 r027 Agerholm-Larsen B (r013) 1997; 127 19246369 - N Engl J Med. 2009 Feb 26;360(9):933; author reply 934-5 18971498 - N Engl J Med. 2008 Oct 30;359(18):1953-5 19256031 - N Engl J Med. 2009 Feb 26;360(9):934; author reply 934-5 19256030 - N Engl J Med. 2009 Feb 26;360(9):933-4; author reply 934-5 19500486 - Curr Atheroscler Rep. 2009 Jul;11(4):245 |
| References_xml | – volume: 48 start-page: 2235 year: 2006 end-page: 2242 ident: r003 article-title: The relative strength of C-reactive protein and lipid levels as determinants of ischemic stroke compared with coronary heart disease in women. publication-title: J Am Coll Cardiol – volume: 335 start-page: 765 year: 1990 end-page: 774 ident: r017 article-title: Blood pressure, stroke, and coronary heart disease. Part 1. Prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias. publication-title: Lancet – volume: 107 start-page: 363 year: 2003 end-page: 369 ident: r001 article-title: Clinical application of C-reactive protein for cardiovascular disease detection and prevention. publication-title: Circulation – volume: 163 start-page: 397 year: 2006 end-page: 403 ident: r036 article-title: Limits to causal inference based on Mendelian randomization: a comparison with randomized controlled trials. publication-title: Am J Epidemiol – volume: 33 start-page: 30 year: 2004 end-page: 42 ident: r007 article-title: Mendelian randomization: prospects, potentials, and limitations. publication-title: Int J Epidemiol – volume: 296 start-page: 2703 year: 2006 end-page: 2711 ident: r028 article-title: Association of polymorphisms in the CRP gene with circulating C-reactive protein levels and cardiovascular events. publication-title: JAMA – volume: 40 start-page: 189 year: 2008 end-page: 197 ident: r031 article-title: Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. publication-title: Nat Genet – volume: 27 start-page: 1331 year: 2006 end-page: 1337 ident: r020 article-title: C-reactive protein gene haplotypes and risk of coronary heart disease: the Rotterdam Study. publication-title: Eur Heart J – volume: 162 start-page: 217 year: 2002 end-page: 219 ident: r022 article-title: Polymorphism in the human C-reactive protein (CRP) gene, plasma concentrations of CRP, and the risk of future arterial thrombosis. publication-title: Atherosclerosis – volume: 178 start-page: 193 year: 2005 end-page: 198 ident: r021 article-title: A novel common single nucleotide polymorphism in the promoter region of the C-reactive protein gene associated with the plasma concentration of C-reactive protein. publication-title: Atherosclerosis – volume: 350 start-page: 1387 year: 2004 end-page: 1397 ident: r002 article-title: C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. publication-title: N Engl J Med – volume: 35 start-page: 922 year: 2006 end-page: 931 ident: r018 article-title: Insight into the nature of the CRP-coronary event association using Mendelian randomization. publication-title: Int J Epidemiol – volume: 165 start-page: 2479 year: 2005 end-page: 2484 ident: r004 article-title: Lipoprotein-associated phospholipase A2, high-sensitivity C-reactive protein, and risk for incident ischemic stroke in middle-aged men and women in the Atherosclerosis Risk in Communities (ARIC) study. publication-title: Arch Intern Med – volume: 37 start-page: 2018 year: 2006 end-page: 2023 ident: r025 article-title: Serum C-reactive protein concentration and genotype in relation to ischemic stroke subtype. publication-title: Stroke – volume: 77 start-page: 64 year: 2005 end-page: 77 ident: r009 article-title: Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels. publication-title: Am J Hum Genet – volume: 40 start-page: 161 year: 2008 end-page: 169 ident: r032 article-title: Newly identified loci that influence lipid concentrations and risk of coronary artery disease. publication-title: Nat Genet – reference: Refinements of the semiparametric proportional hazards model. In: Klein JP, Moeschberger ML. Survival analysis: techniques for censored and truncated data. 2nd ed. New York: Springer-Verlag, 2003:295-325. – volume: 83 start-page: 440 year: 2005 end-page: 447 ident: r034 article-title: Single-nucleotide polymorphisms in the C-reactive protein (CRP) gene promoter that affect transcription factor binding, alter transcriptional activity, and associate with differences in baseline serum CRP level. publication-title: J Mol Med – volume: 298 start-page: 299 year: 2007 end-page: 308 ident: r010 article-title: Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. publication-title: JAMA – volume: 35 start-page: 2270 year: 2004 end-page: 2275 ident: r026 article-title: Proinflammatory genetic profiles in subjects with history of ischemic stroke. publication-title: Stroke – volume: 44 start-page: 864 year: 2005 end-page: 868 ident: r030 article-title: Systemic lupus erythematosus in a multiethnic US cohort (LUMINA). XXX: association between C-reactive protein (CRP) gene polymorphisms and vascular events. publication-title: Rheumatology (Oxford) – volume: 69 start-page: 623 year: 2005 end-page: 638 ident: r008 article-title: Association of common CRP gene variants with CRP levels and cardiovascular events. publication-title: Ann Hum Genet – volume: 23 start-page: 620 year: 2002 end-page: 626 ident: r011 article-title: Coronary heart disease risk factors ranked by importance for the individual and community: a 21 year follow-up of 12 000 men and women from the Copenhagen City Heart Study. publication-title: Eur Heart J – volume: 198 start-page: 166 year: 2008 end-page: 173 ident: r027 article-title: Variation in inflammation-related genes and risk of incident nonfatal myocardial infarction or ischemic stroke. publication-title: Atherosclerosis – volume: 8 start-page: 421 year: 2006 end-page: 428 ident: r006 article-title: C-reactive protein and cardiovascular disease: weighing the evidence. publication-title: Curr Atheroscler Rep – volume: 299 start-page: 2524 year: 2008 end-page: 2532 ident: r012 article-title: Association of loss-of-function mutations in the ABCA1 gene with high-density lipoprotein cholesterol levels and risk of ischemic heart disease. publication-title: JAMA – volume: 298 start-page: 309 year: 2007 end-page: 316 ident: r033 article-title: Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women. publication-title: JAMA – volume: 38 start-page: 2356 year: 2007 end-page: 2359 ident: r024 article-title: CRP gene haplotypes, serum CRP, and cerebral small-vessel disease: the Rotterdam Scan Study and the MEMO Study. publication-title: Stroke – volume: 127 start-page: 346 year: 1997 end-page: 355 ident: r013 article-title: ACE gene polymorphism as a risk factor for ischemic cerebrovascular disease. publication-title: Ann Intern Med – volume: 150 start-page: 341 year: 1999 end-page: 353 ident: r016 article-title: Underestimation of risk associations due to regression dilution in long-term follow-up of prospective studies. publication-title: Am J Epidemiol – volume: 291 start-page: H2752 year: 2006 end-page: H2757 ident: r019 article-title: Association study of CRP gene polymorphisms with serum CRP level and cardiovascular risk in the NHLBI Family Heart Study. publication-title: Am J Physiol Heart Circ Physiol – volume: 113 start-page: 1415 year: 2006 end-page: 1423 ident: r023 article-title: Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level. publication-title: Circulation – volume: 32 start-page: 1 year: 2003 end-page: 22 ident: r035 article-title: `Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? publication-title: Int J Epidemiol – volume: 1067 start-page: 276 year: 2006 end-page: 281 ident: r029 article-title: Association between +1059G/C CRP polymorphism and acute myocardial infarction in a cohort of patients from Sicily: a pilot study. publication-title: Ann N Y Acad Sci – volume: 115 start-page: 981 year: 2007 end-page: 989 ident: r005 article-title: C-reactive protein and prediction of coronary heart disease and global vascular events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). publication-title: Circulation – volume: 35 start-page: 1192 year: 2000 end-page: 1199 ident: r014 article-title: Apolipoprotein E genotype: epsilon32 women are protected while epsilon43 and epsilon44 men are susceptible to ischemic heart disease: the Copenhagen City Heart Study. publication-title: J Am Coll Cardiol – ident: r001 doi: 10.1161/01.CIR.0000053730.47739.3C – ident: r002 doi: 10.1056/NEJMoa032804 – ident: r015 doi: 10.1007/0-387-21645-6_9 – ident: r018 doi: 10.1093/ije/dyl041 – ident: r017 doi: 10.1016/0140-6736(90)90878-9 – ident: r034 doi: 10.1007/s00109-005-0658-0 – ident: r024 doi: 10.1161/STROKEAHA.107.482661 – ident: r025 doi: 10.1161/01.STR.0000231872.86071.68 – ident: r030 doi: 10.1093/rheumatology/keh613 – ident: r032 doi: 10.1038/ng.76 – ident: r012 doi: 10.1001/jama.299.21.2524 – ident: r004 doi: 10.1001/archinte.165.21.2479 – ident: r006 doi: 10.1007/s11883-006-0040-x – ident: r019 doi: 10.1152/ajpheart.01164.2005 – ident: r020 doi: 10.1093/eurheartj/ehl018 – ident: r031 doi: 10.1038/ng.75 – volume: 150 start-page: 341 year: 1999 ident: r016 publication-title: Am J Epidemiol doi: 10.1093/oxfordjournals.aje.a010013 – ident: r009 doi: 10.1086/431366 – ident: r028 doi: 10.1001/jama.296.22.2703 – ident: r033 doi: 10.1001/jama.298.3.309 – ident: r010 doi: 10.1001/jama.298.3.299 – ident: r029 doi: 10.1196/annals.1354.036 – ident: r021 doi: 10.1016/j.atherosclerosis.2004.08.018 – ident: r005 doi: 10.1161/CIRCULATIONAHA.106.643114 – ident: r011 doi: 10.1053/euhj.2001.2842 – ident: r027 doi: 10.1016/j.atherosclerosis.2007.09.031 – ident: r022 doi: 10.1016/S0021-9150(01)00703-1 – ident: r026 doi: 10.1161/01.STR.0000140740.19421.fe – ident: r003 doi: 10.1016/j.jacc.2006.09.030 – ident: r008 doi: 10.1111/j.1529-8817.2005.00210.x – ident: r035 doi: 10.1093/ije/dyg070 – ident: r014 doi: 10.1016/S0735-1097(00)00520-9 – ident: r007 doi: 10.1093/ije/dyh132 – ident: r023 doi: 10.1161/CIRCULATIONAHA.105.591271 – ident: r036 doi: 10.1093/aje/kwj062 – volume: 127 start-page: 346 year: 1997 ident: r013 publication-title: Ann Intern Med doi: 10.7326/0003-4819-127-5-199709010-00002 – reference: 19256030 - N Engl J Med. 2009 Feb 26;360(9):933-4; author reply 934-5 – reference: 19256031 - N Engl J Med. 2009 Feb 26;360(9):934; author reply 934-5 – reference: 18971498 - N Engl J Med. 2008 Oct 30;359(18):1953-5 – reference: 19246369 - N Engl J Med. 2009 Feb 26;360(9):933; author reply 934-5 – reference: 19500486 - Curr Atheroscler Rep. 2009 Jul;11(4):245 |
| SSID | ssj0000149 |
| Score | 2.5066812 |
| Snippet | In a study of four cohorts of patients from Denmark, the subjects were typed for four single-nucleotide polymorphisms in the gene for C-reactive protein (CRP).... Elevated levels of C-reactive protein (CRP) are associated with increased risks of ischemic heart disease and ischemic cerebrovascular disease. We tested... Background Elevated levels of C-reactive protein (CRP) are associated with increased risks of ischemic heart disease and ischemic cerebrovascular disease. We... |
| SourceID | proquest pubmed pascalfrancis crossref mms |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1897 |
| SubjectTerms | Atherosclerosis - blood Biological and medical sciences Biomarkers - blood Blood tests C-Reactive Protein - analysis C-Reactive Protein - genetics Cardiovascular disease Causality Cerebrovascular Disorders - blood Cerebrovascular Disorders - genetics Cohort Studies Cross-Sectional Studies Female General aspects Genetic Predisposition to Disease Genotype & phenotype Humans Male Medical sciences Myocardial Ischemia - blood Myocardial Ischemia - genetics Polymorphism, Genetic Proteins Risk Factors |
| Title | Genetically Elevated C-Reactive Protein and Ischemic Vascular Disease |
| URI | http://dx.doi.org/10.1056/NEJMoa0707402 https://www.ncbi.nlm.nih.gov/pubmed/18971492 https://www.proquest.com/docview/223926349 https://www.proquest.com/docview/69725207 |
| Volume | 359 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT9wwEB7xkBCXqlAKW-jWh4oTEYntxPGpKssiQAIhBNXeomQykUC7WdosSPz7jhPvFg7bSy5xHGvG9nzz0DcA37XKrWZLFVikONAy1EGe8nlESUUhiU1uS5l_dZ2c3-vLUTzytTmNL6uc34ntRV1O0cXIj9mMWZkobX88_Q5c0yiXXPUdNFZh3TGXuYouMzJv2KM8-vUBJE-xyf8_do3mp7mjutE-oDI3SauTSeMKJPOGZVR1zS2Wo8_WCp19hA8ePoqfnb63YIXqbdi48gnyTzB0NNJteHr8KoZjemEoWYpBcEt5e7GJG8fL8FCLvC7FBXu2rjZe_PLlqOK0S9fswP3Z8G5wHvhOCQHGRs8CUkmVhFhgmSqFESE7nsaQJYoRI1sRCz6sKKxQlzYiSbqUSCm7XtYUkn3Rz7BWT2vaA5EoZFDCXytVamR5K4sFxUXOc2qMoh4czYWVoacRd90sxlmbzo6T7J1se3C4GP7U8WcsG9hnyWc1PU6WDninlMV0klENO7G8sv25ljJ_EJtssW168G3xlk-QS4vkNU2fmyyxhkUQmh7sdqr9t9DUGt5D8st_Z96HTelJclV4AGuzP8_0lZHKrOi3-5Gf6SDqw_rJ8Prm9i8UB-Vs |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1LT9tAEB7RINFeqr6bUmAPlFMt7N21nT1UFY-gBEiEEFTcXHs8llolDq1DK35U_2Nn7XUoh_TG2evVet6zM_4GYFur1Gj2VJ5BCj0tfe2lPdZHlJRlktjl1pD5o3E0uNTHV-HVCvxp_4WxbZWtTawNdT5De0e-y27MyEhp8_n6h2eHRtniajtBo5GKE7r9zRlb9Wl4yOz9IOVR_-Jg4LmhAh6GsZ57pKIi8jHDvKcUBoSco8UxGaIQMTAF8Rn9gvwCdW4CkqRzidTjLMXEmQwtzgFb_FWtOJPpwOp-f3x2_g9elYu33ZWVA_XkL961o-1nqQXX0e4Kp3WCj6bTyrZkphVzpWjGaSyPd2u_d_QMnrqAVew1EvYcVqh8AWsjV5J_CX0LXF1fiE9uRX9Cvzh4zcWBd05pbUrFmUWC-FaKtMzFkHNp240vvrgGWHHYFIheweWDkPE1dMpZSW9BRAo5DOK3lco1MoeVwYzCLOU9NQZBFz62xErQAZfb-RmTpC6gh1Fyj7Zd2Fksv24QO5Yt3GTKJyV9ny5dcI8pi-0kx1GcNvPJ1lsuJU71q2QhqF3YWjxlnbWFmLSk2U2VRCZmEvhxF940rL07aM_ELEPy3X933oLHg4vRaXI6HJ-swxPpIHqV_x468583tMFx0jzbdNIp4OtDK8RfOKwjfQ |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEB6VIlVcEO-GvvYAnLBi76692QNCVZOoobSqEEW5GXs8lkCJU3AK6k_rv2PWXgd6CLeevV6t5z07428AXmmVWc2eKrBIcaBlqINswPqIkvJcErvcBjL_9Cw5vtAfpvF0A266f2FcW2VnExtDXSzQ3ZH32Y1ZmSht-6Xvijgfjt9f_gjcAClXaO2mabQSckLXvzl7q99Nhszq11KOR5-PjgM_YCDA2OhlQCopkxBzLAZKYUTI-ZoxZIlixMiWxOcNSwpL1IWNSJIuJNKAMxZrchk7zAO2_veNiiOnYmZq_kGu8pG3v7zy8J787X035H6ROZgd7S9zOnd4bz6vXXNmVjN_ynawxvrIt_GA40fw0Ieu4rCVtcewQdUT2Dr1xfmnMHIQ1s3V-OxajGb0i8PYQhwFnyhrjKo4d5gQ3yqRVYWYcFbt-vLFF98KK4ZtqegZXNwJEZ_DZrWoaBtEopADIn5bqUIj81pZzCnOM95TYxT14G1HrBQ9hLmbpDFLm1J6nKS3aNuDN6vlly12x7qF-0z5tKLv87ULbjFltZ3kiIoTaD7ZTsel1BuBOl2JbA8OVk9Ze11JJqtocVWniTVMgtD04EXL2r8HHVjDMiRf_nfnA9hiNUg_Ts5OduCB9Fi9KtyFzeXPK9rjgGmZ7zeiKeDrXevCH7VSJk0 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Genetically+elevated+C-reactive+protein+and+ischemic+vascular+disease&rft.jtitle=The+New+England+journal+of+medicine&rft.au=Zacho%2C+Jeppe&rft.au=Tybjaerg-Hansen%2C+Anne&rft.au=Jensen%2C+Jan+Skov&rft.au=Grande%2C+Peer&rft.date=2008-10-30&rft.eissn=1533-4406&rft.volume=359&rft.issue=18&rft.spage=1897&rft_id=info:doi/10.1056%2FNEJMoa0707402&rft_id=info%3Apmid%2F18971492&rft.externalDocID=18971492 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0028-4793&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0028-4793&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0028-4793&client=summon |